| KIT | PDGFR | TK | 1t46 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 404 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | B | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5705 | 0.53 | |
| Abl1 (ABL1) | Abl | TK | 1iep | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5703 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5723 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10610 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3mss | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5730 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5734 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5722 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5733 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10611 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10648 | 0.78 | |
| MAPK11 (p38b) | MAPK | CMGC | 3gp0 | A | A | nilotinib | Human | 2768 | 0.42 | |
| MAPK11 (p38b) | MAPK | CMGC | 3gp0 | A | B | nilotinib | Human | 2764 | 0.42 | |
| ABL1 | Abl | TK | 6npu | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10942 | 0.78 | |
| DDR1 | DDR | TK | 4bkj | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3263 | 0.78 | |
| ABL1 | Abl | TK | 5mo4 | A | B | nilotinib | Human | 7526 | 0.42 | |
| DDR1 | DDR | TK | 4bkj | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3259 | 0.78 | |
| CSF1R (FMS) | PDGFR | TK | 4r7i | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2307 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5708 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10645 | 0.78 | |
| DDR1 | DDR | TK | 4bkj | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3255 | 0.78 | |
| ABL1 | Abl | TK | 3pyy | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1049 | 0.78 | |
| ALK | ALK | TK | 5iug | A | A | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6640 | 0.42 | |
| ALK | ALK | TK | 5iui | A | B | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6642 | 0.44 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | B | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14655 | 0.44 | |
| MAPK8 (JNK1) | MAPK | CMGC | 8x5m | A | B | 3-[4-(dimethylamino)butanoylamino]-~{n}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | Human | 15100 | 0.41 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | A | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14645 | 0.44 | |
| MAPK8 (JNK1) | MAPK | CMGC | 8x5m | A | A | 3-[4-(dimethylamino)butanoylamino]-~{n}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | Human | 15099 | 0.41 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5713 | 0.78 | |
| ABL1 | Abl | TK | 3cs9 | B | B | nilotinib | Human | 1112 | 0.42 | |
| ABL1 | Abl | TK | 6npv | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10949 | 0.78 | |
| ABL1 | Abl | TK | 2hyy | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1048 | 0.78 | |
| ABL1 | Abl | TK | 6npv | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10948 | 0.78 | |
| ABL1 | Abl | TK | 3pyy | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1098 | 0.78 | |
| ABL1 | Abl | TK | 3pyy | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1071 | 0.78 | |
| ABL1 | Abl | TK | 6npe | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10947 | 0.78 | |
| ABL1 | Abl | TK | 2hyy | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1078 | 0.78 | |
| ABL1 | Abl | TK | 6npv | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10950 | 0.78 | |
| ABL1 | Abl | TK | 6npe | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10945 | 0.78 | |
| ABL1 | Abl | TK | 3cs9 | C | A | nilotinib | Human | 1046 | 0.42 | |
| ABL1 | Abl | TK | 2hyy | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1092 | 0.78 | |
| ABL1 | Abl | TK | 3pyy | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1062 | 0.78 | |
| ABL1 | Abl | TK | 3cs9 | C | B | nilotinib | Human | 1093 | 0.42 | |
| ABL1 | Abl | TK | 3cs9 | D | B | nilotinib | Human | 1066 | 0.42 | |
| ABL1 | Abl | TK | 3cs9 | A | A | nilotinib | Human | 1080 | 0.42 | |
| ABL1 | Abl | TK | 2e2b | A | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1054 | 0.52 | |
| ABL1 | Abl | TK | 6npu | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10944 | 0.78 | |
| ABL1 | Abl | TK | 5mo4 | A | A | nilotinib | Human | 7527 | 0.42 | |
| ABL1 | Abl | TK | 2hyy | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1068 | 0.78 | |
| ABL1 | Abl | TK | 6npe | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10943 | 0.78 | |
| ABL1 | Abl | TK | 6npv | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10951 | 0.78 | |
| ABL1 | Abl | TK | 6npe | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10946 | 0.78 | |
| ABL1 | Abl | TK | 3cs9 | A | B | nilotinib | Human | 1107 | 0.42 | |
| ABL1 | Abl | TK | 3cs9 | B | A | nilotinib | Human | 1050 | 0.42 | |
| SYK | Syk | TK | 1xbb | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1196 | 0.78 | |
| SYK | Syk | TK | 1xbb | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1184 | 0.78 | |
| SRC | Src | TK | 1y57 | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide | Human | 986 | 0.64 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5166 | 0.78 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hec | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 5035 | 0.78 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | B | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9478 | 0.51 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | A | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9479 | 0.51 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6jol | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 12103 | 0.78 | |
| KIT | PDGFR | TK | 1t46 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 393 | 0.78 | |
| ABL2 | Abl | TK | 3gvu | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 109 | 0.78 | |
| ABL2 | Abl | TK | 3gvu | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 117 | 0.78 | |
| LCK | Src | TK | 2pl0 | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2290 | 0.78 | |
| ALK | ALK | TK | 5iui | A | A | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6641 | 0.44 | |
| ALK | ALK | TK | 5iug | A | B | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6639 | 0.42 | |
| ALK | ALK | TK | 5iuh | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1h-pyrazol-5-yl}benzamide | Human | 6638 | 0.46 | |
| Abl1 (ABL1) | Abl | TK | 1opj | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5732 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3mss | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5719 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10608 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 1iep | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5727 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 1opj | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5736 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd6 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10609 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3ms9 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5706 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3mss | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5702 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 1fpu | A | | n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamide | Mouse | 5728 | 0.53 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10646 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 6hd4 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 10647 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3k5v | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5710 | 0.78 | |
| Abl1 (ABL1) | Abl | TK | 3mss | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Mouse | 5724 | 0.78 | |
| DDR1 | DDR | TK | 4bkj | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3256 | 0.78 | |
| ABL1 | Abl | TK | 2e2b | B | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1065 | 0.52 | |
| ABL1 | Abl | TK | 3cs9 | D | A | nilotinib | Human | 1077 | 0.42 | |
Match: