KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (163 entries covering 79 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
IRAK4	IRAK	TKL	4u9a	A		staurosporine	Human	1751	0.50
IRAK4	IRAK	TKL	4u9a	B		staurosporine	Human	1792	0.50
SYK	Syk	TK	1xbc	A	A	staurosporine	Human	1165	0.50
DYRK1A	DYRK	CMGC	4nct	A		pkc412	Human	3794	0.49
IRAK4	IRAK	TKL	2oic	A		staurosporine	Human	1739	0.50
ERN1 (IRE1)	IRE	Other	4yzc	B	B	staurosporine	Human	6231	0.50
STK16 (MPSK1)	NAK	Other	2buj	A		staurosporine	Human	2229	0.50
LCK	Src	TK	1qpj	A		staurosporine	Human	2283	0.50
MAP3K5	STE11	STE	4bf2	A		staurosporine	Human	4743	0.50
CSK	Csk	TK	1byg	A		staurosporine	Human	2943	0.50
STK16 (MPSK1)	NAK	Other	2buj	B		staurosporine	Human	2230	0.50
MAP3K5	STE11	STE	2clq	B	B	staurosporine	Human	4732	0.50
IRAK4	IRAK	TKL	2oic	D		staurosporine	Human	1755	0.50
EPHB4 (EphB4)	Eph	TK	2yn8	B		staurosporine	Human	349	0.50
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	A	staurosporine	Human	13492	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	A	staurosporine	Human	9847	0.50
PIK3CG (p110g)	PIK	Atypical	1e8z	A		staurosporine	Human	9228	0.50
MAP3K5	STE11	STE	2clq	A	B	staurosporine	Human	4736	0.50
LIMK1	LISK	TKL	3s95	A	B	staurosporine	Human	1248	0.50
IRAK4	IRAK	TKL	2nry	D	A	staurosporine	Human	1789	0.50
LIMK1	LISK	TKL	3s95	A	A	staurosporine	Human	1246	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9j	A		staurosporine	Human	10717	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rer	A		staurosporine	Human	121	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	4rew	A		staurosporine	Human	124	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9g	A		staurosporine	Human	10715	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9h	A		staurosporine	Human	10714	0.50
PRKAA1 (AMPKa1)	CAMKL	CAMK	6c9f	A		staurosporine	Human	10716	0.50
IRAK4	IRAK	TKL	2nry	B	A	staurosporine	Human	1758	0.50
PDPK1 (PDK1)	PDK1	AGC	1oky	A	A	staurosporine	Human	3164	0.50
Prkaa1 (AMPKa1)	CAMKL	CAMK	5ufu	A		staurosporine	Mouse	7590	0.50
CDK2	CDK	CMGC	4ez7	A		staurosporine	Human	4240	0.50
PAK4	STE20	STE	5ved	A		staurosporine	Human	8570	0.50
ERN1 (IRE1)	IRE	Other	4yzc	A	A	staurosporine	Human	6235	0.50
IRAK4	IRAK	TKL	2nry	C	A	staurosporine	Human	1779	0.50
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	A	staurosporine	Human	6611	0.50
GSK3B	GSK	CMGC	1q3d	B		staurosporine	Human	752	0.50
MAP2K1	STE7	STE	3eqf	A		k-252a	Human	3317	0.75
EPHB4 (EphB4)	Eph	TK	2yn8	A		staurosporine	Human	352	0.50
EPHB4 (EphB4)	Eph	TK	3zew	B	B	staurosporine	Human	357	0.50
SYK	Syk	TK	1xbc	A	B	staurosporine	Human	1207	0.50
DYRK1A	DYRK	CMGC	4nct	C		pkc412	Human	3779	0.49
STK32A (YANK1)	YANK	AGC	4fr4	A	B	staurosporine	Human	4690	0.50
ERN1 (IRE1)	IRE	Other	4yzc	A	B	staurosporine	Human	6232	0.50
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	B	staurosporine	Human	13495	0.50
CHEK1 (CHK1)	CAMKL	CAMK	5oor	A		staurosporine	Human	8603	0.50
RIPK2	RIPK	TKL	5ng2	A	B	staurosporine	Human	8056	0.50
RIPK2	RIPK	TKL	5ng2	A	A	staurosporine	Human	8050	0.50
CHEK1 (CHK1)	CAMKL	CAMK	1nvr	A		staurosporine	Human	1585	0.50
CDK2	CDK	CMGC	7nvq	A		staurosporine	Human	13627	0.50
STK24 (MST3)	STE20	STE	3ckx	A		staurosporine	Human	5599	0.50
STK24 (MST3)	STE20	STE	4qmy	A		staurosporine	Human	5592	0.50
RPS6KA1 (RSK3)	RSK	AGC	2z7r	A		staurosporine	Human	2777	0.50
MELK	CAMKL	CAMK	5m5a	A	A	k-252a	Human	8735	0.75
STK32A (YANK1)	YANK	AGC	4fr4	E	B	staurosporine	Human	4685	0.50
LCK	Src	TK	1qpd	A		staurosporine	Human	2267	0.50
MAP3K5	STE11	STE	2clq	A	A	staurosporine	Human	4740	0.50
MAPKAPK2	MAPKAPK	CAMK	1nxk	A		staurosporine	Human	1342	0.50
MKNK2 (MNK2)	MAPKAPK	CAMK	2hw7	A		staurosporine	Human	764	0.50
MAP2K6	STE7	STE	3fme	A		staurosporine	Human	1231	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	C		staurosporine	Human	7980	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	A	staurosporine	Human	6424	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b2e	A		staurosporine	Human	9851	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	C	B	staurosporine	Human	9850	0.50
AAK1	NAK	Other	4wsq	B	B	k-252a	Human	3835	0.75
AAK1	NAK	Other	4wsq	A	A	k-252a	Human	3834	0.75
PRKAA2 (AMPKa2)	CAMKL	CAMK	5iso	A		staurosporine	Human	7981	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	A	staurosporine	Human	6430	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	A	staurosporine	Human	9848	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	C		staurosporine	Human	190	0.50
AAK1	NAK	Other	4wsq	B	A	k-252a	Human	3833	0.75
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	C	B	staurosporine	Human	6426	0.50
TGFBR2 (TGFbR2)	STKR	TKL	5e8y	A		staurosporine	Human	6627	0.50
AAK1	NAK	Other	4wsq	A	B	k-252a	Human	3836	0.75
TTK	TTK	Other	3hmo	A		staurosporine	Human	4707	0.50
PIM1	PIM	CAMK	1yhs	A		staurosporine	Human	2444	0.50
MELK	CAMKL	CAMK	5m5a	A	B	k-252a	Human	8733	0.75
FES	Fer	TK	3cd3	A	A	staurosporine	Human	2814	0.50
FES	Fer	TK	3cbl	A	B	staurosporine	Human	2811	0.50
IRAK4	IRAK	TKL	2nry	A	A	staurosporine	Human	1753	0.50
FES	Fer	TK	3bkb	A	B	staurosporine	Human	2813	0.50
FES	Fer	TK	3bkb	A	A	staurosporine	Human	2810	0.50
CDK2	CDK	CMGC	1aq1	A		staurosporine	Human	4267	0.50
FES	Fer	TK	3cd3	A	B	staurosporine	Human	2815	0.50
ERN1 (IRE1)	IRE	Other	4yzc	B	A	staurosporine	Human	6227	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	C		staurosporine	Human	192	0.50
EPHB4 (EphB4)	Eph	TK	3zew	A	B	staurosporine	Human	377	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cff	A		staurosporine	Human	191	0.50
EPHB4 (EphB4)	Eph	TK	3zew	B	A	staurosporine	Human	351	0.50
CDK2	CDK	CMGC	4erw	A		staurosporine	Human	4370	0.50
Ripk4 (ANKRD3)	RIPK	TKL	5wnl	A		staurosporine	Mouse	9891	0.50
LYN	Src	TK	3a4o	X		staurosporine	Human	1812	0.50
ZAP70	Syk	TK	1u59	A	A	staurosporine	Human	2734	0.50
DYRK1A	DYRK	CMGC	4nct	D		pkc412	Human	3751	0.49
ZAP70	Syk	TK	1u59	A	B	staurosporine	Human	2733	0.50
DYRK1A	DYRK	CMGC	4nct	B		pkc412	Human	3743	0.49
RIPK2	RIPK	TKL	5ng2	B	A	staurosporine	Human	8053	0.50
RIPK2	RIPK	TKL	5ng2	B	B	staurosporine	Human	8052	0.50
IRAK4	IRAK	TKL	4u97	A		staurosporine	Human	1754	0.50
JAK3	JakA	TK	1yvj	A	A	1,2,3,4-tetrahydrogen-staurosporine	Human	460	0.44
MASTL	MAST	AGC	5loh	A	A	staurosporine	Human	7086	0.50
MASTL	MAST	AGC	5loh	B	A	staurosporine	Human	7088	0.50
MASTL	MAST	AGC	5loh	B	B	staurosporine	Human	7087	0.50
MASTL	MAST	AGC	5loh	A	B	staurosporine	Human	7085	0.50
FES	Fer	TK	3cbl	A	A	staurosporine	Human	2808	0.50
ABL1	Abl	TK	2hz4	B		1,2,3,4-tetrahydrogen-staurosporine	Human	1058	0.44
JAK3	JakA	TK	1yvj	A	B	1,2,3,4-tetrahydrogen-staurosporine	Human	451	0.44
GSK3B	GSK	CMGC	1q3d	A		staurosporine	Human	705	0.50
