KLIFS - the structural kinase database

Searching for structures with analogs of Pexidartinib.

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
CSF1R (FMS)	PDGFR	TK	4hw7	A		5-[(5-methoxy-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-[4-(trifluoromethyl)benzyl]pyridin-2-amine	Human	2304	0.62
CSF1R (FMS)	PDGFR	TK	4r7h	A		5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine	Human	2308	1.00
KIT	PDGFR	TK	7khg	A	A	5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine	Human	13786	1.00
KIT	PDGFR	TK	7khg	A	B	5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine	Human	13788	1.00
KIT	PDGFR	TK	4hvs	A		5-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-n-[4-(trifluoromethyl)benzyl]pyridin-2-amine	Human	403	0.60