KLIFS - the structural kinase database

Searching for structures with analogs of Quizartinib.

Search results (27 entries covering 13 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EPHA3 (EphA3)	Eph	TK	4twn	A	B	1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	2865	0.40
RIPK1	RIPK	TKL	4neu	B	A	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	568	0.41
STK10 (LOK)	STE20	STE	6gtt	A	A	1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	10026	0.40
EPHA3 (EphA3)	Eph	TK	4twn	A	A	1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	2846	0.40
MAPK11 (p38b)	MAPK	CMGC	8ygw	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	15234	0.40
BRAF	RAF	TKL	4jvg	C		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	3050	0.40
MAPK14 (p38a)	MAPK	CMGC	1kv2	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	5255	0.40
RIPK2	RIPK	TKL	5ar7	B	A	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea	Human	6178	0.42
RIPK2	RIPK	TKL	5ar7	A	A	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea	Human	6174	0.42
RIPK1	RIPK	TKL	4neu	A	B	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	561	0.41
RIPK1	RIPK	TKL	4neu	B	B	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	573	0.41
RIPK2	RIPK	TKL	5ar7	B	B	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea	Human	6188	0.42
RIPK1	RIPK	TKL	4neu	A	A	1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea	Human	576	0.41
MAPK14 (p38a)	MAPK	CMGC	3hv6	A		1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea	Human	5101	0.51
BRAF	RAF	TKL	4jvg	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	3134	0.40
BRAF	RAF	TKL	4jvg	B		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	3085	0.40
BRAF	RAF	TKL	4jvg	D		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	3059	0.40
MAPK14 (p38a)	MAPK	CMGC	5n66	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	8524	0.40
PTK2B (PYK2)	FAK	TK	3fzs	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	94	0.40
MAPK9 (JNK2)	MAPK	CMGC	3npc	B		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	1237	0.40
MAPK9 (JNK2)	MAPK	CMGC	3npc	A		1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	1235	0.40
RIPK2	RIPK	TKL	5ar7	A	B	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea	Human	6182	0.42
STK10 (LOK)	STE20	STE	6gtt	A	B	1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea	Human	10025	0.40
FLT3	PDGFR	TK	4rt7	A	A	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	Human	626	1.00
FLT3	PDGFR	TK	4rt7	A	B	1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	Human	627	1.00
FLT3	PDGFR	TK	4xuf	B		1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	Human	623	1.00
FLT3	PDGFR	TK	4xuf	A		1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea	Human	624	1.00