KLIFS - the structural kinase database

Searching for structures with analogs of Gedatolisib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
JAK2	JakA	TK	4bbe	B		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3727	0.40
PIK3CG (p110g)	PIK	Atypical	7jwe	A		gedatolisib	Human	13412	1.00
BTK	Tec	TK	5bpy	B		6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide	Human	6094	0.40
PIK3CG (p110g)	PIK	Atypical	3ibe	A		1-(4-{4-morpholin-4-yl-1-[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-6-yl}phenyl)-3-pyridin-4-ylurea	Human	9171	0.46
TTK	TTK	Other	6tn9	A	B	[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone	Human	12269	0.40
JAK2	JakA	TK	4bbe	C		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3649	0.40
JAK2	JakA	TK	4bbe	A		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3670	0.40
BTK	Tec	TK	5bpy	A		6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide	Human	6095	0.40
JAK2	JakA	TK	4bbe	D		n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide	Human	3726	0.40
TTK	TTK	Other	6tn9	A	A	[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone	Human	12271	0.40