| BTK | Tec | TK | 7yc9 | A | B | (7~{s})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14745 | |
| BTK | Tec | TK | 5fbo | A | B | 4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6456 | |
| BTK | Tec | TK | 4rx5 | A | B | n-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide | Human | 6258 | |
| BTK | Tec | TK | 4zlz | A | B | 4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide | Human | 2924 | |
| BTK | Tec | TK | 4zlz | A | A | 4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide | Human | 2923 | |
| BTK | Tec | TK | 6w8i | A | | - | Human | 12990 | |
| BTK | Tec | TK | 4otr | A | | 6-cyclopropyl-2-[3-(5-{[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl]-8-fluoroisoquinolin-1(2h)-one | Human | 2896 | |
| BTK | Tec | TK | 7kxl | A | A | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13563 | |
| BTK | Tec | TK | 6bkw | A | A | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10686 | |
| BTK | Tec | TK | 6nzm | A | B | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11143 | |
| BTK | Tec | TK | 4yhf | A | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2916 | |
| BTK | Tec | TK | 6nzm | D | B | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11142 | |
| BTK | Tec | TK | 7l5p | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14269 | |
| BTK | Tec | TK | 4ot5 | A | | 4-tert-butyl-n-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide | Human | 2913 | |
| BTK | Tec | TK | 3pj3 | A | | 2-methyl-n-(2-phenyl-3h-imidazo[4,5-b]pyridin-6-yl)-5-{[(2e)-3-phenylprop-2-enoyl]amino}benzamide | Human | 2910 | |
| BTK | Tec | TK | 8e2m | A | C | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14551 | |
| BTK | Tec | TK | 6aub | A | A | 4-tert-butyl-n-[2-methyl-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]benzamide | Human | 10466 | |
| BTK | Tec | TK | 8fll | A | A | pirtobrutinib | Human | 14636 | |
| BTK | Tec | TK | 5p9g | A | B | 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one | Human | 7644 | |
| BTK | Tec | TK | 7r61 | A | B | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13936 | |
| BTK | Tec | TK | 8u2e | A | B | (2s)-6-fluoro-5-[(3s)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-2-(4-methylpiperazine-1-carbonyl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 15194 | |
| BTK | Tec | TK | 6bln | A | B | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10684 | |
| BTK | Tec | TK | 8u2e | A | A | (2s)-6-fluoro-5-[(3s)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-2-(4-methylpiperazine-1-carbonyl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 15198 | |
| BTK | Tec | TK | 8gc8 | A | A | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15195 | |
| BTK | Tec | TK | 8gc7 | A | A | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15196 | |
| BTK | Tec | TK | 7n4r | A | B | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14228 | |
| BTK | Tec | TK | 6nfh | A | A | 8-(2,3-dihydro-1h-inden-5-yl)-2-({4-[(2s)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8-dihydropteridine-6,7-dione | Human | 10964 | |
| BTK | Tec | TK | 8ejb | A | B | 5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 14615 | |
| BTK | Tec | TK | 8u2d | A | A | (3r)-2-[n-(1h-indazole-5-carbonyl)-3-methyl-d-phenylalanyl]-n-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 15199 | |
| BTK | Tec | TK | 6hrt | A | | (9~{s})-12-(6-~{tert}-butyl-8-fluoranyl-1-oxidanylidene-phthalazin-2-yl)-6-methyl-4-[(5-morpholin-4-ylcarbonylpyridin-2-yl)amino]-9-oxidanyl-6-azatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,11,13-pentaen-5-one | Human | 10972 | |
| BTK | Tec | TK | 5vgo | A | A | 2-(2-methoxyethoxy)ethanol | Human | 8218 | |
| BTK | Tec | TK | 6o8i | A | B | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 11001 | |
| BTK | Tec | TK | 7lty | A | B | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14069 | |
| BTK | Tec | TK | 6di5 | A | B | 2-(4-phenoxyphenoxy)-6-[(1s,4s)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide | Human | 10481 | |
| BTK | Tec | TK | 6s90 | B | | 4-~{tert}-butyl-~{n}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide | Human | 11635 | |
| BTK | Tec | TK | 5bpy | B | | 6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide | Human | 6094 | |
| BTK | Tec | TK | 6o8i | A | A | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 11002 | |
| BTK | Tec | TK | 7kxo | A | C | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13572 | |
| BTK | Tec | TK | 7n4q | A | A | (2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide | Human | 14227 | |
| BTK | Tec | TK | 6x3o | B | A | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12508 | |
| BTK | Tec | TK | 5j87 | D | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8001 | |
