KLIFS - the structural kinase database

Searching for structures with analogs of Afatinib.

Search results (24 entries covering 16 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	0.62
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.48
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	0.62
EGFR	EGFR	TK	4g5j	A	B	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	852	0.78
EGFR	EGFR	TK	7a6j	A	B	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14124	0.42
EGFR	EGFR	TK	7a6j	A	A	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14125	0.42
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.48
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.48
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	0.62
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.48
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.48
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.48
PKMYT1 (MYT1)	WEE	Other	5vcw	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8346	0.56
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.48
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.48
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.48
EGFR	EGFR	TK	4g5p	A		n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	809	0.78
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.48
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.48
PKMYT1 (MYT1)	WEE	Other	5vcw	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide	Human	8335	0.56
CDK12 (CRK7)	CDK	CMGC	7nxk	A		(e)-n-[4-[(1r,3r)-3-[[5-chloranyl-4-(1h-indol-3-yl)pyrimidin-2-yl]amino]cyclohexyl]oxyphenyl]-4-(dimethylamino)but-2-enamide	Human	13547	0.41
EGFR	EGFR	TK	4g5j	A	A	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	794	0.78
EGFR	EGFR	TK	5y25	A		(2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide	Human	10373	0.51
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.48