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Searching for structures with analogs of
-
.
Search results (14 entries covering 3 PDB structures)
#
Kinase
Family
Group
PDB
Chain
(Alternate) Model
Orthosteric ligand
Organism
Details
Similarity (MFP)
File
NTRK1 (TRKA)
Trk
TK
4aoj
B
B
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3604
0.58
NTRK1 (TRKA)
Trk
TK
4aoj
C
A
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3617
0.58
JAK2
JakA
TK
2xa4
B
B
5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine
Human
3707
0.73
JAK2
JakA
TK
3zmm
A
A
5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine
Human
3674
0.44
JAK2
JakA
TK
3zmm
B
A
5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine
Human
3709
0.44
JAK2
JakA
TK
3zmm
B
B
5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine
Human
3678
0.44
JAK2
JakA
TK
2xa4
B
A
5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine
Human
3628
0.73
JAK2
JakA
TK
2xa4
A
B
5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine
Human
3623
0.73
JAK2
JakA
TK
2xa4
A
A
5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine
Human
3664
0.73
JAK2
JakA
TK
3zmm
A
B
5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine
Human
3667
0.44
NTRK1 (TRKA)
Trk
TK
4aoj
A
B
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3610
0.58
NTRK1 (TRKA)
Trk
TK
4aoj
A
A
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3602
0.58
NTRK1 (TRKA)
Trk
TK
4aoj
C
B
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3621
0.58
NTRK1 (TRKA)
Trk
TK
4aoj
B
A
5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine
Human
3607
0.58
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