Searching for structures with analogs of Onvansertib.
Search results (21 entries covering 17 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| PLK1 | PLK | Other | 22rd | A | 1-(2-hydroxyethyl)-8-[[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl]amino]-4,5-dihydropyrimido[5,4-g]indazole-3-carboxamide | Human | 15471 | 1.00 | |||
| PLK1 | PLK | Other | 2yac | A | 1-(2-hydroxyethyl)-8-[[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl]amino]-4,5-dihydropyrimido[5,4-g]indazole-3-carboxamide | Human | 4957 | 1.00 | |||
| PLK1 | PLK | Other | 3kb7 | A | 8-{[2-methoxy-5-(4-methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4962 | 0.70 | |||
| CDK2 | CDK | CMGC | 2wih | A | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4163 | 0.44 | |||
| PLK1 | PLK | Other | 4a4o | A | 1-methyl-2-(2-{[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one | Human | 4965 | 0.46 | |||
| CDK2 | CDK | CMGC | 2wip | C | 1-methyl-8-(phenylamino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid | Human | 4190 | 0.44 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vd1 | A | A | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8337 | 0.44 | ||
| CDK2 | CDK | CMGC | 2wip | A | 1-methyl-8-(phenylamino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxylic acid | Human | 4520 | 0.44 | |||
| PLK1 | PLK | Other | 4a4l | A | 1-methyl-5-(2-{[5-(4-methylpiperazin-1-yl)-2-(trifluoromethoxy)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 4971 | 0.56 | |||
| PKMYT1 (MYT1) | WEE | Other | 5vd1 | A | B | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8340 | 0.44 | ||
| WEE1 (Wee1) | WEE | Other | 5vc6 | A | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8331 | 0.44 | |||
| MARK3 | CAMKL | CAMK | 9ysq | A | 3-({5-chloro-2-[2-(difluoromethoxy)-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl}amino)thiophene-2-carboxamide | Human | 15737 | 0.41 | |||
| CDK2 | CDK | CMGC | 2wih | C | n,1,4,4-tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4119 | 0.44 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 2xch | A | 8-(cyclohexa-2,5-dien-1-ylideneamino)-1-(piperidin-4-ylmethyl)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 3220 | 0.47 | |||
| PDPK1 (PDK1) | PDK1 | AGC | 2xck | A | 1-methyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-n-[(2-methylpyridin-4-yl)methyl]-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 3201 | 0.46 | |||
| TTK | TTK | Other | 5ntt | A | B | n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8267 | 0.50 | ||
| TTK | TTK | Other | 5mrb | A | ~{n}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8270 | 0.51 | |||
| TTK | TTK | Other | 2x9e | A | n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 4729 | 0.50 | |||
| TTK | TTK | Other | 5ntt | A | A | n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8268 | 0.50 | ||
| TTK | TTK | Other | 5ap7 | A | n-(2,6-diethylphenyl)-1-methyl-8-({4-[(1-methylpiperidin-4-yl)carbamoyl]-2-(trifluoromethoxy)phenyl}amino)-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 6100 | 0.50 | |||
| TTK | TTK | Other | 5o91 | A | ~{n}-(2,6-diethylphenyl)-8-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-1-methyl-4,5-dihydropyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 8269 | 0.51 |
Onvansertib
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