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Searching for structures with analogs of
Poziotinib
.
Search results (30 entries covering 20 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
EGFR
EGFR
TK
7u9a
A
4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol
Human
14527
0.42
EGFR
EGFR
TK
4i23
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
870
0.44
EGFR
EGFR
TK
4g5j
A
B
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
852
0.45
EGFR
EGFR
TK
4i24
B
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
910
0.44
EGFR
EGFR
TK
7a6j
A
B
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14124
0.81
EGFR
EGFR
TK
7a6j
A
A
1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one
Human
14125
0.81
EGFR
EGFR
TK
3ug2
A
A
gefitinib
Human
898
0.44
EGFR
EGFR
TK
2ity
A
gefitinib
Human
790
0.44
GAK
NAK
Other
5y80
A
A
gefitinib
Human
10329
0.44
GAK
NAK
Other
5y80
A
B
gefitinib
Human
10330
0.44
GAK
NAK
Other
5y7z
A
gefitinib
Human
10332
0.44
EGFR
EGFR
TK
4i24
A
(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide
Human
831
0.44
CDK2
CDK
CMGC
1di8
A
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
4577
0.44
GAK
NAK
Other
5y7z
B
gefitinib
Human
10331
0.44
EPHB4 (EphB4)
Eph
TK
2vwu
A
n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Human
370
0.42
RET
Ret
TK
5amn
A
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
6412
0.44
EGFR
EGFR
TK
4i22
A
gefitinib
Human
823
0.44
EGFR
EGFR
TK
2itz
A
gefitinib
Human
789
0.44
EGFR
EGFR
TK
4wkq
A
A
gefitinib
Human
889
0.44
EGFR
EGFR
TK
4g5p
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
809
0.45
EGFR
EGFR
TK
3ug2
A
B
gefitinib
Human
819
0.44
EGFR
EGFR
TK
2ito
A
gefitinib
Human
783
0.44
TTBK1
TTBK
CK1
4btk
A
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
771
0.44
RET
Ret
TK
2ivu
A
4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline
Human
3364
0.44
EGFR
EGFR
TK
4wkq
A
B
gefitinib
Human
837
0.44
EGFR
EGFR
TK
4g5j
A
A
n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide
Human
794
0.45
TTBK2
TTBK
CK1
6u0k
A
A
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
12046
0.44
TTBK2
TTBK
CK1
6u0k
A
B
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
12048
0.44
TTBK2
TTBK
CK1
6u0k
B
B
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
12047
0.44
TTBK2
TTBK
CK1
6u0k
B
A
4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline
Human
12049
0.44
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Poziotinib
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