| TNNI3K (HH498) | MLK | TKL | 7mgj | A | | n-methyl-4-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamide | Human | 13969 | 0.43 | |
| CDK16 (PCTAIRE1) | CDK | CMGC | 5g6v | B | | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 7274 | 1.00 | |
| RIPK2 | RIPK | TKL | 6es0 | A | | 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid | Human | 9574 | 0.51 | |
| RIPK2 | RIPK | TKL | 6es0 | B | | 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid | Human | 9573 | 0.51 | |
| CDK16 (PCTAIRE1) | CDK | CMGC | 5g6v | A | | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 7273 | 1.00 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv7 | A | | 1-[1-(3-aminophenyl)-3-tert-butyl-1h-pyrazol-5-yl]-3-naphthalen-1-ylurea | Human | 5223 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 2baj | A | | 1-(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)-3-(2,3-dichlorophenyl)urea | Human | 5176 | 0.40 | |
| BRAF | RAF | TKL | 1uwj | B | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3105 | 0.40 | |
| BRAF | RAF | TKL | 1uwh | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3127 | 0.40 | |
| CDK8 | CDK | CMGC | 3rgf | A | A | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3841 | 0.40 | |
| PTK2B (PYK2) | FAK | TK | 3fzt | A | | 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3h-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1h-pyrazol-5-yl}urea | Human | 86 | 0.40 | |
| CDK8 | CDK | CMGC | 3rgf | A | B | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3846 | 0.40 | |
| PTK2B (PYK2) | FAK | TK | 4h1m | A | | 7-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)-n-(propan-2-yl)-1h-indole-2-carboxamide | Human | 89 | 0.40 | |
| TEK (TIE2) | Tie | TK | 6mwe | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10713 | 1.00 | |
| TEK (TIE2) | Tie | TK | 6mwe | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10711 | 1.00 | |
| MAP3K7 (TAK1) | MLK | TKL | 2yiy | A | | (1e)-1-[5-tert-butyl-2-(3-fluorophenyl)-1h-pyrazol-3-ylidene]-3-(4-pyridin-3-yloxyphenyl)urea | Human | 1890 | 0.46 | |
| ABL1 | Abl | TK | 3qri | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1103 | 1.00 | |
| ABL1 | Abl | TK | 3qri | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1051 | 1.00 | |
| ABL1 | Abl | TK | 3qrj | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1101 | 1.00 | |
| ABL1 | Abl | TK | 3qrj | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1099 | 1.00 | |
| ABL1 | Abl | TK | 3qrj | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1085 | 1.00 | |
| ABL1 | Abl | TK | 3qrj | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1070 | 1.00 | |
| ABL1 | Abl | TK | 3qri | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1047 | 1.00 | |
| ABL1 | Abl | TK | 3qri | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1076 | 1.00 | |
| KDR | VEGFR | TK | 4asd | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5333 | 0.40 | |
| KDR | VEGFR | TK | 3wze | A | A | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5336 | 0.40 | |
| KDR | VEGFR | TK | 3wze | A | B | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5320 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3nnv | A | A | 1-{3-tert-butyl-1-[4-(hydroxymethyl)phenyl]-1h-pyrazol-5-yl}-3-naphthalen-1-ylurea | Human | 5037 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3heg | A | A | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5112 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3lfb | A | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea | Human | 5001 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3lfb | A | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(1,3-thiazol-2-yl)urea | Human | 4998 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3nnv | A | B | 1-{3-tert-butyl-1-[4-(hydroxymethyl)phenyl]-1h-pyrazol-5-yl}-3-naphthalen-1-ylurea | Human | 5046 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv3 | A | A | 1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 5012 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv4 | B | | 1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 5064 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv4 | A | | 1-{3-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 5121 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv3 | A | B | 1-{4-[(6-aminoquinolin-4-yl)amino]phenyl}-3-[3-tert-butyl-1-(3-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 5232 | 0.42 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv5 | B | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea | Human | 5137 | 0.41 | |
| MAPK14 (p38a) | MAPK | CMGC | 3gcs | A | A | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5077 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv5 | A | B | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea | Human | 5263 | 0.41 | |
| MAPK14 (p38a) | MAPK | CMGC | 3heg | A | B | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5218 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3gcs | A | B | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5052 | 0.40 | |
| MAPK13 (p38d) | MAPK | CMGC | 4eyj | A | | 1-(3-tert-butyl-1-methyl-1h-pyrazol-5-yl)-3-[4-(pyridin-4-yloxy)phenyl]urea | Human | 2949 | 0.40 | |
| PTK2 (FAK) | FAK | TK | 4kao | B | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 253 | 0.41 | |
| PTK2 (FAK) | FAK | TK | 4kao | A | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 248 | 0.41 | |
| TEK (TIE2) | Tie | TK | 6mwe | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10712 | 1.00 | |
| TEK (TIE2) | Tie | TK | 6mwe | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10710 | 1.00 | |
| PRPF4B (PRP4) | DYRK | CMGC | 6cnh | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 9775 | 1.00 | |
| PRPF4B (PRP4) | DYRK | CMGC | 6cnh | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 9776 | 1.00 | |
| BRAF | RAF | TKL | 1uwh | B | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3109 | 0.40 | |
| BRAF | RAF | TKL | 1uwj | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3135 | 0.40 | |
| BRAF | RAF | TKL | 5hi2 | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 6515 | 0.40 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv5 | A | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea | Human | 5203 | 0.41 | |
| MAPK14 (p38a) | MAPK | CMGC | 3hv5 | B | A | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-{3-[(6-nitroquinolin-4-yl)amino]phenyl}urea | Human | 5085 | 0.41 | |
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