| BTK | Tec | TK | 5p9l | A | A | ~{n}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide | Human | 7625 | |
| BMX | Tec | TK | 3sxs | A | | 1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 3483 | |
| BTK | Tec | TK | 7n4q | A | B | (2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide | Human | 14224 | |
| BTK | Tec | TK | 8flv | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14697 | |
| BTK | Tec | TK | 8flv | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14698 | |
| BTK | Tec | TK | 7l5o | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14271 | |
| BTK | Tec | TK | 6x3n | A | B | 4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12510 | |
| BTK | Tec | TK | 7r60 | A | B | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13939 | |
| BTK | Tec | TK | 7r61 | A | A | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13938 | |
| BTK | Tec | TK | 7n4s | A | | (3r,3'r)-3-anilino-1'-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)[1,3'-bipiperidin]-2-one | Human | 14229 | |
| BTK | Tec | TK | 7l5o | A | C | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14268 | |
| BTK | Tec | TK | 8gc8 | A | B | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15192 | |
| BTK | Tec | TK | 7l5p | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14270 | |
| BTK | Tec | TK | 8flv | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14699 | |
| BTK | Tec | TK | 8u2d | A | B | (3r)-2-[n-(1h-indazole-5-carbonyl)-3-methyl-d-phenylalanyl]-n-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 15193 | |
| BTK | Tec | TK | 5fbn | D | B | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6383 | |
| BTK | Tec | TK | 6e4f | A | B | 1,5-anhydro-2-{[5-(2-chloro-4-phenoxybenzene-1-carbonyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-2,3,4-trideoxy-d-erythro-hexitol | Human | 10480 | |
| BTK | Tec | TK | 6hrp | A | | 6-~{tert}-butyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[(5-morpholin-4-ylcarbonylpyridin-2-yl)amino]-6-oxidanylidene-pyridazin-3-yl]phenyl]phthalazin-1-one | Human | 10971 | |
| BTK | Tec | TK | 3p08 | A | | - | Human | 2905 | |
| BTK | Tec | TK | 5j87 | C | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8004 | |
| BTK | Tec | TK | 6x3p | A | B | 4-{8-amino-3-[(6r,8as)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(cyclopropyloxy)-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12517 | |
| BTK | Tec | TK | 5jrs | B | | 4-[2-fluoro-3-(4-oxoquinazolin-3(4h)-yl)phenyl]-7-(2-hydroxypropan-2-yl)-9h-carbazole-1-carboxamide | Human | 7033 | |
| BTK | Tec | TK | 7kxm | A | C | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13567 | |
| BTK | Tec | TK | 6tfp | E | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12022 | |
| BTK | Tec | TK | 4rg0 | A | | 2-{8-fluoro-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl}-2-methylpropanenitrile | Human | 2929 | |
| BTK | Tec | TK | 8fln | A | A | pirtobrutinib | Human | 14642 | |
| BTK | Tec | TK | 8fln | A | C | pirtobrutinib | Human | 14633 | |
| BTK | Tec | TK | 8flg | A | B | n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide | Human | 14634 | |
| BTK | Tec | TK | 8fln | A | B | pirtobrutinib | Human | 14635 | |
| BTK | Tec | TK | 6n9p | A | C | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10888 | |
| BTK | Tec | TK | 8flh | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14637 | |
| BTK | Tec | TK | 8flh | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14638 | |
| BTK | Tec | TK | 8fll | A | B | pirtobrutinib | Human | 14640 | |
| BTK | Tec | TK | 8flg | A | A | n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide | Human | 14641 | |
| BTK | Tec | TK | 5j87 | A | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8003 | |
| BTK | Tec | TK | 5j87 | A | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8002 | |
| BTK | Tec | TK | 7n5r | A | B | 5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13890 | |
| BTK | Tec | TK | 5kup | A | A | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7051 | |
| BTK | Tec | TK | 3pj2 | A | | 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 2911 | |
| BTK | Tec | TK | 1k2p | B | | - | Human | 2919 | |
| BTK | Tec | TK | 7kxm | A | A | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13569 | |
| BTK | Tec | TK | 5zz4 | E | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10470 | |
| BTK | Tec | TK | 4nwm | A | B | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2917 | |
| BTK | Tec | TK | 5fbn | C | A | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6381 | |
| BTK | Tec | TK | 6di0 | A | C | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10628 | |
| BTK | Tec | TK | 6bke | A | B | n-[2-(2-hydroxyethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10683 | |
