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Searching for structures with analogs of
Afatinib
.
Search results (26 entries covering 18 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
EGFR
EGFR
TK
4i23
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
870
0.62
EGFR
EGFR
TK
4g5j
A
B
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
852
0.78
EGFR
EGFR
TK
7a6j
A
B
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14124
0.42
EGFR
EGFR
TK
3ug2
A
A
gefitinib
Human
898
0.48
GAK
NAK
Other
5y80
A
A
gefitinib
Human
10329
0.48
GAK
NAK
Other
5y7z
A
gefitinib
Human
10332
0.48
EGFR
EGFR
TK
4i24
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
831
0.62
GAK
NAK
Other
5y7z
B
gefitinib
Human
10331
0.48
EGFR
EGFR
TK
8f1w
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14944
0.42
EGFR
EGFR
TK
8f1y
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14940
0.42
EGFR
EGFR
TK
3ug2
A
B
gefitinib
Human
819
0.48
EGFR
EGFR
TK
2ito
A
gefitinib
Human
783
0.48
EGFR
EGFR
TK
2itz
A
gefitinib
Human
789
0.48
PKMYT1 (MYT1)
WEE
Other
5vcw
B
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
Human
8346
0.56
PKMYT1 (MYT1)
WEE
Other
5vcw
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide
Human
8335
0.56
EGFR
EGFR
TK
5y25
A
(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide
Human
10373
0.51
EGFR
EGFR
TK
4g5j
A
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
794
0.78
GAK
NAK
Other
5y80
A
B
gefitinib
Human
10330
0.48
CDK12 (CRK7)
CDK
CMGC
7nxk
A
(e)-n-[4-[(1r,3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide
Human
13547
0.41
EGFR
EGFR
TK
4i22
A
gefitinib
Human
823
0.48
EGFR
EGFR
TK
4wkq
A
A
gefitinib
Human
889
0.48
EGFR
EGFR
TK
4g5p
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
809
0.78
EGFR
EGFR
TK
4wkq
A
B
gefitinib
Human
837
0.48
EGFR
EGFR
TK
4i24
B
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
910
0.62
EGFR
EGFR
TK
2ity
A
gefitinib
Human
790
0.48
EGFR
EGFR
TK
7a6j
A
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14125
0.42
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Afatinib
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