KLIFS - the structural kinase database

Searching for structures with analogs of Buparlisib.

Search results (12 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
Pik3cd (p110d)	PIK	Atypical	7r26	A		5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine	Mouse	14231	1.00
PIK3CA (p110a)	PIK	Atypical	7tz7	A	A	(4s,5r)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one	Human	14223	0.48
PIK3CG (p110g)	PIK	Atypical	5jhb	A		[1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol	Human	9238	0.58
PIK3CG (p110g)	PIK	Atypical	5jha	A		[1-{4-[6-amino-4-(trifluoromethyl)pyridin-3-yl]-6-(morpholin-4-yl)pyrimidin-2-yl}-3-(chloromethyl)azetidin-3-yl]methanol	Human	9246	0.76
Pik3cd (p110d)	PIK	Atypical	7r2b	A		(4~{s})-3-[6-[2-azanyl-4-(trifluoromethyl)pyrimidin-5-yl]-2-morpholin-4-yl-pyrimidin-4-yl]-4-methyl-1,3-oxazolidin-2-one	Mouse	14230	0.51
PIK3CA (p110a)	PIK	Atypical	7tz7	A	B	(4s,5r)-3-[2'-amino-2-(morpholin-4-yl)-4'-(trifluoromethyl)[4,5'-bipyrimidin]-6-yl]-4-(hydroxymethyl)-5-methyl-1,3-oxazolidin-2-one	Human	14222	0.48
PIK3CG (p110g)	PIK	Atypical	5oq4	A	A	5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine	Human	9244	0.73
PDPK1 (PDK1)	PDK1	AGC	3qcs	A	B	6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2h-indazol-3-amine	Human	3157	0.40
PIK3CA (p110a)	PIK	Atypical	6oac	A		4-(difluoromethyl)-5-{4-[(3s)-3-methylmorpholin-4-yl]-6-(morpholin-4-yl)-1,3,5-triazin-2-yl}pyridin-2-amine	Human	11381	0.44
PIK3CG (p110g)	PIK	Atypical	5oq4	A	B	5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine	Human	9203	0.73
PIK3CG (p110g)	PIK	Atypical	3sd5	A		5-[2,6-di(morpholin-4-yl)pyrimidin-4-yl]-4-(trifluoromethyl)pyridin-2-amine	Human	9243	1.00
PDPK1 (PDK1)	PDK1	AGC	3qcs	A	A	6-[2-amino-6-(morpholin-4-yl)pyrimidin-4-yl]-2h-indazol-3-amine	Human	3179	0.40