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Search results (136 entries covering 68 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
IGF1RInsRTK5hznA7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6493
IGF1RInsRTK8pykAA5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dioneHuman14900
IGF1RInsRTK3d94AB3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amineHuman6760
IGF1RInsRTK6jk8AA-Human12015
IGF1RInsRTK8pymA5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dioneHuman14901
IGF1RInsRTK3i81A1-{4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-n-(6-fluoropyridin-3-yl)-2-methyl-l-prolinamideHuman1041
IGF1RInsRTK5fxrAA5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amineHuman7095
IGF1RInsRTK3lw0BA-Human993
IGF1RInsRTK5fxsAA2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamideHuman7096
IGF1RInsRTK2zm3D(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dioneHuman1023
IGF1RInsRTK3f5pF4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1029
IGF1RInsRTK5hznF7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6497
IGF1RInsRTK3qquBn~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamineHuman1020
IGF1RInsRTK3f5pH4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1006
IGF1RInsRTK1m7nA-Human1007
IGF1RInsRTK8pynAA5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dioneHuman14902
IGF1RInsRTK3o23A(5s)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dioneHuman1036
IGF1RInsRTK3lvpB3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridineHuman1035
IGF1RInsRTK5hznH7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6492
IGF1RInsRTK1jqhCphosphoaminophosphonic acid-adenylate esterHuman1038
IGF1RInsRTK8pyiA3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-olHuman14903
IGF1RInsRTK3f5pI4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1016
IGF1RInsRTK6jk8BA-Human12018
IGF1RInsRTK6jk8AB-Human12016
IGF1RInsRTK3lvpD3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridineHuman1009
IGF1RInsRTK8pykAB5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dioneHuman14904
IGF1RInsRTK5hznE7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6494
IGF1RInsRTK3nw5An-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2r)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amineHuman998
IGF1RInsRTK3lvpA3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridineHuman1032
IGF1RInsRTK3lw0AA-Human1021
IGF1RInsRTK3lvpC3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridineHuman1003
IGF1RInsRTK3f5pK4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1013
IGF1RInsRTK4d2rABn-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amineHuman1034
IGF1RInsRTK8pyjA5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dioneHuman14905
IGF1RInsRTK1p4oB-Human1026
IGF1RInsRTK3lw0CA-Human1011
IGF1RInsRTK1p4oA-Human1002
IGF1RInsRTK3f5pC4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1022
IGF1RInsRTK5fxsAB2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamideHuman7097
IGF1RInsRTK1m7nB-Human1012
IGF1RInsRTK5hznD7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6496
IGF1RInsRTK2zm3C(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dioneHuman1010
IGF1RInsRTK4d2rAAn-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amineHuman1018
IGF1RInsRTK1k3aAphosphomethylphosphonic acid adenylate esterHuman1028
IGF1RInsRTK3f5pS4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman996
IGF1RInsRTK3nw7An-({4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamideHuman1030
IGF1RInsRTK3f5pG4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1005
IGF1RInsRTK5hznC7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6498
IGF1RInsRTK3qquCn~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamineHuman1014
IGF1RInsRTK5fxqA5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amineHuman7093
IGF1RInsRTK6jk8BB-Human12017
IGF1RInsRTK3f5pR4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1019
IGF1RInsRTK1jqhBphosphoaminophosphonic acid-adenylate esterHuman994
IGF1RInsRTK1jqhAphosphoaminophosphonic acid-adenylate esterHuman999
IGF1RInsRTK3lw0BB-Human1008
IGF1RInsRTK2zm3A(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dioneHuman1004
IGF1RInsRTK3lw0CB-Human1025
INSRInsRTK1irkAA-Human596
INSRInsRTK4ibmBB5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-oneHuman599
INSRInsRTK5e1sAB(5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amineHuman6147
