KLIFS - the structural kinase database

Searching for structures with analogs of Umbralisib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
PIK3CG (p110g)	PIK	Atypical	2v4l	A		3-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenol	Human	9237	0.43
HCK	Src	TK	3vs6	B		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	2656	0.40
HCK	Src	TK	3vs6	A		tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate	Human	2664	0.40
PIK3CA (p110a)	PIK	Atypical	6gvf	A	A	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	11659	0.42
PIK3CA (p110a)	PIK	Atypical	6gvf	A	B	5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine	Human	11658	0.42