| NTRK1 (TRKA) | Trk | TK | 6j5l | A | C | n-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1h-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide | Human | 11437 | |
| NTRK1 (TRKA) | Trk | TK | 6d20 | A | | 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-n-(2-hydroxy-2-methylpropyl)-1-phenyl-1h-pyrazole-3-carboxamide | Human | 9875 | |
| ERBB2 (ErbB2) | EGFR | TK | 8u8x | A | B | 1-{(1r,3r,5s)-3-[(3m)-4-methyl-3-{3-methyl-4-[(1-methyl-1h-benzimidazol-5-yl)oxy]phenyl}-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-8-azabicyclo[3.2.1]octan-8-yl}propan-1-one | Human | 15344 | |
| NTRK1 (TRKA) | Trk | TK | 6dkb | A | | 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide | Human | 10057 | |
| NTRK1 (TRKA) | Trk | TK | 7vkm | A | A | - | Human | 13946 | |
| JAK2 | JakA | TK | 8bx6 | A | A | cerdulatinib | Human | 15033 | |
| JAK2 | JakA | TK | 8bx6 | A | B | cerdulatinib | Human | 15042 | |
| SYK | Syk | TK | 4yjo | A | B | 5-chloro-n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine | Human | 6119 | |
| EGFR | EGFR | TK | 8eme | B | | n-{7-methyl-1-[(3s)-1-(prop-2-enoyl)azepan-3-yl]-1h-benzimidazol-2-yl}-5-(prop-2-enamido)thiophene-3-carboxamide | Human | 15375 | |
| SYK | Syk | TK | 4rx8 | A | B | 3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide | Human | 1168 | |
| EGFR | EGFR | TK | 8to3 | A | A | 3-hydroxy-n-{(3p)-3-[(4p)-2-(methylsulfanyl)-5-{2-[4-(piperazin-1-yl)anilino]pyridin-4-yl}-1h-imidazol-4-yl]phenyl}-2-[(1-oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]benzamide | Human | 15388 | |
| SYK | Syk | TK | 4f4p | A | B | n-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine | Human | 1156 | |
| EGFR | EGFR | TK | 8to4 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 15391 | |
| MET | Met | TK | 7v3s | A | A | ~{n}1'-[3-fluoranyl-4-(10~{h}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 14329 | |
| EGFR | EGFR | TK | 8to4 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 15390 | |
| MET | Met | TK | 7v3r | A | B | ~{n}1'-[3-fluoranyl-4-(2-phenylazanylpyrimidin-4-yl)oxy-phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 14330 | |
| JAK2 | JakA | TK | 3e64 | A | A | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3646 | |
| JAK2 | JakA | TK | 8bpv | A | B | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15036 | |
| JAK2 | JakA | TK | 5wev | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8377 | |
| JAK2 | JakA | TK | 6vgl | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13222 | |
| JAK2 | JakA | TK | 6wtn | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13538 | |
| SYK | Syk | TK | 4fl3 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 1172 | |
| SYK | Syk | TK | 4dfn | A | A | 3-amino-6-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]-n-[(1r,2r,3s,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide | Human | 1201 | |
| KIT | PDGFR | TK | 6kla | A | B | n-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine | Human | 11823 | |
| KIT | PDGFR | TK | 6mob | A | A | n-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-n'-phenylurea | Human | 11469 | |
| ABL1 | Abl | TK | 6xr6 | A | 18 | - | Human | 12912 | |
| KIT | PDGFR | TK | 8pqe | A | B | ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide | Human | 15117 | |
| KIT | PDGFR | TK | 6xva | B | | ~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide | Human | 12281 | |
| KIT | PDGFR | TK | 6gqm | B | | ~{n}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10361 | |
| KIT | PDGFR | TK | 6gql | A | | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10362 | |
| KIT | PDGFR | TK | 1t46 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 404 | |
| KIT | PDGFR | TK | 6gqk | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10355 | |
| KIT | PDGFR | TK | 6hh1 | A | A | ~{n}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{h}-1,2,4-triazol-3-amine | Human | 11629 | |
| KIT | PDGFR | TK | 8pq9 | A | A | (1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15118 | |
| KIT | PDGFR | TK | 7khk | A | | 4,5-dimethyl-n-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazole-3-carboxamide | Human | 13787 | |
| BTK | Tec | TK | 7yc9 | A | B | (7~{s})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14745 | |
| FGFR4 | FGFR | TK | 7ybp | A | | ~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 14500 | |
| FGFR4 | FGFR | TK | 6jpj | A | | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 11051 | |
| FGFR4 | FGFR | TK | 6nvh | A | A | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11388 | |
| KIT | PDGFR | TK | 1pkg | A | | adenosine-5'-diphosphate | Human | 397 | |
| KIT | PDGFR | TK | 6gqk | B | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10360 | |
| KIT | PDGFR | TK | 7zw8 | A | B | ~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | Human | 14624 | |
| KIT | PDGFR | TK | 7khg | A | B | 5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine | Human | 13788 | |
| MET | Met | TK | 7v3s | A | B | ~{n}1'-[3-fluoranyl-4-(10~{h}-pyrido[3,2-b][1,4]benzoxazin-4-yloxy)phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 14327 | |
| MET | Met | TK | 7v3r | A | A | ~{n}1'-[3-fluoranyl-4-(2-phenylazanylpyrimidin-4-yl)oxy-phenyl]-~{n}1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 14328 | |
| FGFR4 | FGFR | TK | 6nvi | A | B | n-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide | Human | 11389 | |
| FGFR1 | FGFR | TK | 7wcl | A | B | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one | Human | 14363 | |
| FGFR4 | FGFR | TK | 4tyg | A | B | - | Human | 933 | |
| JAK2 | JakA | TK | 3lpb | A | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3672 | |
| EGFR | EGFR | TK | 6jwl | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12173 | |
| EGFR | EGFR | TK | 7u98 | A | | 19-chloro-18-fluoro-22-methoxy-8,9,11,12,14,15-hexahydro-21h-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine | Human | 14526 | |
| EGFR | EGFR | TK | 6p8q | C | B | adenosine monophosphate | Human | 11879 | |
| EGFR | EGFR | TK | 5d41 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 6667 | |
| EGFR | EGFR | TK | 3w2q | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 845 | |
| MET | Met | TK | 7y4t | A | | 2-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-(3-nitrophenyl)pyridazin-3-one | Human | 14548 | |
| MET | Met | TK | 8gvj | A | | (1^4z,5^2e)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1h-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione | Human | 14549 | |
| MET | Met | TK | 7y4u | A | | ~{n}-methyl-4-[1-[2-[3-(1-methylpyrazol-4-yl)quinolin-6-yl]ethyl]-6-oxidanylidene-pyridazin-3-yl]-2-(trifluoromethyl)benzamide | Human | 14550 | |
| EGFR | EGFR | TK | 7si1 | A | A | - | Human | 14478 | |
| EGFR | EGFR | TK | 7si1 | A | C | - | Human | 14479 | |
| EGFR | EGFR | TK | 7si1 | A | B | - | Human | 14480 | |
| FGFR4 | FGFR | TK | 4tyi | A | | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 926 | |
| FGFR2 | FGFR | TK | 2pvy | C | | phosphomethylphosphonic acid adenylate ester | Human | 501 | |
| JAK2 | JakA | TK | 5tq6 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7354 | |
| JAK2 | JakA | TK | 4bbf | D | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3663 | |
| FGFR2 | FGFR | TK | 8e1x | A | | (5m)-n-methyl-5-{(6m,8s)-5-{[(3s)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1h-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide | Human | 14511 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | C | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13324 | |
| PTK2 (FAK) | FAK | TK | 4ebw | A | A | - | Human | 218 | |
| PTK2 (FAK) | FAK | TK | 6yxv | A | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13336 | |
| ALK | ALK | TK | 4cli | A | | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 5405 | |
| ALK | ALK | TK | 4cnh | B | | 3-[(1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1h-1,2,3-triazol-5-yl)pyridin-2-amine | Human | 5378 | |
| PTK2B (PYK2) | FAK | TK | 3h3c | A | | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 96 | |
| PTK2 (FAK) | FAK | TK | 4gu9 | A | | n-(2-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 222 | |
| PTK2 (FAK) | FAK | TK | 4k9y | A | A | 1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 230 | |
| BTK | Tec | TK | 5fbo | A | B | 4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6456 | |
| BTK | Tec | TK | 4rx5 | A | B | n-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide | Human | 6258 | |
| BTK | Tec | TK | 4zlz | A | B | 4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide | Human | 2924 | |
| BTK | Tec | TK | 4zlz | A | A | 4-amino-8-(4-methylpyridin-3-yl)cinnoline-3-carboxamide | Human | 2923 | |
| JAK3 | JakA | TK | 4i6q | A | | n-[(1s)-1-cyclopropylethyl]-2-phenoxy-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 432 | |
| BTK | Tec | TK | 6w8i | A | | - | Human | 12990 | |
| BTK | Tec | TK | 4otr | A | | 6-cyclopropyl-2-[3-(5-{[5-(4-ethylpiperazin-1-yl)pyridin-2-yl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(hydroxymethyl)phenyl]-8-fluoroisoquinolin-1(2h)-one | Human | 2896 | |
| SYK | Syk | TK | 5lmb | A | A | 7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | Human | 7050 | |
| LMTK3 (LMR3) | Lmr | TK | 6seq | A | B | - | Human | 12995 | |
| FGFR4 | FGFR | TK | 6v9c | A | A | n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | Human | 12096 | |
| EPHA2 (EphA2) | Eph | TK | 6q7d | A | B | 3-[[4-imidazol-1-yl-6-(4-oxidanylpiperidin-1-yl)-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11928 | |
| BTK | Tec | TK | 7kxl | A | A | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13563 | |
| BTK | Tec | TK | 6bkw | A | A | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10686 | |
| BTK | Tec | TK | 6nzm | A | B | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11143 | |
| BTK | Tec | TK | 4yhf | A | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2916 | |
| KDR | VEGFR | TK | 3c7q | A | | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | 5334 | |
| KDR | VEGFR | TK | 1y6a | A | A | n-[5-(ethylsulfonyl)-2-methoxyphenyl]-5-[3-(2-pyridinyl)phenyl]-1,3-oxazol-2-amine | Human | 5339 | |
| FGFR2 | FGFR | TK | 7kie | B | A | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13282 | |
| FGFR2 | FGFR | TK | 6agx | C | B | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11537 | |
| FGFR2 | FGFR | TK | 6agx | A | B | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11542 | |
| ROS1 (ROS) | Sev | TK | 7z5x | A | | (2r)-2-[5-(6-amino-5-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | Human | 14325 | |
| BTK | Tec | TK | 6nzm | D | B | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11142 | |
| BTK | Tec | TK | 7l5p | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14269 | |
| BTK | Tec | TK | 4ot5 | A | | 4-tert-butyl-n-{3-[8-({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}amino)imidazo[1,2-a]pyrazin-6-yl]phenyl}benzamide | Human | 2913 | |
| FGFR2 | FGFR | TK | 4j95 | D | A | phosphomethylphosphonic acid adenylate ester | Human | 490 | |
| FGFR2 | FGFR | TK | 4j97 | D | B | phosphomethylphosphonic acid adenylate ester | Human | 532 | |
| ABL1 | Abl | TK | 6xr6 | A | 20 | - | Human | 12861 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqi | A | A | (1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15109 | |
| FGFR2 | FGFR | TK | 4j95 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 519 | |
| TYK2-b | JakB | TK | 6nzf | B | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11451 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqj | A | A | - | Human | 15106 | |
| LCK | Src | TK | 6pdj | A | B | n-{4-[(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)amino]-3-methylphenyl}-1-methyl-1h-indazole-3-carboxamide | Human | 11699 | |
| FGFR2 | FGFR | TK | 4j96 | A | B | - | Human | 470 | |
| FGFR2 | FGFR | TK | 6agx | C | A | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11538 | |
| BTK | Tec | TK | 3pj3 | A | | 2-methyl-n-(2-phenyl-3h-imidazo[4,5-b]pyridin-6-yl)-5-{[(2e)-3-phenylprop-2-enoyl]amino}benzamide | Human | 2910 | |
| BTK | Tec | TK | 8e2m | A | C | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14551 | |
| FGFR1 | FGFR | TK | 6itj | B | B | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{h}-pyrazolo[3,4-d]pyridazin-7-one | Human | 11772 | |
| BTK | Tec | TK | 6aub | A | A | 4-tert-butyl-n-[2-methyl-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]benzamide | Human | 10466 | |
| BTK | Tec | TK | 8fll | A | A | pirtobrutinib | Human | 14636 | |
| BTK | Tec | TK | 5p9g | A | B | 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one | Human | 7644 | |
| FGFR2 | FGFR | TK | 4j95 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 477 | |
| EPHA2 (EphA2) | Eph | TK | 4p2k | A | | - | Human | 2091 | |
| EPHA2 (EphA2) | Eph | TK | 4trl | A | | - | Human | 2090 | |
| BTK | Tec | TK | 7r61 | A | B | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13936 | |
| FGFR2 | FGFR | TK | 5ugx | A | B | phosphomethylphosphonic acid adenylate ester | Human | 7448 | |
| FGFR2 | FGFR | TK | 7kia | A | B | 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one | Human | 13285 | |
| FGFR1 | FGFR | TK | 5flf | B | A | - | Human | 6465 | |
| BTK | Tec | TK | 8u2e | A | B | (2s)-6-fluoro-5-[(3s)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-2-(4-methylpiperazine-1-carbonyl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 15194 | |
| FGFR1 | FGFR | TK | 5vnd | A | A | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide | Human | 7646 | |
| LCK | Src | TK | 3kmm | A | | 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 2265 | |
| EGFR | EGFR | TK | 7u99 | A | | 19-chloro-22-methoxy-8,9,11,12,14,15-hexahydro-21h-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine | Human | 14533 | |
| TYK2-b | JakB | TK | 4wov | B | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2197 | |
| FGFR2 | FGFR | TK | 6v6q | C | | phosphomethylphosphonic acid adenylate ester | Human | 12969 | |
| BTK | Tec | TK | 6bln | A | B | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10684 | |
| BTK | Tec | TK | 8u2e | A | A | (2s)-6-fluoro-5-[(3s)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-2-(4-methylpiperazine-1-carbonyl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 15198 | |
| BTK | Tec | TK | 8gc8 | A | A | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15195 | |
| BTK | Tec | TK | 8gc7 | A | A | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15196 | |
| TYK2-b | JakB | TK | 6nzq | A | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11499 | |
| FGFR2 | FGFR | TK | 6lvl | A | | n-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide | Human | 12132 | |
| BTK | Tec | TK | 7n4r | A | B | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14228 | |
| BTK | Tec | TK | 6nfh | A | A | 8-(2,3-dihydro-1h-inden-5-yl)-2-({4-[(2s)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8-dihydropteridine-6,7-dione | Human | 10964 | |
| BTK | Tec | TK | 8ejb | A | B | 5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 14615 | |
| BTK | Tec | TK | 8u2d | A | A | (3r)-2-[n-(1h-indazole-5-carbonyl)-3-methyl-d-phenylalanyl]-n-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 15199 | |
| FGFR2 | FGFR | TK | 6lvl | B | | n-ethyl-2-[[4-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide | Human | 12130 | |
| FGFR1 | FGFR | TK | 5ew8 | B | B | ~{n}'-(3,5-dimethoxyphenyl)-~{n}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{n}-propan-2-yl-ethane-1,2-diamine | Human | 6471 | |
| FGFR1 | FGFR | TK | 5a46 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3578 | |
| FGFR1 | FGFR | TK | 3c4f | B | B | 3-(3-methoxybenzyl)-1h-pyrrolo[2,3-b]pyridine | Human | 3562 | |
| EPHA3 (EphA3) | Eph | TK | 2qod | A | C | - | Human | 2866 | |
| SYK | Syk | TK | 4i0r | A | B | n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1175 | |
| FGFR2 | FGFR | TK | 4j97 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 476 | |
| EGFR | EGFR | TK | 6v6o | F | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12206 | |
| EGFR | EGFR | TK | 5hg9 | A | B | 1-[(3r,4r)-3-[({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]propan-1-one | Human | 6377 | |
| EPHA2 (EphA2) | Eph | TK | 5i9z | A | B | n-[(3e)-5-[(2r)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5h)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide | Human | 7181 | |
| EPHA2 (EphA2) | Eph | TK | 5i9y | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7194 | |
| EPHA2 (EphA2) | Eph | TK | 5ia2 | A | B | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 7172 | |
| EGFR | EGFR | TK | 4i23 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 870 | |
| EGFR | EGFR | TK | 2rfe | A | | - | Human | 836 | |
| FGFR2 | FGFR | TK | 6agx | B | A | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11540 | |
| FGFR4 | FGFR | TK | 5nwz | A | | ~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide | Human | 9789 | |
| EGFR | EGFR | TK | 6v66 | D | A | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12221 | |
| EGFR | EGFR | TK | 7jxp | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13881 | |
| EGFR | EGFR | TK | 3gt8 | D | | phosphoaminophosphonic acid-adenylate ester | Human | 860 | |
| EGFR | EGFR | TK | 4lrm | B | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 867 | |
| EGFR | EGFR | TK | 4ll0 | A | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 804 | |
| EGFR | EGFR | TK | 2gs6 | A | | - | Human | 815 | |
| FGFR2 | FGFR | TK | 4j95 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 498 | |
| FGFR2 | FGFR | TK | 4j95 | C | A | phosphomethylphosphonic acid adenylate ester | Human | 531 | |
| HCK | Src | TK | 3vs3 | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2665 | |
| EGFR | EGFR | TK | 5c8k | A | | 1-cyclopentyl-n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1h-imidazo[4,5-c]pyridin-6-amine | Human | 6201 | |
| EGFR | EGFR | TK | 6v6o | D | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12219 | |
| EGFR | EGFR | TK | 6wa2 | D | A | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13439 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | B | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10340 | |
| HCK | Src | TK | 3vrz | A | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea | Human | 2658 | |
| EGFR | EGFR | TK | 2itn | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 879 | |
| EGFR | EGFR | TK | 5gty | D | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8368 | |
| EPHB4 (EphB4) | Eph | TK | 2vwy | A | A | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | Human | 353 | |
| EPHA2 (EphA2) | Eph | TK | 6hes | A | B | 4-methyl-3-[(2-pyridin-3-ylquinazolin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11566 | |
| EGFR | EGFR | TK | 2itv | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 911 | |
| EGFR | EGFR | TK | 5j9y | A | A | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6946 | |
| EGFR | EGFR | TK | 5u8l | A | A | 4-[(4-{4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride | Human | 7387 | |
| EPHB4 (EphB4) | Eph | TK | 2yn8 | B | | staurosporine | Human | 349 | |
| EGFR | EGFR | TK | 4hjo | A | | [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine | Human | 835 | |
| EGFR | EGFR | TK | 4rj7 | A | B | 2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide | Human | 828 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | C | A | alisertib | Human | 7186 | |
| MET | Met | TK | 8ouu | A | A | 5-(3-ethynyl-5-fluoranyl-1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14821 | |
| MET | Met | TK | 8ouu | A | B | 5-(3-ethynyl-5-fluoranyl-1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14824 | |
| EPHB4 (EphB4) | Eph | TK | 2vwy | A | B | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine | Human | 355 | |
| EGFR | EGFR | TK | 7ukw | A | B | - | Human | 14532 | |
| EGFR | EGFR | TK | 5cno | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 861 | |
| EGFR | EGFR | TK | 4zjv | B | A | - | Human | 904 | |
| EGFR | EGFR | TK | 5uwd | A | | n-(3-{[2-{[4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl]amino}-5-(trifluoromethyl)pyrimidin-4-yl]amino}phenyl)propanamide | Human | 8568 | |
| EPHA3 (EphA3) | Eph | TK | 4twn | A | B | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 2865 | |
| EGFR | EGFR | TK | 6wa2 | D | B | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13437 | |
| EGFR | EGFR | TK | 7a6k | A | B | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14113 | |
| EGFR | EGFR | TK | 2rfe | C | | - | Human | 907 | |
| JAK3 | JakA | TK | 7uyv | A | B | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14332 | |
| FGFR2 | FGFR | TK | 2pwl | A | | phosphomethylphosphonic acid adenylate ester | Human | 523 | |
| JAK2 | JakA | TK | 7uyw | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14333 | |
| EGFR | EGFR | TK | 6vhn | A | | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12171 | |
| EGFR | EGFR | TK | 5feq | A | | ~{n}-[1-[(3~{r})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide | Human | 6883 | |
| MET | Met | TK | 7b3w | A | B | 3-(6-fluoranyl-1~{h}-indazol-4-yl)-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13178 | |
| MET | Met | TK | 3dkf | A | A | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 3030 | |
| MET | Met | TK | 3qti | A | A | 6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | Human | 2994 | |
| MET | Met | TK | 6sdc | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11532 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | C | A | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 11999 | |
| BTK | Tec | TK | 6hrt | A | | (9~{s})-12-(6-~{tert}-butyl-8-fluoranyl-1-oxidanylidene-phthalazin-2-yl)-6-methyl-4-[(5-morpholin-4-ylcarbonylpyridin-2-yl)amino]-9-oxidanyl-6-azatricyclo[9.4.0.0^{2,7}]pentadeca-1(15),2(7),3,11,13-pentaen-5-one | Human | 10972 | |
| NTRK1 (TRKA) | Trk | TK | 5kmi | A | | 1-(9~{h}-fluoren-9-yl)-3-(2-methyl-4-phenyl-pyrimidin-5-yl)urea | Human | 7330 | |
| ABL1 | Abl | TK | 6xr6 | A | 19 | - | Human | 12892 | |
| EGFR | EGFR | TK | 4i21 | A | | - | Human | 824 | |
| EPHA2 (EphA2) | Eph | TK | 6hew | A | C | - | Human | 11553 | |
| BTK | Tec | TK | 5vgo | A | A | 2-(2-methoxyethoxy)ethanol | Human | 8218 | |
| BTK | Tec | TK | 6o8i | A | B | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 11001 | |
| BTK | Tec | TK | 7lty | A | B | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14069 | |
| JAK1 | JakA | TK | 6aah | A | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10392 | |
| JAK1 | JakA | TK | 6aah | A | B | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10396 | |
| JAK1 | JakA | TK | 4ivd | B | B | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1457 | |
| EGFR | EGFR | TK | 7a6i | A | | ~{n}-[5-[4-chloranyl-2-[4-(4-methylpiperazin-1-yl)phenyl]-1~{h}-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]propanamide | Human | 14123 | |
| NTRK1 (TRKA) | Trk | TK | 6dki | A | B | 6-amino-5-{[(3s)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-n-methylpyridine-3-carboxamide | Human | 10061 | |
| NTRK1 (TRKA) | Trk | TK | 6iqn | B | | 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid | Human | 11950 | |
| BTK | Tec | TK | 6di5 | A | B | 2-(4-phenoxyphenoxy)-6-[(1s,4s)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide | Human | 10481 | |
| BTK | Tec | TK | 6s90 | B | | 4-~{tert}-butyl-~{n}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide | Human | 11635 | |
| BTK | Tec | TK | 5bpy | B | | 6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide | Human | 6094 | |
| BTK | Tec | TK | 6o8i | A | A | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 11002 | |
| BTK | Tec | TK | 7kxo | A | C | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13572 | |
| EPHA7 (EphA7) | Eph | TK | 2rei | A | A | - | Human | 4 | |
| EPHA7 (EphA7) | Eph | TK | 7eec | A | B | - | Human | 13790 | |
| EPHA7 (EphA7) | Eph | TK | 7eed | A | | - | Human | 13791 | |
| EPHA7 (EphA7) | Eph | TK | 7eec | A | A | - | Human | 13792 | |
| BTK | Tec | TK | 7n4q | A | A | (2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide | Human | 14227 | |