IGF1RInsRTK2oj9A3-[5-(1h-imidazol-1-yl)-7-methyl-1h-benzimidazol-2-yl]-4-[(pyridin-2-ylmethyl)amino]pyridin-2(1h)-oneHuman1017
IGF1RInsRTK8pylA(5s)-5-methyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dioneHuman14906
IGF1RInsRTK3f5pB4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1044
IGF1RInsRTK3f5pA4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman995
IGF1RInsRTK3qquAn~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamineHuman1024
IGF1RInsRTK5hznB7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6495
IGF1RInsRTK3lw0AB-Human1031
IGF1RInsRTK8pynAB5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dioneHuman14907
INSRInsRTK8u4bA-Human15258
INSRInsRTK8x2mA-Human16058
IGF1RInsRTK3lw0DA-Human1033
IGF1RInsRTK5fxrAB5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amineHuman7094
IGF1RInsRTK3lw0DB-Human1027
IGF1RInsRTK5hznG7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amineHuman6499
INSRInsRTK8dwnA-Human14975
INSRInsRTK4ibmAA5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-oneHuman589
INSRInsRTK7bw7C-Human13505
IGF1RInsRTK3d94AA3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amineHuman6759
IGF1RInsRTK3f5pD4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1015
IGF1RInsRTK3f5pJ4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1040
IGF1RInsRTK3f5pT4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1037
IGF1RInsRTK3f5pE4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1042
IGF1RInsRTK2zm3B(4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dioneHuman1000
IGF1RInsRTK3nw6An-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2s)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amineHuman1043
IGF1RInsRTK3f5pL4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1039
INSRInsRTK1p14A-Human593
INSRInsRTK1gagA-Human586
INSRInsRTK4ibmBA5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-oneHuman604
INSRInsRTK7bw8A-Human13502
INSRInsRTK8xkmA-Human16054
INSRInsRTK5e1sAA(5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amineHuman6146
INSRInsRTK3eknAB2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamideHuman594
INSRInsRTK8xkrE-Human16055
INSRInsRTK7bw8C-Human13503
INSRInsRTK2auhA-Human584
INSRInsRTK3bu3A-Human591
INSRInsRTK9dniC-Human16056
INSRInsRTK3etaBB1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)ureaHuman600
INSRInsRTK6pxwA-Human11593
INSRInsRTK3ekkAA2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamideHuman578
IGF1RInsRTK3qquDn~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamineHuman997
IGF1RInsRTK3f5pM4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrileHuman1001
INSRInsRTK5hhwAB7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineHuman6522
INSRInsRTK4ibmAB5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-oneHuman598
INSRInsRTK7pg4A-Human14100
INSRR (IRR)InsRTK7tymA-Human14611
INSRR (IRR)InsRTK7tykA-Human14612
INSRInsRTK1ir3Aphosphoaminophosphonic acid-adenylate esterHuman602
INSRInsRTK7pg0A-Human14097
INSRInsRTK8yysC-Human16050
INSRInsRTK9puvA-Human16051
INSRInsRTK8x06A-Human16052
INSRInsRTK9dn6C-Human16053
INSRInsRTK4xlvAphosphomethylphosphonic acid adenylate esterHuman577
INSRInsRTK1rqqAthiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diesterHuman7407
INSRInsRTK3eknAA2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamideHuman597
INSRInsRTK1rqqBthiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diesterHuman7406
INSRInsRTK7pg2A-Human14098
INSRInsRTK3bu6A-Human601
INSRInsRTK3etaAA1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)ureaHuman590
INSRInsRTK3bu5Aadenosine-5'-triphosphateHuman595
INSRInsRTK6pxwB-Human11591
INSRInsRTK7bw7A-Human13504
INSRInsRTK8yszB-Human16057
INSRInsRTK6pxvC-Human11590
INSRInsRTK6pxvA-Human11592
INSRInsRTK3ekkAB2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamideHuman581
INSRInsRTK2b4sD-Human583
INSRInsRTK3etaAB1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)ureaHuman579
INSRInsRTK2z8cA[4-({5-(aminocarbonyl)-4-[(3-methylphenyl)amino]pyrimidin-2-yl}amino)phenyl]acetic acidHuman587
INSRInsRTK3etaBA1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)ureaHuman588
INSRInsRTK2b4sB-Human585
INSRInsRTK1i44Aphosphomethylphosphonic acid adenylate esterHuman582
INSRInsRTK7pg3A-Human14099
INSRInsRTK5hhwAA7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amineHuman6523
INSRInsRTK1irkAB-Human603
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