| JAK2 | JakA | TK | 8bx6 | A | A | cerdulatinib | Human | 15033 | |
| JAK2 | JakA | TK | 8bx6 | A | B | cerdulatinib | Human | 15042 | |
| JAK2 | JakA | TK | 3e64 | A | A | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3646 | |
| JAK2 | JakA | TK | 8bpv | A | B | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15036 | |
| JAK2 | JakA | TK | 5wev | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8377 | |
| JAK2 | JakA | TK | 6vgl | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13222 | |
| JAK2 | JakA | TK | 6wtn | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13538 | |
| JAK2 | JakA | TK | 3lpb | A | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3672 | |
| JAK2 | JakA | TK | 5tq6 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7354 | |
| JAK2 | JakA | TK | 4bbf | D | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3663 | |
| JAK3 | JakA | TK | 4i6q | A | | n-[(1s)-1-cyclopropylethyl]-2-phenoxy-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 432 | |
| JAK3 | JakA | TK | 7uyv | A | B | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14332 | |
| JAK2 | JakA | TK | 7uyw | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14333 | |
| JAK1 | JakA | TK | 6aah | A | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10392 | |
| JAK1 | JakA | TK | 6aah | A | B | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10396 | |
| JAK1 | JakA | TK | 4ivd | B | B | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1457 | |
| JAK3 | JakA | TK | 6hzv | D | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11749 | |
| JAK3 | JakA | TK | 4rio | A | | 4-{[(1r,2s)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 440 | |
| JAK3 | JakA | TK | 4qps | A | B | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 458 | |
| JAK3 | JakA | TK | 3zep | A | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 456 | |
| JAK3 | JakA | TK | 7apf | B | B | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13132 | |
| JAK3 | JakA | TK | 5ttu | A | B | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7438 | |
| JAK3 | JakA | TK | 4z16 | C | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6397 | |
| JAK3 | JakA | TK | 7uyv | A | A | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14331 | |
| JAK2 | JakA | TK | 8bm2 | A | A | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15043 | |
| JAK2 | JakA | TK | 7ree | A | B | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13856 | |
| TYK2 | JakA | TK | 6x8g | A | B | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | 12993 | |
| JAK3 | JakA | TK | 6aak | D | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10365 | |
| JAK3 | JakA | TK | 6hzv | A | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11756 | |
| JAK3 | JakA | TK | 3zep | D | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 454 | |
| JAK2 | JakA | TK | 8bxc | A | B | itacitinib | Human | 15041 | |
| JAK3 | JakA | TK | 7apg | B | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13131 | |
| JAK3 | JakA | TK | 4hvh | A | | 2-cyclopropyl-n-[(2r)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 441 | |
| JAK3 | JakA | TK | 6gla | B | A | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10017 | |
| JAK3 | JakA | TK | 5w86 | B | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8551 | |
| JAK3 | JakA | TK | 5ttv | A | A | n-[3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide | Human | 7437 | |
| JAK3 | JakA | TK | 3zep | B | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 437 | |
| JAK2 | JakA | TK | 9t1u | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15577 | |
| JAK2 | JakA | TK | 29rx | A | B | adenosine-5'-diphosphate | Human | 15575 | |
| JAK2 | JakA | TK | 5cf4 | B | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5982 | |
| JAK2 | JakA | TK | 9t1u | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15576 | |
| JAK2 | JakA | TK | 9t1z | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15578 | |
| JAK3 | JakA | TK | 7c3n | A | B | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12391 | |
| JAK1 | JakA | TK | 3eyh | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 1462 | |
| JAK1 | JakA | TK | 6n77 | B | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11018 | |
| JAK1 | JakA | TK | 6tpf | A | B | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12365 | |
| JAK1 | JakA | TK | 6elr | B | A | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10619 | |
| JAK1 | JakA | TK | 5wo4 | B | B | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8703 | |
| JAK1 | JakA | TK | 6n77 | A | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11021 | |
| JAK1 | JakA | TK | 4ivb | A | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1486 | |
| JAK1 | JakA | TK | 6rsh | A | A | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12470 | |
| JAK1 | JakA | TK | 6rse | B | B | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12471 | |
| JAK1 | JakA | TK | 5wo4 | A | B | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8705 | |
| JAK1 | JakA | TK | 4e4l | E | B | - | Human | 1484 | |
| JAK1 | JakA | TK | 6n79 | A | | n-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11031 | |
| JAK1 | JakA | TK | 6rsd | A | A | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12472 | |
| JAK1 | JakA | TK | 6rsh | A | B | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12473 | |
| JAK1 | JakA | TK | 6dbn | A | A | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10393 | |
| JAK1 | JakA | TK | 4e4l | D | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1468 | |
| JAK1 | JakA | TK | 5hx8 | B | A | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6440 | |
| JAK1 | JakA | TK | 6smb | A | A | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12246 | |
| JAK1 | JakA | TK | 6n7a | B | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11026 | |
| JAK1 | JakA | TK | 5khx | A | A | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7167 | |
| JAK1 | JakA | TK | 6tpf | B | B | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12367 | |
| JAK1 | JakA | TK | 6n78 | A | A | n-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11019 | |
| JAK1 | JakA | TK | 6n7c | A | A | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11016 | |
| JAK2 | JakA | TK | 4f08 | B | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3719 | |
| JAK1 | JakA | TK | 6elr | A | A | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10618 | |
| JAK1 | JakA | TK | 6bbu | A | A | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9497 | |
