KLIFS - the structural kinase database

Searching for structures with analogs of Avotaciclib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CLK1	CLK	CMGC	6r3d	A		4-[6,7-bis(chloranyl)-1~{h}-indol-3-yl]pyrimidin-2-amine	Human	12128	0.44
CDK2	CDK	CMGC	4fkl	A	B	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4134	0.40
CDK2	CDK	CMGC	2c5o	C	A	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4414	0.40
CDK2	CDK	CMGC	2c5o	A	A	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4388	0.40
CDK2	CDK	CMGC	3bhv	C	A	9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol	Human	4353	0.42
CDK2	CDK	CMGC	3bhv	A	A	9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol	Human	4531	0.42
CDK2	CDK	CMGC	1pxi	A	A	4-(2,5-dichlorothien-3-yl)pyrimidin-2-amine	Human	4381	0.45
CDK2	CDK	CMGC	4fkl	A	A	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4583	0.40
CDK2	CDK	CMGC	2c5o	A	B	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4440	0.40
CDK2	CDK	CMGC	3bhv	C	B	9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol	Human	4529	0.42
PDPK1 (PDK1)	PDK1	AGC	3nun	A	B	6-(2-aminopyrimidin-4-yl)-1h-indazol-3-amine	Human	3216	0.41
CLK1	CLK	CMGC	7o9y	A		4-(1~{h}-indol-3-yl)pyrimidin-2-amine	Human	14208	0.41
CDK2	CDK	CMGC	3bhv	A	B	9-amino-5-(2-aminopyrimidin-4-yl)pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidin-4-ol	Human	4001	0.42
CDK2	CDK	CMGC	1pxj	A	A	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	3927	0.40
CDK2	CDK	CMGC	2c5o	C	B	4-(2,4-dimethyl-1,3-thiazol-5-yl)pyrimidin-2-amine	Human	4050	0.40
PDPK1 (PDK1)	PDK1	AGC	3nun	A	A	6-(2-aminopyrimidin-4-yl)-1h-indazol-3-amine	Human	3183	0.41