KLIFS - the structural kinase database

Searching for structures with analogs of Dinaciclib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK2	CDK	CMGC	2r3q	A	A	3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide	Human	4038	0.45
CDK2	CDK	CMGC	2r3m	A	A	n-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine	Human	4286	0.41
CDK2	CDK	CMGC	2r3q	A	B	3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide	Human	4459	0.45
CDK2	CDK	CMGC	4kd1	A	B	3-[({3-ethyl-5-[(2s)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium	Human	4525	1.00
CDK2	CDK	CMGC	2r3q	A	C	3-((3-bromo-5-o-tolylpyrazolo[1,5-a]pyrimidin-7-ylamino)methyl)pyridine 1-oxide	Human	3976	0.45
CDK2	CDK	CMGC	5l2w	A		3-[({3-ethyl-5-[(2s)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium	Human	6993	1.00
CDK2	CDK	CMGC	2r3m	A	B	n-((2-aminopyrimidin-5-yl)methyl)-5-(2,6-difluorophenyl)-3-ethylpyrazolo[1,5-a]pyrimidin-7-amine	Human	4576	0.41
CDK1 (CDC2)	CDK	CMGC	6gu6	A		3-[({3-ethyl-5-[(2s)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium	Human	10774	1.00
CDK2	CDK	CMGC	4kd1	A	A	3-[({3-ethyl-5-[(2s)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium	Human	4585	1.00