| EGFR | EGFR | TK | 5x2f | A | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9540 | 0.60 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | A | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8601 | 0.41 | |
| EGFR | EGFR | TK | 5x2a | A | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9545 | 0.87 | |
| EGFR | EGFR | TK | 5x2a | A | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9530 | 0.87 | |
| EGFR | EGFR | TK | 5x2f | D | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9544 | 0.60 | |
| EGFR | EGFR | TK | 5x2a | C | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9547 | 0.87 | |
| EGFR | EGFR | TK | 5uga | A | A | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7517 | 0.41 | |
| CDK2 | CDK | CMGC | 2xnb | A | A | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4217 | 0.40 | |
| EGFR | EGFR | TK | 5x2c | A | C | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9566 | 0.61 | |
| EGFR | EGFR | TK | 5x2f | D | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9528 | 0.60 | |
| EGFR | EGFR | TK | 5x2c | A | A | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9572 | 0.61 | |
| MAPK1 (Erk2) | MAPK | CMGC | 5ngu | A | | 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | Human | 7991 | 0.43 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5op2 | A | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8595 | 0.41 | |
| TNK2 (ACK) | Ack | TK | 7kp6 | A | B | 5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | Human | 14103 | 0.42 | |
| EGFR | EGFR | TK | 5x2a | A | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9539 | 0.87 | |
| EGFR | EGFR | TK | 5x28 | A | | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9538 | 0.60 | |
| EGFR | EGFR | TK | 5uga | A | B | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7511 | 0.41 | |
| EGFR | EGFR | TK | 5x2a | B | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9543 | 0.87 | |
| EGFR | EGFR | TK | 5x2f | B | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9546 | 0.60 | |
| EGFR | EGFR | TK | 5x26 | A | | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9536 | 0.87 | |
| CDK2 | CDK | CMGC | 2wih | A | | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4163 | 0.44 | |
| EGFR | EGFR | TK | 5x2a | C | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9537 | 0.87 | |
| WEE1 (Wee1) | WEE | Other | 5vda | A | | 1-{6-[(1s)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9779 | 0.46 | |
| TNK2 (ACK) | Ack | TK | 7kp6 | A | A | 5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | Human | 14104 | 0.42 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10924 | 0.44 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | B | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10925 | 0.44 | |
| SRC | Src | TK | 6ate | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10920 | 0.44 | |
| EGFR | EGFR | TK | 5x2a | C | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9531 | 0.87 | |
| EGFR | EGFR | TK | 5x2f | A | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9535 | 0.60 | |
| EGFR | EGFR | TK | 5x2a | B | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9526 | 0.87 | |
| EGFR | EGFR | TK | 5x2f | C | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9542 | 0.60 | |
| CDK2 | CDK | CMGC | 2vv9 | A | B | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3881 | 0.44 | |
| CDK2 | CDK | CMGC | 2vv9 | A | A | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3989 | 0.44 | |
| PKMYT1 (MYT1) | WEE | Other | 5vd1 | A | A | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8337 | 0.44 | |
| PKMYT1 (MYT1) | WEE | Other | 5vd0 | A | | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8344 | 0.40 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j7s | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 7429 | 0.44 | |
| MAP3K7 (TAK1) | MLK | TKL | 5e7r | A | | 2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide | Human | 7412 | 0.45 | |
| EGFR | EGFR | TK | 5x27 | A | | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9534 | 0.61 | |
| PKMYT1 (MYT1) | WEE | Other | 5vd1 | A | B | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8340 | 0.44 | |
| PLK1 | PLK | Other | 8bjt | A | | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 14712 | 0.40 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jh6 | A | | 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate | Human | 7427 | 0.44 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j8i | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 7428 | 0.48 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10937 | 0.44 | |
| MAPK1 (Erk2) | MAPK | CMGC | 6g54 | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10938 | 0.44 | |
| JAK2 | JakA | TK | 4ji9 | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3724 | 0.43 | |
| JAK2 | JakA | TK | 4d1s | A | B | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3627 | 0.42 | |
| JAK2 | JakA | TK | 5hez | C | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7253 | 0.43 | |
| JAK2 | JakA | TK | 5hez | D | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7252 | 0.43 | |
| JAK2 | JakA | TK | 4d1s | A | A | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3634 | 0.42 | |
| JAK2 | JakA | TK | 5hez | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7255 | 0.43 | |
| JAK2 | JakA | TK | 5hez | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7254 | 0.43 | |
| JAK2 | JakA | TK | 4ji9 | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3692 | 0.43 | |
| WEE1 (Wee1) | WEE | Other | 5vd9 | A | | 1-{6-[(1r)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9781 | 0.46 | |
| WEE1 (Wee1) | WEE | Other | 8bju | A | B | 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one | Human | 14754 | 0.41 | |
| WEE1 (Wee1) | WEE | Other | 5v5y | A | | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8328 | 0.40 | |
| WEE1 (Wee1) | WEE | Other | 5vc6 | A | | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8331 | 0.44 | |
| WEE1 (Wee1) | WEE | Other | 5vd4 | A | | 6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1-{6-[(1s)-2,2,2-trifluoro-1-hydroxyethyl]pyridin-2-yl}-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 9780 | 0.41 | |
| WEE1 (Wee1) | WEE | Other | 8bju | A | A | 2-(2-methoxyphenyl)-6-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-1-[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]pyrazolo[3,4-d]pyrimidin-3-one | Human | 14755 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | A | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8594 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5op2 | A | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8611 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | B | B | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8596 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq8 | A | | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8606 | 0.41 | |
| CHEK1 (CHK1) | CAMKL | CAMK | 5oq7 | B | A | 5-(4-methylpiperazin-1-yl)-2-phenylmethoxy-~{n}-pyridin-3-yl-benzamide | Human | 8605 | 0.41 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13390 | 0.51 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | B | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12160 | 0.41 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13391 | 0.51 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13392 | 0.51 | |
| LCK | Src | TK | 3byo | A | | 6-(2,6-dimethylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6h)-one | Human | 2272 | 0.45 | |
| EGFR | EGFR | TK | 5ugb | A | | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7515 | 0.41 | |
| EGFR | EGFR | TK | 5x2c | B | A | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9569 | 0.61 | |
| EGFR | EGFR | TK | 5x2c | B | C | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9570 | 0.61 | |
| EGFR | EGFR | TK | 5x2c | B | B | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9571 | 0.61 | |
| EGFR | EGFR | TK | 5x2c | A | B | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9567 | 0.61 | |
| EGFR | EGFR | TK | 5x2f | C | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9527 | 0.60 | |
| EGFR | EGFR | TK | 5x2f | B | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9541 | 0.60 | |
| EGFR | EGFR | TK | 5x2a | B | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9548 | 0.87 | |
| CDK2 | CDK | CMGC | 2xnb | A | B | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4034 | 0.40 | |
| CDK2 | CDK | CMGC | 2wih | C | | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4119 | 0.44 | |
| WEE2 (Wee1B) | WEE | Other | 5vdk | A | | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3h-pyrazolo[3,4-d]pyrimidin-3-one | Human | 8349 | 0.40 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | B | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10926 | 0.44 | |
| MAPK3 (Erk1) | MAPK | CMGC | 6ges | A | A | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10923 | 0.44 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13389 | 0.51 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | A | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12161 | 0.41 | |
Match: