KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (12 entries covering 5 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CDK2	CDK	CMGC	2i40	C	A	5-[5,6-bis(methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxamide	Human	4222	0.54
CDK2	CDK	CMGC	2i40	A	B	5-[5,6-bis(methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxamide	Human	4470	0.54
NEK2	NEK	Other	2xnm	A	B	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	324	0.73
NEK2	NEK	Other	2xnn	A	A	5-(1h-benzimidazol-1-yl)-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	303	0.73
CDK2	CDK	CMGC	2i40	A	A	5-[5,6-bis(methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxamide	Human	4363	0.54
CDK2	CDK	CMGC	2i40	C	B	5-[5,6-bis(methyloxy)-1h-benzimidazol-1-yl]-3-{[1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxamide	Human	4043	0.54
NEK2	NEK	Other	2xno	A	A	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide	Human	319	0.56
NEK2	NEK	Other	2xnn	A	B	5-(1h-benzimidazol-1-yl)-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	308	0.73
NEK2	NEK	Other	2xnp	A	B	4-{5-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-2-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Human	322	0.49
NEK2	NEK	Other	2xno	A	B	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide	Human	313	0.56
NEK2	NEK	Other	2xnp	A	A	4-{5-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-2-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}benzamide	Human	328	0.49
NEK2	NEK	Other	2xnm	A	A	5-{6-[(1-methylpiperidin-4-yl)oxy]-1h-benzimidazol-1-yl}-3-{(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	Human	306	0.73