KLIFS - the structural kinase database

Searching for structures with analogs of Ansornitinib.

Search results (16 entries covering 6 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
KDR	VEGFR	TK	3c7q	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	5334	0.78
MELK	CAMKL	CAMK	5maf	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	8732	0.78
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	C		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2104	0.45
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	E		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2097	0.45
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	A		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2127	0.45
ULK2	ULK	Other	6qat	B		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11226	0.41
ULK2	ULK	Other	6qat	C		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11232	0.41
RET	Ret	TK	6nec	A	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11150	0.78
ULK2	ULK	Other	6qat	D		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11230	0.41
ULK2	ULK	Other	6qat	A		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11227	0.41
AAK1	NAK	Other	5te0	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	7156	0.78
RET	Ret	TK	6nec	C	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11147	0.78
RET	Ret	TK	6nec	A	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11151	0.78
RET	Ret	TK	6nec	C	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11153	0.78
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	D		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2107	0.45
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	B		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2128	0.45