KLIFS - the structural kinase database

Searching for structures with analogs of Deuruxolitinib.

Search results (31 entries covering 13 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
JAK2	JakA	TK	6vnc	B		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13348	0.44
JAK2	JakA	TK	6wto	A	B	baricitinib	Human	13539	0.51
JAK2	JakA	TK	6vgl	A		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13223	0.71
JAK2	JakA	TK	6vnc	A		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13359	0.44
JAK1	JakA	TK	6sm8	A	A	2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile	Human	12248	0.58
JAK1	JakA	TK	6sm8	B	B	2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile	Human	12249	0.58
JAK1	JakA	TK	6sm8	A	B	2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile	Human	12250	0.58
JAK2	JakA	TK	6vsn	C		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13350	0.71
JAK2	JakA	TK	6wtn	A	B	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13540	0.71
JAK2	JakA	TK	6vs3	A		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13349	0.44
JAK2	JakA	TK	6vs3	B		(3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13345	0.44
JAK2	JakA	TK	6vsn	A		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13353	0.71
JAK2	JakA	TK	6vsn	B		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13356	0.71
JAK1	JakA	TK	6sm8	B	A	2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile	Human	12245	0.58
JAK2	JakA	TK	6vnk	D		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13292	0.71
JAK2	JakA	TK	6vnk	A		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13293	0.71
JAK2	JakA	TK	6vgl	D		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13220	0.71
DCLK1	DCAMKL	CAMK	7f3g	A		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13853	0.71
JAK2	JakA	TK	6vgl	C		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13221	0.71
JAK2	JakA	TK	6vnk	C		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13304	0.71
JAK2	JakA	TK	8bxc	A	A	itacitinib	Human	15037	0.42
JAK2	JakA	TK	8bxc	A	B	itacitinib	Human	15041	0.42
BMP2K (BIKE)	NAK	Other	4w9x	A		baricitinib	Human	3273	0.51
JAK2	JakA	TK	6wtn	A	A	(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13538	0.71
JAK2	JakA	TK	6vn8	B		baricitinib	Human	13301	0.51
JAK2	JakA	TK	6vnb	A		(3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13298	0.44
JAK2	JakA	TK	6vnk	B		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13295	0.71
JAK2	JakA	TK	6vsn	D		(3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13343	0.71
JAK2	JakA	TK	6vn8	A		baricitinib	Human	13291	0.51
JAK2	JakA	TK	6vgl	B		(3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile	Human	13222	0.71
JAK2	JakA	TK	6wto	A	A	baricitinib	Human	13536	0.51