KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (21 entries covering 13 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
LCK	Src	TK	3kmm	A		3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one	Human	2265	0.43
WEE1 (Wee1)	WEE	Other	9d0q	A		1-[(6r)-6-(2,6-dichlorophenyl)-8-methyl-2-[4-(4-methylpiperazin-1-yl)anilino]-7,8-dihydropteridin-5(6h)-yl]ethan-1-one	Human	15664	0.41
EGFR	EGFR	TK	6jrx	A		n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide	Human	12157	0.44
EGFR	EGFR	TK	5zto	A		n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide	Human	11070	0.44
EGFR	EGFR	TK	6jrj	A		6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one	Human	12158	0.41
TNK2 (ACK)	Ack	TK	8hmt	A	A	6-(2-bromophenyl)-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[[(2s)-oxolan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Human	15009	0.41
TNK2 (ACK)	Ack	TK	8hmt	A	B	6-(2-bromophenyl)-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[[(2s)-oxolan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one	Human	15010	0.41
ABL1	Abl	TK	2hzi	A	B	6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one	Human	1087	0.41
JAK2	JakA	TK	6vnf	B	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13346	0.44
JAK2	JakA	TK	6vnf	A	A	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13347	0.44
ABL1	Abl	TK	2hzi	A	A	6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one	Human	1102	0.41
JAK2	JakA	TK	6vng	B		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	13341	0.43
JAK2	JakA	TK	6vnf	B	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13352	0.44
WEE1 (Wee1)	WEE	Other	9d0s	A		(8p)-3-(2,6-dichlorophenyl)-1-methyl-8-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]-1,2,3,7-tetrahydro-4h-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-4-one	Human	15668	0.48
EGFR	EGFR	TK	6jrk	A		6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one	Human	12159	0.41
ABL1	Abl	TK	2hzi	B	A	6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one	Human	1108	0.41
ABL1	Abl	TK	2hzi	B	B	6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one	Human	1055	0.41
JAK2	JakA	TK	6vnf	A	B	n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine	Human	13357	0.44
JAK2	JakA	TK	6vng	A		n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide	Human	13358	0.43
MAPK14 (p38a)	MAPK	CMGC	3fsf	A		3-(2,6-dichlorophenyl)-7-({4-[(diethylamino)methoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one	Human	5097	0.44
BTK	Tec	TK	3pj1	A		3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one	Human	2904	0.43