| BTK | Tec | TK | 5jrs | A | | 4-[2-fluoro-3-(4-oxoquinazolin-3(4h)-yl)phenyl]-7-(2-hydroxypropan-2-yl)-9h-carbazole-1-carboxamide | Human | 7032 | |
| BTK | Tec | TK | 5zz4 | C | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10464 | |
| BTK | Tec | TK | 7n5o | A | B | 5-(1h-benzimidazol-2-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13891 | |
| BTK | Tec | TK | 3k54 | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2932 | |
| BTK | Tec | TK | 5xyz | B | B | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9930 | |
| BTK | Tec | TK | 5kup | A | B | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7052 | |
| BTK | Tec | TK | 6x3o | A | B | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12512 | |
| BTK | Tec | TK | 6x3o | A | A | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12513 | |
| BTK | Tec | TK | 6x3n | A | A | 4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12514 | |
| BTK | Tec | TK | 5j87 | B | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8007 | |
| BTK | Tec | TK | 6aua | A | B | n-{3-[(2r)-6-{[3-amino-4-(morpholine-4-carbonyl)phenyl]amino}-5-oxo-2,5-dihydropyrazin-2-yl]-2-methylphenyl}-4-(piperidin-1-yl)benzamide | Human | 10473 | |
| BTK | Tec | TK | 6bkh | A | A | n-[2-(hydroxymethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10682 | |
| BTK | Tec | TK | 6omu | A | A | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11529 | |
| BTK | Tec | TK | 7kxn | A | C | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13570 | |
| BTK | Tec | TK | 4nwm | B | A | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2898 | |
| BTK | Tec | TK | 7n5x | A | A | 5-(1-ethoxyisoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13893 | |
| BTK | Tec | TK | 5bq0 | A | B | 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl)carbonyl]-9h-carbazole-1-carboxamide | Human | 6872 | |
| BTK | Tec | TK | 6w06 | A | B | 4-~{tert}-butyl-~{n}-[[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide | Human | 13098 | |
| BTK | Tec | TK | 4z3v | A | A | 4-amino-8-(5-methyl-1h-indazol-6-yl)cinnoline-3-carboxamide | Human | 2934 | |
| BTK | Tec | TK | 5p9h | A | A | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7631 | |
| BTK | Tec | TK | 6bkw | A | B | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10679 | |
| BTK | Tec | TK | 6tfp | C | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12023 | |
| BTK | Tec | TK | 5vfi | A | B | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-one | Human | 9601 | |
| BTK | Tec | TK | 7kxq | A | B | 3-tert-butyl-n-[(5r)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13565 | |
| BTK | Tec | TK | 7n5r | A | A | 5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13895 | |
| BTK | Tec | TK | 9vdh | A | B | - | Human | 16162 | |
| BTK | Tec | TK | 9y5b | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-[4-(piperidin-4-yl)anilino]-1h-pyrazole-5-carboxamide | Human | 16163 | |
| BTK | Tec | TK | 9zqv | A | B | - | Human | 16164 | |
| BTK | Tec | TK | 7n5y | A | A | 5-(1-{[(3s)-1-propanoylpyrrolidin-3-yl]oxy}isoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13894 | |
| BTK | Tec | TK | 9zqv | A | A | - | Human | 16165 | |
| BTK | Tec | TK | 9yt9 | A | B | - | Human | 16166 | |
| BTK | Tec | TK | 9vdh | A | A | - | Human | 16167 | |
| BTK | Tec | TK | 9yt9 | A | A | - | Human | 16168 | |
| BTK | Tec | TK | 9y57 | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-({6-[(1s)-1-hydroxyethyl]-5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-1h-pyrazole-5-carboxamide | Human | 16161 | |
| BTK | Tec | TK | 7n5y | A | B | 5-(1-{[(3s)-1-propanoylpyrrolidin-3-yl]oxy}isoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13892 | |
| BTK | Tec | TK | 7r60 | A | A | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13937 | |
| ITK | Tec | TK | 4mf0 | A | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 77 | |
| BTK | Tec | TK | 7kxl | A | B | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13561 | |
| BTK | Tec | TK | 7n4r | A | C | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14225 | |
| BTK | Tec | TK | 4nwm | A | A | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2930 | |
| BTK | Tec | TK | 7kxp | A | B | 3-tert-butyl-n-[(1s)-6-{2-[3-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13566 | |
| BTK | Tec | TK | 6x3o | B | B | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12511 | |
| BTK | Tec | TK | 6ep9 | A | | n-[2-methyl-3-[4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin-2-yl]phenyl]-4-(1-piperidyl)benzamide | Human | 10467 | |
| BTK | Tec | TK | 5p9i | A | C | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7638 | |