| JAK1 | JakA | TK | 6tpe | B | | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | Human | 12368 | |
| JAK1 | JakA | TK | 4ei4 | B | | (1r,3r)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8h)-yl)cyclohexanol | Human | 1483 | |
| JAK1 | JakA | TK | 4e4l | A | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1450 | |
| JAK1 | JakA | TK | 5khw | A | | adenosine-5'-diphosphate | Human | 7164 | |
| JAK2 | JakA | TK | 4iva | A | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3673 | |
| JAK1 | JakA | TK | 6w8l | A | | n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | Human | 12133 | |
| JAK1 | JakA | TK | 6elr | A | B | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10616 | |
| JAK1 | JakA | TK | 6n7d | A | A | n-[5-(6-methoxy-1h-indazol-5-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11032 | |
| JAK1 | JakA | TK | 6n78 | A | B | n-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11022 | |
| JAK1 | JakA | TK | 4e4n | A | | tert-butyl [(1r,3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)cyclopentyl]carbamate | Human | 1443 | |
| JAK1 | JakA | TK | 6rse | B | A | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12465 | |
| JAK1 | JakA | TK | 5wo4 | A | A | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8702 | |
| JAK1 | JakA | TK | 6rsd | B | A | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12466 | |
| JAK1 | JakA | TK | 5hx8 | B | B | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6439 | |
| JAK1 | JakA | TK | 6rsb | A | | 1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12482 | |
| JAK1 | JakA | TK | 4ehz | A | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1482 | |
| JAK1 | JakA | TK | 4ivd | A | A | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1489 | |
| JAK1 | JakA | TK | 5khx | A | B | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7166 | |
| JAK1 | JakA | TK | 4i5c | B | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1458 | |
| JAK1 | JakA | TK | 6sm8 | A | B | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12250 | |
| JAK1 | JakA | TK | 4ivd | A | B | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1474 | |
| JAK2 | JakA | TK | 4aqc | B | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3676 | |
| JAK2 | JakA | TK | 3tjd | B | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3626 | |
| JAK2 | JakA | TK | 4e4m | A | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3713 | |
| JAK1 | JakA | TK | 4e5w | B | B | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1477 | |
| JAK1 | JakA | TK | 6n77 | B | C | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11034 | |
| JAK1 | JakA | TK | 6sm8 | B | A | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12245 | |
| JAK1 | JakA | TK | 6hzu | B | B | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11763 | |
| JAK1 | JakA | TK | 4e5w | A | A | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1452 | |
| JAK1 | JakA | TK | 4e4l | D | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1455 | |
| JAK1 | JakA | TK | 6ggh | B | A | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11089 | |
| JAK1 | JakA | TK | 6hzu | A | A | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11764 | |
| JAK1 | JakA | TK | 4e4l | B | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1466 | |
| JAK1 | JakA | TK | 6n7b | A | | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-1h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11020 | |
| JAK3 | JakA | TK | 5vo6 | A | | 4-{[(1r,3s)-3-amino-2,2,3-trimethylcyclopentyl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 7960 | |
| JAK3 | JakA | TK | 7apg | D | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13138 | |
| JAK3 | JakA | TK | 3zep | C | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 462 | |
| JAK3 | JakA | TK | 6aak | B | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10367 | |
| JAK3 | JakA | TK | 3zep | C | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 439 | |
| JAK3 | JakA | TK | 6hzv | B | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11754 | |
| JAK3 | JakA | TK | 6aak | C | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10368 | |
| JAK1 | JakA | TK | 4ivb | B | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1472 | |
| JAK1 | JakA | TK | 6smb | A | B | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12247 | |
| JAK2 | JakA | TK | 4iva | A | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3725 | |
| JAK2 | JakA | TK | 8g8x | A | A | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14804 | |
| JAK2 | JakA | TK | 7teu | A | A | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14806 | |
| JAK2 | JakA | TK | 8g6z | A | A | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14808 | |
| JAK2 | JakA | TK | 8g8o | A | B | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14809 | |
| JAK2 | JakA | TK | 8g8o | A | A | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14807 | |
| JAK2 | JakA | TK | 3jy9 | A | B | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3716 | |
| JAK2 | JakA | TK | 7teu | A | B | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14811 | |
| JAK3 | JakA | TK | 3lxk | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 436 | |
| JAK3 | JakA | TK | 6ny4 | A | | 4-{[(2r,3r)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 11052 | |
| JAK3 | JakA | TK | 7apg | A | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13135 | |
| JAK2 | JakA | TK | 4c61 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3661 | |
| JAK3 | JakA | TK | 7q6h | A | A | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14080 | |
| JAK3 | JakA | TK | 7apg | D | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13133 | |
| JAK3 | JakA | TK | 6hzv | B | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11753 | |
| JAK3 | JakA | TK | 6gl9 | B | A | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10019 | |
| JAK3 | JakA | TK | 6dud | A | B | n-[(1s)-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10720 | |
| JAK3 | JakA | TK | 4v0g | B | A | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6348 | |
| JAK3 | JakA | TK | 6gla | A | A | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10018 | |
| JAK3 | JakA | TK | 3zc6 | A | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 461 | |
| JAK3 | JakA | TK | 6db4 | A | A | n-[(1s)-6-(5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10724 | |
| JAK3 | JakA | TK | 4hvi | A | | 2-cyclopropyl-n-[(2r)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 438 | |
