KLIFS - the structural kinase database

Searching for structures with analogs of Midostaurin.

Search results (182 entries covering 92 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
IRAK4	IRAK	TKL	4u9a	B		staurosporine	Human	1792	0.72
IRAK4	IRAK	TKL	4u9a	A		staurosporine	Human	1751	0.72
SYK	Syk	TK	1xbc	A	A	staurosporine	Human	1165	0.72
DYRK1A	DYRK	CMGC	4nct	A		pkc412	Human	3794	1.00
IRAK4	IRAK	TKL	2oic	A		staurosporine	Human	1739	0.72
ERN1 (IRE1)	IRE	Other	4yzc	B	B	staurosporine	Human	6231	0.72
STK16 (MPSK1)	NAK	Other	2buj	A		staurosporine	Human	2229	0.72
LCK	Src	TK	1qpj	A		staurosporine	Human	2283	0.72
MAP3K5	STE11	STE	4bf2	A		staurosporine	Human	4743	0.72
CSK	Csk	TK	1byg	A		staurosporine	Human	2943	0.72
STK16 (MPSK1)	NAK	Other	2buj	B		staurosporine	Human	2230	0.72
MAP3K5	STE11	STE	2clq	B	B	staurosporine	Human	4732	0.72
IRAK4	IRAK	TKL	2oic	D		staurosporine	Human	1755	0.72
EPHB4 (EphB4)	Eph	TK	2yn8	B		staurosporine	Human	349	0.72
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	A	staurosporine	Human	13492	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	A	staurosporine	Human	9847	0.72
PIK3CG (p110g)	PIK	Atypical	1e8z	A		staurosporine	Human	9228	0.72
EGFR	EGFR	TK	2itu	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	859	0.43
MAP3K5	STE11	STE	2clq	A	B	staurosporine	Human	4736	0.72
EGFR	EGFR	TK	5xgn	A		12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole	Human	8553	0.40
EGFR	EGFR	TK	5xgm	A		12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole	Human	8552	0.40
LIMK1	LISK	TKL	3s95	A	A	staurosporine	Human	1246	0.72
LIMK1	LISK	TKL	3s95	A	B	staurosporine	Human	1248	0.72
IRAK4	IRAK	TKL	2nry	D	A	staurosporine	Human	1789	0.72
PDPK1 (PDK1)	PDK1	AGC	1okz	A		7-hydroxystaurosporine	Human	3209	0.54
EGFR	EGFR	TK	2itq	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	813	0.43
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9j	A		staurosporine	Human	10717	0.72
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rer	A		staurosporine	Human	121	0.72
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rew	A		staurosporine	Human	124	0.72
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9h	A		staurosporine	Human	10714	0.72
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9g	A		staurosporine	Human	10715	0.72
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9f	A		staurosporine	Human	10716	0.72
PDPK1 (PDK1)	PDK1	AGC	1oky	A	A	staurosporine	Human	3164	0.72
IRAK4	IRAK	TKL	2nry	B	A	staurosporine	Human	1758	0.72
Prkaa1 (AMPKa1)	CAMKL	CAMK	5ufu	A		staurosporine	Mouse	7590	0.72
EGFR	EGFR	TK	2itw	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	817	0.43
CDK2	CDK	CMGC	4ez7	A		staurosporine	Human	4240	0.72
PAK4	STE20	STE	5ved	A		staurosporine	Human	8570	0.72
ERN1 (IRE1)	IRE	Other	4yzc	A	A	staurosporine	Human	6235	0.72
IRAK4	IRAK	TKL	2nry	C	A	staurosporine	Human	1779	0.72
GSK3B	GSK	CMGC	1q3d	B		staurosporine	Human	752	0.72