MAP3K5	STE11	STE	2clq	B	A	staurosporine	Human	4755	0.50
ALK	ALK	TK	3lcs	A	A	staurosporine	Human	5381	0.50
MAP3K5	STE11	STE	4bf2	B		staurosporine	Human	4745	0.50
ALK	ALK	TK	3lcs	A	B	staurosporine	Human	5376	0.50
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	B	staurosporine	Human	6617	0.50
STK32A (YANK1)	YANK	AGC	4fr4	C	A	staurosporine	Human	4684	0.50
STK32A (YANK1)	YANK	AGC	4fr4	B	A	staurosporine	Human	4692	0.50
IRAK4	IRAK	TKL	2oic	B		staurosporine	Human	1752	0.50
PDPK1 (PDK1)	PDK1	AGC	1oky	A	B	staurosporine	Human	3195	0.50
IRAK4	IRAK	TKL	4u97	B		staurosporine	Human	1742	0.50
LIMK1	LISK	TKL	3s95	B	B	staurosporine	Human	1247	0.50
LIMK1	LISK	TKL	3s95	B	A	staurosporine	Human	1245	0.50
PRKCQ (PKCt)	PKC	AGC	1xjd	A		staurosporine	Human	5357	0.50
ITK	Tec	TK	1sm2	A		staurosporine	Human	74	0.50
ITK	Tec	TK	1snu	A		staurosporine	Human	82	0.50
IRAK4	IRAK	TKL	2nry	D	B	staurosporine	Human	1746	0.50
ITK	Tec	TK	1sm2	B		staurosporine	Human	73	0.50
IRAK4	IRAK	TKL	2nry	C	B	staurosporine	Human	1750	0.50
ITK	Tec	TK	1snu	B		staurosporine	Human	33	0.50
CHEK1 (CHK1)	CAMKL	CAMK	7ako	A	A	staurosporine	Human	13490	0.50
IRAK4	IRAK	TKL	2nry	B	B	staurosporine	Human	1772	0.50
IRAK4	IRAK	TKL	2oic	C		staurosporine	Human	1734	0.50
IRAK4	IRAK	TKL	2nry	A	B	staurosporine	Human	1777	0.50
STK32A (YANK1)	YANK	AGC	4fr4	B	B	staurosporine	Human	4695	0.50
STK32A (YANK1)	YANK	AGC	4fr4	F	B	staurosporine	Human	4686	0.50
CSK	Csk	TK	3d7t	A		staurosporine	Human	2941	0.50
DAPK1	DAPK	CAMK	1wvy	A		staurosporine	Human	5661	0.50
STK32A (YANK1)	YANK	AGC	4fr4	E	A	staurosporine	Human	4689	0.50
STK32A (YANK1)	YANK	AGC	4fr4	C	B	staurosporine	Human	4694	0.50
STK32A (YANK1)	YANK	AGC	4fr4	F	A	staurosporine	Human	4691	0.50
STK32A (YANK1)	YANK	AGC	4fr4	D	A	staurosporine	Human	4688	0.50
EPHB4 (EphB4)	Eph	TK	3zew	A	A	staurosporine	Human	373	0.50
STK32A (YANK1)	YANK	AGC	4fr4	A	A	staurosporine	Human	4693	0.50
CHEK1 (CHK1)	CAMKL	CAMK	7ako	B	B	staurosporine	Human	13496	0.50
STK32A (YANK1)	YANK	AGC	4fr4	D	B	staurosporine	Human	4687	0.50
MAPKAPK2	MAPKAPK	CAMK	1nxk	C		staurosporine	Human	1312	0.50
MAPKAPK2	MAPKAPK	CAMK	1nxk	D		staurosporine	Human	1334	0.50
MAPKAPK2	MAPKAPK	CAMK	2pzy	C		staurosporine	Human	1279	0.50
MAPKAPK2	MAPKAPK	CAMK	1nxk	B		staurosporine	Human	1292	0.50
FES	Fer	TK	3bkb	A	C	staurosporine	Human	2812	0.50
IKBKB (IKKb)	IKK	Other	4kik	B	B	k-252a	Human	293	0.75
IKBKB (IKKb)	IKK	Other	4kik	A	A	k-252a	Human	290	0.75
IKBKB (IKKb)	IKK	Other	4kik	B	A	k-252a	Human	295	0.75
IKBKB (IKKb)	IKK	Other	4kik	A	B	k-252a	Human	288	0.75
FYN	Src	TK	2dq7	X		staurosporine	Human	1941	0.50
RPS6KB1 (p70S6K)	RSK	AGC	3a61	A		staurosporine	Human	1846	0.50
RPS6KB1 (p70S6K)	RSK	AGC	3a62	A		staurosporine	Human	1867	0.50
TGFBR1 (TGFbR1)	STKR	TKL	5e8x	A	A	staurosporine	Human	6615	0.50
TGFBR1 (TGFbR1)	STKR	TKL	5e8w	A	B	staurosporine	Human	6614	0.50
RPS6KB1 (p70S6K)	RSK	AGC	4rlo	B		staurosporine	Human	7220	0.50
RPS6KB1 (p70S6K)	RSK	AGC	3a60	B		staurosporine	Human	1856	0.50
RPS6KB1 (p70S6K)	RSK	AGC	3a60	A		staurosporine	Human	1852	0.50
MET	Met	TK	1r0p	A		k-252a	Human	2991	0.75
PRKAA2 (AMPKa2)	CAMKL	CAMK	5ezv	A	B	staurosporine	Human	6428	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	6b1u	A	B	staurosporine	Human	9849	0.50
PRKAA2 (AMPKa2)	CAMKL	CAMK	4cfe	A		staurosporine	Human	195	0.50