KLIFS - the structural kinase database

Searching for structures with analogs of Dezapelisib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PIK3CG (p110g)	PIK	Atypical	4wwp	A		n-{(1s)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine	Human	9200	0.40
PIK3CG (p110g)	PIK	Atypical	4wwn	A		n-{(1s)-1-[7-fluoro-2-(pyridin-2-yl)quinolin-3-yl]ethyl}-9h-purin-6-amine	Human	9226	0.41
Pik3cd (p110d)	PIK	Atypical	5ncz	A	A	4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9396	0.42
PIK3CG (p110g)	PIK	Atypical	4wwo	A		n-{(1s)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9h-purin-6-amine	Human	9190	0.52
Pik3cd (p110d)	PIK	Atypical	5ncy	A	A	4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9379	0.43
Pik3cd (p110d)	PIK	Atypical	5ncz	A	B	4-azanyl-6-[[(1~{s})-1-[6-[3-[(dimethylamino)methyl]phenyl]-3-methyl-5-oxidanylidene-[1,3]thiazolo[3,2-a]pyridin-7-yl]ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9388	0.42
Pik3cd (p110d)	PIK	Atypical	5ncy	A	B	4-azanyl-6-[[(1~{s})-1-(3-methyl-5-oxidanylidene-6-phenyl-[1,3]thiazolo[3,2-a]pyridin-7-yl)ethyl]amino]pyrimidine-5-carbonitrile	Mouse	9357	0.43