Search results (109 entries covering 57 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
MAP3K7 (TAK1)MLKTKL5gjfAn-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(3-phenylureido)phenyl)thiazole-4-carboxamideHuman7264
TNNI3K (HH498)MLKTKL4yffBB3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6063
TNNI3K (HH498)MLKTKL4yfiDAn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6072
TNNI3K (HH498)MLKTKL6b5jACn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9798
TNNI3K (HH498)MLKTKL4yfiCAn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6070
MAP3K7 (TAK1)MLKTKL5gjgAn-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(phenylcarbamoyl)phenyl)thiazole-4-carboxamideHuman7265
MAP3K12 (DLK)MLKTKL8degAmethyl (1s,4s)-5-{(4p)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1r,4r)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylateHuman14557
TNNI3K (HH498)MLKTKL4yffCB3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6067
TNNI3K (HH498)MLKTKL6b5jAAn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9791
TNNI3K (HH498)MLKTKL4yffAA3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6068
TNNI3K (HH498)MLKTKL6b5jBBn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9794
TNNI3K (HH498)MLKTKL6b5jDBn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9801
TNNI3K (HH498)MLKTKL4yffCA3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6069
TNNI3K (HH498)MLKTKL4yfiCBn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6073
TNNI3K (HH498)MLKTKL4yfiAAn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6059
TNNI3K (HH498)MLKTKL6b5jCAn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9799
TNNI3K (HH498)MLKTKL6b5jCBn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9793
TNNI3K (HH498)MLKTKL7mgkABn-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-n'-[3-(trifluoromethyl)phenyl]ureaHuman13970
TNNI3K (HH498)MLKTKL4yffDA3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6066
TNNI3K (HH498)MLKTKL4yfiABn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6071
TNNI3K (HH498)MLKTKL4yffDB3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6074
TNNI3K (HH498)MLKTKL6b5jBCn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9797
TNNI3K (HH498)MLKTKL4yffBA3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6065
TNNI3K (HH498)MLKTKL6b5jCCn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9796
TNNI3K (HH498)MLKTKL4yfiDBn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6064
TNNI3K (HH498)MLKTKL7mgkAAn-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-n'-[3-(trifluoromethyl)phenyl]ureaHuman13968
MAP3K9 (MLK1)MLKTKL3dtcA12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12h)-oneHuman3839
MAP3K9 (MLK1)MLKTKL4uy9AB-Human6128
TNNI3K (HH498)MLKTKL4yfiBBn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6060
TNNI3K (HH498)MLKTKL7mgjAn-methyl-4-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamideHuman13969
ILKMLKTKL9d5eAgefitinibHuman15992
ILKMLKTKL9d5hAgefitinibHuman15989
ILKMLKTKL9d5fA4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrileHuman15990
ILKMLKTKL9d5iAadenosine-5'-triphosphateHuman15991
ILKMLKTKL9d5pA[6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amineHuman15993
MAP3K9 (MLK1)MLKTKL4uy9BA-Human6129
MAP3K9 (MLK1)MLKTKL4uy9BB-Human6130
MAP3K9 (MLK1)MLKTKL4uy9AA-Human6127
MAP3K7 (TAK1)MLKTKL5v5nAAn~1~-(1-propyl-1,3-dihydro-2h-benzimidazol-2-ylidene)benzene-1,3-dicarboxamideHuman8350
MAP3K7 (TAK1)MLKTKL7ntiAB~{n}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{n}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{h}-imidazole-4-carboxamideHuman13457
MAP3K7 (TAK1)MLKTKL4l53ABtrans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexanolHuman1892
MAP3K7 (TAK1)MLKTKL4l3pA2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[2,3-c]pyridin-7-amineHuman1891
MAP3K7 (TAK1)MLKTKL5jgbAn-(2-methoxy-4-{[3-(4-methylpiperazin-1-yl)propyl]carbamoyl}phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamideHuman6885
MAP3K7 (TAK1)MLKTKL4gs6AB(3s,5z,8s,9s,11e)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dioneHuman1886
MAP3K7 (TAK1)MLKTKL5gjdA1-(4-((1h-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-3-(5-(4-methylpiperazin-1-yl)naphthalen-2-yl)ureaHuman7263
MAP3K7 (TAK1)MLKTKL5v5nABn~1~-(1-propyl-1,3-dihydro-2h-benzimidazol-2-ylidene)benzene-1,3-dicarboxamideHuman8351
ILKMLKTKL3kmuA-Human4606
ILKMLKTKL3repAadenosine-5'-triphosphateHuman4604
MAP3K12 (DLK)MLKTKL8outAB(1r)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanolHuman14855
MAP3K12 (DLK)MLKTKL8ourAA5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amineHuman14856
MAP3K7 (TAK1)MLKTKL5j7sAn-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamideHuman7429
MAP3K7 (TAK1)MLKTKL2evaABadenosineHuman1882
MAP3K7 (TAK1)MLKTKL5e7rA2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamideHuman7412
MAP3K12 (DLK)MLKTKL8ourAB5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amineHuman14852
MAP3K12 (DLK)MLKTKL8outAA(1r)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanolHuman14853
MAP3K12 (DLK)MLKTKL8ousAB(1s)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-olHuman14854
MAP3K12 (DLK)MLKTKL5vo2AA5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amineHuman8543
TNNI3K (HH498)MLKTKL4yfiBAn-methyl-3-(9h-purin-6-ylamino)benzenesulfonamideHuman6061
TNNI3K (HH498)MLKTKL6b5jBAn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9802
