Searching for structures with analogs of Sapanisertib.

Search results (21 entries covering 16 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
PIK3CG (p110g)PIKAtypical3eneA1-methyl-3-naphthalen-2-yl-1h-pyrazolo[3,4-d]pyrimidin-4-amineHuman91880.49
PIK3CG (p110g)PIKAtypical2v4lA3-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenolHuman92370.60
MAPK1 (Erk2)MAPKCMGC4qp2A5-chloro-1,3-benzoxazol-2-amineHuman60780.40
MTOR (FRAP)PIKKAtypical8eraA1-[6-{[(3m)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1h)-yl]-3-hydroxypropan-1-oneHuman145690.46
MTOR (FRAP)PIKKAtypical4jt5A2-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-1h-indol-5-olHuman91160.49
AURKA (AurA)AurOther6hjkA(~{e})-~{n}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-but-2-enamideHuman104110.42
MTOR (FRAP)PIKKAtypical4jt5B2-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-1h-indol-5-olHuman91040.49
RETRetTK5fm2A1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamineHuman73280.43
HCKSrcTK1qcfA1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamineHuman26410.43
HCKSrcTK3vs6Btert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamateHuman26560.49
HCKSrcTK3vs6Atert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamateHuman26640.49
PIK3CA (p110a)PIKAtypical6gviAA3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamineHuman116560.78
PIK3CA (p110a)PIKAtypical6gvfAA5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amineHuman116591.00
PIK3CA (p110a)PIKAtypical6gvfAB5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amineHuman116581.00
PIK3CA (p110a)PIKAtypical6gvgA5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amineHuman116550.75
PIK3CA (p110a)PIKAtypical6gviAB3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamineHuman116540.78
PIK3CA (p110a)PIKAtypical6gvhAA5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amineHuman116570.71
PIK3CA (p110a)PIKAtypical6gvhAB5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amineHuman116530.71
RETRetTK2ivvA1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamineHuman33730.43
RETRetTK5fm3A1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamineHuman73270.43
Pik3cd (p110d)PIKAtypical2wxnA3-{[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]ethynyl}phenolMouse93650.40