| BTK | Tec | TK | 7ltz | A | B | 1-~{tert}-butyl-~{n}-[(5~{r})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide | Human | 14066 | |
| BTK | Tec | TK | 6vxq | A | A | n-{[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide | Human | 13100 | |
| BTK | Tec | TK | 1k2p | A | | - | Human | 2918 | |
| BTK | Tec | TK | 4zly | A | C | 4-aminocinnoline-3-carboxamide | Human | 2915 | |
| BTK | Tec | TK | 6aua | A | A | n-{3-[(2r)-6-{[3-amino-4-(morpholine-4-carbonyl)phenyl]amino}-5-oxo-2,5-dihydropyrazin-2-yl]-2-methylphenyl}-4-(piperidin-1-yl)benzamide | Human | 10472 | |
| BTK | Tec | TK | 3oct | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2899 | |
| BTK | Tec | TK | 5p9h | A | B | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7643 | |
| BTK | Tec | TK | 6xe4 | A | A | (1s,2s)-n-[2'-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1h)-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo[1,6-dihydro[3,4'-bipyridine]]-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 12515 | |
| BTK | Tec | TK | 3piz | A | | [5-amino-1-(2-methylphenyl)-1h-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone | Human | 2922 | |
| BTK | Tec | TK | 7kxn | A | B | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13571 | |
| BTK | Tec | TK | 6e4f | A | A | 1,5-anhydro-2-{[5-(2-chloro-4-phenoxybenzene-1-carbonyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-2,3,4-trideoxy-d-erythro-hexitol | Human | 10477 | |
| BTK | Tec | TK | 5xyz | B | A | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9931 | |
| BTK | Tec | TK | 6nfi | A | A | n-(3-{[(2,6-dimethylphenyl)methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide | Human | 10962 | |
| BTK | Tec | TK | 5zz4 | A | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10479 | |
| BTK | Tec | TK | 5bpy | A | | 6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide | Human | 6095 | |
| BTK | Tec | TK | 4rfy | A | B | 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydroisoquinolin-1(2h)-one | Human | 2933 | |
| BMX | Tec | TK | 6i99 | B | | ~{n}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide | Human | 12349 | |
| BTK | Tec | TK | 6tfp | A | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12024 | |
| BTK | Tec | TK | 5p9m | A | A | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7634 | |
| BTK | Tec | TK | 7lty | A | C | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14068 | |
| BTK | Tec | TK | 5zz4 | F | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10469 | |
| BTK | Tec | TK | 6di1 | A | B | 4-amino-2-[(3s)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide | Human | 10627 | |
| BTK | Tec | TK | 6vxq | A | B | n-{[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide | Human | 13101 | |
| BTK | Tec | TK | 6j6m | A | A | (7s)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11767 | |
| BTK | Tec | TK | 5fbo | A | A | 4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6455 | |
| BTK | Tec | TK | 8flh | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14639 | |
| BMX | Tec | TK | 3sxr | B | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 3481 | |
| BTK | Tec | TK | 6w7o | A | | [5-({[(3s)-2-(n-methyl-l-alanyl-3-methyl-l-valyl)-3-{[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3r)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazol-1-yl}piperidine-1-carboxylate | Human | 13195 | |
| BTK | Tec | TK | 3piy | A | | 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one | Human | 2909 | |
| BTK | Tec | TK | 6w7o | B | | [5-({[(3s)-2-(n-methyl-l-alanyl-3-methyl-l-valyl)-3-{[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3r)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazol-1-yl}piperidine-1-carboxylate | Human | 13196 | |
| BTK | Tec | TK | 3p08 | B | | - | Human | 2894 | |
| BTK | Tec | TK | 4otf | A | B | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 2921 | |
| BTK | Tec | TK | 7ltz | A | A | 1-~{tert}-butyl-~{n}-[(5~{r})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide | Human | 14067 | |
| BTK | Tec | TK | 4rfy | A | A | 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydroisoquinolin-1(2h)-one | Human | 2935 | |
| BTK | Tec | TK | 5bq0 | A | A | 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl)carbonyl]-9h-carbazole-1-carboxamide | Human | 6871 | |
| BTK | Tec | TK | 5fbn | C | B | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6382 | |
| BTK | Tec | TK | 4otq | A | | 1-{5-[3-(7-tert-butyl-4-oxoquinazolin-3(4h)-yl)-2-methylphenyl]-1-methyl-2-oxo-1,2-dihydropyridin-3-yl}-3-methylurea | Human | 2895 | |
| BTK | Tec | TK | 6j6m | A | B | (7s)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11766 | |
| BTK | Tec | TK | 5t18 | A | A | 6-fluoro-5-(r)-(3-(s)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4h)-yl)-2-methylphenyl)-2-(s)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 7508 | |
