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Search results (64 entries covering 46 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
GRK6 (GPRK6)GRKAGC2acxAphosphoaminophosphonic acid-adenylate esterHuman420
GRK5 (GPRK5)GRKAGC6pjxAAsangivamycinHuman13042
GRK5 (GPRK5)GRKAGC9brmA(3z)-3-[(4-{[(2s)-2-hydroxy-2-(oxan-4-yl)ethyl]carbamoyl}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16142
GRK5 (GPRK5)GRKAGC9ckqA-Human16143
GRK5 (GPRK5)GRKAGC6pjxABsangivamycinHuman13041
GRK5 (GPRK5)GRKAGC4tnbAsangivamycinHuman3276
GRK5 (GPRK5)GRKAGC9brhA(3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-3-carbonyl)amino]-3,5-dimethyl-1h-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2h-indole-5-carboxamideHuman16144
GRK5 (GPRK5)GRKAGC9breA(3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2s)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1h-indole-5-carboxamideHuman16145
GRK5 (GPRK5)GRKAGC9cksAadenosine-5'-triphosphateHuman16146
GRK5 (GPRK5)GRKAGC9briA(3z)-3-[(3,5-dimethyl-4-{[(2s)-5-oxooxolane-2-carbonyl]amino}-1h-pyrrol-2-yl)methylidene]-n-[(1r)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1h-indole-5-carboxamideHuman16147
GRK5 (GPRK5)GRKAGC9brgA(3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-({4-[(furan-2-carbonyl)amino]-3,5-dimethyl-1h-pyrrol-2-yl}methylidene)-2-oxo-3,7-dihydro-2h-indole-5-carboxamideHuman16148
GRK5 (GPRK5)GRKAGC9brlA(3z)-3-({3,5-dimethyl-4-[(4-methylpiperidin-4-yl)carbamoyl]-1h-pyrrol-2-yl}methylidene)-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16149
GRK5 (GPRK5)GRKAGC9ckoAAsangivamycinHuman16150
GRK5 (GPRK5)GRKAGC9brjA(4s)-n-{5-[(z)-(5-{[(1r)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-2,7-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrol-3-yl}-2-methylimidazo[1,2-a]pyridine-3-carboxamideHuman16151
GRK5 (GPRK5)GRKAGC9ckoABsangivamycinHuman16152
GRK5 (GPRK5)GRKAGC9mx2AsangivamycinHuman16153
GRK5 (GPRK5)GRKAGC9broA(3z)-3-[(4-{[(2s)-1-methoxypropan-2-yl]carbamoyl}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16154
GRK5 (GPRK5)GRKAGC9brfA(3z)-3-{[3,5-dimethyl-4-(2-oxo-2-phenylacetamido)-1h-pyrrol-2-yl]methylidene}-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16155
GRK5 (GPRK5)GRKAGC9brnA(3z)-3-[(4-{[2-(dimethylamino)ethyl]carbamoyl}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16156
GRK5 (GPRK5)GRKAGC9brkAtert-butyl (3r)-3-({5-[(z)-(5-{[(1r)-1-(4-fluorophenyl)ethyl]carbamoyl}-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrol-3-yl}carbamoyl)piperazine-1-carboxylateHuman16157
GRK5 (GPRK5)GRKAGC9brpA(3z)-3-[(4-{[(2r)-2-methoxypropyl]carbamoyl}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-n-[(1r)-1-phenylethyl]-3,7-dihydro-2h-indole-5-carboxamideHuman16158
GRK4 (GPRK4)GRKAGC4yhjAamp phosphoramidateHuman422
GRK4 (GPRK4)GRKAGC4yhjBamp phosphoramidateHuman423
GRK2 (BARK1)GRKAGC5uvcAn-benzyl-3-({[5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]methyl}amino)benzamideHuman8256
GRK2 (BARK1)GRKAGC5he1AB(4~{s})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{n}-(1~{h}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{h}-pyrimidine-5-carboxamideHuman6606
GRK2 (BARK1)GRKAGC5ukkAB5-[(3s,4r)-3-{[(2h-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-n-[(pyridin-2-yl)methyl]benzamideHuman7530
GRK2 (BARK1)GRKAGC7pwdAA4-chloranyl-n-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamideHuman13949
GRK2 (BARK1)GRKAGC7pwdAB4-chloranyl-n-[2-(4-chlorophenyl)ethyl]thieno[2,3-c]pyridine-2-carboxamideHuman13950
GRK2 (BARK1)GRKAGC7k7lAA3-benzyl-6-(1h-pyrazol-4-yl)quinazolin-4(3h)-oneHuman12960
