KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (24 entries covering 17 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	7u9a	A		4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol	Human	14527	0.41
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.47
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.47
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.47
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.40
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.47
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.47
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.47
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.47
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.47
EPHB4 (EphB4)	Eph	TK	2vwu	A		n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	Human	370	0.40
MAPK14 (p38a)	MAPK	CMGC	1di9	A		4-[3-methylsulfanylanilino]-6,7-dimethoxyquinazoline	Human	5251	0.42
KSR2	RAF	TKL	5kkr	B		6,7-dimethoxy-~{n}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine	Human	7027	0.42
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.40
RET	Ret	TK	2ivu	A		4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline	Human	3364	0.64
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.47
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.47
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.47
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.47
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.40
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.40
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.40
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.40
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.40