| JAK3 | JakA | TK | 7apg | C | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13140 | |
| JAK3 | JakA | TK | 6gla | B | B | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10022 | |
| JAK3 | JakA | TK | 3zep | B | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 430 | |
| JAK2 | JakA | TK | 5tq3 | B | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7360 | |
| JAK3 | JakA | TK | 4z16 | D | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6394 | |
| JAK3 | JakA | TK | 6db3 | A | A | [(1s)-1-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]cyanamide | Human | 10718 | |
| JAK3 | JakA | TK | 6aak | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10366 | |
| JAK1 | JakA | TK | 5khw | B | | adenosine-5'-diphosphate | Human | 7165 | |
| JAK3 | JakA | TK | 5lwn | A | A | (~{z})-2-cyano-~{n},~{n}-dimethyl-3-[5-[3-[(1~{s},2~{r})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]prop-2-enamide | Human | 7117 | |
| JAK3 | JakA | TK | 7apg | B | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13136 | |
| JAK3 | JakA | TK | 3zc6 | B | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 447 | |
| JAK3 | JakA | TK | 4v0g | A | B | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6346 | |
| JAK2 | JakA | TK | 3q32 | A | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3700 | |
| JAK1 | JakA | TK | 4ehz | B | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1481 | |
| JAK2 | JakA | TK | 8g6z | A | B | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14810 | |
| JAK2 | JakA | TK | 6aaj | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10515 | |
| JAK3 | JakA | TK | 3lxl | A | B | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 443 | |
| JAK3 | JakA | TK | 5toz | A | | 1-{(2s,5r)-2-methyl-5-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7163 | |
| JAK3 | JakA | TK | 6da4 | A | | (z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-4h-1,4-benzoxazin-4-yl}methanimine | Human | 10723 | |
| JAK2 | JakA | TK | 4gfm | A | A | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3680 | |
| JAK1 | JakA | TK | 6rse | A | A | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12481 | |
| JAK3 | JakA | TK | 5lwn | A | B | (2~{s})-2-cyano-~{n},~{n}-dimethyl-3-[5-[3-[(1~{s},2~{r})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]propanamide | Human | 7116 | |
| JAK3 | JakA | TK | 3zc6 | C | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 445 | |
| JAK2 | JakA | TK | 8bx9 | A | B | ilginatinib | Human | 15034 | |
| JAK3 | JakA | TK | 5lwm | A | B | 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{n},~{n}-dimethyl-prop-2-enamide | Human | 7118 | |
| JAK3 | JakA | TK | 6gl9 | A | A | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10014 | |
| JAK3 | JakA | TK | 7apf | A | B | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13130 | |
| JAK3 | JakA | TK | 1yvj | A | A | 1,2,3,4-tetrahydrogen-staurosporine | Human | 460 | |
| JAK3 | JakA | TK | 6glb | A | B | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10023 | |
| JAK3 | JakA | TK | 4hvg | A | | 2-cyclopropyl-n-[(2s)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 450 | |
| JAK3 | JakA | TK | 3zc6 | D | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 459 | |
| JAK3 | JakA | TK | 7q6h | A | C | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14081 | |
| JAK2 | JakA | TK | 6vnj | A | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13340 | |
| JAK2 | JakA | TK | 29ry | A | B | - | Human | 15569 | |
| JAK2 | JakA | TK | 6tpd | A | | 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one | Human | 12350 | |
| JAK2 | JakA | TK | 3io7 | A | | (3s)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-n,n-diethylpiperidine-3-carboxamide | Human | 3636 | |
| JAK2 | JakA | TK | 8bxh | A | A | momelotinib | Human | 15032 | |
| JAK2 | JakA | TK | 4e4m | D | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3669 | |
| JAK2 | JakA | TK | 4ytc | A | B | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3687 | |
| JAK2 | JakA | TK | 9t20 | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15570 | |
| JAK2 | JakA | TK | 6vnh | B | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13342 | |
| JAK2 | JakA | TK | 4aqc | A | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3696 | |
| JAK3 | JakA | TK | 5ttu | A | A | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7435 | |
| JAK3 | JakA | TK | 3zc6 | A | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 442 | |
| JAK3 | JakA | TK | 4v0g | A | A | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6347 | |
| JAK3 | JakA | TK | 5wfj | A | | 4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 8535 | |
| JAK3 | JakA | TK | 6glb | B | A | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10021 | |
| JAK3 | JakA | TK | 4z16 | A | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6395 | |
| JAK3 | JakA | TK | 3zc6 | C | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 433 | |
| JAK3 | JakA | TK | 5tts | A | | 1-{(3r)-3-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7439 | |
| JAK2 | JakA | TK | 6vgl | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13220 | |
| JAK2 | JakA | TK | 6x8e | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13152 | |
| JAK2 | JakA | TK | 5usy | B | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8104 | |
| JAK2 | JakA | TK | 6vn8 | A | | baricitinib | Human | 13291 | |
| JAK2 | JakA | TK | 9t20 | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15572 | |
| JAK2 | JakA | TK | 5tq7 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7355 | |
| JAK2 | JakA | TK | 6wto | A | A | baricitinib | Human | 13536 | |
| JAK2 | JakA | TK | 5tq6 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7361 | |
| JAK2 | JakA | TK | 3jy9 | A | A | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3668 | |
| JAK3 | JakA | TK | 3lxl | A | A | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 434 | |
| JAK2 | JakA | TK | 6bbv | A | | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9504 | |
| JAK3 | JakA | TK | 7c3n | A | A | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12389 | |
| JAK2 | JakA | TK | 4bbe | A | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3670 | |
| JAK2 | JakA | TK | 5cf4 | A | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5980 | |
| JAK3 | JakA | TK | 6hzv | C | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11755 | |
| JAK2 | JakA | TK | 4c62 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3655 | |
| JAK2 | JakA | TK | 9t1z | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15573 | |
