KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (37 entries covering 20 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
KIT	PDGFR	TK	6gql	A		~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	10362	0.45
KIT	PDGFR	TK	6gqk	A	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10353	0.50
KIT	PDGFR	TK	6gqk	A	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10355	0.50
KIT	PDGFR	TK	6gqj	B	B	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10356	0.46
KIT	PDGFR	TK	6gqk	B	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10360	0.50
EGFR	EGFR	TK	7a6j	A	B	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14124	0.40
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.40
SLK	STE20	STE	8bem	A	B	tivozanib	Human	14486	0.45
KDR	VEGFR	TK	3wzd	A	B	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	5350	0.47
EGFR	EGFR	TK	8f1y	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14940	0.40
EGFR	EGFR	TK	8f1w	A		1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14944	0.40
KDR	VEGFR	TK	6gqo	A	B	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10583	0.46
SLK	STE20	STE	8bem	A	A	tivozanib	Human	14487	0.45
FGR	Src	TK	7uy3	A		3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-n-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide	Human	14567	0.41
ABL1	Abl	TK	8ssn	A		6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine	Human	14878	0.40
KDR	VEGFR	TK	6gqp	A	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10584	0.50
KDR	VEGFR	TK	3wzd	A	A	4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	5325	0.47
KDR	VEGFR	TK	6gqq	A	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	10581	0.45
KDR	VEGFR	TK	6gqq	A	B	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	10585	0.45
KDR	VEGFR	TK	4ase	A		tivozanib	Human	5349	0.45
KDR	VEGFR	TK	6gqp	A	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10582	0.50
KDR	VEGFR	TK	6gqo	A	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10580	0.46
FGFR1	FGFR	TK	5zv2	A		4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	10055	0.47
FGFR1	FGFR	TK	5zv2	B		4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide	Human	10054	0.47
KIT	PDGFR	TK	6gqj	A	B	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10354	0.46
KIT	PDGFR	TK	6gqj	A	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10364	0.46
KIT	PDGFR	TK	6gql	B		~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide	Human	10357	0.45
KIT	PDGFR	TK	6gqj	B	A	2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide	Human	10358	0.46
KSR2	RAF	TKL	5kkr	B		6,7-dimethoxy-~{n}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine	Human	7027	0.41
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.40
EGFR	EGFR	TK	7a6j	A	A	1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one	Human	14125	0.40
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.40
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.40
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.40
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.40
KIT	PDGFR	TK	6gqk	B	A	~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide	Human	10363	0.50
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.40