KLIFS - the structural kinase database

Searching for structures with analogs of -.

Search results (46 entries covering 21 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
FGR	Src	TK	7uy0	A	C	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14564	0.49
HCK	Src	TK	3vs3	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2665	0.49
HCK	Src	TK	3vrz	A		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	Human	2658	0.44
FGR	Src	TK	7uy0	B	A	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14566	0.49
HCK	Src	TK	5zj6	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	9987	0.49
FGR	Src	TK	7uy0	B	B	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14565	0.49
FGR	Src	TK	7uy0	A	B	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14563	0.49
HCK	Src	TK	5h0g	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},4-dimethyl-pentanamide	Human	8536	0.41
HCK	Src	TK	3vrz	B		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea	Human	2661	0.44
FGR	Src	TK	7uy0	B	C	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14562	0.49
FGR	Src	TK	7uy0	A	A	7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	14568	0.49
HCK	Src	TK	3vs0	A		n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	Human	2633	0.41
HCK	Src	TK	3vs1	B		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	Human	2636	0.42
HCK	Src	TK	3vs4	A		5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2654	0.49
HCK	Src	TK	3vs0	B		n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide	Human	2644	0.41
HCK	Src	TK	3vs2	B		7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2632	0.49
HCK	Src	TK	3vs5	B		7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2669	0.48
HCK	Src	TK	3vs2	A		7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2651	0.49
HCK	Src	TK	3vs5	A		7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2645	0.48
HCK	Src	TK	4lue	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2655	0.49
HCK	Src	TK	4lue	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2668	0.49
HCK	Src	TK	5h09	A		ethyl (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate	Human	8537	0.42
HCK	Src	TK	5h0h	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},~{n},4-trimethyl-pentanamide	Human	8539	0.41
HCK	Src	TK	3vs3	A		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2643	0.49
HCK	Src	TK	3vry	A		4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	2647	0.52
HCK	Src	TK	5h0e	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide	Human	8538	0.42
HCK	Src	TK	3vry	B		4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	2646	0.52
HCK	Src	TK	5h0b	A		(2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate	Human	8567	0.40
HCK	Src	TK	5zj6	B		7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	9988	0.49
HCK	Src	TK	3vs4	B		5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	2638	0.49
SRC	Src	TK	1yol	B		1-{4-[4-amino-5-(3-methoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]benzyl}piperidin-4-ol	Human	966	0.46
SRC	Src	TK	1yol	A		1-{4-[4-amino-5-(3-methoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]benzyl}piperidin-4-ol	Human	968	0.46
IGF1R	InsR	TK	5hzn	A		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6493	0.81
IGF1R	InsR	TK	5hzn	H		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6492	0.81
IGF1R	InsR	TK	5hzn	E		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6494	0.81
IGF1R	InsR	TK	5hzn	C		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6498	0.81
IGF1R	InsR	TK	5hzn	D		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6496	0.81
IGF1R	InsR	TK	5hzn	B		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6495	0.81
INSR	InsR	TK	5hhw	A	A	7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	Human	6523	0.56
INSR	InsR	TK	5hhw	A	B	7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine	Human	6522	0.56
BTK	Tec	TK	3gen	A	B	4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	2900	0.52
BTK	Tec	TK	3gen	A	A	4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane	Human	2928	0.52
HCK	Src	TK	3vs1	A		1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea	Human	2635	0.42
IGF1R	InsR	TK	5hzn	F		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6497	0.81
IGF1R	InsR	TK	5hzn	G		7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine	Human	6499	0.81
RET	Ret	TK	7run	A		1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one	Human	14072	0.48