KLIFS - the structural kinase database

Searching for structures with analogs of Falnidamol.

Search results (31 entries covering 17 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	0.40
EGFR	EGFR	TK	4g5j	A	B	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	852	0.40
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.44
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.44
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.44
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	0.40
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.44
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.44
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.44
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.44
JAK2	JakA	TK	6vng	B		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	13341	0.42
JAK2	JakA	TK	6vnf	B	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13352	0.40
EGFR	EGFR	TK	4g5j	A	A	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	794	0.40
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.44
JAK2	JakA	TK	6vnh	B		n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide	Human	13342	0.42
JAK2	JakA	TK	6vnf	B	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13346	0.40
JAK2	JakA	TK	6vnh	A		n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide	Human	13344	0.42
JAK2	JakA	TK	6vni	A		2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione	Human	13294	0.41
JAK2	JakA	TK	6vnf	A	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13347	0.40
JAK2	JakA	TK	6vnl	D		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	13297	0.44
JAK2	JakA	TK	6vnl	B		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	13299	0.44
JAK2	JakA	TK	6vnl	C		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	13300	0.44
JAK2	JakA	TK	6vnf	A	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13357	0.40
JAK2	JakA	TK	6vng	A		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	13358	0.42
JAK2	JakA	TK	6vnl	A		4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide	Human	13303	0.44
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.44
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.44
EGFR	EGFR	TK	4g5p	A		n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	809	0.40
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.44
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	0.40
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.44