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	A	staurosporine	Human	6611	0.72
MAP2K1	STE7	STE	3eqf	A		k-252a	Human	3317	0.62
EPHB4 (EphB4)	Eph	TK	2yn8	A		staurosporine	Human	352	0.72
EPHB4 (EphB4)	Eph	TK	3zew	B	B	staurosporine	Human	357	0.72
SYK	Syk	TK	1xbc	A	B	staurosporine	Human	1207	0.72
DYRK1A	DYRK	CMGC	4nct	C		pkc412	Human	3779	1.00
PKN1	PKN	AGC	4otg	A	A	lestaurtinib	Human	548	0.41
STK32A (YANK1)	YANK	AGC	4fr4	A	B	staurosporine	Human	4690	0.72
ERN1 (IRE1)	IRE	Other	4yzc	A	B	staurosporine	Human	6232	0.72
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	B	staurosporine	Human	13495	0.72
CHEK1 (CHK1)	CAMKL	CAMK	5oor	A		staurosporine	Human	8603	0.72
RIPK2	RIPK	TKL	5ng2	A	B	staurosporine	Human	8056	0.72
RIPK2	RIPK	TKL	5ng2	A	A	staurosporine	Human	8050	0.72
CHEK1 (CHK1)	CAMKL	CAMK	1nvs	A		rel-(9r,12s)-9,10,11,12-tetrahydro-9,12-epoxy-1h-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2h)-dione	Human	1591	0.40
CHEK1 (CHK1)	CAMKL	CAMK	1nvr	A		staurosporine	Human	1585	0.72
CDK2	CDK	CMGC	7nvq	A		staurosporine	Human	13627	0.72
STK24 (MST3)	STE20	STE	3ckx	A		staurosporine	Human	5599	0.72
STK24 (MST3)	STE20	STE	4qmy	A		staurosporine	Human	5592	0.72
RPS6KA1 (RSK3)	RSK	AGC	2z7r	A		staurosporine	Human	2777	0.72
CHEK1 (CHK1)	CAMKL	CAMK	1nvq	A		7-hydroxystaurosporine	Human	1642	0.54
MELK	CAMKL	CAMK	5m5a	A	A	k-252a	Human	8735	0.62
STK32A (YANK1)	YANK	AGC	4fr4	E	B	staurosporine	Human	4685	0.72
LCK	Src	TK	1qpd	A		staurosporine	Human	2267	0.72
MAP3K5	STE11	STE	2clq	A	A	staurosporine	Human	4740	0.72
MAPKAPK2	MAPKAPK	CAMK	1nxk	A		staurosporine	Human	1342	0.72
CDK2	CDK	CMGC	1pkd	A		7-hydroxystaurosporine	Human	4170	0.54
MKNK2 (MNK2)	MAPKAPK	CAMK	2hw7	A		staurosporine	Human	764	0.72
MAP2K6	STE7	STE	3fme	A		staurosporine	Human	1231	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	B	staurosporine	Human	9850	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	C		staurosporine	Human	7980	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	B	staurosporine	Human	6426	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	A	staurosporine	Human	6424	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	C		staurosporine	Human	190	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b2e	A		staurosporine	Human	9851	0.72
AAK1	NAK	Other	4wsq	B	A	k-252a	Human	3833	0.62
AAK1	NAK	Other	4wsq	B	B	k-252a	Human	3835	0.62
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	A	staurosporine	Human	9848	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	A		staurosporine	Human	7981	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	A	staurosporine	Human	6430	0.72
AAK1	NAK	Other	4wsq	A	A	k-252a	Human	3834	0.62
EGFR	EGFR	TK	2itq	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	846	0.43
TGFBR2 (TGFbR2)	STKR	TKL	5e8y	A		staurosporine	Human	6627	0.72
EGFR	EGFR	TK	2itu	A	A	1,2,3,4-tetrahydrogen staurosporine	Human	779	0.43
AAK1	NAK	Other	4wsq	A	B	k-252a	Human	3836	0.62
