| JAK2 | JakA | TK | 4bbf | D | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3663 | 0.55 | |
| CDK2 | CDK | CMGC | 2xnb | A | A | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4217 | 0.43 | |
| MAPK1 (Erk2) | MAPK | CMGC | 5ngu | A | | 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | Human | 7991 | 0.40 | |
| CDK2 | CDK | CMGC | 3eid | A | A | (2s)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol | Human | 4386 | 0.40 | |
| RIPK2 | RIPK | TKL | 5ar8 | B | | 2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide | Human | 6179 | 0.40 | |
| EGFR | EGFR | TK | 3lzb | B | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 810 | 0.45 | |
| EGFR | EGFR | TK | 3lzb | D | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 820 | 0.45 | |
| CDK2 | CDK | CMGC | 2uue | A | | 4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine | Human | 4515 | 0.53 | |
| EGFR | EGFR | TK | 3lzb | C | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 808 | 0.45 | |
| CDK2 | CDK | CMGC | 3eid | A | B | (2s)-1-(dimethylamino)-3-(4-{[4-(6-morpholin-4-ylpyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl]amino}phenoxy)propan-2-ol | Human | 4424 | 0.40 | |
| CDK2 | CDK | CMGC | 2uue | C | | 4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amine | Human | 4321 | 0.53 | |
| CDK2 | CDK | CMGC | 2vv9 | A | B | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3881 | 0.43 | |
| CDK2 | CDK | CMGC | 2vv9 | A | A | 2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanol | Human | 3989 | 0.43 | |
| ITK | Tec | TK | 3qgy | B | A | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 52 | 0.43 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3kvx | A | B | n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline | Human | 3430 | 0.47 | |
| RIPK2 | RIPK | TKL | 5ar8 | A | | 2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide | Human | 6176 | 0.40 | |
| ULK3 | ULK | Other | 6fdz | U | | momelotinib | Human | 10390 | 1.00 | |
| JAK2 | JakA | TK | 4bbe | D | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3726 | 0.67 | |
| JAK2 | JakA | TK | 8bxh | A | A | momelotinib | Human | 15032 | 1.00 | |
| JAK2 | JakA | TK | 4bbe | C | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3649 | 0.67 | |
| JAK2 | JakA | TK | 4bbf | C | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3644 | 0.55 | |
| JAK2 | JakA | TK | 4bbe | A | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3670 | 0.67 | |
| JAK2 | JakA | TK | 4bbe | B | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3727 | 0.67 | |
| JAK2 | JakA | TK | 4bbf | B | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3717 | 0.55 | |
| JAK2 | JakA | TK | 4bbf | A | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3723 | 0.55 | |
| JAK2 | JakA | TK | 8bxh | A | B | momelotinib | Human | 15045 | 1.00 | |
| SRC | Src | TK | 1y57 | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide | Human | 986 | 0.42 | |
| MAPK10 (JNK3) | MAPK | CMGC | 3kvx | A | A | n-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)aniline | Human | 3433 | 0.47 | |
| TYK2 | JakA | TK | 6dbk | A | | 4-({4-[(1s,4s)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-n-ethylbenzamide | Human | 10490 | 0.47 | |
| MAPK14 (p38a) | MAPK | CMGC | 3d83 | A | | n-{4'-[(cyclopropylmethyl)carbamoyl]-6-methylbiphenyl-3-yl}-2-morpholin-4-ylpyridine-4-carboxamide | Human | 5028 | 0.42 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13390 | 0.44 | |
| ACVR1 (ALK2) | STKR | TKL | 7nns | B | B | momelotinib | Human | 13464 | 1.00 | |
| ACVR1 (ALK2) | STKR | TKL | 7nns | B | A | momelotinib | Human | 13465 | 1.00 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13391 | 0.44 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13392 | 0.44 | |
| IGF1R | InsR | TK | 3qqu | D | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 997 | 0.40 | |
| IGF1R | InsR | TK | 3qqu | B | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1020 | 0.40 | |
| IGF1R | InsR | TK | 3qqu | C | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1014 | 0.40 | |
| IGF1R | InsR | TK | 3qqu | A | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1024 | 0.40 | |
| EGFR | EGFR | TK | 3lzb | A | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 800 | 0.45 | |
| CDK2 | CDK | CMGC | 2xnb | A | B | 3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-one | Human | 4034 | 0.43 | |
| PDPK1 (PDK1) | PDK1 | AGC | 2xck | A | | 1-methyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-n-[(2-methylpyridin-4-yl)methyl]-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide | Human | 3201 | 0.40 | |
| ITK | Tec | TK | 3qgy | B | B | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 66 | 0.43 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13389 | 0.44 | |
Match: