Searching for structures with analogs of Afatinib.

Search results (22 entries covering 15 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
EGFREGFRTK2ityAgefitinibHuman7900.48
EGFREGFRTK2itzAgefitinibHuman7890.48
EGFREGFRTK3ug2ABgefitinibHuman8190.48
EGFREGFRTK4i22AgefitinibHuman8230.48
EGFREGFRTK4wkqABgefitinibHuman8370.48
EGFREGFRTK4i23A(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman8700.62
EGFREGFRTK3ug2AAgefitinibHuman8980.48
EGFREGFRTK4wkqAAgefitinibHuman8890.48
EGFREGFRTK4g5jAAn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman7940.78
EGFREGFRTK4i24B(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman9100.62
EGFREGFRTK4g5pAn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman8090.78
EGFREGFRTK4g5jABn-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamideHuman8520.78
EGFREGFRTK4i24A(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamideHuman8310.62
EGFREGFRTK2itoAgefitinibHuman7830.48
PKMYT1 (MYT1)WEEOther5vcwA(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamideHuman83350.56
GAKNAKOther5y80AAgefitinibHuman103290.48
GAKNAKOther5y80ABgefitinibHuman103300.48
GAKNAKOther5y7zBgefitinibHuman103310.48
GAKNAKOther5y7zAgefitinibHuman103320.48
EGFREGFRTK5y25A(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamideHuman103730.51
PKMYT1 (MYT1)WEEOther5vcwB(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamideHuman83460.56
CDK12 (CRK7)CDKCMGC7nxkA(e)-n-[4-[(1r,3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamideHuman135470.41