| EPHA7 (EphA7) | Eph | TK | 3dko | A | A | 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide | Human | 1 | |
| EPHA7 (EphA7) | Eph | TK | 2rei | A | B | - | Human | 2 | |
| EPHA7 (EphA7) | Eph | TK | 7eef | A | | - | Human | 13793 | |
| EPHA7 (EphA7) | Eph | TK | 3dko | A | B | 5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide | Human | 3 | |
| TNK2 (ACK) | Ack | TK | 8fe9 | A | | n-[(1s)-1-benzyl-2-[(6-chloro-2-oxo-1h-quinolin-4-yl)methylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1h-quinoline-6-carbo | Human | 14676 | |
| KIT | PDGFR | TK | 8dfm | A | | - | Human | 14677 | |
| KIT | PDGFR | TK | 8dfp | A | | - | Human | 14678 | |
| MET | Met | TK | 3f66 | B | B | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 2992 | |
| NTRK1 (TRKA) | Trk | TK | 7xbi | A | B | 4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]-~{n}-[3-(1-methylpyrazol-4-yl)-1~{h}-indazol-5-yl]-2-(trifluoromethyl)benzamide | Human | 14686 | |
| NTRK1 (TRKA) | Trk | TK | 7xbi | A | A | 4-[[2-fluoranyl-5-(trifluoromethyl)phenyl]carbamoylamino]-~{n}-[3-(1-methylpyrazol-4-yl)-1~{h}-indazol-5-yl]-2-(trifluoromethyl)benzamide | Human | 14687 | |
| FGFR2 | FGFR | TK | 4j98 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 472 | |
| EGFR | EGFR | TK | 5x2f | A | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9540 | |
| MERTK (MER) | Axl | TK | 3bpr | D | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 282 | |
| MERTK (MER) | Axl | TK | 5k0x | B | B | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | 7431 | |
| MERTK (MER) | Axl | TK | 7m5z | A | A | 2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide | Human | 13919 | |
| MERTK (MER) | Axl | TK | 7aaz | A | A | 2-azanyl-~{n}-[(1~{s},2~{s})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide | Human | 12962 | |
| MERTK (MER) | Axl | TK | 3bpr | D | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 279 | |
| MERTK (MER) | Axl | TK | 5k0x | A | B | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | 7432 | |
| MERTK (MER) | Axl | TK | 7aw3 | A | | 2-(1-((5-chloro-1h-pyrrolo[2,3-b]pyridine-3-carboxamido)methyl)-2-azabicyclo[2.1.1]hexan-2-yl)-n-methyl-4-(trifluoromethyl)thiazole-5-carboxamide | Human | 13367 | |
| MERTK (MER) | Axl | TK | 3bpr | B | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 275 | |
| EPHA2 (EphA2) | Eph | TK | 5nk9 | A | A | (2~{z})-~{n}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide | Human | 8073 | |
| EPHA2 (EphA2) | Eph | TK | 5nk6 | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8061 | |
| MERTK (MER) | Axl | TK | 4mh7 | A | | n-butyl-2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-methylpyrimidine-5-carboxamide | Human | 262 | |
| MERTK (MER) | Axl | TK | 2p0c | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 280 | |
| MERTK (MER) | Axl | TK | 3brb | A | A | adenosine-5'-diphosphate | Human | 266 | |
| MERTK (MER) | Axl | TK | 5tc0 | A | | n-(2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}phenyl)-1h-imidazole-2-carboxamide | Human | 7383 | |
| MERTK (MER) | Axl | TK | 7ab2 | A | A | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | Human | 12934 | |
| MERTK (MER) | Axl | TK | 7cqe | A | | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | 12963 | |
| MERTK (MER) | Axl | TK | 5k0k | B | B | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | 7346 | |
| MERTK (MER) | Axl | TK | 5k0k | A | B | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | 7347 | |
| MERTK (MER) | Axl | TK | 4mha | A | A | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | 264 | |
| MERTK (MER) | Axl | TK | 5td2 | A | B | n-[2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1h-imidazole-2-carboxamide | Human | 7380 | |
| MERTK (MER) | Axl | TK | 4mha | A | B | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | 277 | |
| MERTK (MER) | Axl | TK | 7m5z | A | B | 2-(butylamino)-n-[1-(3-fluoropropyl)piperidin-4-yl]-4-{[(1r,4r)-4-hydroxycyclohexyl]amino}pyrimidine-5-carboxamide | Human | 13920 | |
| ABL1 | Abl | TK | 6xrg | A | 9 | - | Human | 12891 | |
| MERTK (MER) | Axl | TK | 7avy | A | | n-(2-(2-cyclopropylethoxy)pyrimidin-5-yl)-7-methoxy-6-(piperidin-4-ylmethoxy)quinazolin-4-amine | Human | 13369 | |
| EGFR | EGFR | TK | 7a6j | A | B | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | 14124 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | B | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11932 | |
| IGF1R | InsR | TK | 5hzn | A | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6493 | |
| MERTK (MER) | Axl | TK | 5k0k | A | A | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | 7345 | |
| MERTK (MER) | Axl | TK | 2p0c | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 287 | |
| IGF1R | InsR | TK | 8pyk | A | A | 5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | Human | 14900 | |
| ABL1 | Abl | TK | 6xrg | A | 1 | - | Human | 12890 | |
| IGF1R | InsR | TK | 3d94 | A | B | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine | Human | 6760 | |
| IGF1R | InsR | TK | 6jk8 | A | A | - | Human | 12015 | |
| IGF1R | InsR | TK | 8pym | A | | 5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | Human | 14901 | |
| IGF1R | InsR | TK | 3i81 | A | | 1-{4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-n-(6-fluoropyridin-3-yl)-2-methyl-l-prolinamide | Human | 1041 | |
| MERTK (MER) | Axl | TK | 4mh7 | B | | - | Human | 265 | |
| IGF1R | InsR | TK | 5fxr | A | A | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine | Human | 7095 | |
| IGF1R | InsR | TK | 3lw0 | B | A | - | Human | 993 | |
| IGF1R | InsR | TK | 5fxs | A | A | 2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamide | Human | 7096 | |
| IGF1R | InsR | TK | 2zm3 | D | | (4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione | Human | 1023 | |
| IGF1R | InsR | TK | 3f5p | F | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1029 | |
| IGF1R | InsR | TK | 5hzn | F | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6497 | |
| IGF1R | InsR | TK | 3qqu | B | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1020 | |
| FGFR4 | FGFR | TK | 4qqc | A | B | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 932 | |
| FGFR2 | FGFR | TK | 8w38 | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15403 | |
| EPHA2 (EphA2) | Eph | TK | 5nka | A | A | 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid | Human | 8075 | |
| MERTK (MER) | Axl | TK | 3brb | B | B | adenosine-5'-diphosphate | Human | 274 | |
| MERTK (MER) | Axl | TK | 3brb | A | B | adenosine-5'-diphosphate | Human | 273 | |
| IGF1R | InsR | TK | 3f5p | H | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1006 | |
| IGF1R | InsR | TK | 1m7n | A | | - | Human | 1007 | |
| IGF1R | InsR | TK | 8pyn | A | A | 5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione | Human | 14902 | |
| IGF1R | InsR | TK | 3o23 | A | | (5s)-5-methyl-1-(quinolin-4-ylmethyl)-3-{4-[(trifluoromethyl)sulfonyl]phenyl}imidazolidine-2,4-dione | Human | 1036 | |
| IGF1R | InsR | TK | 3lvp | B | | 3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine | Human | 1035 | |
| IGF1R | InsR | TK | 5hzn | H | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6492 | |
| ABL1 | Abl | TK | 6npu | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10942 | |
| ABL1 | Abl | TK | 6xrg | A | 4 | - | Human | 12899 | |
| IGF1R | InsR | TK | 1jqh | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1038 | |
| SRC | Src | TK | 6e6e | E | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11479 | |
| IGF1R | InsR | TK | 8pyi | A | | 3-[8-azanyl-1-(4-ethoxy-8-fluoranyl-2-phenyl-quinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutan-1-ol | Human | 14903 | |
| IGF1R | InsR | TK | 3f5p | I | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1016 | |
| IGF1R | InsR | TK | 6jk8 | B | A | - | Human | 12018 | |
| IGF1R | InsR | TK | 6jk8 | A | B | - | Human | 12016 | |
| IGF1R | InsR | TK | 3lvp | D | | 3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine | Human | 1009 | |
| IGF1R | InsR | TK | 8pyk | A | B | 5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | Human | 14904 | |
| IGF1R | InsR | TK | 5hzn | E | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6494 | |
| IGF1R | InsR | TK | 3nw5 | A | | n-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2r)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | Human | 998 | |
| EGFR | EGFR | TK | 6v5p | A | A | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12174 | |
| EGFR | EGFR | TK | 1xkk | A | | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine | Human | 844 | |
| EGFR | EGFR | TK | 6jx0 | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12175 | |
| EGFR | EGFR | TK | 8to3 | A | B | 3-hydroxy-n-{(3p)-3-[(4p)-2-(methylsulfanyl)-5-{2-[4-(piperazin-1-yl)anilino]pyridin-4-yl}-1h-imidazol-4-yl]phenyl}-2-[(1-oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]benzamide | Human | 15389 | |
| EGFR | EGFR | TK | 5x2a | A | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9545 | |
| EGFR | EGFR | TK | 2gs7 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 842 | |
| MERTK (MER) | Axl | TK | 2p0c | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 286 | |
| MERTK (MER) | Axl | TK | 7aw4 | A | B | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | 13371 | |
| MERTK (MER) | Axl | TK | 5k0x | A | A | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | 7433 | |
| MERTK (MER) | Axl | TK | 6mep | A | | cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol | Human | 11602 | |
| MERTK (MER) | Axl | TK | 3bpr | A | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 278 | |
| EPHA2 (EphA2) | Eph | TK | 6hex | A | C | - | Human | 11551 | |
| MERTK (MER) | Axl | TK | 7avz | A | | (r)-n2-(4-(cyclopropylmethoxy)-3,5-difluorophenyl)-5-(3-methylpiperazin-1-yl)-n4-(tetrahydro-2h-pyran-4-yl)pyrimidine-2,4-diamine | Human | 13370 | |
| SRC | Src | TK | 6e6e | G | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11493 | |
| MERTK (MER) | Axl | TK | 5td2 | B | A | - | Human | 7385 | |
| MERTK (MER) | Axl | TK | 7aw0 | A | | 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-n-methyl-9h-purin-6-amine | Human | 13373 | |
| MERTK (MER) | Axl | TK | 5u6c | B | B | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8252 | |
| EGFR | EGFR | TK | 6v5p | D | B | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12186 | |
| EGFR | EGFR | TK | 6v6k | F | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12204 | |
| EGFR | EGFR | TK | 6jx4 | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12176 | |
| EGFR | EGFR | TK | 7lg8 | A | | (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2h-isoindol-2-yl}-n-(1,3-thiazol-2-yl)acetamide | Human | 14120 | |
| EGFR | EGFR | TK | 4i1z | A | A | - | Human | 903 | |
| MERTK (MER) | Axl | TK | 4mha | B | B | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | 270 | |
| MERTK (MER) | Axl | TK | 3bpr | C | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 284 | |
| SRC | Src | TK | 2bdf | B | | {[(4-{[2-(4-aminocyclohexyl)-9-ethyl-9h-purin-6-yl]amino}phenyl)(hydroxy)phosphoryl]methyl}phosphonic acid | Human | 975 | |
| EGFR | EGFR | TK | 5gty | C | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8366 | |
| EGFR | EGFR | TK | 2jiv | A | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 893 | |
| EGFR | EGFR | TK | 4wrg | A | A | - | Human | 854 | |
| MERTK (MER) | Axl | TK | 7cqe | C | | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | 12965 | |
| MERTK (MER) | Axl | TK | 7oam | A | | - | Human | 13556 | |
| ABL1 | Abl | TK | 8h7h | A | | 5-[3-(6-methoxyisoquinolin-7-yl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-~{n}-methyl-~{n}-prop-2-ynyl-pyridine-3-carboxamide | Human | 14666 | |
| EGFR | EGFR | TK | 6v6o | A | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12169 | |
| EGFR | EGFR | TK | 6v66 | B | A | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12205 | |
| EGFR | EGFR | TK | 6tfv | A | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12832 | |
| EGFR | EGFR | TK | 5x2a | A | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9530 | |
| EGFR | EGFR | TK | 5edr | A | A | ~{n}-(1~{h}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{h}-furo[3,4-d]pyrimidin-4-amine | Human | 6254 | |
| EGFR | EGFR | TK | 5x2f | D | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9544 | |
| EGFR | EGFR | TK | 5edr | A | B | ~{n}-(1~{h}-indazol-3-yl)-7,7-dimethyl-2-(2-methylpyrazol-3-yl)-5~{h}-furo[3,4-d]pyrimidin-4-amine | Human | 6255 | |
| EGFR | EGFR | TK | 6tg0 | A | B | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12829 | |
| EGFR | EGFR | TK | 7k1i | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13903 | |
| EGFR | EGFR | TK | 5can | A | | (3r)-3-methyl-1-(4-{[2-methyl-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-yl]amino}pyrimidin-2-yl)pyrrolidine-3-carboxamide | Human | 6203 | |
| EGFR | EGFR | TK | 6v66 | C | B | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12208 | |
| EGFR | EGFR | TK | 3ug2 | A | A | gefitinib | Human | 898 | |
| EGFR | EGFR | TK | 6tg0 | A | A | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12833 | |
| FGFR2 | FGFR | TK | 6agx | B | B | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11536 | |
| EGFR | EGFR | TK | 5x2a | C | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9547 | |
| EGFR | EGFR | TK | 5hg5 | A | A | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6375 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | B | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11935 | |
| EGFR | EGFR | TK | 3w2o | A | A | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9119 | |
| EGFR | EGFR | TK | 6p1l | D | | phosphoaminophosphonic acid-adenylate ester | Human | 11870 | |
| FGFR2 | FGFR | TK | 4j97 | C | A | phosphomethylphosphonic acid adenylate ester | Human | 488 | |
| FGFR2 | FGFR | TK | 6lvk | B | | n-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide | Human | 12129 | |
| FGFR2 | FGFR | TK | 5ugl | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 7450 | |
| EGFR | EGFR | TK | 6v5p | B | A | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12203 | |
| EGFR | EGFR | TK | 5hg7 | A | | 1-{(3r,4r)-3-[({5-chloro-2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}propan-1-one | Human | 6367 | |
| EGFR | EGFR | TK | 6tfy | B | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12831 | |
| EGFR | EGFR | TK | 5gnk | A | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 7525 | |
| EGFR | EGFR | TK | 6v66 | A | B | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12177 | |
| EGFR | EGFR | TK | 5uga | A | A | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7517 | |
| EGFR | EGFR | TK | 6duk | E | A | phosphoaminophosphonic acid-adenylate ester | Human | 11058 | |
| EGFR | EGFR | TK | 7kxz | A | | (20r)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15h,17h-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6h)-one | Human | 14074 | |
| EGFR | EGFR | TK | 6z4b | A | B | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 12974 | |
| FLT3 | PDGFR | TK | 1rjb | A | | - | Human | 625 | |
| JAK3 | JakA | TK | 6hzv | D | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11749 | |
| JAK3 | JakA | TK | 4rio | A | | 4-{[(1r,2s)-2-fluoro-2-methylcyclopentyl]amino}pyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 440 | |
| EGFR | EGFR | TK | 5gtz | A | A | n-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide | Human | 8365 | |
| EGFR | EGFR | TK | 6wa2 | B | A | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13443 | |
| EGFR | EGFR | TK | 3ika | A | B | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 855 | |
| EGFR | EGFR | TK | 5fee | A | | ~{n}-[7-methyl-1-[(3~{r})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide | Human | 6881 | |
| EGFR | EGFR | TK | 6duk | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 11067 | |
| BTK | Tec | TK | 6x3o | B | A | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12508 | |
| IGF1R | InsR | TK | 3lvp | A | | 3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine | Human | 1032 | |
| BTK | Tec | TK | 5j87 | D | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8001 | |
| EPHB4 (EphB4) | Eph | TK | 6fni | A | B | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10333 | |
| IGF1R | InsR | TK | 3lw0 | A | A | - | Human | 1021 | |
| IGF1R | InsR | TK | 3lvp | C | | 3-(4-chloro-1h-pyrrolo[2,3-b]pyridin-2-yl)-5,6-dimethoxy-1-methyl-1h-pyrrolo[3,2-b]pyridine | Human | 1003 | |
| IGF1R | InsR | TK | 3f5p | K | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1013 | |
| IGF1R | InsR | TK | 4d2r | A | B | n-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | Human | 1034 | |
| IGF1R | InsR | TK | 8pyj | A | | 5,5-dimethyl-1-(quinolin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione | Human | 14905 | |
| IGF1R | InsR | TK | 1p4o | B | | - | Human | 1026 | |
| IGF1R | InsR | TK | 3lw0 | C | A | - | Human | 1011 | |
| IGF1R | InsR | TK | 1p4o | A | | - | Human | 1002 | |
| IGF1R | InsR | TK | 3f5p | C | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1022 | |
| IGF1R | InsR | TK | 5fxs | A | B | 2-[4-[4-[[(6z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1h-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-n,n-dimethyl-ethanamide | Human | 7097 | |
| IGF1R | InsR | TK | 1m7n | B | | - | Human | 1012 | |
| EGFR | EGFR | TK | 5x2k | A | | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 9568 | |
| EGFR | EGFR | TK | 6z4d | B | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 12978 | |
| LYN | Src | TK | 5xy1 | A | | n-(1h-indazol-6-yl)-8-piperidin-4-yloxy-6-propyl-quinazolin-2-amine | Human | 8271 | |
| JAK2-b | JakB | TK | 6g3c | A | B | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10976 | |
| JAK2-b | JakB | TK | 6brw | A | A | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5h-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide | Human | 10382 | |
| EGFR | EGFR | TK | 6tfu | B | | ~{n}-[3-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12842 | |
| EGFR | EGFR | TK | 5yu9 | D | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9431 | |
| EGFR | EGFR | TK | 6v6k | G | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12222 | |
| FGFR1 | FGFR | TK | 4uwc | A | B | 3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide | Human | 6017 | |
| EGFR | EGFR | TK | 2j5e | A | | - | Human | 7215 | |
| EGFR | EGFR | TK | 6s89 | A | | ~{n}-[3-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-propan-2-yloxy-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 11729 | |
| EGFR | EGFR | TK | 7ukw | A | A | - | Human | 14531 | |
| EGFR | EGFR | TK | 5x2c | A | C | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9566 | |
| EGFR | EGFR | TK | 5ugc | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7516 | |
| EGFR | EGFR | TK | 5hic | A | | n-{2-[1-(cyclopropylsulfonyl)-1h-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-amine | Human | 6491 | |
| EGFR | EGFR | TK | 7jxi | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 13882 | |
| EGFR | EGFR | TK | 5gtz | A | B | n-[5-[[5-chloranyl-4-[(2-propan-2-ylsulfonylphenyl)amino]pyrimidin-2-yl]amino]-2-(4-ethylpiperazin-1-yl)-4-methoxy-phenyl]prop-2-enamide | Human | 8361 | |
| EGFR | EGFR | TK | 2jiv | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 851 | |
| EGFR | EGFR | TK | 4wd5 | B | | - | Human | 6593 | |
| EGFR | EGFR | TK | 4li5 | A | A | n-(3-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 841 | |
| EGFR | EGFR | TK | 6duk | F | B | phosphoaminophosphonic acid-adenylate ester | Human | 11063 | |
| EGFR | EGFR | TK | 6wak | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13438 | |
| JAK3 | JakA | TK | 4qps | A | B | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 458 | |
| JAK3 | JakA | TK | 3zep | A | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 456 | |
| TYK2-b | JakB | TK | 5c03 | B | A | phosphothiophosphoric acid-adenylate ester | Human | 6042 | |
| MET | Met | TK | 5eyc | A | A | 6-[(1~{r})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one | Human | 6401 | |
| FLT3 | PDGFR | TK | 6jqr | A | | 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | Human | 11802 | |
| BTK | Tec | TK | 5p9l | A | A | ~{n}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide | Human | 7625 | |
| BMX | Tec | TK | 3sxs | A | | 1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 3483 | |
| MET | Met | TK | 5dg5 | B | B | n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7036 | |
| JAK3 | JakA | TK | 7apf | B | B | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13132 | |
| EGFR | EGFR | TK | 5x2f | D | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9528 | |
| EGFR | EGFR | TK | 5cno | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 878 | |
| MET | Met | TK | 4knb | A | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3037 | |
| FGFR4 | FGFR | TK | 4qqt | A | | - | Human | 922 | |
| NTRK1 (TRKA) | Trk | TK | 7xaf | A | | 4^6,14-dimethyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide | Human | 14232 | |
| BTK | Tec | TK | 7n4q | A | B | (2r)-2-(3-chloro-5-fluoroanilino)-2-cyclopropyl-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide | Human | 14224 | |
| FGFR4 | FGFR | TK | 4qqj | A | | - | Human | 935 | |
| NTRK2 (TRKB) | Trk | TK | 4asz | A | | - | Human | 3599 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | B | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10341 | |
| EPHB4 (EphB4) | Eph | TK | 6fnk | A | A | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10344 | |
| EPHB4 (EphB4) | Eph | TK | 2vwz | A | A | n-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]phenyl]methanesulfonamide | Human | 360 | |
| JAK3 | JakA | TK | 5ttu | A | B | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7438 | |
| EGFR | EGFR | TK | 5edp | A | | - | Human | 6252 | |
| EGFR | EGFR | TK | 6tfv | B | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12845 | |
| DDR1 | DDR | TK | 5sb0 | A | | n-{[(1r,2s)-2-{2-[(pyridin-3-yl)oxy]ethyl}cyclohexyl]methyl}-3-(trifluoromethoxy)benzamide | Human | 14264 | |
| BTK | Tec | TK | 8flv | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14697 | |
| BTK | Tec | TK | 8flv | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14698 | |
| DDR1 | DDR | TK | 5sav | A | A | n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide | Human | 14265 | |
| TNK2 (ACK) | Ack | TK | 6vqm | A | | 2-({4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6h-pyrimido[5,4-d][1,3]benzodiazepin-6-one | Human | 13289 | |
| TNK2 (ACK) | Ack | TK | 6vqm | B | | 2-({4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6h-pyrimido[5,4-d][1,3]benzodiazepin-6-one | Human | 13290 | |
| FGFR4 | FGFR | TK | 6jpe | A | | n-[2-[[6-[2-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]amino]pyridin-3-yl]pyrimidin-4-yl]amino]-3-methyl-phenyl]prop-2-enamide | Human | 12230 | |
| EPHA2 (EphA2) | Eph | TK | 8bof | A | B | 4-methyl-~{n}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14652 | |
| JAK3 | JakA | TK | 4z16 | C | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6397 | |
| EGFR | EGFR | TK | 6p1d | C | B | 10-benzyl-8-fluoro-5,10-dihydro-11h-dibenzo[b,e][1,4]diazepin-11-one | Human | 11869 | |
| EGFR | EGFR | TK | 2itq | A | A | 1,2,3,4-tetrahydrogen staurosporine | Human | 813 | |
| JAK3 | JakA | TK | 7uyv | A | A | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14331 | |
| TNK2 (ACK) | Ack | TK | 5zxb | A | A | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10492 | |
| TNK2 (ACK) | Ack | TK | 4id7 | A | | cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol | Human | 3401 | |
| EPHA8 (EphA8) | Eph | TK | 3kul | B | A | - | Human | 1249 | |
| EPHA8 (EphA8) | Eph | TK | 3kul | B | B | - | Human | 1250 | |
| EPHA8 (EphA8) | Eph | TK | 3kul | A | B | - | Human | 1252 | |
| EPHA8 (EphA8) | Eph | TK | 3kul | A | A | - | Human | 1251 | |
| EGFR | EGFR | TK | 7vre | A | | 5-chloranyl-n-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine | Human | 14236 | |
| TNK2 (ACK) | Ack | TK | 3eqr | B | | n~3~-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-n~6~-(4-piperazin-1-ylphenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,6-diamine | Human | 3406 | |