TTK	TTK	Other	3hmo	A		staurosporine	Human	4707	0.72
MELK	CAMKL	CAMK	5m5a	A	B	k-252a	Human	8733	0.62
PIM1	PIM	CAMK	1yhs	A		staurosporine	Human	2444	0.72
FES	Fer	TK	3cd3	A	A	staurosporine	Human	2814	0.72
FES	Fer	TK	3cbl	A	B	staurosporine	Human	2811	0.72
IRAK4	IRAK	TKL	2nry	A	A	staurosporine	Human	1753	0.72
FES	Fer	TK	3bkb	A	A	staurosporine	Human	2810	0.72
FES	Fer	TK	3bkb	A	B	staurosporine	Human	2813	0.72
CDK2	CDK	CMGC	1aq1	A		staurosporine	Human	4267	0.72
FES	Fer	TK	3cd3	A	B	staurosporine	Human	2815	0.72
ERN1 (IRE1)	IRE	Other	4yzc	B	A	staurosporine	Human	6227	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	C		staurosporine	Human	192	0.72
EPHB4 (EphB4)	Eph	TK	3zew	A	B	staurosporine	Human	377	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	A		staurosporine	Human	191	0.72
EGFR	EGFR	TK	2itw	A	B	1,2,3,4-tetrahydrogen staurosporine	Human	914	0.43
EPHB4 (EphB4)	Eph	TK	3zew	B	A	staurosporine	Human	351	0.72
CDK2	CDK	CMGC	1pkd	C		7-hydroxystaurosporine	Human	3973	0.54
Ripk4 (ANKRD3)	RIPK	TKL	5wnj	A		lestaurtinib	Mouse	9893	0.41
Ripk4 (ANKRD3)	RIPK	TKL	5wnl	A		staurosporine	Mouse	9891	0.72
CDK2	CDK	CMGC	4erw	A		staurosporine	Human	4370	0.72
LYN	Src	TK	3a4o	X		staurosporine	Human	1812	0.72
ZAP70	Syk	TK	1u59	A	A	staurosporine	Human	2734	0.72
DYRK1A	DYRK	CMGC	4nct	D		pkc412	Human	3751	1.00
ZAP70	Syk	TK	1u59	A	B	staurosporine	Human	2733	0.72
DYRK1A	DYRK	CMGC	4nct	B		pkc412	Human	3743	1.00
JAK2	JakA	TK	8bpw	A	B	lestaurtinib	Human	15039	0.41
JAK2	JakA	TK	8bpw	A	A	lestaurtinib	Human	15044	0.41
RIPK2	RIPK	TKL	5ng2	B	A	staurosporine	Human	8053	0.72
RIPK2	RIPK	TKL	5ng2	B	B	staurosporine	Human	8052	0.72
IRAK4	IRAK	TKL	4u97	A		staurosporine	Human	1754	0.72
JAK3	JakA	TK	1yvj	A	A	1,2,3,4-tetrahydrogen-staurosporine	Human	460	0.61
MASTL	MAST	AGC	5loh	B	A	staurosporine	Human	7088	0.72
MASTL	MAST	AGC	5loh	B	B	staurosporine	Human	7087	0.72
MASTL	MAST	AGC	5loh	A	B	staurosporine	Human	7085	0.72
MASTL	MAST	AGC	5loh	A	A	staurosporine	Human	7086	0.72
FES	Fer	TK	3cbl	A	A	staurosporine	Human	2808	0.72
ABL1	Abl	TK	2hz4	B		1,2,3,4-tetrahydrogen-staurosporine	Human	1058	0.61
JAK3	JakA	TK	1yvj	A	B	1,2,3,4-tetrahydrogen-staurosporine	Human	451	0.61
GSK3B	GSK	CMGC	1q3d	A		staurosporine	Human	705	0.72
ALK	ALK	TK	3lcs	A	A	staurosporine	Human	5381	0.72
MAP3K5	STE11	STE	2clq	B	A	staurosporine	Human	4755	0.72
MAP3K5	STE11	STE	4bf2	B		staurosporine	Human	4745	0.72
ALK	ALK	TK	3lcs	A	B	staurosporine	Human	5376	0.72
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	B	staurosporine	Human	6617	0.72
STK32A (YANK1)	YANK	AGC	4fr4	B	A	staurosporine	Human	4692	0.72
STK32A (YANK1)	YANK	AGC	4fr4	C	A	staurosporine	Human	4684	0.72
IRAK4	IRAK	TKL	2oic	B		staurosporine	Human	1752	0.72
PDPK1 (PDK1)	PDK1	AGC	1oky	A	B	staurosporine	Human	3195	0.72
IRAK4	IRAK	TKL	4u97	B		staurosporine	Human	1742	0.72
LIMK1	LISK	TKL	3s95	B	B	staurosporine	Human	1247	0.72
LIMK1	LISK	TKL	3s95	B	A	staurosporine	Human	1245	0.72
