| MTOR (FRAP) | PIKK | Atypical | 4jt5 | A | | 2-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-1h-indol-5-ol | Human | 9116 | 0.49 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvh | A | A | 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11657 | 0.71 | |
| PIK3CG (p110g) | PIK | Atypical | 3ene | A | | 1-methyl-3-naphthalen-2-yl-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 9188 | 0.49 | |
| PIK3CG (p110g) | PIK | Atypical | 2v4l | A | | 3-[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]phenol | Human | 9237 | 0.60 | |
| AURKA (AurA) | Aur | Other | 6hjk | A | | (~{e})-~{n}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-but-2-enamide | Human | 10411 | 0.42 | |
| RET | Ret | TK | 5fm2 | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 7328 | 0.43 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvf | A | B | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11658 | 1.00 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvf | A | A | 5-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11659 | 1.00 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvi | A | B | 3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Human | 11654 | 0.78 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvh | A | B | 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11653 | 0.71 | |
| RET | Ret | TK | 5fm3 | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 7327 | 0.43 | |
| MAPK1 (Erk2) | MAPK | CMGC | 4qp2 | A | | 5-chloro-1,3-benzoxazol-2-amine | Human | 6078 | 0.40 | |
| HCK | Src | TK | 3vs6 | B | | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2656 | 0.49 | |
| HCK | Src | TK | 1qcf | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 2641 | 0.43 | |
| HCK | Src | TK | 3vs6 | A | | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2664 | 0.49 | |
| MTOR (FRAP) | PIKK | Atypical | 8era | A | | 1-[6-{[(3m)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1h)-yl]-3-hydroxypropan-1-one | Human | 14569 | 0.46 | |
| MTOR (FRAP) | PIKK | Atypical | 4jt5 | B | | 2-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-1h-indol-5-ol | Human | 9104 | 0.49 | |
| RET | Ret | TK | 2ivv | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 3373 | 0.43 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvi | A | A | 3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Human | 11656 | 0.78 | |
| PIK3CA (p110a) | PIK | Atypical | 6gvg | A | | 5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine | Human | 11655 | 0.75 | |
| Pik3cd (p110d) | PIK | Atypical | 2wxn | A | | 3-{[4-amino-1-(1-methylethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]ethynyl}phenol | Mouse | 9365 | 0.40 | |
Match: