KLIFS - the structural kinase database

Searching for structures with analogs of Nintedanib.

Search results (24 entries covering 9 PDB structures)

Kinase	Family	Group	PDB	Chain	(Alternate) Model	Orthosteric ligand	Organism	Details	Similarity (MFP)
KDR	VEGFR	TK	3c7q	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	5334	1.00
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	E		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2097	0.56
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	C		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2104	0.56
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	A		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2127	0.56
ULK2	ULK	Other	6qat	B		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11226	0.46
ULK2	ULK	Other	6qat	C		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11232	0.46
MELK	CAMKL	CAMK	5mai	A	A	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	8728	0.46
MELK	CAMKL	CAMK	5mai	A	B	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	8730	0.46
MELK	CAMKL	CAMK	5maf	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	8732	1.00
GSK3B	GSK	CMGC	6gjo	A		(3~{z})-5-ethanoyl-3-[[(1-methylpiperidin-4-yl)amino]-phenyl-methylidene]-1~{h}-indol-2-one	Human	10974	0.43
GSK3B	GSK	CMGC	6gjo	B		(3~{z})-5-ethanoyl-3-[[(1-methylpiperidin-4-yl)amino]-phenyl-methylidene]-1~{h}-indol-2-one	Human	10973	0.43
RET	Ret	TK	6nec	A	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11151	1.00
RET	Ret	TK	6nec	A	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11150	1.00
RET	Ret	TK	6nec	C	A	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11147	1.00
RET	Ret	TK	6nec	C	B	methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	11153	1.00
ULK2	ULK	Other	6qat	D		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11230	0.46
ULK2	ULK	Other	6qat	A		n-{(3z)-2-oxo-3-[phenyl({4-[(piperidin-1-yl)methyl]phenyl}amino)methylidene]-2,3-dihydro-1h-indol-5-yl}ethanesulfonamide	Human	11227	0.46
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	D		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2107	0.56
TGFBR1 (TGFbR1)	STKR	TKL	2x7o	B		(3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide	Human	2128	0.56
MAP2K1	STE7	STE	5eym	A	B	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	6969	0.46
MAP2K1	STE7	STE	5eym	B	A	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	6968	0.46
MAP2K1	STE7	STE	5eym	B	B	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	6967	0.46
MAP2K1	STE7	STE	5eym	A	A	3-[(3~{z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{h}-indol-6-yl]-~{n}-ethyl-prop-2-ynamide	Human	6966	0.46
AAK1	NAK	Other	5te0	A		methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate	Human	7156	1.00