PRKCQ (PKCt)	PKC	AGC	1xjd	A		staurosporine	Human	5357	0.72
ITK	Tec	TK	1sm2	A		staurosporine	Human	74	0.72
ITK	Tec	TK	1snu	A		staurosporine	Human	82	0.72
IRAK4	IRAK	TKL	2nry	D	B	staurosporine	Human	1746	0.72
ITK	Tec	TK	1sm2	B		staurosporine	Human	73	0.72
IRAK4	IRAK	TKL	2nry	C	B	staurosporine	Human	1750	0.72
ITK	Tec	TK	1snu	B		staurosporine	Human	33	0.72
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	A	staurosporine	Human	13490	0.72
IRAK4	IRAK	TKL	2nry	B	B	staurosporine	Human	1772	0.72
IRAK4	IRAK	TKL	2oic	C		staurosporine	Human	1734	0.72
IRAK4	IRAK	TKL	2nry	A	B	staurosporine	Human	1777	0.72
STK32A (YANK1)	YANK	AGC	4fr4	B	B	staurosporine	Human	4695	0.72
PKN1	PKN	AGC	4otg	A	B	lestaurtinib	Human	549	0.41
STK32A (YANK1)	YANK	AGC	4fr4	F	B	staurosporine	Human	4686	0.72
CSK	Csk	TK	3d7t	A		staurosporine	Human	2941	0.72
DAPK1	DAPK	CAMK	1wvy	A		staurosporine	Human	5661	0.72
STK32A (YANK1)	YANK	AGC	4fr4	E	A	staurosporine	Human	4689	0.72
STK32A (YANK1)	YANK	AGC	4fr4	C	B	staurosporine	Human	4694	0.72
STK32A (YANK1)	YANK	AGC	4fr4	D	A	staurosporine	Human	4688	0.72
STK32A (YANK1)	YANK	AGC	4fr4	F	A	staurosporine	Human	4691	0.72
EPHB4 (EphB4)	Eph	TK	3zew	A	A	staurosporine	Human	373	0.72
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	B	staurosporine	Human	13496	0.72
STK32A (YANK1)	YANK	AGC	4fr4	D	B	staurosporine	Human	4687	0.72
STK32A (YANK1)	YANK	AGC	4fr4	A	A	staurosporine	Human	4693	0.72
MAPKAPK2	MAPKAPK	CAMK	1nxk	C		staurosporine	Human	1312	0.72
MAPKAPK2	MAPKAPK	CAMK	1nxk	D		staurosporine	Human	1334	0.72
MAPKAPK2	MAPKAPK	CAMK	2pzy	C		staurosporine	Human	1279	0.72
MAPKAPK2	MAPKAPK	CAMK	1nxk	B		staurosporine	Human	1292	0.72
FES	Fer	TK	3bkb	A	C	staurosporine	Human	2812	0.72
PAK1	STE20	STE	2hy8	1		(5s,6r,7r,9r)-12-hydroxy-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9-tetrahydro-5h,14h-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-one	Human	172	0.48
IKBKB (IKKb)	IKK	Other	4kik	B	B	k-252a	Human	293	0.62
IKBKB (IKKb)	IKK	Other	4kik	A	A	k-252a	Human	290	0.62
IKBKB (IKKb)	IKK	Other	4kik	B	A	k-252a	Human	295	0.62
IKBKB (IKKb)	IKK	Other	4kik	A	B	k-252a	Human	288	0.62
FYN	Src	TK	2dq7	X		staurosporine	Human	1941	0.72
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	B	staurosporine	Human	6614	0.72
RPS6KB1 (p70S6K)	RSK	AGC	3a62	A		staurosporine	Human	1867	0.72
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	A	staurosporine	Human	6615	0.72
RPS6KB1 (p70S6K)	RSK	AGC	3a61	A		staurosporine	Human	1846	0.72
RPS6KB1 (p70S6K)	RSK	AGC	4rlo	B		staurosporine	Human	7220	0.72
RPS6KB1 (p70S6K)	RSK	AGC	3a60	B		staurosporine	Human	1856	0.72
RPS6KB1 (p70S6K)	RSK	AGC	3a60	A		staurosporine	Human	1852	0.72
MET	Met	TK	1r0p	A		k-252a	Human	2991	0.62
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	B	staurosporine	Human	9849	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	A		staurosporine	Human	195	0.72
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	B	staurosporine	Human	6428	0.72