KLIFS - the structural kinase database

Searching for structures with analogs of Asnuciclib.

Search results (33 entries covering 12 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK2	CDK	CMGC	4bck	A	C	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4433	0.77
CDK2	CDK	CMGC	4bck	A	A	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4095	0.77
CDK2	CDK	CMGC	4bcp	C	A	2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	3872	0.47
CDK2	CDK	CMGC	4bcn	A	B	2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4298	0.56
CDK2	CDK	CMGC	4bcp	A	B	2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4304	0.47
CDK2	CDK	CMGC	4bco	A	A	2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	3988	0.47
CDK2	CDK	CMGC	4bcn	C	A	2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4436	0.56
CDK2	CDK	CMGC	1pxn	A	A	4-[4-(4-methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	Human	4383	0.41
CDK2	CDK	CMGC	4bcp	C	B	2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4501	0.47
CDK2	CDK	CMGC	4bck	A	B	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	3960	0.77
CDK2	CDK	CMGC	4bcq	C	A	4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile	Human	3996	0.50
CDK2	CDK	CMGC	4bck	C	A	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4268	0.77
CDK2	CDK	CMGC	4bck	C	B	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4506	0.77
CDK2	CDK	CMGC	4bco	A	B	2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4051	0.47
CDK2	CDK	CMGC	4bck	C	D	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4080	0.77
CDK2	CDK	CMGC	4bco	C	B	2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4018	0.47
CDK2	CDK	CMGC	4bck	C	C	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4029	0.77
CDK2	CDK	CMGC	4bcq	A	B	4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile	Human	4415	0.50
CDK9	CDK	CMGC	4bcj	A		2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	2247	0.56
CDK9	CDK	CMGC	4bci	A		3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	2243	0.77
CDK9	CDK	CMGC	4bcf	A		2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	2257	0.47
CDK2	CDK	CMGC	4bcn	A	A	2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4084	0.56
CDK2	CDK	CMGC	4bcp	A	A	2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4552	0.47
CDK2	CDK	CMGC	4bck	A	D	3-[[5-cyano-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidin-2-yl]amino]benzenesulfonamide	Human	4563	0.77
CDK2	CDK	CMGC	4bcn	C	B	2-[(3-hydroxyphenyl)amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4150	0.56
CDK2	CDK	CMGC	4bcq	A	A	4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile	Human	4396	0.50
CDK2	CDK	CMGC	4bcq	C	B	4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]-2-{[3-(morpholin-4-ylcarbonyl)phenyl]amino}pyrimidine-5-carbonitrile	Human	4120	0.50
CDK2	CDK	CMGC	4bco	C	A	2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	4333	0.47
CDK9	CDK	CMGC	4bcg	A		2-[[3-(1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile	Human	2255	0.47
ITK	Tec	TK	3qgw	A	B	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	57	0.43
ITK	Tec	TK	3qgy	A	B	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	72	0.43
ITK	Tec	TK	3qgy	A	A	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	35	0.43
ITK	Tec	TK	3qgw	A	A	3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide	Human	11	0.43