| BTK | Tec | TK | 4rx5 | A | A | n-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide | Human | 6259 | |
| BTK | Tec | TK | 7yc9 | A | A | (7~{s})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14746 | |
| BTK | Tec | TK | 8e2m | A | A | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14552 | |
| ITK | Tec | TK | 3mj1 | A | | 7-[(4-methylpiperazin-1-yl)methyl]-4-[(3-methyl-1h-pyrazol-5-yl)amino]-2-(tetrahydro-2h-pyran-4-yl)phthalazin-1(2h)-one | Human | 27 | |
| ITK | Tec | TK | 4rfm | A | B | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 69 | |
| ITK | Tec | TK | 4ppc | B | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 78 | |
| ITK | Tec | TK | 4mf1 | B | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 12 | |
| ITK | Tec | TK | 3miy | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 46 | |
| ITK | Tec | TK | 3v5l | A | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 30 | |
| ITK | Tec | TK | 4kio | B | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 36 | |
| ITK | Tec | TK | 3t9t | A | B | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 83 | |
| ITK | Tec | TK | 4kio | C | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 75 | |
| ITK | Tec | TK | 4mf1 | A | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 41 | |
| ITK | Tec | TK | 4ppc | A | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 53 | |
| ITK | Tec | TK | 3v8t | A | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 55 | |
| ITK | Tec | TK | 4kio | A | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 79 | |
| ITK | Tec | TK | 3miy | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 8 | |
| ITK | Tec | TK | 3qgw | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 11 | |
| BMX | Tec | TK | 8x2a | A | B | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 15130 | |
| BMX | Tec | TK | 8x2a | A | A | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 15131 | |
| BTK | Tec | TK | 5fbn | D | A | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6384 | |
| ITK | Tec | TK | 4m12 | A | A | - | Human | 22 | |
| ITK | Tec | TK | 4m0y | A | B | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 70 | |
| ITK | Tec | TK | 1snu | A | | staurosporine | Human | 82 | |
| ITK | Tec | TK | 4m0z | A | B | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 47 | |
| ITK | Tec | TK | 4m12 | A | B | - | Human | 51 | |
| ITK | Tec | TK | 3mj2 | A | | n-[5-({5-[(4-acetylpiperazin-1-yl)carbonyl]-4-methoxy-2-methylphenyl}sulfanyl)-1,3-thiazol-2-yl]-4-({[(1s)-1,2,2-trimethylpropyl]amino}methyl)benzamide | Human | 67 | |
| ITK | Tec | TK | 4ppb | A | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 29 | |
| ITK | Tec | TK | 3v5l | D | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 56 | |
| ITK | Tec | TK | 3v8t | B | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 49 | |
| ITK | Tec | TK | 4kio | B | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 48 | |
| ITK | Tec | TK | 4pp9 | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 40 | |
| BTK | Tec | TK | 8yvv | A | A | - | Human | 15353 | |
| BTK | Tec | TK | 7kxq | A | A | 3-tert-butyl-n-[(5r)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13562 | |
| BTK | Tec | TK | 8tu3 | A | B | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15354 | |
| BTK | Tec | TK | 7n5x | A | B | 5-(1-ethoxyisoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13889 | |
| BTK | Tec | TK | 6aub | A | B | 4-tert-butyl-n-[2-methyl-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]benzamide | Human | 10475 | |
| BTK | Tec | TK | 5p9g | A | A | 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one | Human | 7635 | |
| BTK | Tec | TK | 6di0 | A | B | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10626 | |
| BTK | Tec | TK | 5p9i | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7627 | |
| BTK | Tec | TK | 3pix | A | | 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1h-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2h)-one | Human | 2927 | |
| BTK | Tec | TK | 7kxm | A | B | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13564 | |
| BTK | Tec | TK | 9y56 | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-({6-[(1s)-1-methoxyethyl]-5-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-2-yl}amino)-1h-pyrazole-5-carboxamide | Human | 16160 | |
| BTK | Tec | TK | 6s90 | A | | 4-~{tert}-butyl-~{n}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide | Human | 11636 | |
| BTK | Tec | TK | 5p9m | A | B | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7639 | |
| BTK | Tec | TK | 3gen | A | A | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2928 | |
