Searching for structures with analogs of Umbralisib.
Search results (7 entries covering 5 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PIK3CG (p110g) | PIK | Atypical | 2v4l | A | 3-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenol | Human | 9237 | 0.43 | |||
| PIK3CG (p110g) | PIK | Atypical | 9gg9 | A | 3-[(1~{s})-1-[4-azanyl-3-(3-fluoranyl-5-oxidanyl-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-phenyl-isochromen-1-one | Human | 15415 | 0.52 | |||
| HCK | Src | TK | 3vs6 | A | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2664 | 0.40 | |||
| PIK3CD (p110d) | PIK | Atypical | 9gdi | A | 3-[(1s)-1-[4-azanyl-3-(3-fluoranyl-5-oxidanyl-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-4-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)isochromen-1-one | Human | 15480 | 0.45 | |||
| HCK | Src | TK | 3vs6 | B | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2656 | 0.40 | |||
| PIK3CA (p110a) | PIK | Atypical | 6gvf | A | B | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11658 | 0.42 | ||
| PIK3CA (p110a) | PIK | Atypical | 6gvf | A | A | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11659 | 0.42 |
Umbralisib
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