KLIFS - the structural kinase database

Searching for structures with analogs of Entospletinib.

Search results (15 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SYK	Syk	TK	4pv0	A		4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid	Human	1161	0.40
JAK2	JakA	TK	4bbe	B		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3727	0.42
BTK	Tec	TK	4ot5	A		4-tert-butyl-n-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide	Human	2913	0.41
AURKA (AurA)	Aur	Other	2xne	A		3-chloro-n-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amine	Human	7221	0.47
JAK2	JakA	TK	4bbe	C		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3649	0.42
SYK	Syk	TK	5c26	A		3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide	Human	6131	0.42
SYK	Syk	TK	6vov	B		6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine	Human	12040	0.49
AURKA (AurA)	Aur	Other	2xng	A	B	n-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide	Human	2083	0.45
SYK	Syk	TK	4puz	A		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	1163	1.00
JAK2	JakA	TK	4bbe	A		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3670	0.42
SYK	Syk	TK	4puz	B		6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine	Human	1153	1.00
AURKA (AurA)	Aur	Other	2xng	A	A	n-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide	Human	1994	0.45
SYK	Syk	TK	6vov	A		6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine	Human	12041	0.49
JAK2	JakA	TK	4bbe	D		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3726	0.42
BTK	Tec	TK	4ot6	A		4-(methylsulfonyl)-n-[3-(8-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}imidazo[1,2-a]pyrazin-6-yl)phenyl]benzamide	Human	2931	0.49