| BTK | Tec | TK | 5p9k | A | C | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7626 | |
| BTK | Tec | TK | 4yhf | B | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2897 | |
| BTK | Tec | TK | 4rfz | A | | 6-(dimethylamino)-8-fluoro-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]isoquinolin-1(2h)-one | Human | 2925 | |
| BTK | Tec | TK | 5p9f | A | A | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 7632 | |
| BTK | Tec | TK | 5p9k | A | A | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7633 | |
| BTK | Tec | TK | 5p9j | A | C | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7640 | |
| BTK | Tec | TK | 6bik | A | B | 4-tert-butyl-n-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide | Human | 10678 | |
| BTK | Tec | TK | 5p9j | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7637 | |
| BTK | Tec | TK | 5zz4 | D | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10478 | |
| BTK | Tec | TK | 8tu5 | A | A | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15363 | |
| BTK | Tec | TK | 6di5 | A | A | 2-(4-phenoxyphenoxy)-6-[(1s,4s)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide | Human | 10471 | |
| BTK | Tec | TK | 5p9i | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7642 | |
| BTK | Tec | TK | 7n5o | A | A | 5-(1h-benzimidazol-2-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13896 | |
| ITK | Tec | TK | 4m0z | A | A | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 45 | |
| ITK | Tec | TK | 3qgw | B | A | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 65 | |
| ITK | Tec | TK | 3qgw | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 57 | |
| ITK | Tec | TK | 4ppc | A | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 13 | |
| ITK | Tec | TK | 4l7s | B | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 25 | |
| ITK | Tec | TK | 3v8t | A | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 5 | |
| ITK | Tec | TK | 3v5j | A | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 80 | |
| ITK | Tec | TK | 3qgy | B | A | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 52 | |
| ITK | Tec | TK | 4pqn | A | A | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 42 | |
| ITK | Tec | TK | 4qd6 | A | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 59 | |
| ITK | Tec | TK | 4mf1 | B | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 18 | |
| ITK | Tec | TK | 1sm2 | A | | staurosporine | Human | 74 | |
| ITK | Tec | TK | 4kio | A | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 76 | |
| ITK | Tec | TK | 4pp9 | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 20 | |
| ITK | Tec | TK | 4m14 | A | | 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3-carboxamide | Human | 58 | |
| ITK | Tec | TK | 3qgy | B | B | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 66 | |
| ITK | Tec | TK | 4kio | C | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 7 | |
| ITK | Tec | TK | 4hcv | A | | 3-{4-amino-1-[(3s)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 32 | |
| ITK | Tec | TK | 1snx | B | | - | Human | 62 | |
| ITK | Tec | TK | 4qd6 | B | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 24 | |
| ITK | Tec | TK | 3qgy | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 35 | |
| ITK | Tec | TK | 4qd6 | A | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 23 | |
| ITK | Tec | TK | 4rfm | A | A | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 68 | |
| ITK | Tec | TK | 3v5j | B | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 60 | |
| ITK | Tec | TK | 4kio | D | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 85 | |
| ITK | Tec | TK | 3v8w | B | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 10 | |
| ITK | Tec | TK | 4ppb | B | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 84 | |
| ITK | Tec | TK | 3t9t | A | A | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 16 | |
| ITK | Tec | TK | 4kio | D | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 6 | |
| ITK | Tec | TK | 4m13 | A | B | - | Human | 15 | |
| ITK | Tec | TK | 4l7s | A | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 64 | |
| ITK | Tec | TK | 4pqn | A | B | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 19 | |
| ITK | Tec | TK | 4l7s | B | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 37 | |
| ITK | Tec | TK | 4mf1 | A | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 34 | |
| ITK | Tec | TK | 4l7s | A | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 50 | |
| ITK | Tec | TK | 3v5l | C | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 26 | |
| ITK | Tec | TK | 4hct | A | | 3-{1-[(3r)-1-acryloylpiperidin-3-yl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-(3-tert-butylphenyl)benzamide | Human | 44 | |
| ITK | Tec | TK | 3v5l | B | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 54 | |
| ITK | Tec | TK | 4m15 | A | | adenosine-5'-diphosphate | Human | 31 | |
| ITK | Tec | TK | 3qgy | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 72 | |
| ITK | Tec | TK | 4ppc | B | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 63 | |
| ITK | Tec | TK | 4m13 | A | A | - | Human | 17 | |
| ITK | Tec | TK | 4ppa | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 21 | |
| ITK | Tec | TK | 3v8t | B | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 39 | |
| ITK | Tec | TK | 3qgw | B | B | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 14 | |
| ITK | Tec | TK | 1snu | B | | staurosporine | Human | 33 | |
| ITK | Tec | TK | 3v8w | A | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 43 | |
| ITK | Tec | TK | 4m0y | A | A | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 9 | |
| ITK | Tec | TK | 4mf0 | B | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 28 | |
| ITK | Tec | TK | 4ppa | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 38 | |
| ITK | Tec | TK | 4qd6 | B | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 71 | |
| ITK | Tec | TK | 1sm2 | B | | staurosporine | Human | 73 | |
| ITK | Tec | TK | 1snx | A | | - | Human | 61 | |
| ITK | Tec | TK | 4hcu | A | | 3-{4-amino-1-[(3r)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 81 | |
| BTK | Tec | TK | 8tu4 | A | C | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15355 | |
| BTK | Tec | TK | 8tu5 | A | C | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15356 | |
| BTK | Tec | TK | 5p9j | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7628 | |
| BTK | Tec | TK | 7n4r | A | A | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14226 | |
| BTK | Tec | TK | 6n9p | A | B | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10887 | |
| BTK | Tec | TK | 5p9f | A | B | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 7629 | |
| BTK | Tec | TK | 5p9k | A | B | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7636 | |
| BTK | Tec | TK | 5vgo | A | B | 2-(2-methoxyethoxy)ethanol | Human | 8219 | |
| BTK | Tec | TK | 6xe4 | A | B | (1s,2s)-n-[2'-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1h)-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo[1,6-dihydro[3,4'-bipyridine]]-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 12509 | |
| BTK | Tec | TK | 3oct | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2908 | |
| BTK | Tec | TK | 6nzm | D | A | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11141 | |
| BTK | Tec | TK | 8tu4 | A | B | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15357 | |
| BTK | Tec | TK | 3gen | A | B | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2900 | |
| BTK | Tec | TK | 5u9d | A | A | (r)-n-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 7393 | |
| BTK | Tec | TK | 8tu5 | A | B | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15358 | |
| BTK | Tec | TK | 6w07 | A | A | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13096 | |
| BTK | Tec | TK | 5p9l | A | B | ~{n}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide | Human | 7630 | |
| BTK | Tec | TK | 6nfh | A | B | 8-(2,3-dihydro-1h-inden-5-yl)-2-({4-[(2s)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8-dihydropteridine-6,7-dione | Human | 10965 | |
| BTK | Tec | TK | 8tu3 | A | C | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15359 | |
| BTK | Tec | TK | 3pj1 | A | | 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 2904 | |
| BTK | Tec | TK | 5zz4 | B | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10468 | |
| BTK | Tec | TK | 7lty | A | D | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14064 | |
| BTK | Tec | TK | 6w8i | B | | - | Human | 12991 | |
| BTK | Tec | TK | 6di1 | A | A | 4-amino-2-[(3s)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide | Human | 10630 | |
| BTK | Tec | TK | 8tu4 | A | A | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15360 | |
| BTK | Tec | TK | 8yvv | A | B | - | Human | 15361 | |
| BTK | Tec | TK | 5vfi | A | A | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-one | Human | 9602 | |
| BTK | Tec | TK | 6di3 | A | | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 10474 | |
| BTK | Tec | TK | 6di9 | A | B | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide | Human | 10476 | |
| BTK | Tec | TK | 5xyz | A | A | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9929 | |
| BTK | Tec | TK | 6tfp | D | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12021 | |
| BTK | Tec | TK | 4z3v | A | B | 4-amino-8-(5-methyl-1h-indazol-6-yl)cinnoline-3-carboxamide | Human | 2914 | |
