KLIFS - the structural kinase database

Searching for structures with analogs of Tamnorzatinib.

Search results (13 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
MET	Met	TK	3u6h	A	B	n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	2965	0.45
MET	Met	TK	3u6h	A	A	n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	2996	0.45
KDR	VEGFR	TK	3b8q	A		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5332	0.48
KDR	VEGFR	TK	3b8q	B		n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5319	0.48
KDR	VEGFR	TK	3b8r	B		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5341	0.45
KDR	VEGFR	TK	3b8r	A		n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide	Human	5327	0.45
KDR	VEGFR	TK	3u6j	A		n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	5318	0.45
SYK	Syk	TK	3tuc	A		1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide	Human	1195	0.61
SYK	Syk	TK	3tub	A		1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]urea	Human	1179	0.57
FGFR1	FGFR	TK	4rwl	B		6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide	Human	3596	0.45
EIF2AK3 (PEK)	PEK	Other	4x7h	A	B	n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	7240	0.61
EIF2AK3 (PEK)	PEK	Other	4x7h	A	A	n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-1-methyl-3-oxo-2-phenyl-5-(pyridin-4-yl)-2,3-dihydro-1h-pyrazole-4-carboxamide	Human	7247	0.61
MET	Met	TK	3vw8	A		n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide	Human	2985	0.43