| IGF1R | InsR | TK | 5hzn | D | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6496 | |
| IGF1R | InsR | TK | 2zm3 | C | | (4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione | Human | 1010 | |
| TNK2 (ACK) | Ack | TK | 4hzr | B | A | - | Human | 3396 | |
| TNK2 (ACK) | Ack | TK | 4hzr | A | B | - | Human | 3399 | |
| TNK2 (ACK) | Ack | TK | 4hzs | A | | - | Human | 3407 | |
| IGF1R | InsR | TK | 4d2r | A | A | n-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1h-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine | Human | 1018 | |
| IGF1R | InsR | TK | 1k3a | A | | phosphomethylphosphonic acid adenylate ester | Human | 1028 | |
| IGF1R | InsR | TK | 3f5p | S | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 996 | |
| IGF1R | InsR | TK | 3nw7 | A | | n-({4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide | Human | 1030 | |
| IGF1R | InsR | TK | 3f5p | G | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1005 | |
| IGF1R | InsR | TK | 5hzn | C | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6498 | |
| IGF1R | InsR | TK | 3qqu | C | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1014 | |
| IGF1R | InsR | TK | 5fxq | A | | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine | Human | 7093 | |
| IGF1R | InsR | TK | 6jk8 | B | B | - | Human | 12017 | |
| TNK2 (ACK) | Ack | TK | 5zxb | A | B | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10494 | |
| IGF1R | InsR | TK | 3f5p | R | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1019 | |
| IGF1R | InsR | TK | 1jqh | B | | phosphoaminophosphonic acid-adenylate ester | Human | 994 | |
| IGF1R | InsR | TK | 1jqh | A | | phosphoaminophosphonic acid-adenylate ester | Human | 999 | |
| BTK | Tec | TK | 7l5o | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14271 | |
| IGF1R | InsR | TK | 3lw0 | B | B | - | Human | 1008 | |
| IGF1R | InsR | TK | 2zm3 | A | | (4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione | Human | 1004 | |
| IGF1R | InsR | TK | 3lw0 | C | B | - | Human | 1025 | |
| MET | Met | TK | 5hor | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7276 | |
| BTK | Tec | TK | 6x3n | A | B | 4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12510 | |
| MET | Met | TK | 3qti | B | B | 6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | Human | 3024 | |
| MERTK (MER) | Axl | TK | 7dxl | A | | 3-[4-[6-chloranyl-5-[[(3r)-pyrrolidin-3-yl]amino]-1h-indazol-3-yl]pyrazol-1-yl]benzenecarbonitrile | Human | 13941 | |
| EGFR | EGFR | TK | 2itw | A | A | 1,2,3,4-tetrahydrogen staurosporine | Human | 817 | |
| TYK2-b | JakB | TK | 7k7o | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13835 | |
| TYK2-b | JakB | TK | 7k7o | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 13837 | |
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | B | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13887 | |
| ERBB2 (ErbB2) | EGFR | TK | 7jxh | A | A | (2e)-n-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | Human | 13888 | |
| SRC | Src | TK | 7ng7 | A | | tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino)piperidin-1-yl)ethyl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate | Human | 13900 | |
| EGFR | EGFR | TK | 7sz1 | A | | - | Human | 14029 | |
| EGFR | EGFR | TK | 7b85 | A | | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14121 | |
| EGFR | EGFR | TK | 4i24 | A | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 831 | |
| JAK2 | JakA | TK | 8bm2 | A | A | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15043 | |
| EGFR | EGFR | TK | 6lub | A | A | n-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine | Human | 12918 | |
| EGFR | EGFR | TK | 6v5n | A | B | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12180 | |
| NTRK1 (TRKA) | Trk | TK | 7vko | A | | repotrectinib | Human | 13943 | |
| BTK | Tec | TK | 7r60 | A | B | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13939 | |
| MERTK (MER) | Axl | TK | 7olx | A | | ~{n}-[[3-[4-[(dimethylamino)methyl]phenyl]imidazo[1,2-a]pyridin-6-yl]methyl]-~{n}-methyl-5-[3-methyl-5-(1,3,5-trimethylpyrazol-4-yl)pyridin-2-yl]-1,3,4-oxadiazol-2-amine | Human | 13897 | |
| EGFR | EGFR | TK | 5gty | D | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8356 | |
| KDR | VEGFR | TK | 3wze | A | B | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5320 | |
| EGFR | EGFR | TK | 4i22 | A | | gefitinib | Human | 823 | |
| FGFR4 | FGFR | TK | 5nud | B | | 3-chloranyl-~{n}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine | Human | 9790 | |
| FGFR4 | FGFR | TK | 7yc3 | A | | 6-bromanyl-~{n}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 14501 | |
| FGFR4 | FGFR | TK | 4tyg | A | A | - | Human | 929 | |
| KDR | VEGFR | TK | 3wze | A | A | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5336 | |
| KIT | PDGFR | TK | 8pqa | A | A | 6-(1-methylpyrazol-4-yl)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazine | Human | 15124 | |
| EGFR | EGFR | TK | 2ity | A | | gefitinib | Human | 790 | |
| EGFR | EGFR | TK | 6tg1 | A | B | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12843 | |
| MET | Met | TK | 8k78 | A | B | elzovantinib | Human | 15351 | |
| MET | Met | TK | 8k78 | A | A | elzovantinib | Human | 15352 | |
| FGFR4 | FGFR | TK | 6yi8 | A | B | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 12811 | |
| FGFR4 | FGFR | TK | 6yi8 | B | A | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 12813 | |
| FGFR4 | FGFR | TK | 6yi8 | B | B | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 12814 | |
| FGFR4 | FGFR | TK | 6nvj | A | | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-fluorophenyl]propanamide | Human | 11391 | |
| FGFR4 | FGFR | TK | 5nud | A | | 3-chloranyl-~{n}-(3-nitropyridin-2-yl)-5-(trifluoromethyl)pyridin-2-amine | Human | 9787 | |
| FGFR4 | FGFR | TK | 7vjl | A | | n-[5-(aminomethyl)-4-(2-methoxyethylamino)pyridin-2-yl]-7-[2,2,2-tris(fluoranyl)ethanoyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 14109 | |
| EGFR | EGFR | TK | 5gty | E | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8359 | |
| EGFR | EGFR | TK | 4rj6 | A | | n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1h-pyrazol-4-yl)-3h-imidazo[4,5-c]pyridin-6-amine | Human | 832 | |
| EGFR | EGFR | TK | 6lud | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12919 | |
| PTK2 (FAK) | FAK | TK | 6yt6 | B | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13271 | |
| FGFR4 | FGFR | TK | 6nvi | A | A | n-[3-chloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-5-fluorophenyl]propanamide | Human | 11392 | |
| TYK2-b | JakB | TK | 7k7q | A | B | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13836 | |
| FGFR4 | FGFR | TK | 4r6v | A | | n-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | Human | 931 | |
| DDR1 | DDR | TK | 7feh | A | A | n-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide | Human | 14309 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | A | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14650 | |
| EPHB1 (EphB1) | Eph | TK | 6umw | A | A | 7-chlorotetracycline | Human | 12924 | |
| EGFR | EGFR | TK | 7jxl | A | A | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 13878 | |
| EGFR | EGFR | TK | 4jr3 | A | | n-[3-(4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]acetamide | Human | 915 | |
| EGFR | EGFR | TK | 7vra | A | A | 25-chloro-11-(ethylsulfonyl)-44-morpholino-11h-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane | Human | 14235 | |
| JAK2 | JakA | TK | 7ree | A | B | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13856 | |
| KIT | PDGFR | TK | 8pqb | A | B | (1~{s})-1-(4-fluorophenyl)-~{n},~{n}-dimethyl-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15120 | |
| FGFR4 | FGFR | TK | 6nvk | A | A | n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide | Human | 11395 | |
| EGFR | EGFR | TK | 6tfz | B | B | ~{n}-[2-(2-hydroxyethyloxy)-5-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12839 | |
| EGFR | EGFR | TK | 6wak | D | B | phosphoaminophosphonic acid-adenylate ester | Human | 13445 | |
| EGFR | EGFR | TK | 8kfq | A | | ~{n}-[3-[[6-chloranyl-2-[(1-ethylpyrazol-4-yl)amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | Human | 15367 | |
| FGFR4 | FGFR | TK | 4tye | A | | - | Human | 927 | |
| FGFR4 | FGFR | TK | 4uxq | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 930 | |
| EGFR | EGFR | TK | 5em6 | A | | 4-[(2-azanylpyrimidin-4-yl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6305 | |
| JAK2-b | JakB | TK | 6m9h | A | A | 4-({4-amino-6-[4-(2-hydroxyethyl)-1h-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | Human | 10384 | |
| BTK | Tec | TK | 7r61 | A | A | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13938 | |
| KIT | PDGFR | TK | 8pqg | A | B | (1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15112 | |
| FGFR2 | FGFR | TK | 6v6q | B | | phosphomethylphosphonic acid adenylate ester | Human | 12966 | |
| FGFR4 | FGFR | TK | 5nwz | B | | ~{n}-[3-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-5-yl]-2-(propanoylamino)benzamide | Human | 9788 | |
| FGFR2 | FGFR | TK | 4j99 | D | B | phosphomethylphosphonic acid adenylate ester | Human | 481 | |
| FGFR4 | FGFR | TK | 4xcu | A | B | n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide | Human | 924 | |
| FGFR4 | FGFR | TK | 7dtz | A | | n-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide | Human | 13506 | |
| EGFR | EGFR | TK | 7tvd | A | | - | Human | 14107 | |
| MET | Met | TK | 5eyd | A | B | 6-[(1~{r})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one | Human | 6399 | |
| MET | Met | TK | 5uab | A | B | n-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide | Human | 7964 | |
| EGFR | EGFR | TK | 4wkq | A | A | gefitinib | Human | 889 | |
| EGFR | EGFR | TK | 7oxb | A | | 2-[2-(3-methoxyphenyl)pyrimidin-4-yl]-1'-prop-2-enoyl-spiro[5,6-dihydro-1~{h}-pyrrolo[3,2-c]pyridine-7,4'-piperidine]-4-one | Human | 13948 | |
| FGFR2 | FGFR | TK | 4j95 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 529 | |
| FGFR2 | FGFR | TK | 4j97 | B | C | phosphomethylphosphonic acid adenylate ester | Human | 510 | |
| FGFR2 | FGFR | TK | 4j97 | C | C | phosphomethylphosphonic acid adenylate ester | Human | 483 | |
| MET | Met | TK | 3dkg | A | B | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 3019 | |
| MET | Met | TK | 4mxc | A | B | n-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 3025 | |
| TYK2 | JakA | TK | 6x8g | A | B | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | 12993 | |
| RET | Ret | TK | 6nec | A | A | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | 11151 | |
| FGFR2 | FGFR | TK | 5uhn | B | A | phosphomethylphosphonic acid adenylate ester | Human | 7451 | |
| JAK3 | JakA | TK | 6aak | D | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10365 | |
| RET | Ret | TK | 6nec | A | B | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | 11150 | |
| FGFR2 | FGFR | TK | 5ugx | B | B | phosphomethylphosphonic acid adenylate ester | Human | 7445 | |
| JAK3 | JakA | TK | 6hzv | A | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11756 | |
| EGFR | EGFR | TK | 2rgp | A | | n-[1-(3-fluorobenzyl)-1h-indazol-5-yl]-5-[(piperidin-1-ylamino)methyl]pyrimidine-4,6-diamine | Human | 6757 | |
| JAK3 | JakA | TK | 3zep | D | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 454 | |
| RET | Ret | TK | 6nec | C | B | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | 11153 | |
| EGFR | EGFR | TK | 4wkq | A | B | gefitinib | Human | 837 | |
| MET | Met | TK | 2wd1 | A | B | 1-[(2-nitrophenyl)sulfonyl]-1h-pyrrolo[3,2-b]pyridine-6-carboxamide | Human | 2976 | |
| BTK | Tec | TK | 7n4s | A | | (3r,3'r)-3-anilino-1'-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)[1,3'-bipiperidin]-2-one | Human | 14229 | |
| JAK2 | JakA | TK | 8bxc | A | B | itacitinib | Human | 15041 | |
| FGFR1 | FGFR | TK | 8jmz | A | A | n-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1h-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | Human | 15228 | |
| EGFR | EGFR | TK | 7lgs | D | B | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15374 | |
| BTK | Tec | TK | 7l5o | A | C | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14268 | |
| BTK | Tec | TK | 8gc8 | A | B | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15192 | |
| BTK | Tec | TK | 7l5p | A | B | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14270 | |
| BTK | Tec | TK | 8flv | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}ethan-1-one | Human | 14699 | |
| FGFR2 | FGFR | TK | 6v6q | A | | phosphomethylphosphonic acid adenylate ester | Human | 12968 | |
| KIT | PDGFR | TK | 8pqc | A | A | (1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15122 | |
| KIT | PDGFR | TK | 8pqc | A | B | (1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15123 | |
| JAK3 | JakA | TK | 7apg | B | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13131 | |
| FGFR1 | FGFR | TK | 8jmz | A | B | n-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1h-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | Human | 15227 | |
| SYK | Syk | TK | 6zcy | A | B | ~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | Human | 13638 | |
| FGFR4 | FGFR | TK | 7v29 | A | | n-[2-[[3-(3,5-dimethoxyphenyl)-2-oxidanylidene-1-[3-(4-propanoylpiperazin-1-yl)propyl]-4h-pyrimido[4,5-d]pyrimidin-7-yl]amino]phenyl]propanamide | Human | 14165 | |
| JAK3 | JakA | TK | 4hvh | A | | 2-cyclopropyl-n-[(2r)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 441 | |
| JAK3 | JakA | TK | 6gla | B | A | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10017 | |
| EGFR | EGFR | TK | 6xl4 | A | | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 13759 | |
| FGFR4 | FGFR | TK | 6iuo | A | | n-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide | Human | 11757 | |
| FGFR2 | FGFR | TK | 2psq | B | | - | Human | 530 | |
| FGFR2 | FGFR | TK | 2q0b | B | | phosphomethylphosphonic acid adenylate ester | Human | 499 | |
| ABL1 | Abl | TK | 3cs9 | C | B | nilotinib | Human | 1093 | |
| ABL1 | Abl | TK | 3cs9 | D | B | nilotinib | Human | 1066 | |
| BTK | Tec | TK | 8u2d | A | B | (3r)-2-[n-(1h-indazole-5-carbonyl)-3-methyl-d-phenylalanyl]-n-methyl-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 15193 | |
| ABL1 | Abl | TK | 3cs9 | A | B | nilotinib | Human | 1107 | |
| INSR | InsR | TK | 1irk | A | A | - | Human | 596 | |
| EGFR | EGFR | TK | 5d41 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 6665 | |
| INSR | InsR | TK | 4ibm | B | B | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one | Human | 599 | |
| INSR | InsR | TK | 5e1s | A | B | (5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amine | Human | 6147 | |
| FGFR2 | FGFR | TK | 2py3 | B | | phosphomethylphosphonic acid adenylate ester | Human | 484 | |
| FGFR2 | FGFR | TK | 4j95 | D | B | phosphomethylphosphonic acid adenylate ester | Human | 492 | |
| FGFR2 | FGFR | TK | 6agx | D | A | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11543 | |
| FGFR2 | FGFR | TK | 2pwl | B | | phosphomethylphosphonic acid adenylate ester | Human | 534 | |
| ABL1 | Abl | TK | 3cs9 | B | A | nilotinib | Human | 1050 | |
| FGFR4 | FGFR | TK | 4qrc | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 923 | |
| KDR | VEGFR | TK | 3vid | A | | 4,5,6,11-tetrahydro-1h-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole | Human | 5335 | |
| KDR | VEGFR | TK | 3vnt | A | A | 2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | Human | 5312 | |
| NTRK1 (TRKA) | Trk | TK | 7vkn | A | B | repotrectinib | Human | 13944 | |
| NTRK1 (TRKA) | Trk | TK | 7vkn | A | A | repotrectinib | Human | 13945 | |
| MET | Met | TK | 3q6w | A | | 3-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-n-(pyridin-2-ylmethyl)propanamide | Human | 2969 | |
| BTK | Tec | TK | 5fbn | D | B | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6383 | |
| IGF1R | InsR | TK | 2oj9 | A | | 3-[5-(1h-imidazol-1-yl)-7-methyl-1h-benzimidazol-2-yl]-4-[(pyridin-2-ylmethyl)amino]pyridin-2(1h)-one | Human | 1017 | |
| IGF1R | InsR | TK | 8pyl | A | | (5s)-5-methyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfanyl)phenyl]imidazolidine-2,4-dione | Human | 14906 | |
| IGF1R | InsR | TK | 3f5p | B | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1044 | |
| IGF1R | InsR | TK | 3f5p | A | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 995 | |
| IGF1R | InsR | TK | 3qqu | A | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 1024 | |
| FGFR2 | FGFR | TK | 5ugl | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 7442 | |
| KIT | PDGFR | TK | 8pqe | A | A | ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]prop-2-enamide | Human | 15119 | |
| IGF1R | InsR | TK | 5hzn | B | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6495 | |
| IGF1R | InsR | TK | 3lw0 | A | B | - | Human | 1031 | |
| IGF1R | InsR | TK | 8pyn | A | B | 5,5-dimethyl-1-(1h-pyrrolo[2,3-b]pyridin-4-ylmethyl)-3-[4-(trifluoromethylsulfonyl)phenyl]imidazolidine-2,4-dione | Human | 14907 | |
| EGFR | EGFR | TK | 5hg9 | A | A | 1-[(3r,4r)-3-[({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-(trifluoromethyl)pyrrolidin-1-yl]propan-1-one | Human | 6379 | |
| EGFR | EGFR | TK | 6v66 | B | B | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12217 | |
| JAK3 | JakA | TK | 5w86 | B | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8551 | |
| FGFR2 | FGFR | TK | 8u1f | A | | n-[4-(4-amino-7-methyl-5-{4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7h-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl]-2-methylpropanamide | Human | 15202 | |
| FGFR2 | FGFR | TK | 5ugl | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 7449 | |
| JAK3 | JakA | TK | 5ttv | A | A | n-[3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide | Human | 7437 | |
| FGFR1 | FGFR | TK | 5uq0 | A | B | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide | Human | 7458 | |
| MERTK (MER) | Axl | TK | 9bhi | A | | (5p)-2-amino-5-(1-methyl-1h-pyrazol-4-yl)-n-{(1r,2s)-2-[(4'-{2-[4-(2-oxoethyl)piperazin-1-yl]propan-2-yl}[1,1'-biphenyl]-4-yl)methoxy]cyclopentyl}pyridine-3-carboxamide | Human | 15434 | |
| MERTK (MER) | Axl | TK | 9kry | A | | ~{n}-[4-[5-(3-aminophenyl)-6-(1-methylpyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxyphenyl]-2-(4-fluorophenyl)-1-methyl-3-oxidanylidene-pyrazole-4-carboxamide | Human | 15435 | |
| MERTK (MER) | Axl | TK | 9krz | A | | ~{n}-[4-[5-[3-[(dimethylamino)methyl]phenyl]-6-(1-methylpyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxyphenyl]-2-(4-fluorophenyl)-1-methyl-3-oxidanylidene-pyrazole-4-carboxamide | Human | 15436 | |
| MERTK (MER) | Axl | TK | 9ks9 | A | | ~{n}-[4-[5-(3-aminophenyl)-6-(1-methylpyrazol-4-yl)furo[2,3-d]pyrimidin-4-yl]oxyphenyl]-1-(4-fluorophenyl)-2-oxidanylidene-pyridine-3-carboxamide | Human | 15437 | |
| FGFR3 | FGFR | TK | 8udv | A | | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15203 | |
| EGFR | EGFR | TK | 5x2c | A | A | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9572 | |
| FES | Fer | TK | 8xkp | A | | 7-[[(1r,2s)-2-azanylcyclohexyl]amino]-5-[[3-[(2s,6r)-2,6-dimethylmorpholin-4-yl]phenyl]amino]-4-oxidanylidene-3h-pyrido[3,4-d]pyridazine-8-carbonitrile | Human | 15449 | |
| EPHB4 (EphB4) | Eph | TK | 2xvd | A | A | {4-methyl-3-[(1-methylethyl)(2-{[3-(methylsulfonyl)-5-morpholin-4-ylphenyl]amino}pyrimidin-4-yl)amino]phenyl}methanol | Human | 363 | |
| ERBB3 (ErbB3) | EGFR | TK | 4riw | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1932 | |
| NTRK1 (TRKA) | Trk | TK | 6dkg | A | A | 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide | Human | 10059 | |
| JAK3 | JakA | TK | 3zep | B | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 437 | |
| EGFR | EGFR | TK | 5yu9 | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9430 | |
| EGFR | EGFR | TK | 6tfz | A | B | ~{n}-[2-(2-hydroxyethyloxy)-5-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12846 | |
| EPHB4 (EphB4) | Eph | TK | 2x9f | A | A | n^4^-1h-indazol-4-yl-n^2^-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | Human | 354 | |
| EPHB4 (EphB4) | Eph | TK | 2vwv | A | B | n'-(3-chloro-4-methoxy-phenyl)-n-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine | Human | 369 | |
| FGFR3 | FGFR | TK | 9cd7 | A | | (3p)-5-[(1r)-1-(3,5-dichloropyridin-4-yl)ethoxy]-3-{6-[6-(methanesulfonyl)-2,6-diazaspiro[3.3]heptan-2-yl]pyridin-3-yl}-1h-indazole | Human | 15469 | |
| FGFR3 | FGFR | TK | 12ww | A | | (2s)-2-{[(6p,8s)-3-chloro-6-(1-{1-[(z)-iminomethyl]piperidin-4-yl}-5-methyl-1h-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy}-2-(5-fluoropyridin-2-yl)ethan-1-ol | Human | 15470 | |
| BTK | Tec | TK | 6e4f | A | B | 1,5-anhydro-2-{[5-(2-chloro-4-phenoxybenzene-1-carbonyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-2,3,4-trideoxy-d-erythro-hexitol | Human | 10480 | |
| BTK | Tec | TK | 6hrp | A | | 6-~{tert}-butyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[(5-morpholin-4-ylcarbonylpyridin-2-yl)amino]-6-oxidanylidene-pyridazin-3-yl]phenyl]phthalazin-1-one | Human | 10971 | |
| BTK | Tec | TK | 3p08 | A | | - | Human | 2905 | |
| BTK | Tec | TK | 5j87 | C | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8004 | |
| BTK | Tec | TK | 6x3p | A | B | 4-{8-amino-3-[(6r,8as)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(cyclopropyloxy)-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12517 | |
| BTK | Tec | TK | 5jrs | B | | 4-[2-fluoro-3-(4-oxoquinazolin-3(4h)-yl)phenyl]-7-(2-hydroxypropan-2-yl)-9h-carbazole-1-carboxamide | Human | 7033 | |
| DDR1 | DDR | TK | 9sp9 | A | | ~{n}-(1-imidazo[1,2-a]pyridin-3-ylcarbonyl-2,3-dihydroindol-6-yl)-3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)benzamide | Human | 15544 | |
| BTK | Tec | TK | 7kxm | A | C | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13567 | |
| JAK2 | JakA | TK | 9t1u | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15577 | |
| JAK2 | JakA | TK | 29rx | A | B | adenosine-5'-diphosphate | Human | 15575 | |
| JAK2 | JakA | TK | 5cf4 | B | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5982 | |
| JAK2 | JakA | TK | 9t1u | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15576 | |
| JAK2 | JakA | TK | 9t1z | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15578 | |
| SYK | Syk | TK | 8wyw | A | | ski-o-592 | Human | 15579 | |
| SYK | Syk | TK | 8xq1 | A | | cyclopropyl-[5-[[4-[4-[[(3~{r},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-pyrrolo[2,3-b]pyridin-3-yl]methanone | Human | 15580 | |
| SYK | Syk | TK | 8xq2 | A | | cyclopropyl-[1-(2-fluoranylethyl)-5-[[4-[4-[[(3~{r},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]indol-3-yl]methanone | Human | 15581 | |
| SYK | Syk | TK | 8xq0 | A | | cyclopropyl-[5-[[4-[4-[[(3~{s},4~{s})-3-methoxy-4-oxidanyl-pyrrolidin-1-yl]methyl]-3-methyl-pyrazol-1-yl]pyrimidin-2-yl]amino]-1-methyl-indol-3-yl]methanone | Human | 15582 | |
| BTK | Tec | TK | 6tfp | E | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12022 | |
| BTK | Tec | TK | 4rg0 | A | | 2-{8-fluoro-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl}-2-methylpropanenitrile | Human | 2929 | |
| ROR2 | Ror | TK | 4gt4 | B | B | - | Human | 408 | |
| HCK | Src | TK | 9byj | A | A | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 15592 | |
| HCK | Src | TK | 9byj | A | B | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 15593 | |
| SRC | Src | TK | 9ns1 | A | 17 | - | Human | 15594 | |
| EGFR | EGFR | TK | 8gb4 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 15235 | |
| SRC | Src | TK | 9ns0 | A | 15 | - | Human | 15598 | |
| EGFR | EGFR | TK | 8gb4 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 15236 | |
| EGFR | EGFR | TK | 8tjl | A | | 1-{3-[(4-amino-1-tert-butyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)oxy]azetidin-1-yl}propan-1-one | Human | 15237 | |
| SRC | Src | TK | 9ns1 | A | 12 | - | Human | 15595 | |
| SRC | Src | TK | 9ns1 | A | 1 | - | Human | 15599 | |
| SRC | Src | TK | 9ns1 | A | 10 | - | Human | 15600 | |
| SRC | Src | TK | 9ns0 | A | 2 | - | Human | 15601 | |
| SRC | Src | TK | 9ns1 | A | 13 | - | Human | 15602 | |
| SRC | Src | TK | 9ns1 | A | 11 | - | Human | 15596 | |
| SRC | Src | TK | 9ns0 | A | 20 | - | Human | 15597 | |
