KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (44 entries covering 20 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
SYK	Syk	TK	3srv	B	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1181	0.52
SYK	Syk	TK	3srv	A	A	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1154	0.52
SYK	Syk	TK	3fqe	A		2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1155	0.71
SYK	Syk	TK	4rx8	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	1158	0.42
SYK	Syk	TK	3srv	B	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1206	0.52
SYK	Syk	TK	4rx8	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide	Human	1168	0.42
CDK1 (CDC2)	CDK	CMGC	6gu4	A		~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10777	0.43
MAP4K1 (HPK1)	STE20	STE	7m0k	B	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13470	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	D	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13471	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	C	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13474	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	D	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13479	0.44
CDK2	CDK	CMGC	6guf	A		n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	10770	0.43
CDK2	CDK	CMGC	6guk	A	A	~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10773	0.43
SYK	Syk	TK	5tt7	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	7283	0.45
SYK	Syk	TK	4rx7	A	A	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	1189	0.77
SYK	Syk	TK	3srv	A	B	2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide	Human	1162	0.52
CDK2	CDK	CMGC	6guk	A	B	~{n}2-[(1~{r},2~{s})-2-azanylcyclohexyl]-~{n}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine	Human	10768	0.43
SYK	Syk	TK	4rx7	A	B	3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide	Human	1182	0.77
PAK4	STE20	STE	2cdz	A	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	1374	0.43
PAK4	STE20	STE	2cdz	A	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	1378	0.43
LCK	Src	TK	3ac5	A		5-{[(1r,2s)-2-aminocyclohexyl]amino}-7-[(3,5-dimethoxyphenyl)amino]-2-(3-hydroxyphenyl)[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide	Human	2277	0.41
CDK2	CDK	CMGC	6guf	C		n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	10762	0.43
PAK5	STE20	STE	2f57	B	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	199	0.43
PAK5	STE20	STE	2f57	B	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	201	0.43
SYK	Syk	TK	4rx9	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	1194	1.00
SYK	Syk	TK	5tt7	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one	Human	7281	0.45
MAP4K1 (HPK1)	STE20	STE	7m0k	C	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13473	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	A	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13480	0.44
MAP4K1 (HPK1)	STE20	STE	7m0k	A	B	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13481	0.44
FES	Fer	TK	6jmf	A		6-{[(1r,2s)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide	Human	11140	0.50
JAK2-b	JakB	TK	5ut2	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	8039	1.00
JAK2-b	JakB	TK	5ut2	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	8040	1.00
CAMK1D (CaMK1d)	CAMK1	CAMK	6t6f	B	A	2-[(3~{s})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide	Human	11941	0.43
SYK	Syk	TK	4rx9	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	1190	1.00
MAP4K1 (HPK1)	STE20	STE	7m0k	B	A	4-anilino-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide	Human	13476	0.44
CAMK1D (CaMK1d)	CAMK1	CAMK	6t6f	A	A	2-[(3~{s})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide	Human	11939	0.43
CAMK1D (CaMK1d)	CAMK1	CAMK	6t6f	A	B	2-[(3~{s})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide	Human	11940	0.43
CAMK1D (CaMK1d)	CAMK1	CAMK	6t6f	B	B	2-[(3~{s})-3-azanylpiperidin-1-yl]-4-[[3-(trifluoromethyl)phenyl]amino]pyrimidine-5-carboxamide	Human	11942	0.43
SYK	Syk	TK	8x5k	A	A	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	15103	1.00
SYK	Syk	TK	8x5k	A	B	2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide	Human	15102	1.00
LCK	Src	TK	3ac1	A		5-{[(1r,2s)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide	Human	2287	0.46
CSNK1G3 (CK1g3)	CK1	CK1	2izt	A	A	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	2216	0.43
CSNK1G3 (CK1g3)	CK1	CK1	2izt	A	B	n2-[(1r,2s)-2-aminocyclohexyl]-n6-(3-chlorophenyl)-9-ethyl-9h-purine-2,6-diamine	Human	2215	0.43
INSR	InsR	TK	2z8c	A		[4-({5-(aminocarbonyl)-4-[(3-methylphenyl)amino]pyrimidin-2-yl}amino)phenyl]acetic acid	Human	587	0.42