| JAK2 | JakA | TK | 6vs3 | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13345 | |
| JAK2 | JakA | TK | 5cf5 | B | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5976 | |
| JAK3 | JakA | TK | 3pjc | A | | 3-(1h-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1h-pyrrole-2,5-dione | Human | 444 | |
| JAK3 | JakA | TK | 3zc6 | D | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 446 | |
| JAK2 | JakA | TK | 3fup | B | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3654 | |
| JAK2 | JakA | TK | 4d1s | A | B | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3627 | |
| JAK2 | JakA | TK | 4c61 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3645 | |
| JAK2 | JakA | TK | 6wtq | A | B | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13537 | |
| JAK2 | JakA | TK | 3zmm | B | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3709 | |
| JAK2 | JakA | TK | 4e6d | B | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3631 | |
| JAK2 | JakA | TK | 8bxc | A | A | itacitinib | Human | 15037 | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | |
| JAK2 | JakA | TK | 6vnk | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13293 | |
| JAK2 | JakA | TK | 4yti | A | A | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3641 | |
| JAK2 | JakA | TK | 4e6q | A | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3624 | |
| JAK2 | JakA | TK | 4p7e | B | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3701 | |
| JAK2 | JakA | TK | 3kck | A | B | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3722 | |
| JAK2 | JakA | TK | 5l3a | A | A | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6561 | |
| JAK2 | JakA | TK | 8bx9 | A | A | ilginatinib | Human | 15038 | |
| JAK2 | JakA | TK | 4yth | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3702 | |
| JAK2 | JakA | TK | 4ytf | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3690 | |
| JAK2 | JakA | TK | 5hez | C | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7253 | |
| JAK2 | JakA | TK | 3e63 | A | A | 5-phenyl-1h-indazol-3-amine | Human | 3675 | |
| JAK2 | JakA | TK | 8g8x | A | B | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14805 | |
| JAK2 | JakA | TK | 5tq3 | A | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7359 | |
| JAK2 | JakA | TK | 4gmy | A | | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3684 | |
| JAK2 | JakA | TK | 6x8e | B | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13153 | |
| JAK2 | JakA | TK | 6vnk | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13295 | |
| JAK2 | JakA | TK | 6x8e | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13154 | |
| JAK2 | JakA | TK | 3q32 | B | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3639 | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | |
| JAK2 | JakA | TK | 6wto | A | B | baricitinib | Human | 13539 | |
| JAK2 | JakA | TK | 5tq4 | A | | 6-(2-ethyl-4-hydroxyphenyl)-1h-indazole-3-carboxamide | Human | 7351 | |
| JAK2 | JakA | TK | 5hez | D | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7252 | |
| JAK2 | JakA | TK | 7q7w | A | A | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14087 | |
| JAK2 | JakA | TK | 4bbe | B | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3727 | |
| JAK2 | JakA | TK | 6vnc | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13348 | |
| JAK2 | JakA | TK | 7q7i | A | B | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14088 | |
| JAK2 | JakA | TK | 6vne | A | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13296 | |
| JAK2 | JakA | TK | 5cf6 | B | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5977 | |
| JAK2 | JakA | TK | 6vs3 | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13349 | |
| JAK2 | JakA | TK | 5cf8 | A | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5981 | |
| JAK2 | JakA | TK | 4f09 | A | | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3622 | |
| JAK2 | JakA | TK | 6vnm | B | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13351 | |
| JAK2 | JakA | TK | 6wtn | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13540 | |
| JAK2 | JakA | TK | 5tq8 | A | | {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2h-indazol-3-yl]-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone | Human | 7357 | |
| JAK2 | JakA | TK | 6vnl | D | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13297 | |
| JAK2 | JakA | TK | 6drw | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10512 | |
| JAK2 | JakA | TK | 4c62 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3625 | |
| JAK2 | JakA | TK | 4aqc | A | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3720 | |
| JAK2 | JakA | TK | 5tq5 | A | | 6-(2-ethyl-4-hydroxyphenyl)-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide | Human | 7358 | |
| JAK2 | JakA | TK | 6vsn | A | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13353 | |
| JAK2 | JakA | TK | 4jia | A | B | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3640 | |
| JAK2 | JakA | TK | 29ry | A | A | - | Human | 15574 | |
| JAK2 | JakA | TK | 3ugc | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3651 | |
| JAK2 | JakA | TK | 2b7a | B | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3728 | |
| JAK2 | JakA | TK | 7q7w | A | B | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14089 | |
| JAK2 | JakA | TK | 3lpb | A | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3698 | |
| JAK2 | JakA | TK | 5usy | B | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8103 | |
| JAK2 | JakA | TK | 4zim | A | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3659 | |
| JAK2 | JakA | TK | 6drw | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10513 | |
| JAK2 | JakA | TK | 6vn8 | B | | baricitinib | Human | 13301 | |
| JAK2 | JakA | TK | 3ugc | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3632 | |
| JAK2 | JakA | TK | 4zim | A | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3704 | |
| JAK2 | JakA | TK | 6vsn | B | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13356 | |
| JAK2 | JakA | TK | 3tjc | B | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3688 | |
| JAK2 | JakA | TK | 3lpb | B | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3635 | |
| JAK2 | JakA | TK | 4jia | A | A | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3691 | |
| JAK2 | JakA | TK | 4zim | B | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3697 | |
| JAK2 | JakA | TK | 3e62 | A | A | 5-bromo-1h-indazol-3-amine | Human | 3665 | |
| JAK2 | JakA | TK | 5usy | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8101 | |
| JAK2 | JakA | TK | 5l3a | A | B | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6560 | |
| JAK2 | JakA | TK | 4yth | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3710 | |
| JAK2 | JakA | TK | 4hge | A | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3658 | |
| JAK2 | JakA | TK | 4aqc | B | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3679 | |
| JAK2 | JakA | TK | 5tq7 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7353 | |
| JAK2 | JakA | TK | 7q7i | A | A | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14085 | |
| JAK2 | JakA | TK | 3krr | A | A | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3643 | |
| JAK2 | JakA | TK | 4hge | B | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3706 | |
| JAK2 | JakA | TK | 7q7k | A | A | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14091 | |
| JAK2 | JakA | TK | 6vnb | A | | (3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13298 | |
| JAK2 | JakA | TK | 6vsn | D | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13343 | |
| JAK2 | JakA | TK | 6vng | B | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13341 | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | |
| TYK2 | JakA | TK | 4gii | A | | 2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3331 | |
| TYK2 | JakA | TK | 6dbk | A | | 4-({4-[(1s,4s)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-n-ethylbenzamide | Human | 10490 | |
| TYK2 | JakA | TK | 6vnv | A | | (1s,2s)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12138 | |
| TYK2 | JakA | TK | 6vns | A | A | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12139 | |
| TYK2 | JakA | TK | 6x8f | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13159 | |
| TYK2 | JakA | TK | 5f1z | A | B | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6357 | |
| JAK2 | JakA | TK | 5aep | A | B | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3686 | |
| JAK2 | JakA | TK | 3krr | A | B | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3695 | |
| JAK2 | JakA | TK | 4f08 | A | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3662 | |
| JAK1 | JakA | TK | 4fk6 | A | B | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1460 | |
| JAK1 | JakA | TK | 6rsc | A | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12468 | |
| JAK1 | JakA | TK | 3eyg | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1445 | |
| JAK1 | JakA | TK | 4i5c | A | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1446 | |
| JAK1 | JakA | TK | 4ivb | B | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1444 | |
| JAK1 | JakA | TK | 6rsc | B | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12469 | |
| JAK1 | JakA | TK | 6smb | B | A | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12244 | |
| JAK1 | JakA | TK | 4fk6 | B | A | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1487 | |
| JAK1 | JakA | TK | 6n7a | A | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11017 | |
| JAK1 | JakA | TK | 4i5c | A | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1471 | |
| JAK1 | JakA | TK | 6rsc | A | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12477 | |
| JAK1 | JakA | TK | 6c7y | A | A | adenosine-5'-diphosphate | Human | 9866 | |
| JAK1 | JakA | TK | 6elr | B | B | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10617 | |
| JAK1 | JakA | TK | 6rsd | A | B | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12478 | |
| JAK1 | JakA | TK | 6rsb | B | | 1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12479 | |
| JAK3 | JakA | TK | 6db4 | A | B | n-[(1s)-6-(5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10721 | |
| JAK3 | JakA | TK | 6gl9 | A | B | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10016 | |
| JAK3 | JakA | TK | 9r5z | A | | 3-(3-cyclohexyl-3,8,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-5-yl)benzenesulfonyl fluoride | Human | 15522 | |
| JAK3 | JakA | TK | 5w86 | C | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8550 | |
| JAK3 | JakA | TK | 6dud | A | A | n-[(1s)-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10722 | |
| JAK3 | JakA | TK | 6hzv | C | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11752 | |
| JAK3 | JakA | TK | 6gla | A | B | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10012 | |
| JAK3 | JakA | TK | 7apg | A | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13134 | |
| JAK3 | JakA | TK | 6glb | A | A | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10020 | |
| JAK3 | JakA | TK | 4qps | A | A | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 453 | |
| JAK3 | JakA | TK | 6glb | B | B | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10015 | |
| JAK3 | JakA | TK | 5lwm | A | A | 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{n},~{n}-dimethyl-prop-2-enamide | Human | 7115 | |
| JAK3 | JakA | TK | 7q6h | A | B | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14082 | |
| JAK3 | JakA | TK | 4qps | C | A | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 435 | |
| JAK3 | JakA | TK | 1yvj | A | B | 1,2,3,4-tetrahydrogen-staurosporine | Human | 451 | |
| JAK3 | JakA | TK | 4qt1 | A | | 1-{(3s)-1-[(2-methylpropyl)sulfonyl]piperidin-3-yl}-3-(5h-pyrrolo[2,3-b]pyrazin-2-yl)urea | Human | 452 | |
| JAK3 | JakA | TK | 6gl9 | B | B | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10013 | |
| JAK3 | JakA | TK | 7apf | B | A | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13137 | |
| JAK3 | JakA | TK | 4hvd | A | | 2-cyclopropyl-n-[(2s)-3,3-dimethylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 431 | |
| JAK3 | JakA | TK | 4qps | C | B | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 455 | |
| JAK3 | JakA | TK | 3zep | A | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 448 | |
| JAK3 | JakA | TK | 4v0g | B | B | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6345 | |
| JAK3 | JakA | TK | 4z16 | B | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6396 | |
| JAK3 | JakA | TK | 6db3 | A | B | [(1s)-1-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]cyanamide | Human | 10719 | |
| JAK3 | JakA | TK | 7c3n | A | C | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12390 | |
| JAK3 | JakA | TK | 5ttv | A | B | n-[3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide | Human | 7436 | |
| JAK3 | JakA | TK | 8rpn | A | | 3-[4-[[(3~{r})-1-(2-cyanoethanoyl)piperidin-3-yl]amino]pyrimidin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 15523 | |