| SRC | Src | TK | 9ns0 | A | 1 | - | Human | 15603 | |
| SRC | Src | TK | 9ns1 | A | 15 | - | Human | 15604 | |
| SRC | Src | TK | 9ns1 | A | 6 | - | Human | 15605 | |
| BTK | Tec | TK | 8fln | A | A | pirtobrutinib | Human | 14642 | |
| SRC | Src | TK | 9ns0 | A | 8 | - | Human | 15606 | |
| SRC | Src | TK | 9ns1 | A | 2 | - | Human | 15607 | |
| SRC | Src | TK | 9ns0 | A | 3 | - | Human | 15608 | |
| SRC | Src | TK | 9ns0 | A | 18 | - | Human | 15609 | |
| SRC | Src | TK | 9ns0 | A | 5 | - | Human | 15610 | |
| SRC | Src | TK | 9ns0 | A | 13 | - | Human | 15611 | |
| NTRK1 (TRKA) | Trk | TK | 6dki | A | A | 6-amino-5-{[(3s)-4,4-difluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}pyrrolidin-3-yl]oxy}-n-methylpyridine-3-carboxamide | Human | 10060 | |
| JAK3 | JakA | TK | 7c3n | A | B | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12391 | |
| BTK | Tec | TK | 8fln | A | C | pirtobrutinib | Human | 14633 | |
| SRC | Src | TK | 9ns0 | A | 16 | - | Human | 15624 | |
| PTK2B (PYK2) | FAK | TK | 8ygx | A | B | - | Human | 15244 | |
| PTK2B (PYK2) | FAK | TK | 8ygx | A | A | - | Human | 15245 | |
| BTK | Tec | TK | 8flg | A | B | n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide | Human | 14634 | |
| BTK | Tec | TK | 8fln | A | B | pirtobrutinib | Human | 14635 | |
| BTK | Tec | TK | 6n9p | A | C | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10888 | |
| BTK | Tec | TK | 8flh | A | A | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14637 | |
| BTK | Tec | TK | 8flh | A | B | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14638 | |
| BTK | Tec | TK | 8fll | A | B | pirtobrutinib | Human | 14640 | |
| BTK | Tec | TK | 8flg | A | A | n~2~-(3-chlorophenyl)-n-[(3r)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]glycinamide | Human | 14641 | |
| BTK | Tec | TK | 5j87 | A | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8003 | |
| BTK | Tec | TK | 5j87 | A | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8002 | |
| BTK | Tec | TK | 7n5r | A | B | 5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13890 | |
| BTK | Tec | TK | 5kup | A | A | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7051 | |
| BTK | Tec | TK | 3pj2 | A | | 2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-6-(4-fluorophenoxy)-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 2911 | |
| JAK1 | JakA | TK | 3eyh | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 1462 | |
| FGFR1 | FGFR | TK | 43xk | A | B | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)thiolan-2-yl]methyl]prop-2-enamide | Human | 15684 | |
| FGFR1 | FGFR | TK | 44ac | A | | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-2-fluoranyl-prop-2-enamide | Human | 15685 | |
| FGFR1 | FGFR | TK | 9wfk | A | B | (2~{r},3~{r},4~{s},5~{r})-2-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Human | 15686 | |
| FGFR1 | FGFR | TK | 9wfk | A | A | (2~{r},3~{r},4~{s},5~{r})-2-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Human | 15687 | |
| FGFR1 | FGFR | TK | 43zy | A | A | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-[2-(3,5-dimethoxyphenyl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]prop-2-enamide | Human | 15688 | |
| BTK | Tec | TK | 1k2p | B | | - | Human | 2919 | |
| FGFR1 | FGFR | TK | 9w1a | A | | xs8148 | Human | 15679 | |
| FGFR1 | FGFR | TK | 43zy | A | B | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-[2-(3,5-dimethoxyphenyl)ethynyl]pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]prop-2-enamide | Human | 15680 | |
| FGFR1 | FGFR | TK | 44ah | A | A | derazantinib | Human | 15681 | |
| FGFR1 | FGFR | TK | 44ad | A | A | 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-3-yl]-6-(4-methylpiperazin-1-yl)-1~{h}-benzimidazole | Human | 15682 | |
| FGFR1 | FGFR | TK | 44aa | A | A | (2~{r},3~{s},4~{r},5~{r})-2-[[(azanylidene-$l^{4}-azanylidene)amino]methyl]-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol | Human | 15683 | |
| FGFR1 | FGFR | TK | 43zv | A | | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]prop-2-enamide | Human | 15689 | |
| FGFR1 | FGFR | TK | 9wgt | A | A | (2~{r},3~{s},4~{r},5~{r})-2-(aminomethyl)-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol | Human | 15690 | |
| FGFR1 | FGFR | TK | 9uhi | A | | ~{n}-[1-methyl-3-[3-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]quinoxalin-5-yl]indol-6-yl]propanamide | Human | 15691 | |
| FGFR1 | FGFR | TK | 9wgt | A | B | (2~{r},3~{s},4~{r},5~{r})-2-(aminomethyl)-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol | Human | 15692 | |
| JAK1 | JakA | TK | 6n77 | B | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11018 | |
| JAK1 | JakA | TK | 6tpf | A | B | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12365 | |
| JAK1 | JakA | TK | 6elr | B | A | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10619 | |
| BTK | Tec | TK | 7kxm | A | A | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13569 | |
| BTK | Tec | TK | 5zz4 | E | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10470 | |
| BTK | Tec | TK | 4nwm | A | B | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2917 | |
| BTK | Tec | TK | 5fbn | C | A | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6381 | |
| JAK1 | JakA | TK | 5wo4 | B | B | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8703 | |
| JAK1 | JakA | TK | 6n77 | A | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11021 | |
| JAK1 | JakA | TK | 4ivb | A | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1486 | |
| BTK | Tec | TK | 6di0 | A | C | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10628 | |
| BTK | Tec | TK | 6bke | A | B | n-[2-(2-hydroxyethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10683 | |
| BTK | Tec | TK | 5jrs | A | | 4-[2-fluoro-3-(4-oxoquinazolin-3(4h)-yl)phenyl]-7-(2-hydroxypropan-2-yl)-9h-carbazole-1-carboxamide | Human | 7032 | |
| BTK | Tec | TK | 5zz4 | C | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10464 | |
| BTK | Tec | TK | 7n5o | A | B | 5-(1h-benzimidazol-2-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13891 | |
| BTK | Tec | TK | 3k54 | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2932 | |
| BTK | Tec | TK | 5xyz | B | B | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9930 | |
| BTK | Tec | TK | 5kup | A | B | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-6-oxidanylidene-5-(pyrimidin-4-ylamino)pyridin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7052 | |
| JAK1 | JakA | TK | 6rsh | A | A | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12470 | |
| JAK1 | JakA | TK | 6rse | B | B | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12471 | |
| JAK1 | JakA | TK | 5wo4 | A | B | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8705 | |
| CSF1R (FMS) | PDGFR | TK | 8jot | A | | n-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1h-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide | Human | 15255 | |
| INSR | InsR | TK | 8u4b | A | | - | Human | 15258 | |
| BTK | Tec | TK | 6x3o | A | B | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12512 | |
| BTK | Tec | TK | 6x3o | A | A | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12513 | |
| BTK | Tec | TK | 6x3n | A | A | 4-{8-amino-3-[(6r,8as)-3-oxohexahydro-3h-[1,3]oxazolo[3,4-a]pyridin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12514 | |
| BTK | Tec | TK | 5j87 | B | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8007 | |
| BTK | Tec | TK | 6aua | A | B | n-{3-[(2r)-6-{[3-amino-4-(morpholine-4-carbonyl)phenyl]amino}-5-oxo-2,5-dihydropyrazin-2-yl]-2-methylphenyl}-4-(piperidin-1-yl)benzamide | Human | 10473 | |
| BTK | Tec | TK | 6bkh | A | A | n-[2-(hydroxymethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10682 | |
| BTK | Tec | TK | 6omu | A | A | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11529 | |
| JAK1 | JakA | TK | 4e4l | E | B | - | Human | 1484 | |
| KIT | PDGFR | TK | 8s19 | A | B | staurosporine | Human | 15755 | |
| KIT | PDGFR | TK | 8s17 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 15756 | |
| KIT | PDGFR | TK | 9sxf | A | A | 3-(aminocarbonylamino)-5-(3-fluorophenyl)-~{n}-[(3~{r})-pyrrolidin-3-yl]thiophene-2-carboxamide | Human | 15757 | |
| JAK1 | JakA | TK | 6n79 | A | | n-{5-[5-chloro-2-(difluoromethoxy)phenyl]-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11031 | |
| KIT | PDGFR | TK | 8s1a | A | A | 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1h-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine | Human | 15758 | |
| JAK1 | JakA | TK | 6rsd | A | A | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12472 | |
| JAK1 | JakA | TK | 6rsh | A | B | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12473 | |
| KIT | PDGFR | TK | 35ua | A | A | ~{n}-(3,4-dichlorophenyl)-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]ethanamide | Human | 15746 | |
| KIT | PDGFR | TK | 8s13 | A | A | - | Human | 15747 | |
| KIT | PDGFR | TK | 8s19 | A | A | staurosporine | Human | 15748 | |
| KIT | PDGFR | TK | 8s13 | A | B | - | Human | 15749 | |
| KIT | PDGFR | TK | 8s17 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 15750 | |
| KIT | PDGFR | TK | 35ua | A | B | ~{n}-(3,4-dichlorophenyl)-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]ethanamide | Human | 15751 | |
| KIT | PDGFR | TK | 8s1b | A | A | ~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | Human | 15752 | |
| KIT | PDGFR | TK | 9sxf | A | B | 3-(aminocarbonylamino)-5-(3-fluorophenyl)-~{n}-[(3~{r})-pyrrolidin-3-yl]thiophene-2-carboxamide | Human | 15753 | |
| KIT | PDGFR | TK | 8s16 | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 15754 | |
| JAK1 | JakA | TK | 6dbn | A | A | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10393 | |
| FGFR2 | FGFR | TK | 2pvy | A | | phosphomethylphosphonic acid adenylate ester | Human | 489 | |
| FGFR2 | FGFR | TK | 4j99 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 495 | |
| FGFR2 | FGFR | TK | 8swe | A | A | n-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide | Human | 15200 | |
| FGFR2 | FGFR | TK | 5ugx | A | A | phosphomethylphosphonic acid adenylate ester | Human | 7443 | |
| JAK1 | JakA | TK | 4e4l | D | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1468 | |
| JAK1 | JakA | TK | 5hx8 | B | A | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6440 | |
| JAK1 | JakA | TK | 6smb | A | A | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12246 | |
| JAK1 | JakA | TK | 6n7a | B | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11026 | |
| JAK1 | JakA | TK | 5khx | A | A | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7167 | |
| FGFR4 | FGFR | TK | 7wcw | A | | ~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | Human | 14168 | |
| BTK | Tec | TK | 7kxn | A | C | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13570 | |
| JAK1 | JakA | TK | 6tpf | B | B | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12367 | |
| JAK1 | JakA | TK | 6n78 | A | A | n-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11019 | |
| JAK1 | JakA | TK | 6n7c | A | A | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11016 | |
| EPHA3 (EphA3) | Eph | TK | 2qoq | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 2890 | |
| ROS1 (ROS) | Sev | TK | 9qek | A | | zidesamtinib | Human | 15786 | |
| JAK2 | JakA | TK | 4f08 | B | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3719 | |
| EPHB4 (EphB4) | Eph | TK | 4aw5 | A | B | (3z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1h-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 376 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | A | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10336 | |
| BTK | Tec | TK | 4nwm | B | A | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2898 | |
| BTK | Tec | TK | 7n5x | A | A | 5-(1-ethoxyisoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13893 | |
| EPHA3 (EphA3) | Eph | TK | 4gk2 | A | A | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2841 | |
| EPHB4 (EphB4) | Eph | TK | 6fni | A | A | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10338 | |
| JAK1 | JakA | TK | 6elr | A | A | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10618 | |
| JAK1 | JakA | TK | 6bbu | A | A | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9497 | |
| DDR1 | DDR | TK | 5sb1 | A | A | 4-chloro-n-[(3s,4r)-4-phenylpyrrolidin-3-yl]-3-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | Human | 14252 | |
| SYK | Syk | TK | 4yjq | A | A | 3-[1h-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol | Human | 6114 | |
| BTK | Tec | TK | 5bq0 | A | B | 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl)carbonyl]-9h-carbazole-1-carboxamide | Human | 6872 | |
| JAK1 | JakA | TK | 6tpe | B | | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | Human | 12368 | |
| SYK | Syk | TK | 6zcs | A | A | (3~{r},4~{r})-~{n}4-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine | Human | 13639 | |
| SYK | Syk | TK | 5cy3 | A | B | (5r)-5-[(1r)-1-{[6-(1-methyl-1h-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one | Human | 6056 | |
| SYK | Syk | TK | 4yjv | A | B | 3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol | Human | 6148 | |
| EPHA2 (EphA2) | Eph | TK | 7kja | B | A | phosphomethylphosphonic acid adenylate ester | Human | 13249 | |
| EPHA2 (EphA2) | Eph | TK | 6hes | A | A | 4-methyl-3-[(2-pyridin-3-ylquinazolin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11550 | |
| JAK1 | JakA | TK | 4ei4 | B | | (1r,3r)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8h)-yl)cyclohexanol | Human | 1483 | |
| JAK1 | JakA | TK | 4e4l | A | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1450 | |
| EGFR | EGFR | TK | 9q0s | A | | n-(3-bromo-2-fluorophenyl)-7,8-dihydro[1,4]dioxino[2,3-g]quinazolin-4-amine | Human | 15877 | |
| EGFR | EGFR | TK | 9u8c | A | | ~{n}-[5-[[6-[(3~{r})-3-[3,5-bis(fluoranyl)phenyl]-1,2-oxazolidin-2-yl]pyrimidin-4-yl]amino]-2-[4-(4-cyclopropylpiperazin-1-yl)piperidin-1-yl]-4-methoxy-phenyl]propanamide | Human | 15878 | |
| EGFR | EGFR | TK | 9h42 | A | | 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]phenyl]amino]-5-ethyl-8-phenyl-pyrido[2,3-d]pyrimidin-7-one | Human | 15879 | |
| EGFR | EGFR | TK | 9ou9 | A | | 4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl (2r)-2,4-dimethylpiperazine-1-carboxylate | Human | 15880 | |
| EGFR | EGFR | TK | 9nhw | A | | oritinib, bound form | Human | 15881 | |
| JAK1 | JakA | TK | 5khw | A | | adenosine-5'-diphosphate | Human | 7164 | |
| ABL1 | Abl | TK | 2g2f | B | | phosphothiophosphoric acid-adenylate ester | Human | 1079 | |
| ABL1 | Abl | TK | 4twp | A | | axitinib | Human | 1091 | |
| KDR | VEGFR | TK | 3wzd | A | B | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 5350 | |
| KDR | VEGFR | TK | 3cjf | A | B | n~4~-(3-methyl-1h-indazol-6-yl)-n~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 6794 | |
| JAK2 | JakA | TK | 4iva | A | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3673 | |
| EGFR | EGFR | TK | 9by6 | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 15876 | |
| EGFR | EGFR | TK | 9gdv | A | | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15896 | |
| EGFR | EGFR | TK | 9pmz | A | | icotinib | Human | 15897 | |
| EGFR | EGFR | TK | 9d3w | A | | (4s)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-n-{2-[(3s,4r)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-2-methyl-1h-imidazo[1,2-b]pyrazol-6-amine | Human | 15898 | |
| EGFR | EGFR | TK | 9nj7 | A | | almonertinib, bound form | Human | 15899 | |
| JAK1-b | JakB | TK | 4l00 | A | A | - | Human | 1421 | |
| JAK1 | JakA | TK | 6w8l | A | | n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | Human | 12133 | |
| JAK1 | JakA | TK | 6elr | A | B | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10616 | |
| JAK1 | JakA | TK | 6n7d | A | A | n-[5-(6-methoxy-1h-indazol-5-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11032 | |
| JAK1 | JakA | TK | 6n78 | A | B | n-{3-[5-chloro-2-(difluoromethoxy)phenyl]-1-methyl-1h-pyrazol-4-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11022 | |
| BTK | Tec | TK | 6w06 | A | B | 4-~{tert}-butyl-~{n}-[[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide | Human | 13098 | |
| DDR1 | DDR | TK | 5sav | A | B | n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide | Human | 14261 | |
| DDR1 | DDR | TK | 4bkj | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3263 | |
| JAK1 | JakA | TK | 4e4n | A | | tert-butyl [(1r,3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)cyclopentyl]carbamate | Human | 1443 | |
| JAK1 | JakA | TK | 6rse | B | A | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12465 | |
| JAK1 | JakA | TK | 5wo4 | A | A | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8702 | |
| JAK1 | JakA | TK | 6rsd | B | A | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12466 | |
| JAK1 | JakA | TK | 5hx8 | B | B | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6439 | |
| HCK | Src | TK | 2hck | B | | 3,5,7,3',4'-pentahydroxyflavone | Human | 9482 | |
| BTK | Tec | TK | 4z3v | A | A | 4-amino-8-(5-methyl-1h-indazol-6-yl)cinnoline-3-carboxamide | Human | 2934 | |
| BTK | Tec | TK | 5p9h | A | A | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7631 | |
| BTK | Tec | TK | 6bkw | A | B | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10679 | |
| BTK | Tec | TK | 6tfp | C | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12023 | |
| JAK1 | JakA | TK | 6rsb | A | | 1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12482 | |
| JAK1 | JakA | TK | 4ehz | A | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1482 | |
| JAK1 | JakA | TK | 4ivd | A | A | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1489 | |
| JAK1 | JakA | TK | 5khx | A | B | ~{n}-[3-[methyl(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | Human | 7166 | |
| JAK1 | JakA | TK | 4i5c | B | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1458 | |
| PTK2 (FAK) | FAK | TK | 9sdi | A | | 6-(1~{h}-pyrazol-4-yl)pyridine-3-carboxylic acid | Human | 15988 | |
| JAK1 | JakA | TK | 6sm8 | A | B | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12250 | |
| JAK1 | JakA | TK | 4ivd | A | B | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1474 | |
| JAK2 | JakA | TK | 4aqc | B | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3676 | |
| ABL1 | Abl | TK | 7cc2 | A | | [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl]-2-methyl-phenyl]boronic acid | Human | 13620 | |
| ABL1 | Abl | TK | 7dt2 | A | | [4-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl]-2-methanoyl-5-methoxy-phenyl]boronic acid | Human | 13621 | |
| ERBB2 (ErbB2) | EGFR | TK | 9qbf | A | | - | Human | 16004 | |
| ERBB2 (ErbB2) | EGFR | TK | 9qbh | A | | - | Human | 16005 | |
| BTK | Tec | TK | 5vfi | A | B | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-one | Human | 9601 | |
| INSR | InsR | TK | 8x2m | A | | - | Human | 16058 | |
| BTK | Tec | TK | 7kxq | A | B | 3-tert-butyl-n-[(5r)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13565 | |
| MET | Met | TK | 11hq | A | | (1r,6m)-1-benzyl-6-[(3p)-3-(1-ethyl-1h-pyrazol-4-yl)-5-fluorophenyl]-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one | Human | 16130 | |
| MET | Met | TK | 8vi1 | A | | n-(3,5-difluoro-4-{[6-(2-hydroxyethoxy)-7-methoxyquinolin-4-yl]oxy}phenyl)-4-methoxypyridine-3-carboxamide | Human | 16131 | |
| BTK | Tec | TK | 7n5r | A | A | 5-phenyl-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13895 | |
| SYK | Syk | TK | 4yjs | A | | 3-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1h-indazol-4-yl)amino]propan-1-ol | Human | 6117 | |
| MET | Met | TK | 9ivb | A | | bozitinib | Human | 16132 | |
| MET | Met | TK | 9t08 | A | | sitravatinib | Human | 16133 | |
| NTRK1 (TRKA) | Trk | TK | 9dai | A | | staurosporine | Human | 16134 | |
| BTK | Tec | TK | 9vdh | A | B | - | Human | 16162 | |
| BTK | Tec | TK | 9y5b | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-[4-(piperidin-4-yl)anilino]-1h-pyrazole-5-carboxamide | Human | 16163 | |
| BTK | Tec | TK | 9zqv | A | B | - | Human | 16164 | |
| BTK | Tec | TK | 7n5y | A | A | 5-(1-{[(3s)-1-propanoylpyrrolidin-3-yl]oxy}isoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13894 | |
| BTK | Tec | TK | 9zqv | A | A | - | Human | 16165 | |
| BTK | Tec | TK | 9yt9 | A | B | - | Human | 16166 | |
| BTK | Tec | TK | 9vdh | A | A | - | Human | 16167 | |
| BTK | Tec | TK | 9yt9 | A | A | - | Human | 16168 | |
| FGFR1 | FGFR | TK | 2fgi | B | | 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea | Human | 3541 | |
| FGFR1 | FGFR | TK | 3gql | B | | (e)-[4-(3,5-difluorophenyl)-3h-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | Human | 3506 | |
| EGFR | EGFR | TK | 7vra | A | B | 25-chloro-11-(ethylsulfonyl)-44-morpholino-11h-5,12-dioxa-3-aza-1(3,6)-indola-2(4,2)-pyrimidina-4(1,3)-benzenacyclododecaphane | Human | 14237 | |
| EGFR | EGFR | TK | 2j5f | A | | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 862 | |
| BTK | Tec | TK | 9y57 | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-({6-[(1s)-1-hydroxyethyl]-5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-1h-pyrazole-5-carboxamide | Human | 16161 | |
| FGFR1 | FGFR | TK | 5ur1 | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 7969 | |
| FGFR1 | FGFR | TK | 1fgk | B | B | - | Human | 3557 | |
| FGFR1 | FGFR | TK | 5am7 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3488 | |
| EGFR | EGFR | TK | 5ug9 | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7512 | |
| EGFR | EGFR | TK | 5yu9 | C | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9432 | |
| EGFR | EGFR | TK | 6tg0 | B | B | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12835 | |
| ABL1 | Abl | TK | 5mo4 | A | B | nilotinib | Human | 7526 | |
| JAK2 | JakA | TK | 3tjd | B | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3626 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | B | | - | Human | 9322 | |
| BTK | Tec | TK | 7n5y | A | B | 5-(1-{[(3s)-1-propanoylpyrrolidin-3-yl]oxy}isoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13892 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | A | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13327 | |
| ALK | ALK | TK | 7r7r | A | | (2r)-2-[5-(6-amino-5-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | Human | 14266 | |
| BTK | Tec | TK | 7r60 | A | A | 2-(4-phenoxyphenoxy)-5-[(3r)-1-(prop-2-enoyl)piperidin-3-yl]pyridine-3-carboxamide | Human | 13937 | |
| ITK | Tec | TK | 4mf0 | A | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 77 | |
| FGFR2 | FGFR | TK | 4j97 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 493 | |
| FGFR2 | FGFR | TK | 5ui0 | A | B | - | Human | 7447 | |
| DDR1 | DDR | TK | 5bvn | A | | n-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide | Human | 3261 | |
| JAK2 | JakA | TK | 4e4m | A | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3713 | |
| IGF1R | InsR | TK | 3lw0 | D | A | - | Human | 1033 | |
| IGF1R | InsR | TK | 5fxr | A | B | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-n-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine | Human | 7094 | |
| IGF1R | InsR | TK | 3lw0 | D | B | - | Human | 1027 | |
| IGF1R | InsR | TK | 5hzn | G | | 7-[cis-3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-(benzyloxy)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6499 | |
| JAK2-b | JakB | TK | 6occ | A | | 2-[4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenyl]-1,3-oxazole-4-carboxylic acid | Human | 12100 | |
| DDR1 | DDR | TK | 4bkj | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3259 | |
| DDR1 | DDR | TK | 5saz | A | B | 2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-n-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide | Human | 14260 | |
| EGFR | EGFR | TK | 7ltx | A | | phosphoaminophosphonic acid-adenylate ester | Human | 14122 | |
| NTRK2 (TRKB) | Trk | TK | 4at3 | A | | (5z)-5-(carbamoylimino)-3-[(5r)-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-ylsulfanyl]-2,5-dihydroisothiazole-4-carboxamide | Human | 3600 | |
| DDR1 | DDR | TK | 6fil | A | A | 2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide | Human | 10746 | |
| BTK | Tec | TK | 7kxl | A | B | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13561 | |
