Searching for structures with analogs of Toceranib.
Search results (48 entries covering 25 PDB structures)
| # | Kinase | Family | Group | PDB | Chain | (Alternate) Model | Orthosteric ligand | Organism | Details | Similarity (MFP) | File |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CDK2 | CDK | CMGC | 3ti1 | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 4201 | 0.73 | ||
| GRK5 (GPRK5) | GRK | AGC | 9brk | A | tert-butyl (3r)-3-({5-[(z)-(5-{[(1r)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrol-3-yl}carbamoyl)piperazine-1-carboxylate | Human | 16157 | 0.42 | |||
| GRK5 (GPRK5) | GRK | AGC | 9bri | A | (3z)-3-[(3,5-dimethyl-4-{[(2s)-5-oxooxolane-2-carbonyl]amino}-1h-pyrrol-2-yl)methylidene]-n-[(1r)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1h-indole-5-carboxamide | Human | 16147 | 0.48 | |||
| STK10 (LOK) | STE20 | STE | 2j7t | A | B | (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxoindoline-5-sulfonamide | Human | 960 | 0.42 | ||
| STK10 (LOK) | STE20 | STE | 2j7t | A | A | (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxoindoline-5-sulfonamide | Human | 946 | 0.42 | ||
| PAK6 | STE20 | STE | 4ks8 | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 4683 | 0.73 | ||
| PAK6 | STE20 | STE | 4ks8 | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 4680 | 0.73 | ||
| STK24 (MST3) | STE20 | STE | 4qmz | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 5578 | 0.73 | |||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | B | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1897 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | C | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1896 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1894 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | B | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1895 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1893 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | C | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1900 | 0.73 | ||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | D | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1899 | 0.73 | ||
| KDR | VEGFR | TK | 4agd | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 5322 | 0.73 | |||
| CAMKK2 (CaMKK2) | CAMKK | Other | 5yvc | A | 3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid | Human | 10754 | 0.40 | |||
| GRK5 (GPRK5) | GRK | AGC | 8uaq | A | (3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2s)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1h-indole-5-carboxamide | Human | 15092 | 0.42 | |||
| GRK5 (GPRK5) | GRK | AGC | 8uap | A | (3z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1h-pyrrol-2-yl]methylidene}-n-[(1r)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1h-indole-5-carboxamide | Human | 15093 | 0.49 | |||
| CDK2 | CDK | CMGC | 3ti1 | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 4213 | 0.73 | ||
| ITK | Tec | TK | 3miy | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 46 | 0.73 | |||
| ITK | Tec | TK | 3miy | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 8 | 0.73 | |||
| PDGFRA (PDGFRa) | PDGFR | TK | 6jok | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 12105 | 0.73 | |||
| KIT | PDGFR | TK | 3g0e | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 401 | 0.73 | ||
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11074 | 0.73 | |||
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11073 | 0.73 | |||
| PHKG2 (PHKg2) | PHK | CAMK | 2y7j | D | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1898 | 0.73 | ||
| CAMK1G (CaMK1g) | CAMK1 | CAMK | 2jam | A | B | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1221 | 0.58 | ||
| CAMK1G (CaMK1g) | CAMK1 | CAMK | 2jam | A | A | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1218 | 0.58 | ||
| CAMK1G (CaMK1g) | CAMK1 | CAMK | 2jam | B | A | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1220 | 0.58 | ||
| CAMK1G (CaMK1g) | CAMK1 | CAMK | 2jam | B | B | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 1219 | 0.58 | ||
| KIT | PDGFR | TK | 3g0e | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 398 | 0.73 | ||
| KIT | PDGFR | TK | 3g0f | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 400 | 0.73 | |||
| KIT | PDGFR | TK | 3g0f | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 395 | 0.73 | |||
| MAP4K1 (HPK1) | STE20 | STE | 6ng0 | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11071 | 0.73 | |||
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11077 | 0.73 | ||
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11075 | 0.73 | ||
| MAP4K1 (HPK1) | STE20 | STE | 6nfz | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11078 | 0.73 | |||
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | B | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11076 | 0.73 | ||
| MAP4K1 (HPK1) | STE20 | STE | 6nfy | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 11072 | 0.73 | ||
| STK25 (YSK1) | STE20 | STE | 4nzw | B | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 464 | 0.58 | |||
| STK25 (YSK1) | STE20 | STE | 2xik | A | B | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 465 | 0.58 | ||
| STK25 (YSK1) | STE20 | STE | 2xik | A | A | 5-[(e)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-[2-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 463 | 0.58 | ||
| NEK2 | NEK | Other | 2jav | A | B | 5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 323 | 0.55 | ||
| NEK2 | NEK | Other | 2jav | A | A | 5-[(z)-(5-chloro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-n-(diethylamino)ethyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 332 | 0.55 | ||
| MET | Met | TK | 2wkm | A | (3z)-5-[(2,6-dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3021 | 0.47 | |||
| Tbk1 (TBK1) | IKK | Other | 4jlc | A | 3-{2,4-dimethyl-5-[(z)-(2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl}propanoic acid | Mouse | 5698 | 0.40 | |||
| GRK5 (GPRK5) | GRK | AGC | 9bre | A | (3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2s)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1h-indole-5-carboxamide | Human | 16145 | 0.42 |
Toceranib
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