| JAK3 | JakA | TK | 7apg | C | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13139 | |
| JAK3 | JakA | TK | 5w86 | D | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8548 | |
| JAK3 | JakA | TK | 5w86 | A | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8549 | |
| JAK3 | JakA | TK | 7apf | A | A | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13141 | |
| JAK3 | JakA | TK | 3zep | D | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 457 | |
| JAK3 | JakA | TK | 3zc6 | B | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 449 | |
| JAK3 | JakA | TK | 6hzv | A | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11751 | |
| JAK3 | JakA | TK | 6hzv | D | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11750 | |
| JAK2 | JakA | TK | 6wtq | A | A | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13535 | |
| JAK2 | JakA | TK | 4bbe | D | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3726 | |
| JAK2 | JakA | TK | 3kck | A | A | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3683 | |
| JAK2 | JakA | TK | 29rx | A | A | adenosine-5'-diphosphate | Human | 15571 | |
| JAK2 | JakA | TK | 5cf8 | B | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5983 | |
| JAK2 | JakA | TK | 4bbe | C | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3649 | |
| JAK2 | JakA | TK | 7ll4 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14035 | |
| JAK2 | JakA | TK | 4ytf | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3693 | |
| JAK2 | JakA | TK | 7ree | A | A | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13855 | |
| JAK2 | JakA | TK | 6vgl | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13221 | |
| JAK2 | JakA | TK | 4e6d | B | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3647 | |
| JAK2 | JakA | TK | 5tq3 | A | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7356 | |
| JAK2 | JakA | TK | 2xa4 | B | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3707 | |
| JAK2 | JakA | TK | 4bbf | C | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3644 | |
| JAK2 | JakA | TK | 8bm2 | A | B | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15035 | |
| JAK2 | JakA | TK | 4e6d | A | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3689 | |
| JAK2 | JakA | TK | 6vnh | A | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13344 | |
| JAK2 | JakA | TK | 5cf8 | A | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5978 | |
| JAK2 | JakA | TK | 4p7e | A | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3682 | |
| JAK2 | JakA | TK | 3lpb | B | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3681 | |
| JAK2 | JakA | TK | 3zmm | A | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3674 | |
| JAK2 | JakA | TK | 6vnk | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13292 | |
| JAK2 | JakA | TK | 4ji9 | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3724 | |
| JAK2 | JakA | TK | 4zim | B | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3660 | |
| JAK2 | JakA | TK | 3e64 | A | B | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3653 | |
| JAK2 | JakA | TK | 8bpw | A | B | lestaurtinib | Human | 15039 | |
| JAK2 | JakA | TK | 4e6q | B | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3671 | |
| JAK2 | JakA | TK | 5tq3 | B | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7352 | |
| JAK2 | JakA | TK | 6vni | A | | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | 13294 | |
| JAK2 | JakA | TK | 7uyw | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14334 | |
| JAK2 | JakA | TK | 4e6d | A | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3656 | |
| JAK2 | JakA | TK | 3tjc | A | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3685 | |
| JAK2 | JakA | TK | 2w1i | A | | 4-[(2-{4-[(cyclopropylcarbamoyl)amino]-1h-pyrazol-3-yl}-1h-benzimidazol-6-yl)methyl]morpholin-4-ium | Human | 3652 | |
| JAK2 | JakA | TK | 3tjd | A | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3677 | |
| JAK2 | JakA | TK | 3e63 | A | B | 5-phenyl-1h-indazol-3-amine | Human | 3711 | |
| JAK2 | JakA | TK | 4yti | A | B | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3657 | |
| JAK2 | JakA | TK | 6vgl | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13223 | |
| JAK2 | JakA | TK | 3iok | A | A | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3694 | |
| JAK2 | JakA | TK | 7q7k | A | B | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14086 | |
| JAK2 | JakA | TK | 8bpv | A | A | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15040 | |
| JAK2 | JakA | TK | 4e4m | B | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3712 | |
| JAK2 | JakA | TK | 7rn6 | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13955 | |
| JAK2 | JakA | TK | 6vsn | C | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13350 | |
| JAK2 | JakA | TK | 6wtp | A | A | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13541 | |
| JAK2 | JakA | TK | 6vnl | B | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13299 | |
| JAK2 | JakA | TK | 7q7l | A | B | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14090 | |
| JAK2 | JakA | TK | 4gfm | A | B | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3705 | |
| JAK2 | JakA | TK | 4e4m | E | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3637 | |
| JAK2 | JakA | TK | 4d1s | A | A | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3634 | |
| JAK2 | JakA | TK | 4d0x | A | A | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3699 | |
| JAK2 | JakA | TK | 5cf8 | B | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5985 | |
| JAK2 | JakA | TK | 6vnm | A | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13354 | |
| JAK2 | JakA | TK | 5hez | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7255 | |
| JAK2 | JakA | TK | 6vnl | C | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13300 | |
| JAK2 | JakA | TK | 5wev | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8376 | |
| JAK2 | JakA | TK | 4hge | A | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3703 | |
| JAK2 | JakA | TK | 4bbf | B | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3717 | |
| JAK2 | JakA | TK | 3zmm | B | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3678 | |
| JAK2 | JakA | TK | 7rn6 | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13956 | |
| JAK2 | JakA | TK | 2xa4 | B | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3628 | |
| JAK2 | JakA | TK | 3fup | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3721 | |
| JAK2 | JakA | TK | 4bbf | A | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3723 | |
