Search results (110 entries covering 51 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
TYK2-bJakBTK6nzfBA6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11451
TYK2-bJakBTK4wovBB2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamideHuman2197
TYK2-bJakBTK6nzqAB6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamideHuman11499
JAK2-bJakBTK6g3cAB2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-oneHuman10976
JAK2-bJakBTK6brwAA4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5h-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamideHuman10382
TYK2-bJakBTK5c03BAphosphothiophosphoric acid-adenylate esterHuman6042
TYK2-bJakBTK7k7oAA6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman13835
TYK2-bJakBTK7k7oAB6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman13837
TYK2-bJakBTK7k7qAB6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamideHuman13836
JAK2-bJakBTK6m9hAA4-({4-amino-6-[4-(2-hydroxyethyl)-1h-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrileHuman10384
JAK1-bJakBTK4l00AA-Human1421
JAK2-bJakBTK6occA2-[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenyl]-1,3-oxazole-4-carboxylic acidHuman12100
TYK2-bJakBTK6nzrABn-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamideHuman11503
TYK2-bJakBTK6nslBA6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman11955
JAK2-bJakBTK6bssAo6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineHuman10386
TYK2-bJakBTK8tb5ABn-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamideHuman14955
TYK2-bJakBTK8tb6AAn-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]ureaHuman14956
TYK2-bJakBTK8tb6ABn-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]ureaHuman14957
JAK2-bJakBTK5uszAB4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamideHuman8043
TYK2-bJakBTK6nzpBA6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman11496
TYK2-bJakBTK6nzfAB6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11449
JAK2-bJakBTK5ut0AB1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}ureaHuman8047
JAK2-bJakBTK6m9hAB4-({4-amino-6-[4-(2-hydroxyethyl)-1h-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrileHuman10383
JAK2-bJakBTK5ut1AB(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-oneHuman8049
TYK2-bJakBTK5c03AAphosphothiophosphoric acid-adenylate esterHuman6043
TYK2-bJakBTK3zonA5-phenyl-2-ureidothiophene-3-carboxamideHuman2200
TYK2-bJakBTK6nzpBB6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman11497
TYK2-bJakBTK7ax4A2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamideHuman13499
JAK2-bJakBTK5ut2AB2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamideHuman8039
JAK2-bJakBTK5ut2AA2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamideHuman8040
JAK2-bJakBTK5uszAA4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamideHuman8048
JAK2-bJakBTK6g3cAA2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-oneHuman10978
JAK2-bJakBTK6brwAB4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5h-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamideHuman10377
JAK2-bJakBTK5ut5AAn-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamideHuman8042
JAK2-bJakBTK5i4nABadenosine-5'-triphosphateHuman6524
JAK2-bJakBTK5ut5ABn-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamideHuman8037
JAK2-bJakBTK6oblA[4-({5-amino-3-[(4-cyanophenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acidHuman12101
JAK2-bJakBTK5ut4A8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxalineHuman8038
JAK2-bJakBTK5ut0AA1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}ureaHuman8041
JAK2-bJakBTK6obfA[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acidHuman12098
JAK2-bJakBTK5wimA1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}ureaHuman10385
JAK2-bJakBTK5wijA4-{[6-(cyclohexylmethoxy)-7h-purin-2-yl]amino}-n,n-diethylbenzamideHuman10388
JAK2-bJakBTK6oavA5-amino-3-[(4-cyanophenyl)amino]-n-phenyl-1h-1,2,4-triazole-1-carboxamideHuman12099
JAK2-bJakBTK5ut3A5-phenyl-2-ureidothiophene-3-carboxamideHuman8044
JAK2-bJakBTK5ut6AB4-({4-amino-6-[3-(hydroxymethyl)-1h-pyrazol-1-yl]pyrimidin-2-yl}amino)benzonitrileHuman8045
JAK2-bJakBTK5wikB(7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-oneHuman10387
JAK2-bJakBTK4fvqAadenosine-5'-triphosphateHuman1224
JAK2-bJakBTK4fvrAadenosine-5'-triphosphateHuman1223
TYK2-bJakBTK6nzqBB6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamideHuman11506
TYK2-bJakBTK5c01B-Human7223
TYK2-bJakBTK4wovBA2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamideHuman2195
