| PTK2 (FAK) | FAK | TK | 6yoj | A | B | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{h}-quinolin-2-one | Human | 13316 | 0.59 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | C | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13324 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yxv | A | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13336 | 0.46 | |
| PTK2B (PYK2) | FAK | TK | 3h3c | A | | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 96 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 3bz3 | A | A | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 228 | 1.00 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | A | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13327 | 0.89 | |
| PTK2B (PYK2) | FAK | TK | 3fzr | A | | n-methyl-n-{2-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide | Human | 87 | 0.81 | |
| PTK2B (PYK2) | FAK | TK | 3et7 | A | | 5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2h-indol-2-one | Human | 90 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yxv | D | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13308 | 0.46 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | C | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13311 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | D | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13314 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yvs | D | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13318 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yt6 | B | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13272 | 0.74 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | A | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13332 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | D | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13333 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yvs | B | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13335 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yvs | C | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13307 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yvy | B | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13267 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yvs | D | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13309 | 0.66 | |
| MELK | CAMKL | CAMK | 5mah | A | A | ~{n}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | Human | 8729 | 0.52 | |
| MELK | CAMKL | CAMK | 5mah | A | B | ~{n}-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | Human | 8734 | 0.52 | |
| PTK2 (FAK) | FAK | TK | 6yvs | A | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13310 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | B | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13312 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | A | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13313 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yvy | C | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13268 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | C | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13315 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 3bz3 | A | B | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 227 | 1.00 | |
| PTK2 (FAK) | FAK | TK | 6yvy | C | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13269 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | B | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13317 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yvy | A | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13270 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yoj | A | A | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{h}-quinolin-2-one | Human | 13319 | 0.59 | |
| PTK2 (FAK) | FAK | TK | 6yt6 | B | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13271 | 0.74 | |
| PTK2 (FAK) | FAK | TK | 6yvs | C | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13320 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | D | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13321 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yxv | C | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13322 | 0.46 | |
| PTK2 (FAK) | FAK | TK | 6yvs | A | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13323 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | A | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13325 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | B | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13326 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yvy | D | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13273 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | B | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13328 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yxv | B | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13329 | 0.46 | |
| PTK2 (FAK) | FAK | TK | 6yvy | D | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13274 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | D | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13330 | 0.89 | |
| PTK2 (FAK) | FAK | TK | 6yvs | B | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13331 | 0.66 | |
| PTK2 (FAK) | FAK | TK | 6yvy | A | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13275 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | C | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13334 | 0.58 | |
| PTK2 (FAK) | FAK | TK | 6yvy | B | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13276 | 0.40 | |
| PTK2B (PYK2) | FAK | TK | 8xox | A | A | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 15171 | 1.00 | |
| PTK2B (PYK2) | FAK | TK | 5tob | A | | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 8686 | 1.00 | |
| PTK2B (PYK2) | FAK | TK | 8xox | A | B | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 15172 | 1.00 | |
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