| BTK | Tec | TK | 4ot6 | A | | 4-(methylsulfonyl)-n-[3-(8-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}imidazo[1,2-a]pyrazin-6-yl)phenyl]benzamide | Human | 2931 | |
| BTK | Tec | TK | 5j87 | C | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8006 | |
| BTK | Tec | TK | 6omu | A | B | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11530 | |
| BTK | Tec | TK | 6di9 | A | A | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide | Human | 10465 | |
| BTK | Tec | TK | 7kxo | A | B | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13568 | |
| BTK | Tec | TK | 6omu | A | C | - | Human | 11528 | |
| BTK | Tec | TK | 6bik | A | A | 4-tert-butyl-n-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide | Human | 10680 | |
| BTK | Tec | TK | 6bkh | A | B | n-[2-(hydroxymethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10677 | |
| BTK | Tec | TK | 3k54 | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2906 | |
| BTK | Tec | TK | 8tu3 | A | A | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15362 | |
| BTK | Tec | TK | 6w07 | A | C | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13097 | |
| BTK | Tec | TK | 4yhf | B | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2912 | |
| BTK | Tec | TK | 4nwm | B | B | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2903 | |
| BTK | Tec | TK | 4zly | A | B | 4-aminocinnoline-3-carboxamide | Human | 2920 | |
| BTK | Tec | TK | 7lty | A | A | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14065 | |
| BTK | Tec | TK | 5t18 | A | B | 6-fluoro-5-(r)-(3-(s)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4h)-yl)-2-methylphenyl)-2-(s)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 7507 | |
| BTK | Tec | TK | 8gc7 | A | B | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15197 | |
| BTK | Tec | TK | 8ejb | A | A | 5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 14614 | |
| BTK | Tec | TK | 6w06 | A | A | 4-~{tert}-butyl-~{n}-[[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide | Human | 13099 | |
| BTK | Tec | TK | 6bke | A | A | n-[2-(2-hydroxyethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10681 | |
| BTK | Tec | TK | 5p9m | A | C | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7641 | |
| BTK | Tec | TK | 5u9d | A | B | (r)-n-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 7392 | |
| BTK | Tec | TK | 6di0 | A | A | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10629 | |
| BTK | Tec | TK | 5j87 | D | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8008 | |
| BTK | Tec | TK | 7kxo | A | A | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13573 | |
| BTK | Tec | TK | 6nfi | A | B | n-(3-{[(2,6-dimethylphenyl)methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide | Human | 10963 | |
| BTK | Tec | TK | 6tfp | B | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12020 | |
| BTK | Tec | TK | 4zly | A | A | 4-aminocinnoline-3-carboxamide | Human | 2926 | |
| BTK | Tec | TK | 4yhf | A | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2902 | |
| BTK | Tec | TK | 6x3p | A | A | 4-{8-amino-3-[(6r,8as)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(cyclopropyloxy)-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12516 | |
| BTK | Tec | TK | 4otf | A | A | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 2901 | |
| BTK | Tec | TK | 8e2m | A | B | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14553 | |
| BTK | Tec | TK | 7l5o | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14272 | |
| BTK | Tec | TK | 7kxn | A | A | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13574 | |
| BTK | Tec | TK | 7kxp | A | A | 3-tert-butyl-n-[(1s)-6-{2-[3-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13575 | |
| BTK | Tec | TK | 3ocs | A | | 4-tert-butyl-n-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide | Human | 2907 | |
| BTK | Tec | TK | 6w07 | A | B | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13102 | |
| BTK | Tec | TK | 6nzm | A | A | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11144 | |
| BTK | Tec | TK | 7r61 | A | C | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13940 | |
| BTK | Tec | TK | 7kxl | A | C | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13576 | |
| BTK | Tec | TK | 6n9p | A | A | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10886 | |
| BTK | Tec | TK | 6bln | A | A | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10685 | |
| BTK | Tec | TK | 5xyz | A | B | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9932 | |
| BTK | Tec | TK | 5j87 | B | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8005 | |
| BMX | Tec | TK | 3sxr | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 3482 | |
| BMX | Tec | TK | 6i99 | A | | ~{n}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide | Human | 12348 | |