| JAK2 | JakA | TK | 5aep | A | A | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3629 | |
| JAK2 | JakA | TK | 2xa4 | A | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3623 | |
| JAK2 | JakA | TK | 2xa4 | A | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3664 | |
| JAK2 | JakA | TK | 2b7a | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3708 | |
| JAK2 | JakA | TK | 3zmm | A | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3667 | |
| JAK2 | JakA | TK | 3e62 | A | B | 5-bromo-1h-indazol-3-amine | Human | 3630 | |
| JAK2 | JakA | TK | 3iok | A | B | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3718 | |
| JAK2 | JakA | TK | 5hez | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7254 | |
| JAK2 | JakA | TK | 6x8e | B | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13155 | |
| JAK2 | JakA | TK | 6vne | B | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13302 | |
| JAK2 | JakA | TK | 3rvg | A | | 1-(cyclohexylamino)-7-(1-methyl-1h-pyrazol-4-yl)-5h-pyrido[4,3-b]indole-4-carboxamide | Human | 3638 | |
| JAK2 | JakA | TK | 4d0w | A | B | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3650 | |
| JAK2 | JakA | TK | 7ll5 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14036 | |
| JAK2 | JakA | TK | 6aaj | B | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10514 | |
| JAK2 | JakA | TK | 8bpw | A | A | lestaurtinib | Human | 15044 | |
| JAK2 | JakA | TK | 6vnl | A | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13303 | |
| JAK2 | JakA | TK | 6vnk | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13304 | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | |
| JAK2 | JakA | TK | 5cf5 | A | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5984 | |
| JAK2 | JakA | TK | 5cf6 | A | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5979 | |
| JAK2 | JakA | TK | 4hge | B | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3715 | |
| JAK2 | JakA | TK | 7q7l | A | A | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14092 | |
| JAK2 | JakA | TK | 7ll4 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14037 | |
| JAK2 | JakA | TK | 6vng | A | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13358 | |
| JAK2 | JakA | TK | 7ll5 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14038 | |
| JAK2 | JakA | TK | 2w1i | B | | - | Human | 3648 | |
| JAK2 | JakA | TK | 8bxh | A | B | momelotinib | Human | 15045 | |
| JAK2 | JakA | TK | 4ji9 | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3692 | |
| JAK2 | JakA | TK | 6vnc | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13359 | |
| JAK2 | JakA | TK | 4ytc | A | A | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3633 | |
| JAK2 | JakA | TK | 4d0x | A | B | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3642 | |
| JAK2 | JakA | TK | 4d0w | A | A | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3666 | |
| JAK2 | JakA | TK | 6wtp | A | B | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13542 | |
| TYK2 | JakA | TK | 6vns | A | B | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12137 | |
| TYK2 | JakA | TK | 6ova | A | B | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | 11981 | |
| TYK2 | JakA | TK | 4gj3 | A | | 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3345 | |
| TYK2 | JakA | TK | 7uyr | A | B | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | 14335 | |
| TYK2 | JakA | TK | 4gfo | A | A | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3336 | |
| TYK2 | JakA | TK | 6dbm | A | B | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10488 | |
| TYK2 | JakA | TK | 6x8f | C | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13156 | |
| TYK2 | JakA | TK | 7uys | A | B | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 14336 | |
| TYK2 | JakA | TK | 6x8f | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13157 | |
| TYK2 | JakA | TK | 4gfo | A | B | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3338 | |
| TYK2 | JakA | TK | 6aam | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10489 | |
| TYK2 | JakA | TK | 6ova | A | A | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | 11980 | |
| TYK2 | JakA | TK | 6dbm | A | A | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10491 | |
| TYK2 | JakA | TK | 6vnx | A | | (1s)-2,2-difluoro-n-[(1s,5r,6r)-3-{5-fluoro-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12136 | |
| TYK2 | JakA | TK | 5wal | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8374 | |
| TYK2 | JakA | TK | 3lxn | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3337 | |
| TYK2 | JakA | TK | 3lxp | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3340 | |
| TYK2 | JakA | TK | 4gvj | A | | adenosine-5'-diphosphate | Human | 3334 | |
| TYK2 | JakA | TK | 6x8g | A | A | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | 12992 | |
| TYK2 | JakA | TK | 6vny | A | | n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | Human | 12135 | |
| TYK2 | JakA | TK | 4gih | A | A | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3339 | |
| TYK2 | JakA | TK | 4gj2 | A | | 2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3344 | |
| TYK2 | JakA | TK | 7uyu | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14337 | |
| TYK2 | JakA | TK | 4gih | A | B | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3332 | |
| TYK2 | JakA | TK | 6x8f | C | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13158 | |
| TYK2 | JakA | TK | 7uyr | A | A | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | 14338 | |
| TYK2 | JakA | TK | 3nyx | A | A | n-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | Human | 3341 | |
| TYK2 | JakA | TK | 4py1 | A | | 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine | Human | 3333 | |
| TYK2 | JakA | TK | 7uys | A | A | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 14339 | |
| TYK2 | JakA | TK | 3nyx | A | B | n-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | Human | 3343 | |
| TYK2 | JakA | TK | 7uyt | A | B | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14340 | |
| TYK2 | JakA | TK | 7uyu | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14341 | |
| TYK2 | JakA | TK | 5f1z | A | A | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6356 | |
| TYK2 | JakA | TK | 5wal | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8375 | |
| TYK2 | JakA | TK | 7uyt | A | A | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14342 | |
| TYK2 | JakA | TK | 3nz0 | A | A | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3342 | |