| BTK | Tec | TK | 7n4r | A | C | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14225 | |
| BTK | Tec | TK | 4nwm | A | A | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2930 | |
| FGFR4 | FGFR | TK | 6yi8 | A | A | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2h-1,8-naphthyridine-1-carboxamide | Human | 12812 | |
| FGFR4 | FGFR | TK | 9k0j | A | | ~{n}-[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]-2-fluoranyl-6-(propanoylamino)benzamide | Human | 15404 | |
| FGFR4 | FGFR | TK | 7ybo | A | | ~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 14499 | |
| FGFR4 | FGFR | TK | 5jkg | A | | 2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | Human | 7089 | |
| FGFR4 | FGFR | TK | 6nvk | A | B | n-[(3s,4s)-3-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}oxan-4-yl]propanamide | Human | 11390 | |
| BTK | Tec | TK | 7kxp | A | B | 3-tert-butyl-n-[(1s)-6-{2-[3-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13566 | |
| BTK | Tec | TK | 6x3o | B | B | 4-{8-amino-3-[(6r,8as)-3-oxo-3,5,6,7,8,8a-hexahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-methoxy-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12511 | |
| FGFR4 | FGFR | TK | 4qqc | A | A | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 934 | |
| BTK | Tec | TK | 6ep9 | A | | n-[2-methyl-3-[4-methyl-6-[4-(4-methylpiperazine-1-carbonyl)anilino]-5-oxo-pyrazin-2-yl]phenyl]-4-(1-piperidyl)benzamide | Human | 10467 | |
| FGFR4 | FGFR | TK | 6iup | A | B | n-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | Human | 11796 | |
| DDR1 | DDR | TK | 3zos | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3258 | |
| FGFR4 | FGFR | TK | 6nvg | A | | n-[3,5-dichloro-2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)phenyl]propanamide | Human | 11394 | |
| FGFR2 | FGFR | TK | 6v6q | D | | phosphomethylphosphonic acid adenylate ester | Human | 12967 | |
| FGFR2 | FGFR | TK | 4j99 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 474 | |
| FGFR2 | FGFR | TK | 8w2x | A | | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]propan-1-one | Human | 15406 | |
| FGFR2 | FGFR | TK | 5ui0 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 7440 | |
| FGFR2 | FGFR | TK | 2pz5 | A | | phosphomethylphosphonic acid adenylate ester | Human | 511 | |
| BTK | Tec | TK | 5p9i | A | C | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7638 | |
| FGFR2 | FGFR | TK | 4j97 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 496 | |
| FGFR2 | FGFR | TK | 2pz5 | B | | phosphomethylphosphonic acid adenylate ester | Human | 513 | |
| FGFR2 | FGFR | TK | 4j99 | A | C | phosphomethylphosphonic acid adenylate ester | Human | 469 | |
| FGFR2 | FGFR | TK | 4j99 | C | B | phosphomethylphosphonic acid adenylate ester | Human | 506 | |
| FGFR2 | FGFR | TK | 5eg3 | A | | phosphomethylphosphonic acid adenylate ester | Human | 6368 | |
| FGFR2 | FGFR | TK | 2pvf | A | | phosphomethylphosphonic acid adenylate ester | Human | 525 | |
| FGFR2 | FGFR | TK | 5uhn | A | B | phosphomethylphosphonic acid adenylate ester | Human | 7441 | |
| FGFR2 | FGFR | TK | 9u3n | A | | ~{n}-[4-[4-azanyl-7-methyl-5-[2-(3-methylimidazo[4,5-b]pyridin-6-yl)ethynyl]pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]prop-2-enamide | Human | 15407 | |
| FGFR2 | FGFR | TK | 4j99 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 518 | |
| FGFR2 | FGFR | TK | 6lvk | A | | n-ethyl-2-[[4-[[4-(4-methylpiperazin-1-yl)-3-(2-morpholin-4-ylethoxy)phenyl]amino]-1,3,5-triazin-2-yl]amino]benzenesulfonamide | Human | 12131 | |
| FGFR2 | FGFR | TK | 2pzp | B | | phosphomethylphosphonic acid adenylate ester | Human | 524 | |
| FGFR2 | FGFR | TK | 4j98 | A | B | - | Human | 475 | |
| FGFR2 | FGFR | TK | 4j98 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 516 | |
| FGFR2 | FGFR | TK | 2pvy | D | | phosphomethylphosphonic acid adenylate ester | Human | 482 | |
| FGFR2 | FGFR | TK | 5uhn | B | B | phosphomethylphosphonic acid adenylate ester | Human | 7444 | |
| FGFR2 | FGFR | TK | 4j96 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 486 | |
| FGFR2 | FGFR | TK | 8w3b | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15408 | |
| FGFR2 | FGFR | TK | 7ozy | A | A | 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1h-indazol-6-yl]phenol | Human | 13999 | |
| FGFR2 | FGFR | TK | 5ugl | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 7452 | |
| DDR1 | DDR | TK | 3zos | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3260 | |
| BTK | Tec | TK | 7ltz | A | B | 1-~{tert}-butyl-~{n}-[(5~{r})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide | Human | 14066 | |
| FGFR2 | FGFR | TK | 6agx | D | B | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11539 | |
| FGFR2 | FGFR | TK | 2pzr | A | | phosphomethylphosphonic acid adenylate ester | Human | 526 | |
| FGFR2 | FGFR | TK | 8w3d | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15409 | |
| FGFR2 | FGFR | TK | 4j99 | D | A | phosphomethylphosphonic acid adenylate ester | Human | 533 | |
| FGFR2 | FGFR | TK | 1gjo | A | | - | Human | 478 | |
| FGFR2 | FGFR | TK | 5ugx | B | A | phosphomethylphosphonic acid adenylate ester | Human | 7454 | |
| FGFR2 | FGFR | TK | 4j99 | C | C | phosphomethylphosphonic acid adenylate ester | Human | 471 | |
| FGFR2 | FGFR | TK | 7kia | A | A | 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one | Human | 13283 | |
| FGFR2 | FGFR | TK | 2pzp | A | | phosphomethylphosphonic acid adenylate ester | Human | 497 | |
| FGFR2 | FGFR | TK | 7kie | B | B | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13284 | |
| FGFR2 | FGFR | TK | 2q0b | A | | phosphomethylphosphonic acid adenylate ester | Human | 512 | |
| FGFR2 | FGFR | TK | 5uhn | A | A | phosphomethylphosphonic acid adenylate ester | Human | 7455 | |
| FGFR2 | FGFR | TK | 4j97 | D | A | phosphomethylphosphonic acid adenylate ester | Human | 507 | |
| FGFR2 | FGFR | TK | 8w3d | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15410 | |
| FGFR2 | FGFR | TK | 4j97 | A | C | phosphomethylphosphonic acid adenylate ester | Human | 521 | |
| FGFR2 | FGFR | TK | 3b2t | A | | 5'-o-[(s)-hydroxy{[(s)-hydroxy(methyl)phosphoryl]oxy}phosphoryl]adenosine | Human | 520 | |
| FGFR2 | FGFR | TK | 8w38 | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15411 | |
| TNK2 (ACK) | Ack | TK | 1u4d | B | | debromohymenialdisine | Human | 3392 | |
| DDR1 | DDR | TK | 6few | A | B | 2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide | Human | 10740 | |
| FGFR2 | FGFR | TK | 9vlm | A | | ~{n}-[3-[2-[[3-[2-(dimethylamino)ethylsulfamoylmethyl]phenyl]amino]pyrimidin-4-yl]-1-methyl-indol-6-yl]propanamide | Human | 15413 | |
| FGFR2 | FGFR | TK | 7kie | A | B | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13286 | |
| FGFR2 | FGFR | TK | 2pvy | B | | phosphomethylphosphonic acid adenylate ester | Human | 504 | |
| FGFR2 | FGFR | TK | 7kie | A | A | n-{4-[(e)-2-{4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl}ethenyl]phenyl}prop-2-enamide | Human | 13287 | |
| FGFR2 | FGFR | TK | 7kia | B | B | 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one | Human | 13288 | |
| FGFR2 | FGFR | TK | 6agx | A | A | ethyl [4-({3-[2-(3,5-dimethoxyphenyl)ethyl]-5h-pyrrolo[2,3-b]pyrazin-5-yl}sulfonyl)-1h-imidazol-1-yl]acetate | Human | 11541 | |
| FGFR2 | FGFR | TK | 4j96 | A | A | - | Human | 473 | |
| TNK2 (ACK) | Ack | TK | 7kp6 | A | B | 5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | Human | 14103 | |
| EPHA3 (EphA3) | Eph | TK | 4gk4 | A | A | 8-butyl-1-methyl-7-(5-methyl-1h-indazol-4-yl)-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2854 | |
| EPHA3 (EphA3) | Eph | TK | 2qof | A | C | - | Human | 2870 | |
| EPHA3 (EphA3) | Eph | TK | 2qol | A | B | - | Human | 2836 | |
| EPHA3 (EphA3) | Eph | TK | 4gk2 | A | B | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2858 | |
| EPHA3 (EphA3) | Eph | TK | 2qo7 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 2874 | |
| TNK2 (ACK) | Ack | TK | 5zxb | B | A | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10493 | |
| TNK2 (ACK) | Ack | TK | 1u54 | A | | phosphomethylphosphonic acid adenylate ester | Human | 3409 | |
| TNK2 (ACK) | Ack | TK | 4hzs | B | | - | Human | 3400 | |
| TNK2 (ACK) | Ack | TK | 4ewh | A | | 6-{4-[2-(dimethylamino)ethoxy]phenyl}-n-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 3410 | |
| EPHA3 (EphA3) | Eph | TK | 2qoq | A | C | phosphoaminophosphonic acid-adenylate ester | Human | 2879 | |
| EPHA3 (EphA3) | Eph | TK | 4p5z | A | | 2-amino-1-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenyl]-1h-pyrrolo[2,3-b]quinoxaline-3-carboxamide | Human | 2887 | |
| EPHA3 (EphA3) | Eph | TK | 4p4c | A | | 2-amino-1-(3-methoxyphenyl)-1h-pyrrolo[2,3-b]quinoxaline-3-carboxamide | Human | 2875 | |
| EPHA3 (EphA3) | Eph | TK | 2qo9 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 2862 | |
| EPHA3 (EphA3) | Eph | TK | 2qob | A | A | - | Human | 2889 | |
| EPHA3 (EphA3) | Eph | TK | 2qo7 | A | C | phosphoaminophosphonic acid-adenylate ester | Human | 2839 | |
| EPHA3 (EphA3) | Eph | TK | 4two | A | B | 5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid | Human | 2848 | |
| SRC | Src | TK | 4mxo | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 978 | |
| CSF1R (FMS) | PDGFR | TK | 3krl | A | B | 5-cyano-n-[4-(4-methylpiperazin-1-yl)-2-piperidin-1-ylphenyl]furan-2-carboxamide | Human | 2311 | |
| CSF1R (FMS) | PDGFR | TK | 3lcd | A | B | n~3~-(2,6-dichlorobenzyl)-5-(4-{[(2r)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}phenyl)pyrazine-2,3-diamine | Human | 1242 | |
| CSF1R (FMS) | PDGFR | TK | 4r7h | A | | 5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine | Human | 2308 | |
| CSF1R (FMS) | PDGFR | TK | 4r7i | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2307 | |
| CSF1R (FMS) | PDGFR | TK | 3lco | A | B | 3-({4-methoxy-5-[(4-methoxybenzyl)oxy]pyridin-2-yl}methoxy)-5-(1-methyl-1h-pyrazol-4-yl)pyrazin-2-amine | Human | 2313 | |
| JAK1 | JakA | TK | 4e5w | B | B | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1477 | |
| JAK1 | JakA | TK | 6n77 | B | C | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11034 | |
| EPHA3 (EphA3) | Eph | TK | 2qod | A | A | - | Human | 2869 | |
| EPHA3 (EphA3) | Eph | TK | 3dzq | A | A | n-[2-methyl-5-({[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide | Human | 2852 | |
| EPHA3 (EphA3) | Eph | TK | 6in0 | A | A | 1,4,7,10,13,16-hexaoxacyclooctadecane | Human | 11792 | |
| EPHA3 (EphA3) | Eph | TK | 2qob | A | C | - | Human | 2850 | |
| EPHA3 (EphA3) | Eph | TK | 6in0 | A | B | 1,4,7,10,13,16-hexaoxacyclooctadecane | Human | 11793 | |
| EPHA3 (EphA3) | Eph | TK | 2qoc | A | B | - | Human | 2856 | |
| EPHA3 (EphA3) | Eph | TK | 2qon | A | A | - | Human | 2867 | |
| CSF1R (FMS) | PDGFR | TK | 3dpk | A | B | 8-cyclohexyl-n-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | Human | 2305 | |
| JAK1 | JakA | TK | 6sm8 | B | A | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12245 | |
| JAK1 | JakA | TK | 6hzu | B | B | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11763 | |
| EPHA3 (EphA3) | Eph | TK | 2qo7 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 2857 | |
| EPHA3 (EphA3) | Eph | TK | 3fxx | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 2860 | |
| EPHA3 (EphA3) | Eph | TK | 4gk3 | A | B | 8-butyl-1-methyl-7-(2-methylphenyl)-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2885 | |
| EPHA3 (EphA3) | Eph | TK | 2qoo | A | B | - | Human | 2881 | |
| EPHA3 (EphA3) | Eph | TK | 2qon | A | B | - | Human | 2853 | |
| EPHA3 (EphA3) | Eph | TK | 4g2f | A | B | 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5h)-one | Human | 2838 | |
| EPHA2 (EphA2) | Eph | TK | 5ek7 | B | | - | Human | 6321 | |
| KDR | VEGFR | TK | 5ew3 | A | | 2-(pyridin-4-ylmethylamino)-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 6289 | |
| FGFR1 | FGFR | TK | 5flf | D | A | - | Human | 6468 | |
| TYK2-b | JakB | TK | 6nzr | A | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11503 | |
| TYK2-b | JakB | TK | 6nsl | B | A | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11955 | |
| JAK1 | JakA | TK | 4e5w | A | A | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1452 | |
| JAK1 | JakA | TK | 4e4l | D | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1455 | |
| EPHA2 (EphA2) | Eph | TK | 5nk6 | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(4-oxidanylcyclohexyl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8094 | |
| EPHA2 (EphA2) | Eph | TK | 5nka | A | B | 4-[[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylamino]cyclohexane-1-carboxylic acid | Human | 8086 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | A | A | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10422 | |
| EPHA2 (EphA2) | Eph | TK | 7kja | B | B | phosphomethylphosphonic acid adenylate ester | Human | 13251 | |
| EPHA2 (EphA2) | Eph | TK | 5nka | A | C | - | Human | 8083 | |
| EPHA2 (EphA2) | Eph | TK | 6hes | A | C | - | Human | 11554 | |
| EPHA2 (EphA2) | Eph | TK | 5nkf | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)-5-(trifluoromethyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8087 | |
| EPHA2 (EphA2) | Eph | TK | 6q7c | A | B | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpiperidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11930 | |
| EPHA2 (EphA2) | Eph | TK | 5nkg | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-ethyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8079 | |
| TNK2 (ACK) | Ack | TK | 3eqp | A | | n-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide | Human | 3403 | |
| TNK2 (ACK) | Ack | TK | 4hzs | C | | - | Human | 3393 | |
| KDR | VEGFR | TK | 1y6b | A | | n-(cyclopropylmethyl)-4-(methyloxy)-3-({5-[3-(3-pyridinyl)phenyl]-1,3-oxazol-2-yl}amino)benzenesulfonamide | Human | 5345 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | C | B | alisertib | Human | 7175 | |
| EPHA2 (EphA2) | Eph | TK | 6fnf | A | A | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10417 | |
| EPHA2 (EphA2) | Eph | TK | 6q7d | A | A | 3-[[4-imidazol-1-yl-6-(4-oxidanylpiperidin-1-yl)-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11937 | |
| EPHA2 (EphA2) | Eph | TK | 5i9z | A | A | n-[(3e)-5-[(2r)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5h)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide | Human | 7180 | |
| EPHA2 (EphA2) | Eph | TK | 1mqb | A | | phosphoaminophosphonic acid-adenylate ester | Human | 2088 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7189 | |
| EPHA2 (EphA2) | Eph | TK | 8bok | A | A | ~{n}-(3,5-dimethoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14648 | |
| EPHA2 (EphA2) | Eph | TK | 6heu | A | B | 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11552 | |
| EGFR | EGFR | TK | 8d73 | A | B | (3s,4r)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol | Human | 14310 | |
| EPHA2 (EphA2) | Eph | TK | 5i9x | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 7182 | |
| EPHA2 (EphA2) | Eph | TK | 6q7e | A | A | 3-[[4-imidazol-1-yl-6-[(3~{r})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11926 | |
| EPHB3 (EphB3) | Eph | TK | 3zfy | A | B | - | Human | 538 | |
| TNK2 (ACK) | Ack | TK | 4hzs | D | | - | Human | 3404 | |
| TNK2 (ACK) | Ack | TK | 4hzr | B | B | - | Human | 3391 | |
| EPHA2 (EphA2) | Eph | TK | 5nke | A | B | 2-[[3-bromanyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8063 | |
| EPHA2 (EphA2) | Eph | TK | 6hey | A | B | 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11558 | |
| EPHA2 (EphA2) | Eph | TK | 8bio | A | B | 8-(4-azanylbutyl)-6-[2-chloranyl-5-(trifluoromethyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14513 | |
| EPHA2 (EphA2) | Eph | TK | 6fng | A | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10416 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | B | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14649 | |
| EPHA2 (EphA2) | Eph | TK | 6fnf | A | B | 4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10420 | |
| EGFR | EGFR | TK | 8d76 | A | A | (3s,4r)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol | Human | 14311 | |
| EGFR | EGFR | TK | 8d73 | A | A | (3s,4r)-3-fluoro-1-(4-{[4-(methylamino)-1-(propan-2-yl)pyrido[3,4-d]pyridazin-7-yl]amino}pyrimidin-2-yl)piperidin-4-ol | Human | 14312 | |
| EGFR | EGFR | TK | 8d76 | A | B | (3s,4r)-3-fluoro-1-(4-{[8-{3-[(methanesulfonyl)methyl]azetidin-1-yl}-5-(propan-2-yl)-2,7-naphthyridin-3-yl]amino}pyrimidin-2-yl)-3-methylpiperidin-4-ol | Human | 14313 | |
| ERBB2 (ErbB2) | EGFR | TK | 7pcd | A | A | 1-[4-[4-[[3,5-bis(chloranyl)-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]-4-(3-fluoranylazetidin-1-yl)butan-1-one | Human | 14320 | |
| EPHA2 (EphA2) | Eph | TK | 5nke | A | A | 2-[[3-bromanyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8078 | |
| EPHA2 (EphA2) | Eph | TK | 6hev | A | B | 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11565 | |
| EPHA2 (EphA2) | Eph | TK | 5nk5 | A | C | - | Human | 8091 | |
| EPHA2 (EphA2) | Eph | TK | 6q7b | A | A | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpyrrolidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11927 | |
| EPHA2 (EphA2) | Eph | TK | 5nk4 | A | A | 2-[[3-[[(4~{r})-3,3-bis(fluoranyl)piperidin-4-yl]carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8070 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | B | B | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10413 | |
| EPHA2 (EphA2) | Eph | TK | 8boc | A | B | ~{n}-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 15002 | |
| EPHA2 (EphA2) | Eph | TK | 5nk7 | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{r},4~{r})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8081 | |
| SYK | Syk | TK | 4f4p | A | A | n-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine | Human | 1178 | |
| EPHA2 (EphA2) | Eph | TK | 5i9w | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 7178 | |
| EPHA2 (EphA2) | Eph | TK | 5nk0 | A | B | 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8096 | |
| EPHA2 (EphA2) | Eph | TK | 5nkd | A | B | 2-[(3~{r})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidin-3-yl]ethanoic acid | Human | 8082 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | C | B | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10419 | |
| EPHA2 (EphA2) | Eph | TK | 5nkh | A | B | 2-[[3-(2-aminophenyl)-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8077 | |
| EPHA2 (EphA2) | Eph | TK | 7kja | A | B | phosphomethylphosphonic acid adenylate ester | Human | 13255 | |
| EPHA2 (EphA2) | Eph | TK | 6hew | A | A | 4-methyl-3-[(1-methyl-6-pyrimidin-5-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11549 | |
| MET | Met | TK | 8an8 | A | | 3-[bis(fluoranyl)methyl]-~{n}-methyl-~{n}-[(1~{r})-8-methyl-5-(3-methyl-1~{h}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide | Human | 14355 | |
| MET | Met | TK | 8ans | A | | 3-[bis(fluoranyl)methyl]-~{n}-methyl-~{n}-[(1~{r})-8-methyl-5-(3-methyl-1~{h}-indazol-6-yl)-1,2,3,4-tetrahydronaphthalen-1-yl]pyridine-2-carboxamide | Human | 14356 | |
| JAK1 | JakA | TK | 6ggh | B | A | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11089 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | B | A | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10421 | |
| EPHA2 (EphA2) | Eph | TK | 5nkh | A | A | 2-[[3-(2-aminophenyl)-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8074 | |
| EPHA2 (EphA2) | Eph | TK | 5nk1 | A | A | 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8064 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | A | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11933 | |
| EPHA2 (EphA2) | Eph | TK | 5ia4 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7168 | |
| BTK | Tec | TK | 6vxq | A | A | n-{[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide | Human | 13100 | |
| JAK1 | JakA | TK | 6hzu | A | A | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11764 | |
| JAK1 | JakA | TK | 4e4l | B | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1466 | |
| JAK1 | JakA | TK | 6n7b | A | | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-1h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11020 | |
| MERTK (MER) | Axl | TK | 5td2 | A | A | n-[2-{4-[(2s)-4-(methylsulfonyl)morpholin-2-yl]-1,3-thiazol-2-yl}-4-(morpholin-4-yl)phenyl]-1h-imidazole-2-carboxamide | Human | 7384 | |
| MERTK (MER) | Axl | TK | 4mha | B | A | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-n-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide | Human | 268 | |
| MERTK (MER) | Axl | TK | 7avx | A | | 1-(4-fluorophenyl)-n-[3-fluoro-4-[(3-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide | Human | 13372 | |
| MERTK (MER) | Axl | TK | 2p0c | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 271 | |
| MERTK (MER) | Axl | TK | 4m3q | A | | trans-4-{[2-(butylamino)-5-(pyridin-2-yl)pyrimidin-4-yl]amino}cyclohexanol | Human | 283 | |
| MERTK (MER) | Axl | TK | 7aw4 | A | A | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | 13374 | |
| EPHA2 (EphA2) | Eph | TK | 8bk0 | A | B | ~{n}-(2-chlorophenyl)-6-piperidin-4-yl-imidazo[1,2-a]pyridine-3-carboxamide | Human | 14503 | |
| EPHA2 (EphA2) | Eph | TK | 8bk0 | A | A | ~{n}-(2-chlorophenyl)-6-piperidin-4-yl-imidazo[1,2-a]pyridine-3-carboxamide | Human | 14504 | |
| JAK3 | JakA | TK | 5vo6 | A | | 4-{[(1r,3s)-3-amino-2,2,3-trimethylcyclopentyl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 7960 | |
| JAK3 | JakA | TK | 7apg | D | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13138 | |
| JAK3 | JakA | TK | 3zep | C | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 462 | |
| EPHB4 (EphB4) | Eph | TK | 6fnj | A | B | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10334 | |
| EPHB4 (EphB4) | Eph | TK | 6fnl | A | A | - | Human | 10343 | |
| EPHB4 (EphB4) | Eph | TK | 2vx0 | A | A | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | Human | 375 | |
| EPHB4 (EphB4) | Eph | TK | 4bb4 | A | A | n-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide | Human | 364 | |
| EPHB4 (EphB4) | Eph | TK | 2yn8 | A | | staurosporine | Human | 352 | |
| EGFR | EGFR | TK | 8g63 | A | | ralimetinib | Human | 14937 | |
| EGFR | EGFR | TK | 8eme | A | | - | Human | 14938 | |
| EGFR | EGFR | TK | 8f1z | A | | (2p)-3-(3-chloro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one | Human | 14939 | |
| EGFR | EGFR | TK | 8f1y | A | | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | 14940 | |
| EGFR | EGFR | TK | 8hy7 | A | | ~{n}-[3-[[6-fluoranyl-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]quinazolin-4-yl]amino]phenyl]prop-2-enamide | Human | 14941 | |
| EGFR | EGFR | TK | 8f1x | A | A | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14942 | |
| EGFR | EGFR | TK | 8f1x | A | B | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14943 | |
| JAK3 | JakA | TK | 6aak | B | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10367 | |
| JAK3 | JakA | TK | 3zep | C | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 439 | |
| JAK3 | JakA | TK | 6hzv | B | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11754 | |
| FGR | Src | TK | 7uy0 | B | A | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14566 | |
| EGFR | EGFR | TK | 8f1w | A | | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | 14944 | |
| EGFR | EGFR | TK | 8h7x | A | | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | 14945 | |
| EGFR | EGFR | TK | 8dsw | A | | phosphoaminophosphonic acid-adenylate ester | Human | 14946 | |
| EGFR | EGFR | TK | 8f1h | A | | n-[(5p,8s,10r)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | Human | 14947 | |
| JAK2-b | JakB | TK | 6bss | A | | o6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine | Human | 10386 | |
| TYK2-b | JakB | TK | 8tb5 | A | B | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14955 | |
| JAK3 | JakA | TK | 6aak | C | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10368 | |
| TYK2-b | JakB | TK | 8tb6 | A | A | n-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]urea | Human | 14956 | |
| TYK2-b | JakB | TK | 8tb6 | A | B | n-[(3m)-3-{6-[(3r)-3-methoxyoxolan-3-yl]pyridin-2-yl}-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]urea | Human | 14957 | |
