| EGFR | EGFR | TK | 4i23 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | 0.49 | |
| EGFR | EGFR | TK | 2jiv | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 893 | 0.57 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcw | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8346 | 1.00 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcw | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-7-ethoxyquinolin-6-yl}-4-(dimethylamino)but-2-enamide | Human | 8335 | 1.00 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcz | A | B | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8336 | 0.41 | |
| PKMYT1 (MYT1) | WEE | Other | 5vcz | A | A | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8342 | 0.41 | |
| WEE1 (Wee1) | WEE | Other | 5vc4 | A | | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 8334 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | F | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1029 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | H | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1006 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | I | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1016 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | K | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1013 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | C | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1022 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | G | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1005 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | R | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1019 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | L | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1039 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | B | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1044 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | A | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 995 | 0.41 | |
| EGFR | EGFR | TK | 3w2q | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 874 | 0.57 | |
| EGFR | EGFR | TK | 2jiv | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 851 | 0.57 | |
| EGFR | EGFR | TK | 4g5p | A | | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | 0.41 | |
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | 0.41 | |
| EGFR | EGFR | TK | 4i24 | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | 0.49 | |
| EGFR | EGFR | TK | 2jiv | B | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 812 | 0.57 | |
| EGFR | EGFR | TK | 4i24 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | 0.49 | |
| EGFR | EGFR | TK | 2jiv | B | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 830 | 0.57 | |
| EGFR | EGFR | TK | 3w2q | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 845 | 0.57 | |
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | B | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13887 | 0.63 | |
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | A | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13888 | 0.63 | |
| IGF1R | InsR | TK | 3f5p | E | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1042 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | S | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 996 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | J | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1040 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | M | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1001 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | T | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1037 | 0.41 | |
| IGF1R | InsR | TK | 3f5p | D | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1015 | 0.41 | |
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | 0.41 | |
| STK10 (LOK) | STE20 | STE | 4bc6 | A | B | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 961 | 0.41 | |
| STK10 (LOK) | STE20 | STE | 4bc6 | A | A | 4-[(3,5-dichloro-4-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 942 | 0.41 | |
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