GRK2 (BARK1)GRKAGC5wg3A2-fluoro-5-[(3s,4r)-3-{[(1h-indazol-5-yl)oxy]methyl}piperidin-4-yl]-n-[(1h-pyrazol-3-yl)methyl]benzamideHuman9439
GRK2 (BARK1)GRKAGC3krwAbalanolHuman1707
GRK2 (BARK1)GRKAGC4mk0AB5-{[(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-1h-isoindol-1-oneHuman1704
GRK2 (BARK1)GRKAGC4pnkAA(4s)-4-(4-fluorophenyl)-n-(2h-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamideHuman1703
GRK2 (BARK1)GRKAGC6c2yA(4r,5r,6s)-4-[4-fluoro-3-({[3-(methoxymethyl)-1,2,4-oxadiazol-5-yl]methyl}carbamoyl)phenyl]-n-(2h-indazol-5-yl)-6-methyl-2-oxohexahydropyrimidine-5-carboxamideHuman9854
GRK2 (BARK1)GRKAGC5uuuAB3-({[4-methyl-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]methyl}amino)-n-[2-(trifluoromethyl)benzyl]benzamideHuman8254
GRK2 (BARK1)GRKAGC4pnkAB(4s)-4-(4-fluorophenyl)-n-(2h-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamideHuman1708
GRK2 (BARK1)GRKAGC5wg5AA5-{[(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-2h-indazoleHuman9437
GRK6 (GPRK6)GRKAGC3nyoAadenosine monophosphateHuman418
GRK6 (GPRK6)GRKAGC3nyoBadenosine monophosphateHuman421
GRK6 (GPRK6)GRKAGC3nynAsangivamycinHuman419
GRK6 (GPRK6)GRKAGC2acxBphosphoaminophosphonic acid-adenylate esterHuman417
GRK6 (GPRK6)GRKAGC3nynBsangivamycinHuman416
GRK5 (GPRK5)GRKAGC8uaqA(3z)-n-[(1r)-1-(4-fluorophenyl)ethyl]-3-[(4-{[(2s)-2-(furan-2-yl)-2-hydroxyacetyl]amino}-3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-2-oxo-2,3-dihydro-1h-indole-5-carboxamideHuman15092
GRK5 (GPRK5)GRKAGC8uapA(3z)-3-{[4-(2-chloroacetamido)-3,5-dimethyl-1h-pyrrol-2-yl]methylidene}-n-[(1r)-1-(4-fluorophenyl)ethyl]-2-oxo-2,3-dihydro-1h-indole-5-carboxamideHuman15093
GRK5 (GPRK5)GRKAGC9ckpAsangivamycinHuman16141
GRK5 (GPRK5)GRKAGC9ckrAadenosine-5'-triphosphateHuman16159
GRK2 (BARK1)GRKAGC7k7zAB3-benzyl-7-(1h-pyrazol-4-yl)quinazolin-4(3h)-oneHuman12961
GRK5 (GPRK5)GRKAGC4tndAphosphoaminophosphonic acid-adenylate esterHuman3275
GRK2 (BARK1)GRKAGC5wg5AB5-{[(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-2h-indazoleHuman9440
GRK2 (BARK1)GRKAGC5wg4AB2-fluoro-5-[(3s,4r)-3-{[(1h-indazol-5-yl)oxy]methyl}piperidin-4-yl]-n-[(pyridin-2-yl)methyl]benzamideHuman9438
GRK2 (BARK1)GRKAGC3v5wAAparoxetineHuman1705
GRK2 (BARK1)GRKAGC7k7lAB3-benzyl-6-(1h-pyrazol-4-yl)quinazolin-4(3h)-oneHuman12958
GRK2 (BARK1)GRKAGC7k7zAA3-benzyl-7-(1h-pyrazol-4-yl)quinazolin-4(3h)-oneHuman12959
GRK2 (BARK1)GRKAGC5ukkAA5-[(3s,4r)-3-{[(2h-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-n-[(pyridin-2-yl)methyl]benzamideHuman7529
GRK2 (BARK1)GRKAGC5uklAA2-{5-[(3s,4r)-3-{[(2h-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-n-[2-(1h-pyrazol-4-yl)ethyl]acetamideHuman7528
GRK2 (BARK1)GRKAGC3v5wABparoxetineHuman1711
GRK2 (BARK1)GRKAGC4mk0AA5-{[(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methoxy}-1h-isoindol-1-oneHuman1710
GRK2 (BARK1)GRKAGC5uuuAA3-({[4-methyl-5-(pyridin-4-yl)-4h-1,2,4-triazol-3-yl]methyl}amino)-n-[2-(trifluoromethyl)benzyl]benzamideHuman8255
GRK2 (BARK1)GRKAGC3krxAbalanolHuman1709
GRK2 (BARK1)GRKAGC6u7cA5-[(3s,4r)-3-{[(2h-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-n-[(2h-indazol-3-yl)methyl]benzamideHuman12162
GRK2 (BARK1)GRKAGC3cikA-Human1706
GRK2 (BARK1)GRKAGC5he1AA(4~{s})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{n}-(1~{h}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{h}-pyrimidine-5-carboxamideHuman6605
GRK2 (BARK1)GRKAGC5wg4AA2-fluoro-5-[(3s,4r)-3-{[(1h-indazol-5-yl)oxy]methyl}piperidin-4-yl]-n-[(pyridin-2-yl)methyl]benzamideHuman9441
GRK2 (BARK1)GRKAGC5uklAB2-{5-[(3s,4r)-3-{[(2h-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-n-[2-(1h-pyrazol-4-yl)ethyl]acetamideHuman7531
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