KLIFS - the structural kinase database

Searching for structures with analogs of Acalabrutinib.

Search results (11 entries covering 5 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
BTK	Tec	TK	5fbo	A	B	4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6456	0.40
TNK2 (ACK)	Ack	TK	4id7	A		cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol	Human	3401	0.40
BTK	Tec	TK	6x3n	A	B	4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	12510	0.49
BTK	Tec	TK	5fbn	C	A	4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6381	0.52
BTK	Tec	TK	6x3n	A	A	4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	12514	0.49
BTK	Tec	TK	5fbo	A	A	4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6455	0.40
BTK	Tec	TK	5fbn	C	B	4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6382	0.52
Btk (BTK)	Tec	TK	8fd9	A	A	acalabrutinib	Mouse	14836	1.00
Btk (BTK)	Tec	TK	8fd9	A	B	acalabrutinib	Mouse	14835	1.00
BTK	Tec	TK	5fbn	D	A	4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6384	0.52
BTK	Tec	TK	5fbn	D	B	4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	Human	6383	0.52