| SYK | Syk | TK | 4puz | B | | 6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine | Human | 1153 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bbt | B | | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine | Human | 2825 | |
| DDR1 | DDR | TK | 3zos | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3253 | |
| DDR1 | DDR | TK | 5fdp | A | | (4~{s})-4-methyl-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinoline-7-carboxamide | Human | 6676 | |
| DDR1 | DDR | TK | 4bkj | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3255 | |
| JAK1 | JakA | TK | 4ivb | B | A | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1472 | |
| JAK1 | JakA | TK | 6smb | A | B | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12247 | |
| ABL1 | Abl | TK | 6xr6 | A | 11 | - | Human | 12872 | |
| ABL1 | Abl | TK | 6xr6 | A | 14 | - | Human | 12873 | |
| INSR | InsR | TK | 8dwn | A | | - | Human | 14975 | |
| MET | Met | TK | 8aw1 | A | B | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 14980 | |
| JAK2 | JakA | TK | 4iva | A | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3725 | |
| HCK | Src | TK | 5zj6 | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9987 | |
| LMTK3 (LMR3) | Lmr | TK | 6seq | A | A | - | Human | 12994 | |
| NTRK1 (TRKA) | Trk | TK | 8j63 | A | | 4^6-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-11-oxo-5-oxa-10,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Human | 14984 | |
| RET | Ret | TK | 2x2l | A | C | (3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3367 | |
| MET | Met | TK | 8aw1 | A | A | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 14981 | |
| MET | Met | TK | 8au3 | A | | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 14982 | |
| MET | Met | TK | 8au5 | A | | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 14983 | |
| RET | Ret | TK | 5fm2 | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 7328 | |
| NTRK1 (TRKA) | Trk | TK | 8j5w | A | | n-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Human | 14985 | |
| FGFR3 | FGFR | TK | 6pnx | A | A | phosphomethylphosphonic acid adenylate ester | Human | 11948 | |
| EGFR | EGFR | TK | 5zwj | A | | (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-n-(1,3-thiazol-2-yl)acetamide | Human | 10372 | |
| NTRK1 (TRKA) | Trk | TK | 8j5x | A | | n-(3-cyclopropyl-5-((4-methylpiperazin-1-yl)methyl)phenyl)-4^6-methyl-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Human | 14987 | |
| SYK | Syk | TK | 5t68 | A | | n~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine | Human | 7119 | |
| EGFR | EGFR | TK | 3bel | A | | 4-amino-6-{[1-(3-fluorobenzyl)-1h-indazol-5-yl]amino}pyrimidine-5-carbaldehyde o-(2-methoxyethyl)oxime | Human | 6758 | |
| EGFR | EGFR | TK | 6s9c | A | A | ~{n}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-2-phenyl-pyridine-4-carboxamide | Human | 11806 | |
| EGFR | EGFR | TK | 6tfy | A | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12825 | |
| EGFR | EGFR | TK | 2rfd | A | | - | Human | 875 | |
| EGFR | EGFR | TK | 5cap | A | B | 2-methyl-n-[2-(2-methyl-2-methylsulfonyl-propoxy)pyrimidin-4-yl]-1-propan-2-yl-imidazo[4,5-c]pyridin-6-amine | Human | 6198 | |
| EGFR | EGFR | TK | 6v6k | A | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12168 | |
| EGFR | EGFR | TK | 5x28 | A | | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9538 | |
| FGFR3 | FGFR | TK | 6lvm | A | | 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-n-ethyl-benzenesulfonamide | Human | 12134 | |
| FGFR3 | FGFR | TK | 6pnx | A | B | phosphomethylphosphonic acid adenylate ester | Human | 11946 | |
| EGFR | EGFR | TK | 7zym | A | | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | 14726 | |
| EGFR | EGFR | TK | 3gop | A | A | - | Human | 853 | |
| FGFR2 | FGFR | TK | 8h75 | A | | 4-[9-(2-chlorophenyl)-6-methyl-2,4,5,8,12-pentazatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3,6,8,11,13-hexaen-13-yl]morpholine | Human | 14860 | |
| EGFR | EGFR | TK | 6v5n | C | A | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12197 | |
| EGFR | EGFR | TK | 6v5p | A | B | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12172 | |
| DDR1 | DDR | TK | 5saw | A | B | 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide | Human | 14251 | |
| EPHA3 (EphA3) | Eph | TK | 3fy2 | A | B | - | Human | 2837 | |
| FGFR4 | FGFR | TK | 7f3m | A | | 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one | Human | 14034 | |
| EPHA2 (EphA2) | Eph | TK | 5i9y | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7176 | |
| FGFR3 | FGFR | TK | 7dhl | A | | 5-[2-(3,5-dimethoxyphenyl)ethyl]-n-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]pyrimidin-2-amine | Human | 13258 | |
| FGFR4 | FGFR | TK | 7wcx | A | | ~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | Human | 14166 | |
| FGFR2 | FGFR | TK | 4j96 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 485 | |
| JAK2 | JakA | TK | 8g8x | A | A | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14804 | |
| JAK2 | JakA | TK | 7teu | A | A | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14806 | |
| FGFR3 | FGFR | TK | 4k33 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 1870 | |
| SYK | Syk | TK | 5tr6 | A | B | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one | Human | 7284 | |
| EGFR | EGFR | TK | 5gty | H | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8362 | |
| MERTK (MER) | Axl | TK | 4m3q | B | | trans-4-{[2-(butylamino)-5-(pyridin-2-yl)pyrimidin-4-yl]amino}cyclohexanol | Human | 269 | |
| MERTK (MER) | Axl | TK | 5k0x | B | A | (7s)-7-amino-n-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentaazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamide | Human | 7434 | |
| KDR | VEGFR | TK | 6gqo | A | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10583 | |
| JAK2 | JakA | TK | 8g6z | A | A | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14808 | |
| JAK2 | JakA | TK | 8g8o | A | B | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14809 | |
| MERTK (MER) | Axl | TK | 5tc0 | B | | - | Human | 7381 | |
| MERTK (MER) | Axl | TK | 7ab1 | A | | 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | Human | 12933 | |
| MERTK (MER) | Axl | TK | 7aw1 | A | | n-(6-(4-(3-(4-((5,6-dihydroimidazo[1,2-a]pyrazin-7(8h)-yl)methyl)-3-(trifluoromethyl)phenyl)ureido)phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide | Human | 13366 | |
| EGFR | EGFR | TK | 5uga | A | B | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7511 | |
| EGFR | EGFR | TK | 4rj5 | A | | n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridin-6-amine | Human | 912 | |
| EGFR | EGFR | TK | 3w2r | A | A | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 822 | |
| MERTK (MER) | Axl | TK | 7aaz | A | B | 2-azanyl-~{n}-[(1~{s},2~{s})-2-[[4-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]methoxy]cyclopentyl]-5-(1-methylpyrazol-4-yl)pyridine-3-carboxamide | Human | 12964 | |
| MERTK (MER) | Axl | TK | 7ab0 | A | A | - | Human | 12937 | |
| JAK2-b | JakB | TK | 5usz | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8043 | |
| JAK2 | JakA | TK | 8g8o | A | A | [1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}-3-(4-methylpiperazin-1-yl)azetidin-3-yl]acetonitrile | Human | 14807 | |
| EGFR | EGFR | TK | 7a2a | B | A | (2r)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-2-phenyl-n-(1,3-thiazol-2-yl)acetamide | Human | 12970 | |
| EGFR | EGFR | TK | 7syd | A | B | - | Human | 14027 | |
| FGFR3 | FGFR | TK | 6pnx | B | B | phosphomethylphosphonic acid adenylate ester | Human | 11949 | |
| FGFR3 | FGFR | TK | 4k33 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 1871 | |
| EGFR | EGFR | TK | 5x2a | B | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9543 | |
| JAK2 | JakA | TK | 3jy9 | A | B | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3716 | |
| EGFR | EGFR | TK | 5cnn | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 839 | |
| EGFR | EGFR | TK | 5czi | A | | - | Human | 6110 | |
| FGFR3 | FGFR | TK | 6pnx | B | A | phosphomethylphosphonic acid adenylate ester | Human | 11947 | |
| DDR1 | DDR | TK | 5fdx | B | | 3-[(4-methylpiperazin-1-yl)methyl]-~{n}-[(4~{r})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide | Human | 7130 | |
| EGFR | EGFR | TK | 6jrx | A | | n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide | Human | 12157 | |
| EGFR | EGFR | TK | 4i21 | B | | - | Human | 776 | |
| EGFR | EGFR | TK | 5x2f | B | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9546 | |
| EGFR | EGFR | TK | 4zjv | A | A | - | Human | 798 | |
| EGFR | EGFR | TK | 7aem | A | | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | 13482 | |
| JAK2 | JakA | TK | 7teu | A | B | 3-{(4s)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-n-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14811 | |
| MERTK (MER) | Axl | TK | 5k0k | B | A | 15-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-4,5,6,7,9,10,11,12-octahydro-2,16-(azenometheno)pyrrolo[2,1-d][1,3,5,9]tetraazacyclotetradecin-8(3h)-one | Human | 7348 | |
| EGFR | EGFR | TK | 4i20 | A | | - | Human | 850 | |
| EGFR | EGFR | TK | 5x26 | A | | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9536 | |
| EGFR | EGFR | TK | 3ika | B | A | - | Human | 863 | |
| EGFR | EGFR | TK | 5x2a | D | A | phosphoaminophosphonic acid-adenylate ester | Human | 9529 | |
| EGFR | EGFR | TK | 4lrm | E | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 825 | |
| EGFR | EGFR | TK | 6wa2 | C | B | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13436 | |
| JAK3 | JakA | TK | 3lxk | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 436 | |
| JAK3 | JakA | TK | 6ny4 | A | | 4-{[(2r,3r)-1,3-dihydroxybutan-2-yl]amino}-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 11052 | |
| JAK3 | JakA | TK | 7apg | A | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13135 | |
| EGFR | EGFR | TK | 3ug2 | A | B | gefitinib | Human | 819 | |
| EGFR | EGFR | TK | 3w2o | A | B | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9118 | |
| EPHB3 (EphB3) | Eph | TK | 5l6p | A | | ~{n}-(4-phenylazanylquinazolin-7-yl)ethanamide | Human | 6937 | |
| EPHB3 (EphB3) | Eph | TK | 3zfy | B | B | - | Human | 536 | |
| EPHB3 (EphB3) | Eph | TK | 3zfy | A | A | - | Human | 537 | |
| EPHB3 (EphB3) | Eph | TK | 3zfy | B | A | - | Human | 539 | |
| EPHB3 (EphB3) | Eph | TK | 5l6o | A | | 1-(4-phenylazanylquinazolin-7-yl)ethanone | Human | 6938 | |
| EPHB1 (EphB1) | Eph | TK | 5mjb | A | | 2-chloranyl-~{n}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide | Human | 7584 | |
| EGFR | EGFR | TK | 5zto | A | | n-{trans-4-[3-(2-chlorophenyl)-7-{[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]cyclohexyl}propanamide | Human | 11070 | |
| EGFR | EGFR | TK | 7a6k | A | C | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14112 | |
| EGFR | EGFR | TK | 2jiu | B | | - | Human | 895 | |
| EGFR | EGFR | TK | 7jxl | A | B | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 13879 | |
| BTK | Tec | TK | 1k2p | A | | - | Human | 2918 | |
| BTK | Tec | TK | 4zly | A | C | 4-aminocinnoline-3-carboxamide | Human | 2915 | |
| DDR1 | DDR | TK | 7bcm | B | | ~{n}-[[4-[[(2~{s})-4-cyclohexyl-1-[[(3~{s})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide | Human | 13381 | |
| EGFR | EGFR | TK | 6z4d | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 12971 | |
| BTK | Tec | TK | 6aua | A | A | n-{3-[(2r)-6-{[3-amino-4-(morpholine-4-carbonyl)phenyl]amino}-5-oxo-2,5-dihydropyrazin-2-yl]-2-methylphenyl}-4-(piperidin-1-yl)benzamide | Human | 10472 | |
| BTK | Tec | TK | 3oct | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2899 | |
| BTK | Tec | TK | 5p9h | A | B | 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one | Human | 7643 | |
| DDR1 | DDR | TK | 6gwr | B | B | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10487 | |
| EGFR | EGFR | TK | 2itn | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 833 | |
| BTK | Tec | TK | 6xe4 | A | A | (1s,2s)-n-[2'-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1h)-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo[1,6-dihydro[3,4'-bipyridine]]-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 12515 | |
| BTK | Tec | TK | 3piz | A | | [5-amino-1-(2-methylphenyl)-1h-pyrazol-4-yl]{3-[1-(methylsulfonyl)piperidin-4-yl]phenyl}methanone | Human | 2922 | |
| BTK | Tec | TK | 7kxn | A | B | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13571 | |
| BTK | Tec | TK | 6e4f | A | A | 1,5-anhydro-2-{[5-(2-chloro-4-phenoxybenzene-1-carbonyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}-2,3,4-trideoxy-d-erythro-hexitol | Human | 10477 | |
| BTK | Tec | TK | 5xyz | B | A | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9931 | |
| BTK | Tec | TK | 6nfi | A | A | n-(3-{[(2,6-dimethylphenyl)methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide | Human | 10962 | |
| EPHB1 (EphB1) | Eph | TK | 7kpl | A | A | - | Human | 13384 | |
| EGFR | EGFR | TK | 6v5n | C | B | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12196 | |
| EGFR | EGFR | TK | 4zse | C | A | phosphoaminophosphonic acid-adenylate ester | Human | 6693 | |
| BTK | Tec | TK | 5zz4 | A | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10479 | |
| BTK | Tec | TK | 5bpy | A | | 6-{(3r)-3-[(4-tert-butylbenzoyl)amino]piperidin-1-yl}-2-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}pyridine-3-carboxamide | Human | 6095 | |
| BTK | Tec | TK | 4rfy | A | B | 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydroisoquinolin-1(2h)-one | Human | 2933 | |
| EGFR | EGFR | TK | 4rix | B | | adenosine-5'-diphosphate | Human | 811 | |
| EGFR | EGFR | TK | 7zyn | A | A | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 14727 | |
| NTRK3 (TRKC) | Trk | TK | 6kzc | A | | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methyl-~{n}-[3-(4-methylpiperazin-1-yl)-5-(trifluoromethyl)phenyl]benzamide | Human | 11696 | |
| NTRK3 (TRKC) | Trk | TK | 3v5q | A | | 1-(3-{[(3z)-2-oxo-3-(1h-pyrrol-2-ylmethylidene)-2,3-dihydro-1h-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea | Human | 102 | |
| NTRK3 (TRKC) | Trk | TK | 4ymj | B | A | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile | Human | 100 | |
| BMX | Tec | TK | 6i99 | B | | ~{n}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide | Human | 12349 | |
| EGFR | EGFR | TK | 4zse | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 6696 | |
| EGFR | EGFR | TK | 3lzb | B | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 810 | |
| BTK | Tec | TK | 6tfp | A | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12024 | |
| EGFR | EGFR | TK | 5d41 | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 6664 | |
| EGFR | EGFR | TK | 5y9t | A | | 6-ethyl-3-[[4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-[(3r)-1-prop-2-enoylpyrrolidin-3-yl]oxy-pyrazine-2-carboxamide | Human | 10053 | |
| EGFR | EGFR | TK | 2ito | A | | gefitinib | Human | 783 | |
| EGFR | EGFR | TK | 5gty | E | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8353 | |
| EGFR | EGFR | TK | 4wrg | A | B | - | Human | 814 | |
| EGFR | EGFR | TK | 3lzb | D | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 820 | |
| BTK | Tec | TK | 5p9m | A | A | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7634 | |
| BTK | Tec | TK | 7lty | A | C | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14068 | |
| BTK | Tec | TK | 5zz4 | F | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10469 | |
| BTK | Tec | TK | 6di1 | A | B | 4-amino-2-[(3s)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide | Human | 10627 | |
| BTK | Tec | TK | 6vxq | A | B | n-{[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl}benzamide | Human | 13101 | |
| BTK | Tec | TK | 6j6m | A | A | (7s)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11767 | |
| EGFR | EGFR | TK | 6v6k | A | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12179 | |
| EGFR | EGFR | TK | 6wxn | A | A | - | Human | 13558 | |
| EGFR | EGFR | TK | 6duk | C | B | phosphoaminophosphonic acid-adenylate ester | Human | 11068 | |
| BTK | Tec | TK | 5fbo | A | A | 4-[8-azanyl-3-[(3~{r},6~{s})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6455 | |
| EGFR | EGFR | TK | 6v6o | B | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12228 | |
| EGFR | EGFR | TK | 6v6k | B | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12229 | |
| BTK | Tec | TK | 8flh | A | C | 2-(3,5-dichloroanilino)-1-{(3r)-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | Human | 14639 | |
| ALK | ALK | TK | 3lct | A | B | adenosine-5'-diphosphate | Human | 5400 | |
| ALK | ALK | TK | 6edl | A | A | n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine | Human | 11267 | |
| ALK | ALK | TK | 2yjr | A | B | - | Human | 5380 | |
| BMX | Tec | TK | 3sxr | B | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 3481 | |
| JAK2 | JakA | TK | 4c61 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3661 | |
| ALK | ALK | TK | 3aox | A | A | 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile | Human | 5387 | |
| ALK | ALK | TK | 5a9u | A | A | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6692 | |
| BTK | Tec | TK | 6w7o | A | | [5-({[(3s)-2-(n-methyl-l-alanyl-3-methyl-l-valyl)-3-{[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3r)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazol-1-yl}piperidine-1-carboxylate | Human | 13195 | |
| BTK | Tec | TK | 3piy | A | | 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one | Human | 2909 | |
| BTK | Tec | TK | 6w7o | B | | [5-({[(3s)-2-(n-methyl-l-alanyl-3-methyl-l-valyl)-3-{[(1r)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl}-1,2,3,4-tetrahydroisoquinolin-7-yl]oxy}methyl)pyrazin-2-yl]methyl (3r)-3-{5-amino-4-carbamoyl-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazol-1-yl}piperidine-1-carboxylate | Human | 13196 | |
| BTK | Tec | TK | 3p08 | B | | - | Human | 2894 | |
| JAK3 | JakA | TK | 7q6h | A | A | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14080 | |
| EGFR | EGFR | TK | 2itz | A | | gefitinib | Human | 789 | |
| JAK3 | JakA | TK | 7apg | D | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13133 | |
| JAK3 | JakA | TK | 6hzv | B | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11753 | |
| JAK3 | JakA | TK | 6gl9 | B | A | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10019 | |
| JAK3 | JakA | TK | 6dud | A | B | n-[(1s)-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10720 | |
| EGFR | EGFR | TK | 6v6o | H | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12211 | |
| JAK3 | JakA | TK | 4v0g | B | A | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6348 | |
| JAK3 | JakA | TK | 6gla | A | A | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10018 | |
| JAK3 | JakA | TK | 3zc6 | A | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 461 | |
| JAK3 | JakA | TK | 6db4 | A | A | n-[(1s)-6-(5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10724 | |
| JAK3 | JakA | TK | 4hvi | A | | 2-cyclopropyl-n-[(2r)-1-oxo-1-(piperidin-1-yl)propan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 438 | |
| EGFR | EGFR | TK | 5gty | B | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8367 | |
| TYK2-b | JakB | TK | 6nzp | B | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11496 | |
| TYK2-b | JakB | TK | 6nzf | A | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11449 | |
| BTK | Tec | TK | 4otf | A | B | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 2921 | |
| BTK | Tec | TK | 7ltz | A | A | 1-~{tert}-butyl-~{n}-[(5~{r})-8-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-2-(oxetan-3-yl)-1,3,4,5-tetrahydro-2-benzazepin-5-yl]-1,2,3-triazole-4-carboxamide | Human | 14067 | |
| BTK | Tec | TK | 4rfy | A | A | 6-(dimethylamino)-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]-3,4-dihydroisoquinolin-1(2h)-one | Human | 2935 | |
| BTK | Tec | TK | 5bq0 | A | A | 4-(2-chlorophenyl)-7-[(4-methylpiperazin-1-yl)carbonyl]-9h-carbazole-1-carboxamide | Human | 6871 | |
| BTK | Tec | TK | 5fbn | C | B | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6382 | |
| BTK | Tec | TK | 4otq | A | | 1-{5-[3-(7-tert-butyl-4-oxoquinazolin-3(4h)-yl)-2-methylphenyl]-1-methyl-2-oxo-1,2-dihydropyridin-3-yl}-3-methylurea | Human | 2895 | |
| JAK3 | JakA | TK | 7apg | C | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13140 | |
| JAK3 | JakA | TK | 6gla | B | B | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10022 | |
| JAK3 | JakA | TK | 3zep | B | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 430 | |
| JAK2 | JakA | TK | 5tq3 | B | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7360 | |
| PTK2B (PYK2) | FAK | TK | 3fzr | A | | n-methyl-n-{2-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide | Human | 87 | |
| EGFR | EGFR | TK | 6wxn | A | B | - | Human | 13557 | |
| EGFR | EGFR | TK | 2jiu | A | | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 858 | |
| EGFR | EGFR | TK | 5gty | G | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8369 | |
| BTK | Tec | TK | 6j6m | A | B | (7s)-2-(4-phenoxyphenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11766 | |
| BTK | Tec | TK | 5t18 | A | A | 6-fluoro-5-(r)-(3-(s)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4h)-yl)-2-methylphenyl)-2-(s)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 7508 | |
| JAK3 | JakA | TK | 4z16 | D | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6394 | |
| JAK3 | JakA | TK | 6db3 | A | A | [(1s)-1-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]cyanamide | Human | 10718 | |
| JAK3 | JakA | TK | 6aak | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10366 | |
| EGFR | EGFR | TK | 6jrj | A | | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one | Human | 12158 | |
| PTK2B (PYK2) | FAK | TK | 3cc6 | A | A | - | Human | 93 | |
| PTK2B (PYK2) | FAK | TK | 3cc6 | A | B | - | Human | 92 | |
| BTK | Tec | TK | 4rx5 | A | A | n-(6-fluoro-2-methyl-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl)-1-benzothiophene-2-carboxamide | Human | 6259 | |
| EGFR | EGFR | TK | 5cao | A | | n~2~-[2-methyl-2-(methylsulfonyl)propyl]-n~4~-[2-methyl-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-yl]pyrimidine-2,4-diamine | Human | 6206 | |
| JAK1 | JakA | TK | 5khw | B | | adenosine-5'-diphosphate | Human | 7165 | |
| EGFR | EGFR | TK | 7t4i | A | | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14530 | |
| TNK2 (ACK) | Ack | TK | 3eqp | B | | n-(2,6-dimethylphenyl)-4-(2-ethoxyphenoxy)-2-({4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl}amino)pyrimidine-5-carboxamide | Human | 3402 | |
| TNK2 (ACK) | Ack | TK | 1u46 | A | | - | Human | 3411 | |
| TNK2 (ACK) | Ack | TK | 4ewh | B | | 6-{4-[2-(dimethylamino)ethoxy]phenyl}-n-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 3405 | |
| EGFR | EGFR | TK | 5hg8 | A | B | n-[3-({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]propanamide | Human | 6378 | |
| EGFR | EGFR | TK | 2itv | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 834 | |
| PTK2B (PYK2) | FAK | TK | 3fzs | A | | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 94 | |
| PTK2B (PYK2) | FAK | TK | 3et7 | A | | 5-{[4-{[2-(pyrrolidin-1-ylsulfonyl)benzyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1,3-dihydro-2h-indol-2-one | Human | 90 | |
| PTK2B (PYK2) | FAK | TK | 3fzp | A | | phosphothiophosphoric acid-adenylate ester | Human | 88 | |
| PTK2B (PYK2) | FAK | TK | 3fzt | A | | 1-[5-tert-butyl-2-(4-methylphenyl)-1,2-dihydro-3h-pyrazol-3-ylidene]-3-{3-[(pyridin-3-yloxy)methyl]-1h-pyrazol-5-yl}urea | Human | 86 | |
| EGFR | EGFR | TK | 7lgs | A | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 13906 | |
| JAK3 | JakA | TK | 5lwn | A | A | (~{z})-2-cyano-~{n},~{n}-dimethyl-3-[5-[3-[(1~{s},2~{r})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]prop-2-enamide | Human | 7117 | |
| JAK3 | JakA | TK | 7apg | B | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13136 | |
| EGFR | EGFR | TK | 6v5p | C | A | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12210 | |
| EGFR | EGFR | TK | 5d41 | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 6666 | |