| TYK2 | JakA | TK | 3nz0 | A | B | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3335 | |
| TYK2 | JakA | TK | 5f20 | A | | 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6355 | |
| JAK2 | JakA | TK | 6vnj | B | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13355 | |
| JAK2 | JakA | TK | 4iva | A | C | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3714 | |
| JAK2 | JakA | TK | 5usy | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8102 | |
| JAK1 | JakA | TK | 4fk6 | A | A | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1465 | |
| JAK1 | JakA | TK | 4e4l | B | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1464 | |
| JAK1 | JakA | TK | 6n7c | B | A | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11033 | |
| JAK1 | JakA | TK | 6rsh | B | A | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12467 | |
| JAK1 | JakA | TK | 6dbn | A | B | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10391 | |
| JAK1 | JakA | TK | 6n7a | A | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11028 | |
| JAK1 | JakA | TK | 4e4l | A | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1488 | |
| JAK1 | JakA | TK | 4k6z | A | | (1r,2s)-2-{[8-oxo-2-(1h-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile | Human | 1478 | |
| JAK1 | JakA | TK | 5wo4 | B | A | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8704 | |
| JAK1 | JakA | TK | 6smb | B | B | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12243 | |
| JAK1 | JakA | TK | 6aah | B | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10394 | |
| JAK1 | JakA | TK | 5e1e | A | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6250 | |
| JAK1 | JakA | TK | 6c7y | A | B | adenosine-5'-diphosphate | Human | 9867 | |
| JAK1 | JakA | TK | 4ehz | D | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1485 | |
| JAK1 | JakA | TK | 5hx8 | A | B | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6438 | |
| JAK1 | JakA | TK | 6ggh | B | B | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11086 | |
| JAK1 | JakA | TK | 6tpf | B | A | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12363 | |
| JAK1 | JakA | TK | 6n7c | B | B | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11023 | |
| JAK1 | JakA | TK | 6n7a | B | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11015 | |
| JAK1 | JakA | TK | 4ehz | D | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1451 | |
| JAK1 | JakA | TK | 6tpe | A | | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | Human | 12364 | |
| JAK1 | JakA | TK | 4i5c | B | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1467 | |
| JAK1 | JakA | TK | 4ivb | A | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1479 | |
| JAK1 | JakA | TK | 4k77 | B | | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7h)-one | Human | 1475 | |
| JAK1 | JakA | TK | 6hzu | B | A | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11765 | |
| JAK1 | JakA | TK | 4ei4 | A | | (1r,3r)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8h)-yl)cyclohexanol | Human | 1480 | |
| JAK1 | JakA | TK | 4fk6 | B | B | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1459 | |
| JAK1 | JakA | TK | 5e1e | B | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6251 | |
| JAK1 | JakA | TK | 4e4n | B | | tert-butyl [(1r,3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)cyclopentyl]carbamate | Human | 1454 | |
| JAK1 | JakA | TK | 4ehz | C | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1470 | |
| JAK1 | JakA | TK | 4e5w | B | A | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1447 | |
| JAK1 | JakA | TK | 4ivc | B | | (trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)acetonitrile | Human | 1456 | |
| JAK1 | JakA | TK | 6hzu | A | B | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11762 | |
| JAK1 | JakA | TK | 6rsc | B | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12474 | |
| JAK1 | JakA | TK | 4ehz | C | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1476 | |
| JAK1 | JakA | TK | 4ehz | A | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1463 | |
| JAK1 | JakA | TK | 3eyg | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1453 | |
| JAK1 | JakA | TK | 6rsd | B | B | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12475 | |
| JAK1 | JakA | TK | 6tpf | A | A | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12366 | |
| JAK1 | JakA | TK | 6aah | B | B | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10395 | |
| JAK1 | JakA | TK | 5e1e | B | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6249 | |
| JAK1 | JakA | TK | 4e4l | E | A | - | Human | 1469 | |
| JAK1 | JakA | TK | 5hx8 | A | A | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6441 | |
| JAK1 | JakA | TK | 6rse | A | B | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12476 | |
| JAK1 | JakA | TK | 6bbu | A | B | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9496 | |
| JAK1 | JakA | TK | 6ggh | A | A | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11087 | |
| JAK1 | JakA | TK | 6n77 | A | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11024 | |
| JAK1 | JakA | TK | 6ggh | A | B | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11088 | |
| JAK1 | JakA | TK | 4e5w | A | B | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1473 | |
| JAK1 | JakA | TK | 6n77 | A | C | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11029 | |
| JAK1 | JakA | TK | 6n7d | A | B | n-[5-(6-methoxy-1h-indazol-5-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11025 | |
| JAK1 | JakA | TK | 6n77 | B | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11030 | |
| JAK1 | JakA | TK | 6n7c | A | B | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11027 | |
| JAK1 | JakA | TK | 4ehz | B | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1448 | |
| JAK1 | JakA | TK | 6sm8 | A | A | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12248 | |
| JAK1 | JakA | TK | 6sm8 | B | B | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12249 | |
| JAK1 | JakA | TK | 6rsh | B | B | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12480 | |
| JAK1 | JakA | TK | 4ivc | A | | (trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)acetonitrile | Human | 1461 | |
| JAK1 | JakA | TK | 4k77 | A | | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7h)-one | Human | 1449 | |
| JAK1 | JakA | TK | 4ivd | B | A | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1490 | |
| JAK1 | JakA | TK | 5e1e | A | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6248 | |
