Searching for structures with analogs of -.

Search results (92 entries covering 33 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
JAK2JakATK4bbfB(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman37170.50
CDK2CDKCMGC1pxoAA[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman45120.53
CDK2CDKCMGC4fkoAB2-chloro-n~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n~1~,n~1~-dimethylbenzene-1,4-diamineHuman45340.45
CDK2CDKCMGC2c5vAA4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-[4-(trifluoromethyl)phenyl]pyrimidin-2-amineHuman40120.48
EGFREGFRTK5x2aCCn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95470.40
CDK2CDKCMGC2wevCB[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman38590.53
AURKA (AurA)AurOther2xneA3-chloro-n-(4-morpholin-4-ylphenyl)-6-pyridin-3-ylimidazo[1,2-a]pyrazin-8-amineHuman72210.40
CDK2CDKCMGC2c5nCBn-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamineHuman39030.49
CDK2CDKCMGC2xnbAA3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-oneHuman42170.56
CDK2CDKCMGC2wevCC[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman42880.53
CDK2CDKCMGC1pxnAA4-[4-(4-methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenolHuman43830.56
MYLK4 (SgK085)MLCKCAMK2x4fBA4-(2-amino-4-methyl-1,3-thiazol-5-yl)-n-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amineHuman48660.62
MYLK4 (SgK085)MLCKCAMK2x4fAA4-(2-amino-4-methyl-1,3-thiazol-5-yl)-n-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amineHuman48650.62
MYLK4 (SgK085)MLCKCAMK2x4fAB4-(2-amino-4-methyl-1,3-thiazol-5-yl)-n-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amineHuman48670.62
CDK2CDKCMGC3sw4ABn'-[4-(2-amino-4-methyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n,n-dimethylbenzene-1,4-diamineHuman44390.64
CDK2CDKCMGC2c5nAAn-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamineHuman40630.49
EGFREGFRTK5x2aCAn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95370.40
CDK2CDKCMGC2xnbAB3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-oneHuman40340.56
CDK2CDKCMGC4fkoAA2-chloro-n~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n~1~,n~1~-dimethylbenzene-1,4-diamineHuman44490.45
CDK2CDKCMGC3sw4AAn'-[4-(2-amino-4-methyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n,n-dimethylbenzene-1,4-diamineHuman40760.64
EGFREGFRTK5x2aAAn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95450.40
CDK2CDKCMGC2wevAA[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman40670.53
CDK2CDKCMGC2wevCA[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman45030.53
CDK2CDKCMGC3sw7AAn~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n~1~,n~1~-dimethyl-2-nitrobenzene-1,4-diamineHuman41980.43
CDK2CDKCMGC2wevAB[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman45800.53
CDK2CDKCMGC2c5nCAn-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamineHuman41610.49
JAK2JakATK4bbfC(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman36440.50
CDK2CDKCMGC2wevAC[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman40070.53
RIPK2RIPKTKL5ar8B2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamideHuman61790.41
RIPK2RIPKTKL5ar8A2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamideHuman61760.41
CDK2CDKCMGC1pxoAC[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman45460.53
MAPK1 (Erk2)MAPKCMGC5nguA2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneHuman79910.41
JAK2JakATK4bbeCn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman36490.59
JAK2JakATK4d1sAB2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamideHuman36270.44
JAK2JakATK4bbeBn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman37270.59
NEK1NEKOther4b9dBA[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman12140.53
CDK2CDKCMGC2xmyAB4-[4-(3,4-dimethyl-2-oxo-2,3-dihydro-thiazol-5-yl)-pyrimidin-2-ylamino]-n-(2-methoxy-ethyl)-benzenesulfonamideHuman39850.40
MAPK10 (JNK3)MAPKCMGC6emhAA4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105080.43
MAPK10 (JNK3)MAPKCMGC6emhBA4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105060.43
MAPK10 (JNK3)MAPKCMGC6emhCB4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105050.43
MAPK10 (JNK3)MAPKCMGC6emhDA4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman104970.43
MAPK10 (JNK3)MAPKCMGC3kvxAAn-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)anilineHuman34330.50
MAPK10 (JNK3)MAPKCMGC6emhAB4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105030.43
NEK1NEKOther4b9dBB[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman12090.53
