KLIFS - the structural kinase database

Searching for structures with analogs of Palbociclib.

Search results (21 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	5x2f	A	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9540	0.41
EGFR	EGFR	TK	5x2f	D	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9544	0.41
EGFR	EGFR	TK	5x2c	A	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9566	0.42
EGFR	EGFR	TK	5x2f	D	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9528	0.41
EGFR	EGFR	TK	5x2c	A	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9572	0.42
CDK6	CDK	CMGC	3nux	A		4-[5-chloro-3-(1-methylethyl)-1h-pyrazol-4-yl]-n-(5-piperazin-1-ylpyridin-2-yl)pyrimidin-2-amine	Human	2807	0.42
CDK6	CDK	CMGC	5l2t	A		7-cyclopentyl-n,n-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7h-pyrrolo[2,3-d]pyrimidine-6-carboxamide	Human	6992	0.63
CDK6	CDK	CMGC	2euf	B		6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	2804	1.00
EGFR	EGFR	TK	5x28	A		9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9538	0.41
EGFR	EGFR	TK	5x2f	B	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9546	0.41
EGFR	EGFR	TK	5x2f	A	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9535	0.41
EGFR	EGFR	TK	5x2f	C	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9542	0.41
EGFR	EGFR	TK	5x27	A		9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9534	0.42
CDK6	CDK	CMGC	4tth	B		9-cyclopentyl-n-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine	Human	2803	0.62
CDK6	CDK	CMGC	5l2i	A		6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7(8h)-one	Human	6991	1.00
EGFR	EGFR	TK	5x2c	B	A	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9569	0.42
EGFR	EGFR	TK	5x2c	B	C	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9570	0.42
EGFR	EGFR	TK	5x2c	B	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9571	0.42
EGFR	EGFR	TK	5x2c	A	B	9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9567	0.42
EGFR	EGFR	TK	5x2f	C	A	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9527	0.41
EGFR	EGFR	TK	5x2f	B	B	9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine	Human	9541	0.41