TNNI3K (HH498)MLKTKL6b5jDAn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9792
TNNI3K (HH498)MLKTKL6b5jABn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9800
TNNI3K (HH498)MLKTKL6b5jDCn-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamideHuman9795
MAP3K7 (TAK1)MLKTKL7nthAA2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{r})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{h}-imidazol-2-yl]carbonyl]isoindole-5-carboxamideHuman13456
MAP3K7 (TAK1)MLKTKL2yiyA(1e)-1-[5-tert-butyl-2-(3-fluorophenyl)-1h-pyrazol-3-ylidene]-3-(4-pyridin-3-yloxyphenyl)ureaHuman1890
MAP3K7 (TAK1)MLKTKL4l53AAtrans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexanolHuman1887
MAP3K7 (TAK1)MLKTKL5jh6A2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoateHuman7427
MAP3K7 (TAK1)MLKTKL9fpdA6-[5-[6-(4-oxidanylcyclohexyl)oxy-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-1,2-oxazol-3-yl]pyridine-2-carboxamideHuman15551
MAP3K7 (TAK1)MLKTKL5j9lAn-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamideHuman7426
MAP3K7 (TAK1)MLKTKL4o91An-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)benzamideHuman1888
MAP3K7 (TAK1)MLKTKL4l52AB1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}piperidin-1-yl)ethanoneHuman1889
MAP3K7 (TAK1)MLKTKL2evaAAadenosineHuman1884
MAP3K7 (TAK1)MLKTKL7nthAB2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{r})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{h}-imidazol-2-yl]carbonyl]isoindole-5-carboxamideHuman13458
MAP3K7 (TAK1)MLKTKL4l52AA1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}piperidin-1-yl)ethanoneHuman1883
MAP3K7 (TAK1)MLKTKL8gw3A-Human14877
MAP3K7 (TAK1)MLKTKL4gs6AA(3s,5z,8s,9s,11e)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dioneHuman1885
MAP3K7 (TAK1)MLKTKL7ntiAA~{n}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{n}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{h}-imidazole-4-carboxamideHuman13459
MAP3K7 (TAK1)MLKTKL5jgdAn-(2-isopropoxy-3-(4-methylpiperazine-1-carbonyl)phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamideHuman6884
MAP3K7 (TAK1)MLKTKL5jgaAn-[5-(4-methylpiperazine-1-carbonyl)[1,1'-biphenyl]-2-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamideHuman6886
MAP3K7 (TAK1)MLKTKL5j8iAn-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamideHuman7428
MAP3K7 (TAK1)MLKTKL5jk3A~{n}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamideHuman7430
MAP3K21 (MLK4)MLKTKL4uyaAphosphothiophosphoric acid-adenylate esterHuman6126
MAP3K20 (ZAK)MLKTKL5hesABn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6458
MAP3K20 (ZAK)MLKTKL5hesBAn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6459
MAP3K20 (ZAK)MLKTKL5x5oAAn-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamideHuman9449
MAP3K20 (ZAK)MLKTKL7yawAA~{n}-[3-[[5-[1-[2,6-bis(fluoranyl)-3-[(3-phenylphenyl)sulfonylamino]phenyl]-1,2,3-triazol-4-yl]-1~{h}-pyrazolo[3,4-b]pyridin-3-yl]oxy]propyl]propanamideHuman14891
MAP3K20 (ZAK)MLKTKL7yazAB~{n}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{s})-1-propanoylpyrrolidin-3-yl]oxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamideHuman14892
MAP3K20 (ZAK)MLKTKL5hesAAn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6460
MAP3K20 (ZAK)MLKTKL5x5oABn-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamideHuman9448
MAP3K20 (ZAK)MLKTKL6juuAB~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]naphthalene-1-sulfonamideHuman12166
MAP3K20 (ZAK)MLKTKL7yawAB~{n}-[3-[[5-[1-[2,6-bis(fluoranyl)-3-[(3-phenylphenyl)sulfonylamino]phenyl]-1,2,3-triazol-4-yl]-1~{h}-pyrazolo[3,4-b]pyridin-3-yl]oxy]propyl]propanamideHuman14893
MAP3K20 (ZAK)MLKTKL5hesBBn-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamideHuman6457
MAP3K20 (ZAK)MLKTKL7yazAA~{n}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{s})-1-propanoylpyrrolidin-3-yl]oxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamideHuman14894
MAP3K20 (ZAK)MLKTKL6juuAA~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]naphthalene-1-sulfonamideHuman12167
MAP3K20 (ZAK)MLKTKL6jutA~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamideHuman11462
ILKMLKTKL6mibA-Human10687
ILKMLKTKL3kmwAadenosine-5'-triphosphateHuman4605
MAP3K12 (DLK)MLKTKL5cepABn-(5-piperidin-4-yl-1-propan-2-yl-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amineHuman6154
MAP3K12 (DLK)MLKTKL5cenAA-Human6157
MAP3K12 (DLK)MLKTKL5ceqAA2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrileHuman6159
MAP3K12 (DLK)MLKTKL5cepAAn-(5-piperidin-4-yl-1-propan-2-yl-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amineHuman6158
MAP3K12 (DLK)MLKTKL5ceoAA2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrileHuman6156
MAP3K12 (DLK)MLKTKL5ceqAB2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrileHuman6153
MAP3K12 (DLK)MLKTKL5cenAB-Human6160
MAP3K12 (DLK)MLKTKL5vo2AB5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amineHuman8542
MAP3K12 (DLK)MLKTKL8ousAA(1s)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-olHuman14857
MAP3K12 (DLK)MLKTKL5vo1AB5-{5-[(1r,5s,6r)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amineHuman8541
MAP3K12 (DLK)MLKTKL5vo1AA5-{5-[(1r,5s,6r)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amineHuman8540
MAP3K12 (DLK)MLKTKL5ceoAB2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrileHuman6155
TNNI3K (HH498)MLKTKL4yffAB3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamideHuman6062