KLIFS - the structural kinase database

Searching for structures with analogs of Dovitinib.

Search results (20 entries covering 7 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CHEK1 (CHK1)	CAMKL	CAMK	2gdo	A		4-[(3s)-1-azabicyclo[2.2.2]oct-3-ylamino]-3-(1h-benzimidazol-2-yl)-6-chloroquinolin-2(1h)-one	Human	1606	0.41
FGFR1	FGFR	TK	5am6	A	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3494	0.86
FGFR1	FGFR	TK	5am7	A	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3488	0.86
FGFR1	FGFR	TK	5am7	B	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3531	0.86
FGFR1	FGFR	TK	5a46	B	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3526	0.86
FGFR1	FGFR	TK	5am7	A	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3533	0.86
FGFR1	FGFR	TK	5a46	A	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3532	0.86
FGFR1	FGFR	TK	5am6	A	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3514	0.86
FGFR1	FGFR	TK	5a46	B	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3578	0.86
FGFR1	FGFR	TK	5am7	B	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3588	0.86
FGFR1	FGFR	TK	5am6	B	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3587	0.86
FGFR4	FGFR	TK	4tyi	A		4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	926	0.86
FGFR1	FGFR	TK	5a46	A	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3505	0.86
FGFR1	FGFR	TK	5am6	B	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	3521	0.86
STK10 (LOK)	STE20	STE	5owq	A	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	8385	0.86
STK10 (LOK)	STE20	STE	5owq	A	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	8386	0.86
STK10 (LOK)	STE20	STE	5owq	B	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	8387	0.86
STK10 (LOK)	STE20	STE	5owq	B	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	8389	0.86
STK17B (DRAK2)	DAPK	CAMK	7akg	A	B	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	13004	0.86
STK17B (DRAK2)	DAPK	CAMK	7akg	A	A	4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one	Human	13005	0.86