KLIFS - the structural kinase database

Searching for structures with analogs of Gilteritinib.

Search results (13 entries covering 11 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EGFR	EGFR	TK	7lg8	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	14120	0.56
FLT3	PDGFR	TK	6jqr	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	11802	1.00
FGFR2	FGFR	TK	6lvl	A		n-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide	Human	12132	0.48
PLK2	PLK	Other	4i5m	A		4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide	Human	5557	0.40
FGFR3	FGFR	TK	6lvm	A		2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-n-ethyl-benzenesulfonamide	Human	12134	0.44
FGFR3	FGFR	TK	7dhl	A		5-[2-(3,5-dimethoxyphenyl)ethyl]-n-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine	Human	13258	0.48
MERTK (MER)	Axl	TK	7ab1	A		6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide	Human	12933	1.00
PLK1	PLK	Other	2rku	A	B	4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide	Human	4966	0.40
EGFR	EGFR	TK	5y9t	A		6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide	Human	10053	0.56
CAMKK2 (CaMKK2)	CAMKK	Other	6bqq	A		4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide	Human	9063	0.40
FGFR2	FGFR	TK	6lvl	B		n-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide	Human	12130	0.48
PLK1	PLK	Other	2rku	A	A	4-{[(7r)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-n-(1-methylpiperidin-4-yl)benzamide	Human	4969	0.40
TTK	TTK	Other	7cht	A		2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonitrile	Human	13554	0.40