KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (18 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MET	Met	TK	3dkf	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	3030	0.46
MET	Met	TK	3qti	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	2994	0.41
MET	Met	TK	3qti	B	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	3024	0.41
MET	Met	TK	3dkg	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	3019	0.46
MET	Met	TK	3zc5	A		6-{(1s)-1-[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline	Human	3003	0.43
DYRK1A	DYRK	CMGC	6s11	A	A	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11361	0.42
DYRK1A	DYRK	CMGC	6s11	B	B	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11372	0.42
DYRK1A	DYRK	CMGC	6s11	B	A	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11378	0.42
DYRK1A	DYRK	CMGC	6s11	A	B	6-pyridin-4-yl-3-[3-(trifluoromethyloxy)phenyl]imidazo[1,2-b]pyridazine	Human	11364	0.42
MET	Met	TK	5eob	A	A	6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	7100	0.67
MET	Met	TK	3zbx	A		6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	3036	0.44
MET	Met	TK	5eob	A	B	6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	Human	7101	0.67
MET	Met	TK	3dkf	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	3029	0.46
MET	Met	TK	3qti	A	B	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	3028	0.41
MET	Met	TK	3dkf	A	C	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	2984	0.46
MET	Met	TK	3dkg	A	C	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	3006	0.46
MET	Met	TK	3qti	B	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline	Human	3017	0.41
MET	Met	TK	3dkg	A	A	6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline	Human	2993	0.46