| EGFR | EGFR | TK | 2itx | A | | phosphoaminophosphonic acid-adenylate ester | Human | 865 | |
| FGR | Src | TK | 7uy0 | B | C | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14562 | |
| JAK3 | JakA | TK | 3zc6 | B | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 447 | |
| JAK3 | JakA | TK | 4v0g | A | B | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6346 | |
| FGR | Src | TK | 7uy0 | A | C | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14564 | |
| FGR | Src | TK | 7uy3 | A | | 3-[(6,7-dimethoxyquinazolin-4-yl)oxy]-n-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methylbenzamide | Human | 14567 | |
| FGR | Src | TK | 7uy0 | A | A | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14568 | |
| ABL1 | Abl | TK | 6bl8 | A | A | purvalanol b | Human | 9699 | |
| EGFR | EGFR | TK | 4i1z | A | B | - | Human | 906 | |
| EGFR | EGFR | TK | 5yu9 | B | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9433 | |
| EGFR | EGFR | TK | 6duk | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 11060 | |
| JAK2 | JakA | TK | 3q32 | A | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3700 | |
| EGFR | EGFR | TK | 8a2b | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14459 | |
| EGFR | EGFR | TK | 8a2a | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14460 | |
| EGFR | EGFR | TK | 8a2a | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14466 | |
| EGFR | EGFR | TK | 7jxq | A | A | (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2h-isoindol-2-yl}-n-(1,3-thiazol-2-yl)acetamide | Human | 13886 | |
| SYK | Syk | TK | 5cxz | A | B | n-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine | Human | 6041 | |
| DDR1 | DDR | TK | 5sb2 | A | A | 3-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-5-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | Human | 14250 | |
| DDR1 | DDR | TK | 5bvo | A | | n-(5-{(1s)-1-[(5-fluoro-1,3-benzoxazol-2-yl)amino]ethyl}-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide | Human | 3250 | |
| DDR1 | DDR | TK | 5bvk | A | | 1-(2-chlorophenyl)-3-(pyridin-3-ylmethyl)urea | Human | 3251 | |
| DDR1 | DDR | TK | 4ckr | A | A | 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | Human | 3257 | |
| DDR1 | DDR | TK | 4bkj | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 3256 | |
| DDR1 | DDR | TK | 5fdx | A | | 3-[(4-methylpiperazin-1-yl)methyl]-~{n}-[(4~{r})-4-methyl-2-pyrimidin-5-yl-3,4-dihydro-1~{h}-isoquinolin-7-yl]-5-(trifluoromethyl)benzamide | Human | 7131 | |
| DDR1 | DDR | TK | 5sau | A | A | 3-[(6-aminopyridin-3-yl)ethynyl]-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 14253 | |
| ROR2 | Ror | TK | 3zzw | B | A | - | Human | 415 | |
| TNK2 (ACK) | Ack | TK | 7kp6 | A | A | 5-chloro-n~2~-[4-(4-methylpiperazin-1-yl)phenyl]-n~4~-{[(2r)-oxolan-2-yl]methyl}pyrimidine-2,4-diamine | Human | 14104 | |
| DDR1 | DDR | TK | 6fin | A | B | 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{h}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Human | 10747 | |
| DDR1 | DDR | TK | 7be6 | A | A | 5-amino-n-(4-(((2s)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1h-pyrazole-4-carboxamide | Human | 13378 | |
| DDR1 | DDR | TK | 5sb2 | A | B | 3-chloro-n-[(1r,2s)-2-phenylcyclopropyl]-5-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | Human | 14254 | |
| DDR1 | DDR | TK | 5sb1 | A | B | 4-chloro-n-[(3s,4r)-4-phenylpyrrolidin-3-yl]-3-{[(1h-pyrrolo[2,3-b]pyridin-5-yl)oxy]methyl}benzamide | Human | 14257 | |
| DDR1 | DDR | TK | 6fio | A | B | 2-[1'-(1~{h}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10749 | |
| DDR1 | DDR | TK | 5sau | A | B | 3-[(6-aminopyridin-3-yl)ethynyl]-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 14258 | |
| DDR1 | DDR | TK | 5saw | A | A | 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide | Human | 14259 | |
| DDR1 | DDR | TK | 6gwr | A | B | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10484 | |
| DDR1 | DDR | TK | 6bsd | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 10761 | |
| DDR1 | DDR | TK | 6hp9 | A | | (2~{r})-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{h}-indene-5-carboxamide | Human | 10885 | |
| DDR1 | DDR | TK | 6fin | A | A | 3-[(3-cyclopropyl-1,2,4-oxadiazol-5-yl)methyl]-8-(1~{h}-indazol-5-ylcarbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one | Human | 10743 | |
| DDR1 | DDR | TK | 5sax | A | A | 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide | Human | 14262 | |
| DDR1 | DDR | TK | 7feh | A | B | n-[(5-chloranyl-2-ethylsulfonyl-phenyl)methyl]-3-piperazin-1-yl-5-(trifluoromethyloxy)benzamide | Human | 14308 | |
| DDR1 | DDR | TK | 6fil | A | B | 2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide | Human | 10739 | |
| DDR1 | DDR | TK | 6fiq | A | | 1-(1~{h}-indazol-5-ylcarbonyl)-5'-methoxy-1'-[2-oxidanylidene-2-[(2~{s})-2-(trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-2'-one | Human | 10742 | |
| DDR1 | DDR | TK | 7be6 | A | B | 5-amino-n-(4-(((2s)-4-cyclohexyl-1-((1-(methylsulfonyl)piperidin-3-yl)amino)-1-oxobutan-2-yl)carbamoyl)benzyl)-1-phenyl-1h-pyrazole-4-carboxamide | Human | 13380 | |
| DDR1 | DDR | TK | 6fex | A | A | 2-[4-bromanyl-2-oxidanylidene-1'-(1~{h}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10741 | |
| DDR1 | DDR | TK | 6few | A | A | 2-[8-(2~{h}-indazol-5-ylcarbonyl)-4-oxidanylidene-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-~{n}-methyl-ethanamide | Human | 10738 | |
| DDR1 | DDR | TK | 3zos | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3262 | |
| DDR1 | DDR | TK | 6y23 | C | | - | Human | 12743 | |
| JAK1 | JakA | TK | 4ehz | B | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1481 | |
| FES | Fer | TK | 6jmf | A | | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide | Human | 11140 | |
| FES | Fer | TK | 3cd3 | A | A | staurosporine | Human | 2814 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | G | | - | Human | 554 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | A | | - | Human | 560 | |
| EPHB1 (EphB1) | Eph | TK | 5mja | B | | 2-chloranyl-~{n}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide | Human | 7583 | |
| EPHB1 (EphB1) | Eph | TK | 7kpl | A | B | - | Human | 13383 | |
| SYK | Syk | TK | 4yjv | A | C | 3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol | Human | 6149 | |
| BTK | Tec | TK | 7yc9 | A | A | (7~{s})-2-(4-bromanyl-3,5-dimethoxy-phenyl)-7-(1-propanoylpiperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14746 | |
| JAK2 | JakA | TK | 8g6z | A | B | (3r)-3-cyclopentyl-3-[(4m)-4-{5-methyl-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-1h-pyrazol-1-yl]propanenitrile | Human | 14810 | |
| EPHB4 (EphB4) | Eph | TK | 2vww | A | B | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3,4,5- trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 358 | |
| FES | Fer | TK | 3cbl | A | B | staurosporine | Human | 2811 | |
| JAK2 | JakA | TK | 6aaj | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10515 | |
| CSF1R (FMS) | PDGFR | TK | 3lco | A | A | 3-({4-methoxy-5-[(4-methoxybenzyl)oxy]pyridin-2-yl}methoxy)-5-(1-methyl-1h-pyrazol-4-yl)pyrazin-2-amine | Human | 2314 | |
| CSF1R (FMS) | PDGFR | TK | 3bea | A | | 8-(2,3-dihydro-1h-inden-5-yl)-2-({4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]phenyl}amino)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | Human | 6761 | |
| CSF1R (FMS) | PDGFR | TK | 2i0y | A | | 5-cyano-furan-2-carboxylic acid [5-hydroxymethyl-2-(4-methyl-piperidin-1-yl)-phenyl]-amide | Human | 2315 | |
| JAK2-b | JakB | TK | 5ut0 | A | B | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}urea | Human | 8047 | |
| JAK3 | JakA | TK | 3lxl | A | B | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 443 | |
| MET | Met | TK | 8ow3 | A | | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14818 | |
| MET | Met | TK | 8owg | A | | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14819 | |
| MET | Met | TK | 8ouv | A | A | 5-(1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14820 | |
| FGFR3 | FGFR | TK | 8udu | A | B | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15204 | |
| FES | Fer | TK | 4e93 | A | A | 5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine | Human | 2816 | |
| FES | Fer | TK | 3bkb | A | B | staurosporine | Human | 2813 | |
| EGFR | EGFR | TK | 8hv6 | A | A | ~{n}-quinolin-7-ylprop-2-enamide | Human | 15071 | |
| FES | Fer | TK | 3bkb | A | A | staurosporine | Human | 2810 | |
| MET | Met | TK | 8ouv | A | B | 5-(1h-indazol-7-yl)-1-[(1s)-1-phenylethyl]pyrimidine-2,4-dione | Human | 14823 | |
| EGFR | EGFR | TK | 6p1d | D | B | 10-benzyl-8-fluoro-5,10-dihydro-11h-dibenzo[b,e][1,4]diazepin-11-one | Human | 11885 | |
| EGFR | EGFR | TK | 5gty | A | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8352 | |
| ROR2 | Ror | TK | 3zzw | B | B | - | Human | 411 | |
| EPHB4 (EphB4) | Eph | TK | 2vwx | A | A | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide | Human | 361 | |
| EPHB4 (EphB4) | Eph | TK | 6fnm | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 10339 | |
| ROR2 | Ror | TK | 3zzw | A | A | - | Human | 410 | |
| EPHB4 (EphB4) | Eph | TK | 2vwz | A | B | n-[3-[[4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl]amino]phenyl]methanesulfonamide | Human | 362 | |
| ROR2 | Ror | TK | 4gt4 | A | A | - | Human | 414 | |
| ROR2 | Ror | TK | 3zzw | A | B | - | Human | 412 | |
| EGFR | EGFR | TK | 7t4j | A | | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14529 | |
| EPHB4 (EphB4) | Eph | TK | 6fnm | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 10342 | |
| EPHB4 (EphB4) | Eph | TK | 2xvd | A | B | {4-methyl-3-[(1-methylethyl)(2-{[3-(methylsulfonyl)-5-morpholin-4-ylphenyl]amino}pyrimidin-4-yl)amino]phenyl}methanol | Human | 372 | |
| SRC | Src | TK | 6ate | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 10920 | |
| EGFR | EGFR | TK | 4zjv | B | B | - | Human | 780 | |
| EPHB4 (EphB4) | Eph | TK | 2vx1 | A | B | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzamide | Human | 374 | |
| EGFR | EGFR | TK | 5x2a | C | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9531 | |
| FES | Fer | TK | 3cd3 | A | B | staurosporine | Human | 2815 | |
| MET | Met | TK | 8ov7 | A | | 5-[3,5-bis(fluoranyl)phenyl]-1-[(1s)-1-[3-(1h-imidazol-5-yl)phenyl]ethyl]pyrimidine-2,4-dione | Human | 14817 | |
| EPHB4 (EphB4) | Eph | TK | 4aw5 | A | A | (3z)-5-[(1-ethylpiperidin-4-yl)amino]-3-[(5-methoxy-1h-benzimidazol-2-yl)(phenyl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 367 | |
| JAK3 | JakA | TK | 5toz | A | | 1-{(2s,5r)-2-methyl-5-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7163 | |
| JAK3 | JakA | TK | 6da4 | A | | (z)-1-{2,2-difluoro-6-[5-(2-methoxyethyl)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-4h-1,4-benzoxazin-4-yl}methanimine | Human | 10723 | |
| EGFR | EGFR | TK | 6v6k | H | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12216 | |
| EGFR | EGFR | TK | 6v5n | B | A | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12227 | |
| MET | Met | TK | 8ovz | A | | 1-[(1s)-1-[3-(1h-imidazol-4-yl)phenyl]ethyl]-5-(1h-indazol-7-yl)pyrimidine-2,4-dione | Human | 14822 | |
| EGFR | EGFR | TK | 7k1i | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13904 | |
| JAK2-b | JakB | TK | 6m9h | A | B | 4-({4-amino-6-[4-(2-hydroxyethyl)-1h-imidazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | Human | 10383 | |
| TNK2 (ACK) | Ack | TK | 1u4d | A | | debromohymenialdisine | Human | 3398 | |
| EGFR | EGFR | TK | 6s9b | A | | 3-fluoranyl-~{n}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-5-pyridin-3-yl-benzamide | Human | 11805 | |
| EGFR | EGFR | TK | 6p8q | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 11882 | |
| FGFR2 | FGFR | TK | 3ri1 | B | | (6s)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | Human | 528 | |
| EPHA2 (EphA2) | Eph | TK | 8qqy | A | B | 6-(4-fluoranyl-3-methoxy-phenyl)-13$l^{6}-thia-2,4,8,12,19-pentazatricyclo[12.3.1.1^{3,7}]nonadeca-1(18),3,5,7(19),14,16-hexaene 13,13-dioxide | Human | 15000 | |
| EGFR | EGFR | TK | 6v5p | D | A | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12218 | |
| MERTK (MER) | Axl | TK | 7aw4 | B | B | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | 13368 | |
| EPHB4 (EphB4) | Eph | TK | 3zew | B | A | staurosporine | Human | 351 | |
| JAK2-b | JakB | TK | 5ut1 | A | B | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 8049 | |
| EPHA2 (EphA2) | Eph | TK | 8boc | A | A | ~{n}-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 15003 | |
| EGFR | EGFR | TK | 5u8l | A | B | 4-[(4-{4-[(3-cyclopropyl-1h-pyrazol-5-yl)amino]-6-[(prop-2-yn-1-yl)carbamoyl]pyrimidin-2-yl}piperazin-1-yl)methyl]benzene-1-sulfonyl fluoride | Human | 7386 | |
| TNK2 (ACK) | Ack | TK | 8hmt | A | A | 6-(2-bromophenyl)-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[[(2s)-oxolan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one | Human | 15009 | |
| TNK2 (ACK) | Ack | TK | 8hmt | A | B | 6-(2-bromophenyl)-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[[(2s)-oxolan-2-yl]methyl]pyrido[2,3-d]pyrimidin-7-one | Human | 15010 | |
| JAK2 | JakA | TK | 4gfm | A | A | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3680 | |
| EGFR | EGFR | TK | 6p8q | D | A | adenosine monophosphate | Human | 11871 | |
| EGFR | EGFR | TK | 5gmp | A | B | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8168 | |
| EGFR | EGFR | TK | 4riw | B | | adenosine-5'-diphosphate | Human | 877 | |
| FGR | Src | TK | 7uy0 | B | B | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14565 | |
| BTK | Tec | TK | 8e2m | A | A | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14552 | |
| JAK1 | JakA | TK | 6rse | A | A | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12481 | |
| DDR1 | DDR | TK | 6fio | A | A | 2-[1'-(1~{h}-indazol-5-ylcarbonyl)-4-methyl-2-oxidanylidene-spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10748 | |
| DDR1 | DDR | TK | 6y23 | A | | - | Human | 12741 | |
| DDR1 | DDR | TK | 6y23 | B | | - | Human | 12742 | |
| DDR1 | DDR | TK | 6hp9 | B | | (2~{r})-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{h}-indene-5-carboxamide | Human | 10884 | |
| DDR1 | DDR | TK | 6brj | A | | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 10760 | |
| JAK3 | JakA | TK | 5lwn | A | B | (2~{s})-2-cyano-~{n},~{n}-dimethyl-3-[5-[3-[(1~{s},2~{r})-2-methylcyclohexyl]-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl]furan-2-yl]propanamide | Human | 7116 | |
| FGR | Src | TK | 7uy0 | A | B | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 14563 | |
| DDR1 | DDR | TK | 5saz | A | A | 2-chloro-5-{3-chloro-4-[(2-hydroxyethyl)amino]benzamido}-n-(1h-pyrrolo[2,3-b]pyridin-5-yl)benzamide | Human | 14255 | |
| JAK3 | JakA | TK | 3zc6 | C | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 445 | |
| DDR1 | DDR | TK | 7bcm | A | | ~{n}-[[4-[[(2~{s})-4-cyclohexyl-1-[[(3~{s})-1-methylsulfonylpiperidin-3-yl]amino]-1-oxidanylidene-butan-2-yl]carbamoyl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide | Human | 13379 | |
| DDR1 | DDR | TK | 5say | A | | n-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide | Human | 14256 | |
| ABL1 | Abl | TK | 6xr7 | A | 11 | - | Human | 12866 | |
| ABL1 | Abl | TK | 2e2b | B | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1065 | |
| ABL1 | Abl | TK | 3ue4 | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 1074 | |
| ABL1 | Abl | TK | 4wa9 | B | | axitinib | Human | 1063 | |
| ABL1 | Abl | TK | 6xr7 | A | 1 | - | Human | 12867 | |
| ABL1 | Abl | TK | 3qrk | A | | (3s)-6-(3-tert-butyl-5-{[(2,3-dichlorophenyl)carbamoyl]amino}-1h-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | Human | 1056 | |
| ABL1 | Abl | TK | 6xr7 | A | 14 | - | Human | 12865 | |
| ABL1 | Abl | TK | 6xrg | A | 7 | - | Human | 12868 | |
| ABL1 | Abl | TK | 6npe | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10947 | |
| ABL1 | Abl | TK | 3cs9 | D | A | nilotinib | Human | 1077 | |
| ABL1 | Abl | TK | 8i7t | A | | [3-[5-[5-(dimethylcarbamoyl)pyridin-3-yl]-1h-pyrrolo[2,3-b]pyridin-3-yl]-4-methoxy-phenyl] ethanesulfonate | Human | 15563 | |
| ABL1 | Abl | TK | 2hzi | A | B | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1087 | |
| ABL1 | Abl | TK | 2g2f | A | | - | Human | 1097 | |
| ABL1 | Abl | TK | 6xr6 | A | 13 | - | Human | 12869 | |
| ABL1 | Abl | TK | 6xr7 | A | 17 | - | Human | 12870 | |
| ABL1 | Abl | TK | 4xey | B | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1100 | |
| TYK2-b | JakB | TK | 5c03 | A | A | phosphothiophosphoric acid-adenylate ester | Human | 6043 | |
| EGFR | EGFR | TK | 5x2f | C | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9542 | |
| TYK2-b | JakB | TK | 3zon | A | | 5-phenyl-2-ureidothiophene-3-carboxamide | Human | 2200 | |
| ABL1 | Abl | TK | 3qrj | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1101 | |
| ABL1 | Abl | TK | 3cs9 | C | A | nilotinib | Human | 1046 | |
| ABL1 | Abl | TK | 2g1t | C | | - | Human | 1064 | |
| ABL1 | Abl | TK | 6xr7 | A | 2 | - | Human | 12883 | |
| ABL1 | Abl | TK | 2hyy | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1092 | |
| ABL1 | Abl | TK | 6xrg | A | 5 | - | Human | 12884 | |
| ABL1 | Abl | TK | 3ue4 | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 1057 | |
| ABL1 | Abl | TK | 6xr6 | A | 9 | - | Human | 12885 | |
| ABL1 | Abl | TK | 2f4j | A | | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 1090 | |
| ZAP70 | Syk | TK | 1u59 | A | B | staurosporine | Human | 2733 | |
| JAK2 | JakA | TK | 8bx9 | A | B | ilginatinib | Human | 15034 | |
| ABL1 | Abl | TK | 3pyy | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1062 | |
| ABL1 | Abl | TK | 9ks5 | A | | - | Human | 15564 | |
| ABL1 | Abl | TK | 2g2h | B | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1089 | |
| ABL1 | Abl | TK | 6xrg | A | 16 | - | Human | 12887 | |
| ABL1 | Abl | TK | 6xrg | A | 20 | - | Human | 12888 | |
| ABL1 | Abl | TK | 6xrg | A | 10 | - | Human | 12889 | |
| ABL1 | Abl | TK | 4twp | B | | axitinib | Human | 1081 | |
| TYK2-b | JakB | TK | 6nzp | B | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11497 | |
| TYK2-b | JakB | TK | 7ax4 | A | | 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide | Human | 13499 | |
| JAK2-b | JakB | TK | 5ut2 | A | B | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 8039 | |
| JAK2-b | JakB | TK | 5ut2 | A | A | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 8040 | |
| JAK2-b | JakB | TK | 5usz | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8048 | |
| JAK2-b | JakB | TK | 6g3c | A | A | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10978 | |
| JAK2-b | JakB | TK | 6brw | A | B | 4-[(5,10-dimethyl-6-oxo-6,10-dihydro-5h-pyrimido[5,4-b]thieno[3,2-e][1,4]diazepin-2-yl)amino]benzenesulfonamide | Human | 10377 | |
| ABL1 | Abl | TK | 8i7z | A | | 5-[3-(2-methoxy-5-oxidanyl-phenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethyl-pyridine-3-carboxamide | Human | 15565 | |
| ABL1 | Abl | TK | 5hu9 | A | A | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6754 | |
| ABL1 | Abl | TK | 2e2b | A | | n-[3-(4,5'-bipyrimidin-2-ylamino)-4-methylphenyl]-4-{[(3s)-3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-(trifluoromethyl)benzamide | Human | 1054 | |
| ABL1 | Abl | TK | 6npu | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10944 | |
| ABL1 | Abl | TK | 8i7s | A | | 5-[3-(2-methoxy-5-oxidanyl-phenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethyl-pyridine-3-carboxamide | Human | 15566 | |
| ABL1 | Abl | TK | 5mo4 | A | A | nilotinib | Human | 7527 | |
| ABL1 | Abl | TK | 6xr7 | A | 3 | - | Human | 12900 | |
| JAK2-b | JakB | TK | 5ut5 | A | A | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 8042 | |
| JAK2-b | JakB | TK | 5i4n | A | B | adenosine-5'-triphosphate | Human | 6524 | |
| JAK2-b | JakB | TK | 5ut5 | A | B | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 8037 | |
| JAK3 | JakA | TK | 5lwm | A | B | 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{n},~{n}-dimethyl-prop-2-enamide | Human | 7118 | |
| ABL1 | Abl | TK | 6npv | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10951 | |
| ABL1 | Abl | TK | 6xr7 | A | 7 | - | Human | 12907 | |
| ABL1 | Abl | TK | 3qrj | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1070 | |
| ABL1 | Abl | TK | 6xr7 | A | 18 | - | Human | 12909 | |
| ABL1 | Abl | TK | 8ssn | A | | 6,7-dimethoxy-n-(4-phenoxyphenyl)quinazolin-4-amine | Human | 14878 | |
| ABL1 | Abl | TK | 2gqg | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1053 | |
| LYN | Src | TK | 3a4o | X | | staurosporine | Human | 1812 | |
| JAK2-b | JakB | TK | 6obl | A | | [4-({5-amino-3-[(4-cyanophenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acid | Human | 12101 | |
| JAK2-b | JakB | TK | 5ut4 | A | | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 8038 | |
| JAK2-b | JakB | TK | 5ut0 | A | A | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}urea | Human | 8041 | |
| JAK3 | JakA | TK | 6gl9 | A | A | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10014 | |
| KDR | VEGFR | TK | 2p2i | A | | n-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide | Human | 5326 | |
| KDR | VEGFR | TK | 3efl | B | | n-(3,3-dimethyl-2,3-dihydro-1h-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide | Human | 5330 | |
| KDR | VEGFR | TK | 5ew3 | B | | 2-(pyridin-4-ylmethylamino)-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 6290 | |
| KDR | VEGFR | TK | 3cjg | A | A | n~4~-methyl-n~4~-(3-methyl-1h-indazol-6-yl)-n~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 6791 | |
| KDR | VEGFR | TK | 3vhe | A | | 1-{2-fluoro-4-[(5-methyl-5h-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea | Human | 5331 | |
| KDR | VEGFR | TK | 4agd | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 5322 | |
| KDR | VEGFR | TK | 3vhk | A | | {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol | Human | 5342 | |
| KDR | VEGFR | TK | 3b8r | B | | n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5341 | |
| KDR | VEGFR | TK | 3b8r | A | | n-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5327 | |
| KDR | VEGFR | TK | 3ewh | A | | n-[4-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)naphthalen-1-yl]-6-(trifluoromethyl)-1h-benzimidazol-2-amine | Human | 5351 | |
| KDR | VEGFR | TK | 3cjf | A | A | n~4~-(3-methyl-1h-indazol-6-yl)-n~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 6792 | |
| KDR | VEGFR | TK | 3dtw | B | | 6-chloro-n-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide | Human | 5308 | |
| KDR | VEGFR | TK | 3be2 | A | | n-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]benzamide | Human | 5337 | |
| KDR | VEGFR | TK | 6gqq | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10585 | |
| KDR | VEGFR | TK | 3cp9 | B | | 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1h)-one | Human | 6790 | |
| JAK2-b | JakB | TK | 6obf | A | | [4-({5-amino-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carbonyl}amino)phenoxy]acetic acid | Human | 12098 | |
| JAK2-b | JakB | TK | 5wim | A | | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}urea | Human | 10385 | |
| JAK2-b | JakB | TK | 5wij | A | | 4-{[6-(cyclohexylmethoxy)-7h-purin-2-yl]amino}-n,n-diethylbenzamide | Human | 10388 | |
| JAK2-b | JakB | TK | 6oav | A | | 5-amino-3-[(4-cyanophenyl)amino]-n-phenyl-1h-1,2,4-triazole-1-carboxamide | Human | 12099 | |
| JAK2-b | JakB | TK | 5ut3 | A | | 5-phenyl-2-ureidothiophene-3-carboxamide | Human | 8044 | |
| JAK2-b | JakB | TK | 5ut6 | A | B | 4-({4-amino-6-[3-(hydroxymethyl)-1h-pyrazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | Human | 8045 | |
| JAK3 | JakA | TK | 7apf | A | B | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13130 | |
| KDR | VEGFR | TK | 3wzd | A | A | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 5325 | |
| KDR | VEGFR | TK | 3vnt | A | B | 2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | Human | 5328 | |
| KDR | VEGFR | TK | 3efl | A | | n-(3,3-dimethyl-2,3-dihydro-1h-indol-6-yl)-2-[(pyridin-4-ylmethyl)amino]pyridine-3-carboxamide | Human | 5344 | |
| KDR | VEGFR | TK | 6gqq | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10581 | |
| KDR | VEGFR | TK | 4asd | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 5333 | |
