KLIFS - the kinase structures database

Searching for structures with analogs of Poziotinib.

Search results (27 entries covering 18 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
EPHB4 (EphB4)	Eph	TK	2vwu	A		n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine	Human	370	0.42
EGFR	EGFR	TK	2ity	A		gefitinib	Human	790	0.44
EGFR	EGFR	TK	2itz	A		gefitinib	Human	789	0.44
TTBK1	TTBK	CK1	4btk	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	771	0.44
EGFR	EGFR	TK	3ug2	A	B	gefitinib	Human	819	0.44
EGFR	EGFR	TK	4i22	A		gefitinib	Human	823	0.44
EGFR	EGFR	TK	4i24	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	831	0.44
EGFR	EGFR	TK	4g5p	A		n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	809	0.45
EGFR	EGFR	TK	4wkq	A	B	gefitinib	Human	837	0.44
EGFR	EGFR	TK	4i23	A		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	870	0.44
EGFR	EGFR	TK	4g5j	A	B	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	852	0.45
EGFR	EGFR	TK	4wkq	A	A	gefitinib	Human	889	0.44
EGFR	EGFR	TK	4i24	B		(2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide	Human	910	0.44
EGFR	EGFR	TK	3ug2	A	A	gefitinib	Human	898	0.44
EGFR	EGFR	TK	4g5j	A	A	n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide	Human	794	0.45
RET	Ret	TK	2ivu	A		4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline	Human	3364	0.44
RET	Ret	TK	5amn	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	6412	0.44
EGFR	EGFR	TK	2ito	A		gefitinib	Human	783	0.44
CDK2	CDK	CMGC	1di8	A		4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	4577	0.44
GAK	NAK	Other	5y7z	A		gefitinib	Human	10332	0.44
GAK	NAK	Other	5y7z	B		gefitinib	Human	10331	0.44
GAK	NAK	Other	5y80	A	B	gefitinib	Human	10330	0.44
GAK	NAK	Other	5y80	A	A	gefitinib	Human	10329	0.44
TTBK2	TTBK	CK1	6u0k	A	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12046	0.44
TTBK2	TTBK	CK1	6u0k	B	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12047	0.44
TTBK2	TTBK	CK1	6u0k	A	B	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12048	0.44
TTBK2	TTBK	CK1	6u0k	B	A	4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline	Human	12049	0.44