TYK2-bJakBTK5tkdBA6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman7325
TYK2-bJakBTK5tkdAA6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman7323
TYK2-bJakBTK8s99AA(8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14847
TYK2-bJakBTK8s98AB(8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14846
TYK2-bJakBTK8s9aAA(8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14848
TYK2-bJakBTK8s98AA(8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14849
JAK1-bJakBTK4l01AA-Human1424
JAK2-bJakBTK5winA4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamideHuman10378
TYK2-bJakBTK5tkdBB6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman7324
JAK2-bJakBTK5wilA5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamideHuman10379
JAK2-bJakBTK5ut6AA4-({4-amino-6-[3-(hydroxymethyl)-1h-pyrazol-1-yl]pyrimidin-2-yl}amino)benzonitrileHuman8036
JAK2-bJakBTK5i4nAAadenosine-5'-triphosphateHuman6525
JAK2-bJakBTK6g3cBA2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-oneHuman10977
JAK2-bJakBTK6bs0AA4-(5-aminopyrazin-2-yl)-1h-pyrrolo[2,3-b]pyridin-6-amineHuman10380
JAK2-bJakBTK6bs0AB4-(5-aminopyrazin-2-yl)-1h-pyrrolo[2,3-b]pyridin-6-amineHuman10381
JAK2-bJakBTK5ut1AA(7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-oneHuman8046
JAK2-bJakBTK6d2iA1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}ureaHuman10967
JAK2-bJakBTK6g3cBB2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-oneHuman10975
JAK2-bJakBTK6d2iB1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}ureaHuman10966
JAK2-bJakBTK6obbA5-amino-n-phenyl-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carboxamideHuman12097
JAK2-bJakBTK4fvpA-Human1222
TYK2-bJakBTK6nslBB6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman11953
TYK2-bJakBTK6nzeAB4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamideHuman11444
TYK2-bJakBTK7ax4B2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamideHuman13498
TYK2-bJakBTK5tkdAB6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman7326
TYK2-bJakBTK6nzqBA6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamideHuman11495
TYK2-bJakBTK6nzpAB6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman11501
TYK2-bJakBTK6nzrAAn-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamideHuman11505
TYK2-bJakBTK4wovAB2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamideHuman2199
TYK2-bJakBTK6nzhAA6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11450
TYK2-bJakBTK6nzfBB6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11445
TYK2-bJakBTK6nzhBB6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11452
TYK2-bJakBTK4wovAA2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamideHuman2196
TYK2-bJakBTK8s99AB(8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14850
TYK2-bJakBTK6nzeAA4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamideHuman11453
TYK2-bJakBTK6nslAB6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman11954
TYK2-bJakBTK6nslAA6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamideHuman11952
TYK2-bJakBTK4oliA2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamideHuman2198
TYK2-bJakBTK6nzrBAn-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamideHuman11498
TYK2-bJakBTK6nzhAB6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11442
TYK2-bJakBTK8s9aAB(8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamideHuman14851
TYK2-bJakBTK6nzeBA4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamideHuman11448
TYK2-bJakBTK5c03ABphosphothiophosphoric acid-adenylate esterHuman6044
TYK2-bJakBTK8tb5AAn-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamideHuman14958
TYK2-bJakBTK6nzqAA6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamideHuman11502
TYK2-bJakBTK6nzfAA6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11446
TYK2-bJakBTK6nzhBA6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamideHuman11447
TYK2-bJakBTK6nzrBBn-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamideHuman11500
TYK2-bJakBTK5c03BBphosphothiophosphoric acid-adenylate esterHuman6045
TYK2-bJakBTK6nzeBB4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamideHuman11443
TYK2-bJakBTK7k7qAA6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamideHuman13838
TYK2-bJakBTK5c01A-Human7222
TYK2-bJakBTK6nzpAA6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamideHuman11504
JAK1-bJakBTK4l01BA-Human1417
JAK1-bJakBTK4l00BA-Human1422
JAK1-bJakBTK4l00AB-Human1420
JAK1-bJakBTK4l01AB-Human1418
JAK1-bJakBTK4l00BB-Human1423
JAK1-bJakBTK4l01BB-Human1419