Searching for structures with analogs of -.

Search results (32 entries covering 14 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetailsSimilarity (MFP)File
ITKTecTK3qgyBAn-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamideHuman520.40
ITKTecTK3qgyBBn-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamideHuman660.40
MAPK1 (Erk2)MAPKCMGC5nhvA7-[2-(oxan-4-ylamino)pyrimidin-4-yl]-3,4-dihydro-2~{h}-pyrrolo[1,2-a]pyrazin-1-oneHuman79950.44
MAPK1 (Erk2)MAPKCMGC5nguA2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-oneHuman79910.41
MAPK10 (JNK3)MAPKCMGC3kvxAAn-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)anilineHuman34330.48
JAK2JakATK4bbeCn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman36490.69
JAK2JakATK4bbfC(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman36441.00
JAK2JakATK4bbeDn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman37260.69
JAK2JakATK4bbeBn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman37270.69
JAK2JakATK4bbfA(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman37231.00
CDK2CDKCMGC2xnbAA3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-oneHuman42170.44
EGFREGFRTK3lzbAn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8000.44
EGFREGFRTK3lzbCn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8080.44
EGFREGFRTK3lzbDn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8200.44
EGFREGFRTK3lzbBn-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamideHuman8100.44
JAK2JakATK4bbeAn-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamideHuman36700.69
TTKTTKOther5ljjAn~6~-cyclohexyl-n~2~-(4-morpholin-4-ylphenyl)-9h-purine-2,6-diamineHuman70920.46
JAK2JakATK4bbfB(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman37171.00
ULK3ULKOther6fdzUmomelotinibHuman103900.55
CDK2CDKCMGC2uueC4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amineHuman43210.50
JAK2JakATK4bbfD(2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamideHuman36631.00
CDK2CDKCMGC2uueA4-methyl-5-{(2e)-2-[(4-morpholin-4-ylphenyl)imino]-2,5-dihydropyrimidin-4-yl}-1,3-thiazol-2-amineHuman45150.50
CDK2CDKCMGC2xnbAB3,4-dimethyl-5-(2-{[(1z)-4-piperazin-1-ylcyclohexa-2,4-dien-1-ylidene]amino}pyrimidin-4-yl)-1,3-thiazol-2(3h)-oneHuman40340.44
ACVR1 (ALK2)STKRTKL7c3gAA~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133890.41
ACVR1 (ALK2)STKRTKL7c3gBA~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133920.41
ACVR1 (ALK2)STKRTKL7c3gBB~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133910.41
ACVR1 (ALK2)STKRTKL7nnsBBmomelotinibHuman134640.55
ACVR1 (ALK2)STKRTKL7nnsBAmomelotinibHuman134650.55
ACVR1 (ALK2)STKRTKL7c3gAB~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amineHuman133900.41
MAPK10 (JNK3)MAPKCMGC3kvxABn-[(2z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1h)-ylidene]-4-(3-morpholin-4-yl-1h-1,2,4-triazol-1-yl)anilineHuman34300.48
CDK2CDKCMGC2vv9AB2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanolHuman38810.44
CDK2CDKCMGC2vv9AA2-{4-[4-({4-[2-methyl-1-(1-methylethyl)-1h-imidazol-5-yl]pyrimidin-2-yl}amino)phenyl]piperazin-1-yl}-2-oxoethanolHuman39890.44