NEK1NEKOther4b9dAA[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman12110.53
JAK2JakATK4bbfA(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman37230.50
NEK1NEKOther4b9dAB[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman12130.53
ACVR1 (ALK2)STKRTKL7nnsBAmomelotinibHuman134650.53
JAK2JakATK4bbeAn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman36700.59
CDK2CDKCMGC2vv9AB2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanolHuman38810.42
CDK2CDKCMGC2vv9AA2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanolHuman39890.42
CDK2CDKCMGC3sw7ABn~4~-[4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-yl]-n~1~,n~1~-dimethyl-2-nitrobenzene-1,4-diamineHuman45840.43
CDK2CDKCMGC1pxmAA3-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenolHuman39440.48
CDK2CDKCMGC2c5vCB4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-[4-(trifluoromethyl)phenyl]pyrimidin-2-amineHuman42090.48
EGFREGFRTK5x2aCBn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95310.40
EGFREGFRTK5x2aACn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95390.40
EGFREGFRTK5x2aBCn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95430.40
EGFREGFRTK5x26An2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95360.40
EGFREGFRTK3lzbBn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8100.46
MAPK10 (JNK3)MAPKCMGC6emhBB4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105010.43
EGFREGFRTK3lzbDn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8200.46
EGFREGFRTK5x2aABn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95300.40
CDK2CDKCMGC4ek8AA4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-(3-nitrophenyl)pyrimidin-2-amineHuman40790.42
EGFREGFRTK3lzbCn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8080.46
JAK2JakATK4bbfD(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman36630.50
EGFREGFRTK3lzbAn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8000.46
EGFREGFRTK5x2aBAn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95260.40
EGFREGFRTK5x2aBBn2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamineHuman95480.40
CDK2CDKCMGC2c5vCA4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-[4-(trifluoromethyl)phenyl]pyrimidin-2-amineHuman43840.48
CDK2CDKCMGC2c5vAB4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-[4-(trifluoromethyl)phenyl]pyrimidin-2-amineHuman43380.48
CDK2CDKCMGC4ek8AB4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-(3-nitrophenyl)pyrimidin-2-amineHuman38710.42
CDK2CDKCMGC1pxoAD[4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amineHuman41670.53
ULK3ULKOther6fdzUmomelotinibHuman103900.53
CDK2CDKCMGC2uueA4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amineHuman45151.00
CDK2CDKCMGC2xmyAA4-[4-(3,4-dimethyl-2-oxo-2,3-dihydro-thiazol-5-yl)-pyrimidin-2-ylamino]-n-(2-methoxy-ethyl)-benzenesulfonamideHuman45260.40
CDK2CDKCMGC2uueC4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amineHuman43211.00
CDK2CDKCMGC1pxpAAn-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamineHuman43160.49
CDK2CDKCMGC1pxlAA4-(2,4-dimethyl-1,3-thiazol-5-yl)-n-[4-(trifluoromethyl)phenyl]pyrimidin-2-amineHuman42330.48
JAK2JakATK4bbeDn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman37260.59
CDK2CDKCMGC2c5nABn-[4-(2,4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4-diamineHuman42230.49
ACVR1 (ALK2)STKRTKL7c3gAA~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133890.45
ACVR1 (ALK2)STKRTKL7c3gBB~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133910.45
ACVR1 (ALK2)STKRTKL7c3gBA~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133920.45
ACVR1 (ALK2)STKRTKL7nnsBBmomelotinibHuman134640.53
ACVR1 (ALK2)STKRTKL7c3gAB~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133900.45
MAPK10 (JNK3)MAPKCMGC6ekdAA4-(4-methyl-2-methylsulfanyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman104980.42
JAK2JakATK4d1sAA2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamideHuman36340.44
MAPK10 (JNK3)MAPKCMGC6emhDB4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman104960.43
MAPK10 (JNK3)MAPKCMGC6ekdAB4-(4-methyl-2-methylsulfanyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105020.42
MAPK10 (JNK3)MAPKCMGC6emhCA4-(4-methyl-1~{h}-imidazol-5-yl)-~{n}-(4-morpholin-4-ylphenyl)pyridin-2-amineHuman105070.43
MAPK10 (JNK3)MAPKCMGC3kvxABn-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)anilineHuman34300.50
MYLK4 (SgK085)MLCKCAMK2x4fBB4-(2-amino-4-methyl-1,3-thiazol-5-yl)-n-(3-dioxaziridin-3-ylphenyl)pyrimidin-2-amineHuman48680.62