| KDR | VEGFR | TK | 2qu6 | A | | 4-({2-[(4-chloro-3-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-n-methylpyridine-2-carboxamide | Human | 5316 | |
| KDR | VEGFR | TK | 3vo3 | A | A | n-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1h-pyrazole-5-carboxamide | Human | 5329 | |
| KDR | VEGFR | TK | 4ase | A | | tivozanib | Human | 5349 | |
| KDR | VEGFR | TK | 2oh4 | A | B | methyl (5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-1h-benzimidazol-2-yl)carbamate | Human | 5324 | |
| KDR | VEGFR | TK | 2p2h | A | | 4-(2-anilinopyridin-3-yl)-n-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine | Human | 5310 | |
| KDR | VEGFR | TK | 2qu6 | B | | 4-({2-[(4-chloro-3-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-n-methylpyridine-2-carboxamide | Human | 5340 | |
| KDR | VEGFR | TK | 3cpc | B | | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1h)-one | Human | 5309 | |
| JAK3 | JakA | TK | 1yvj | A | A | 1,2,3,4-tetrahydrogen-staurosporine | Human | 460 | |
| JAK3 | JakA | TK | 6glb | A | B | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10023 | |
| KDR | VEGFR | TK | 2xir | A | | n,2-dimethyl-6-{[7-(2-morpholin-4-ylethoxy)quinolin-4-yl]oxy}-1-benzofuran-3-carboxamide | Human | 6789 | |
| KDR | VEGFR | TK | 6gqp | A | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10582 | |
| KDR | VEGFR | TK | 3cpc | A | | 3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1h)-one | Human | 5346 | |
| KDR | VEGFR | TK | 1vr2 | A | | - | Human | 5338 | |
| KDR | VEGFR | TK | 4ag8 | A | | axitinib | Human | 5311 | |
| KDR | VEGFR | TK | 3cp9 | A | | 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1h)-one | Human | 6786 | |
| KDR | VEGFR | TK | 2qu5 | A | | 4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3h-benzimidazol-5-yl]oxy]-n-methyl-pyridine-2-carboxamide | Human | 5317 | |
| ITK | Tec | TK | 3mj1 | A | | 7-[(4-methylpiperazin-1-yl)methyl]-4-[(3-methyl-1h-pyrazol-5-yl)amino]-2-(tetrahydro-2h-pyran-4-yl)phthalazin-1(2h)-one | Human | 27 | |
| JAK3 | JakA | TK | 4hvg | A | | 2-cyclopropyl-n-[(2s)-3-hydroxy-3-methylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 450 | |
| JAK3 | JakA | TK | 3zc6 | D | B | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 459 | |
| JAK3 | JakA | TK | 7q6h | A | C | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14081 | |
| JAK2 | JakA | TK | 6vnj | A | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13340 | |
| JAK2 | JakA | TK | 29ry | A | B | - | Human | 15569 | |
| JAK2 | JakA | TK | 6tpd | A | | 3-methyl-4-phenyl-2,7-dihydropyrazolo[3,4-b]pyridin-6-one | Human | 12350 | |
| JAK2 | JakA | TK | 3io7 | A | | (3s)-1-[6-(2-aminopyrazolo[1,5-a]pyrimidin-3-yl)pyrimidin-4-yl]-n,n-diethylpiperidine-3-carboxamide | Human | 3636 | |
| JAK2 | JakA | TK | 8bxh | A | A | momelotinib | Human | 15032 | |
| JAK2 | JakA | TK | 4e4m | D | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3669 | |
| FES | Fer | TK | 3cbl | A | A | staurosporine | Human | 2808 | |
| JAK2 | JakA | TK | 4ytc | A | B | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3687 | |
| JAK2 | JakA | TK | 9t20 | A | A | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15570 | |
| JAK2 | JakA | TK | 6vnh | B | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13342 | |
| JAK2 | JakA | TK | 4aqc | A | B | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3696 | |
| JAK3 | JakA | TK | 5ttu | A | A | 1-[(3ar,7ar)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)octahydro-6h-pyrrolo[2,3-c]pyridin-6-yl]propan-1-one | Human | 7435 | |
| JAK3 | JakA | TK | 3zc6 | A | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 442 | |
| JAK3 | JakA | TK | 4v0g | A | A | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6347 | |
| JAK3 | JakA | TK | 5wfj | A | | 4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-b]pyridazine-3-carboxamide | Human | 8535 | |
| JAK3 | JakA | TK | 6glb | B | A | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10021 | |
| JAK3 | JakA | TK | 4z16 | A | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6395 | |
| JAK3 | JakA | TK | 3zc6 | C | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 433 | |
| JAK3 | JakA | TK | 5tts | A | | 1-{(3r)-3-[(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one | Human | 7439 | |
| JAK2 | JakA | TK | 6vgl | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13220 | |
| JAK2 | JakA | TK | 6x8e | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13152 | |
| JAK2 | JakA | TK | 5usy | B | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8104 | |
| ABL1 | Abl | TK | 3pyy | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1049 | |
| JAK2 | JakA | TK | 6vn8 | A | | baricitinib | Human | 13291 | |
| JAK2 | JakA | TK | 9t20 | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15572 | |
| JAK2 | JakA | TK | 5tq7 | A | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7355 | |
| JAK2 | JakA | TK | 6wto | A | A | baricitinib | Human | 13536 | |
| JAK2 | JakA | TK | 5tq6 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}(pyrrolidin-1-yl)methanone | Human | 7361 | |
| JAK2 | JakA | TK | 3jy9 | A | A | (3s)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3h)-one | Human | 3668 | |
| EPHA2 (EphA2) | Eph | TK | 5ia1 | A | | 4-{[9-chloro-7-(2,6-difluorophenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid | Human | 7191 | |
| MERTK (MER) | Axl | TK | 7xhy | A | | ~{n}-[4-(2-azanyl-3-chloranyl-pyridin-4-yl)oxy-3-fluoranyl-phenyl]-5-(4-fluorophenyl)-4-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 14517 | |
| JAK3 | JakA | TK | 3lxl | A | A | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 434 | |
| FGFR4 | FGFR | TK | 6iup | A | A | n-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2h-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | Human | 11797 | |
| FGFR4 | FGFR | TK | 4qq5 | A | | n-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)propanamide | Human | 921 | |
| JAK2 | JakA | TK | 6bbv | A | | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9504 | |
| JAK3 | JakA | TK | 7c3n | A | A | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12389 | |
| JAK2 | JakA | TK | 4bbe | A | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3670 | |
| JAK2 | JakA | TK | 5cf4 | A | | n,n-dicyclopropyl-6-ethyl-4-[(3-methoxypropyl)amino]-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5980 | |
| JAK3 | JakA | TK | 6hzv | C | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11755 | |
| JAK2 | JakA | TK | 4c62 | A | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3655 | |
| JAK2 | JakA | TK | 9t1z | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 15573 | |
| JAK2 | JakA | TK | 6vs3 | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13345 | |
| JAK2 | JakA | TK | 5cf5 | B | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5976 | |
| JAK3 | JakA | TK | 3pjc | A | | 3-(1h-indol-3-yl)-4-[2-(4-oxopiperidin-1-yl)-5-(trifluoromethyl)pyrimidin-4-yl]-1h-pyrrole-2,5-dione | Human | 444 | |
| JAK3 | JakA | TK | 3zc6 | D | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 446 | |
| JAK2 | JakA | TK | 3fup | B | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3654 | |
| EPHB4 (EphB4) | Eph | TK | 2vx0 | A | B | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3-morpholin-4-ylphenyl)pyrimidine-2,4-diamine | Human | 368 | |
| ABL1 | Abl | TK | 2hz4 | A | | - | Human | 1059 | |
| JAK2 | JakA | TK | 4d1s | A | B | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3627 | |
| JAK2 | JakA | TK | 4c61 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-n4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine | Human | 3645 | |
| JAK2 | JakA | TK | 6wtq | A | B | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13537 | |
| JAK2 | JakA | TK | 3zmm | B | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3709 | |
| JAK2 | JakA | TK | 4e6d | B | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3631 | |
| JAK2 | JakA | TK | 8bxc | A | A | itacitinib | Human | 15037 | |
| JAK2 | JakA | TK | 6vnf | B | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13346 | |
| JAK2-b | JakB | TK | 5wik | B | | (7r)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 10387 | |
| JAK2-b | JakB | TK | 4fvq | A | | adenosine-5'-triphosphate | Human | 1224 | |
| JAK2-b | JakB | TK | 4fvr | A | | adenosine-5'-triphosphate | Human | 1223 | |
| ABL1 | Abl | TK | 4xey | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1094 | |
| JAK2 | JakA | TK | 6vnk | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13293 | |
| JAK2 | JakA | TK | 4yti | A | A | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3641 | |
| JAK2 | JakA | TK | 4e6q | A | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3624 | |
| JAK2 | JakA | TK | 4p7e | B | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3701 | |
| JAK2 | JakA | TK | 3kck | A | B | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3722 | |
| JAK2 | JakA | TK | 5l3a | A | A | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6561 | |
| JAK2 | JakA | TK | 8bx9 | A | A | ilginatinib | Human | 15038 | |
| ABL1 | Abl | TK | 6xrg | A | 3 | - | Human | 12893 | |
| JAK2 | JakA | TK | 4yth | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3702 | |
| JAK2 | JakA | TK | 4ytf | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3690 | |
| JAK2 | JakA | TK | 5hez | C | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7253 | |
| JAK2 | JakA | TK | 3e63 | A | A | 5-phenyl-1h-indazol-3-amine | Human | 3675 | |
| JAK2 | JakA | TK | 8g8x | A | B | 3-cyclopropyl-1-{5-methyl-2-[(3-methyl-1,2-thiazol-5-yl)amino]pyrimidin-4-yl}azetidin-3-ol | Human | 14805 | |
| JAK2 | JakA | TK | 5tq3 | A | A | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7359 | |
| JAK2 | JakA | TK | 4gmy | A | | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3684 | |
| JAK2 | JakA | TK | 6x8e | B | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13153 | |
| JAK2 | JakA | TK | 6vnk | B | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13295 | |
| JAK2 | JakA | TK | 6x8e | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13154 | |
| JAK2 | JakA | TK | 3q32 | B | | 2-(2,6-difluoro-4-methoxyphenyl)-1-(4-{4-[(3-methyl-1h-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}piperazin-1-yl)ethanone | Human | 3639 | |
| JAK2 | JakA | TK | 6vnf | A | A | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13347 | |
| JAK2 | JakA | TK | 6wto | A | B | baricitinib | Human | 13539 | |
| JAK2 | JakA | TK | 5tq4 | A | | 6-(2-ethyl-4-hydroxyphenyl)-1h-indazole-3-carboxamide | Human | 7351 | |
| JAK2 | JakA | TK | 5hez | D | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7252 | |
| JAK2 | JakA | TK | 7q7w | A | A | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14087 | |
| JAK2 | JakA | TK | 4bbe | B | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3727 | |
| JAK2 | JakA | TK | 6vnc | B | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13348 | |
| JAK2 | JakA | TK | 7q7i | A | B | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14088 | |
| JAK2 | JakA | TK | 6vne | A | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13296 | |
| JAK2 | JakA | TK | 5cf6 | B | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5977 | |
| JAK2 | JakA | TK | 6vs3 | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13349 | |
| JAK2 | JakA | TK | 5cf8 | A | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5981 | |
| JAK2 | JakA | TK | 4f09 | A | | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3622 | |
| JAK2 | JakA | TK | 6vnm | B | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13351 | |
| JAK2 | JakA | TK | 6wtn | A | B | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13540 | |
| JAK2 | JakA | TK | 5tq8 | A | | {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2h-indazol-3-yl]-3,4,6,7-tetrahydro-5h-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone | Human | 7357 | |
| JAK2 | JakA | TK | 6vnl | D | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13297 | |
| JAK2 | JakA | TK | 6drw | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10512 | |
| SYK | Syk | TK | 6hm7 | A | B | 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{h}-3-benzazepine | Human | 10615 | |
| JAK2 | JakA | TK | 4c62 | B | | n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(1-methylimidazol-4-yl)-6-morpholino-1,3,5-triazine-2,4-diamine | Human | 3625 | |
| JAK2 | JakA | TK | 4aqc | A | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3720 | |
| ABL1 | Abl | TK | 6xr6 | A | 3 | - | Human | 12908 | |
| JAK2 | JakA | TK | 5tq5 | A | | 6-(2-ethyl-4-hydroxyphenyl)-n-(6-methylpyridin-3-yl)-1h-indazole-3-carboxamide | Human | 7358 | |
| JAK2 | JakA | TK | 6vsn | A | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13353 | |
| JAK2 | JakA | TK | 4jia | A | B | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3640 | |
| JAK2 | JakA | TK | 29ry | A | A | - | Human | 15574 | |
| JAK2 | JakA | TK | 3ugc | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3651 | |
| JAK2 | JakA | TK | 2b7a | B | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3728 | |
| JAK2 | JakA | TK | 7q7w | A | B | 4-[2-[5-(dimethylamino)pentylamino]-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14089 | |
| ITK | Tec | TK | 4rfm | A | B | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 69 | |
| JAK2 | JakA | TK | 3lpb | A | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3698 | |
| JAK2 | JakA | TK | 5usy | B | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8103 | |
| JAK2 | JakA | TK | 4zim | A | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3659 | |
| JAK2 | JakA | TK | 6drw | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10513 | |
| JAK2 | JakA | TK | 6vn8 | B | | baricitinib | Human | 13301 | |
| JAK2 | JakA | TK | 3ugc | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 3632 | |
| JAK2 | JakA | TK | 4zim | A | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3704 | |
| JAK2 | JakA | TK | 6vsn | B | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13356 | |
| JAK2 | JakA | TK | 3tjc | B | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3688 | |
| JAK2 | JakA | TK | 3lpb | B | A | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3635 | |
| JAK2 | JakA | TK | 4jia | A | A | 5-(4-methoxyphenyl)-n-[4-(4-methylpiperazin-1-yl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3691 | |
| JAK2 | JakA | TK | 4zim | B | B | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3697 | |
| JAK2 | JakA | TK | 3e62 | A | A | 5-bromo-1h-indazol-3-amine | Human | 3665 | |
| JAK2 | JakA | TK | 5usy | A | A | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8101 | |
| JAK2 | JakA | TK | 5l3a | A | B | ~{n}-(1~{h}-indazol-4-yl)methanesulfonamide | Human | 6560 | |
| ABL1 | Abl | TK | 6xrg | A | 11 | - | Human | 12877 | |
| JAK2 | JakA | TK | 4yth | A | A | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-2-methyl-n-(2,2,2-trifluoroethyl)-d-alaninamide | Human | 3710 | |
| JAK2 | JakA | TK | 4hge | A | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3658 | |
| JAK2 | JakA | TK | 4aqc | B | A | 8-(4-methylsulfonylphenyl)-n-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine | Human | 3679 | |
| SYK | Syk | TK | 5y5t | A | | 2-[[(1s,2s)-2-azanylcyclohexyl]amino]-4-[(4-methylsulfonylphenyl)amino]-6h-pyrido[4,3-d]pyrimidin-5-one | Human | 10028 | |
| SYK | Syk | TK | 4wnm | A | | n~3~-(tetrahydro-2h-pyran-4-yl)-n~6~-[5-(tetrahydro-2h-pyran-4-ylmethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-1h-indazole-3,6-diamine | Human | 6358 | |
| ABL1 | Abl | TK | 6xrg | A | 12 | - | Human | 12882 | |
| SYK | Syk | TK | 5cy3 | A | A | (5r)-5-[(1r)-1-{[6-(1-methyl-1h-pyrazol-4-yl)-2,1-benzothiazol-4-yl]oxy}ethyl]-1,3-oxazolidin-2-one | Human | 6058 | |
| SYK | Syk | TK | 3srv | A | B | 2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | Human | 1162 | |
| SYK | Syk | TK | 6hm6 | A | B | 2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine | Human | 10613 | |
| SYK | Syk | TK | 4xg3 | A | | 4-{[5-fluoro-4-(3-{[(3r)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1h-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate | Human | 6308 | |
| SYK | Syk | TK | 4yjt | A | A | n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine | Human | 6125 | |
| SYK | Syk | TK | 4puz | A | | 6-(1h-indazol-6-yl)-n-[4-(morpholin-4-yl)phenyl]imidazo[1,2-a]pyrazin-8-amine | Human | 1163 | |
| SYK | Syk | TK | 5y5u | B | | 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8h-pyrido[4,3-d]pyrimidin-5-one | Human | 10029 | |
| SYK | Syk | TK | 4yjv | A | A | 3-[6-({4-[ethyl(1h-indazol-4-yl)amino]-5-fluoropyrimidin-2-yl}amino)-2,4-dihydro-1h-indazol-1-yl]propan-1-ol | Human | 6150 | |
| ERBB3 (ErbB3) | EGFR | TK | 7mn8 | A | | - | Human | 13966 | |
| ABL1 | Abl | TK | 2hzi | A | A | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1102 | |
| SYK | Syk | TK | 4xg4 | A | | (3r)-1-{[1-(5-fluoro-2-{[4-(2-hydroxyethoxy)-3,5-dimethylphenyl]amino}pyrimidin-4-yl)-4-methyl-1h-pyrrol-3-yl]methyl}pyrrolidin-3-ol | Human | 6319 | |
| SYK | Syk | TK | 6zcu | A | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 13635 | |
| SYK | Syk | TK | 5ghv | A | | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1h-pyrrol-3-yl}methyl)azetidin-3-ol | Human | 6743 | |
| SYK | Syk | TK | 6hm6 | A | A | 2-(4-methylphenyl)-3-(pyridin-2-ylmethoxy)pyridine | Human | 10614 | |
| SYK | Syk | TK | 3tuc | A | | 1-benzyl-n-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 1195 | |
| SYK | Syk | TK | 1xbc | A | B | staurosporine | Human | 1207 | |
| PTK2 (FAK) | FAK | TK | 6i8z | A | | 3-methoxy-~{n}-(1-methylpiperidin-1-ium-4-yl)-4-[[4-[(3-oxidanylidene-1,2-dihydroinden-4-yl)oxy]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide | Human | 10904 | |
| PTK2 (FAK) | FAK | TK | 4ebv | A | B | - | Human | 231 | |
| SYK | Syk | TK | 6vov | B | | 6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine | Human | 12040 | |
| PTK2 (FAK) | FAK | TK | 6yvs | B | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13335 | |
| KDR | VEGFR | TK | 1y6a | A | B | n-[5-(ethylsulfonyl)-2-methoxyphenyl]-5-[3-(2-pyridinyl)phenyl]-1,3-oxazol-2-amine | Human | 5323 | |
| SYK | Syk | TK | 1xba | A | | - | Human | 1193 | |
| SYK | Syk | TK | 6zcx | A | A | ~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | Human | 13642 | |
| SYK | Syk | TK | 3tub | A | | 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1r,2s)-2-phenylcyclopropyl]urea | Human | 1179 | |
| SYK | Syk | TK | 1xbc | A | A | staurosporine | Human | 1165 | |
| SYK | Syk | TK | 4rss | A | A | 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6169 | |
| EGFR | EGFR | TK | 8hv9 | A | A | ~{n}-(4-phenylpyridin-2-yl)prop-2-enamide | Human | 15063 | |
| ALK | ALK | TK | 5aa9 | A | B | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6687 | |
| EPHA2 (EphA2) | Eph | TK | 8bog | A | C | ~{n}-[4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]phenyl]-3-(trifluoromethyl)benzamide | Human | 14654 | |
| ALK | ALK | TK | 5aa9 | A | A | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6682 | |
| EGFR | EGFR | TK | 8hv2 | A | A | ~{n}-pyridin-2-ylprop-2-enamide | Human | 15077 | |
| EPHA2 (EphA2) | Eph | TK | 8bof | A | A | 4-methyl-~{n}-(3-methylphenyl)-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14656 | |
| EGFR | EGFR | TK | 8hv4 | A | | ~{n}-pyridin-2-ylprop-2-enamide | Human | 15075 | |
| EGFR | EGFR | TK | 8hva | A | | ~{n}-[6-(1-methylindol-3-yl)pyrimidin-4-yl]prop-2-enamide | Human | 15076 | |
| ABL1 | Abl | TK | 4wa9 | A | | axitinib | Human | 1061 | |
| ABL1 | Abl | TK | 4yc8 | B | | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-n-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide | Human | 6420 | |
| TYK2-b | JakB | TK | 6nzq | B | B | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11506 | |
| TYK2-b | JakB | TK | 5c01 | B | | - | Human | 7223 | |
| TYK2-b | JakB | TK | 4wov | B | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2195 | |
| JAK2 | JakA | TK | 5tq7 | B | | {(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}[(3r)-3-(phenylsulfonyl)pyrrolidin-1-yl]methanone | Human | 7353 | |
| EPHA2 (EphA2) | Eph | TK | 8boh | A | A | 4-methyl-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14647 | |
| SYK | Syk | TK | 6ssb | A | | ~{n}-[4-[5-[(dimethylamino)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-yl]-3-methyl-1-(5-methyl-1,3,4-oxadiazol-2-yl)imidazo[1,5-a]pyridin-7-amine | Human | 12817 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | B | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14655 | |
| EPHA2 (EphA2) | Eph | TK | 8boh | A | B | 4-methyl-~{n}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14651 | |
| TNK2 (ACK) | Ack | TK | 3eqr | A | | n~3~-(2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-n~6~-(4-piperazin-1-ylphenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,6-diamine | Human | 3395 | |
| TYK2-b | JakB | TK | 5tkd | B | A | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7325 | |
| TYK2-b | JakB | TK | 5tkd | A | A | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7323 | |
| PTK2B (PYK2) | FAK | TK | 4h1m | A | | 7-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)-n-(propan-2-yl)-1h-indole-2-carboxamide | Human | 89 | |
| TNK2 (ACK) | Ack | TK | 5zxb | B | B | n-{3-[7-{[6-(4-acetylpiperazin-1-yl)pyridin-3-yl]amino}-1-methyl-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide | Human | 10495 | |
| JAK2 | JakA | TK | 7q7i | A | A | 4-[8-methoxy-2-[(1-methylpyrazol-4-yl)amino]quinazolin-6-yl]phenol | Human | 14085 | |
| JAK2 | JakA | TK | 3krr | A | A | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3643 | |
| JAK2 | JakA | TK | 4hge | B | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3706 | |
| ABL1 | Abl | TK | 6xr6 | A | 15 | - | Human | 12862 | |
| ABL1 | Abl | TK | 6xr6 | A | 1 | - | Human | 12905 | |
| JAK2 | JakA | TK | 7q7k | A | A | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14091 | |
| SRC | Src | TK | 2bdf | A | | {[(4-{[2-(4-aminocyclohexyl)-9-ethyl-9h-purin-6-yl]amino}phenyl)(hydroxy)phosphoryl]methyl}phosphonic acid | Human | 980 | |
| SRC | Src | TK | 6e6e | E | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11478 | |
| SRC | Src | TK | 6e6e | H | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11475 | |
| HCK | Src | TK | 2c0t | A | A | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2653 | |
| HCK | Src | TK | 2c0t | B | A | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2642 | |
| HCK | Src | TK | 2c0o | A | A | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2666 | |
| HCK | Src | TK | 4lue | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2668 | |
| HCK | Src | TK | 5h09 | A | | ethyl (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanoate | Human | 8537 | |
| HCK | Src | TK | 5h0h | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},~{n},4-trimethyl-pentanamide | Human | 8539 | |
| HCK | Src | TK | 2c0t | B | B | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2634 | |
| HCK | Src | TK | 2c0o | A | B | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2652 | |
| HCK | Src | TK | 2hk5 | A | | 3-{[2-(1h-benzimidazol-1-yl)-6-{[2-(diethylamino)ethyl]amino}pyrimidin-4-yl]amino}-4-methylphenol | Human | 2639 | |
| HCK | Src | TK | 3vs3 | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2643 | |
| HCK | Src | TK | 3vs6 | A | | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2664 | |
| HCK | Src | TK | 4lud | A | | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole | Human | 2660 | |
| HCK | Src | TK | 2c0i | A | B | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2649 | |
| ABL1 | Abl | TK | 2gqg | B | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1082 | |
| ABL1 | Abl | TK | 6xrg | A | 13 | - | Human | 12904 | |
| SRC | Src | TK | 8jf3 | A | | 2-[4-[4-[bis(oxidanylidene)-$l^5-sulfanyl]oxyphenyl]carbonylpiperazin-1-yl]-6-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]-n-prop-2-ynyl-pyrimidine-4-carboxamide | Human | 15226 | |
| SRC | Src | TK | 9ns0 | A | 6 | - | Human | 15613 | |
| SRC | Src | TK | 1yom | A | | 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol | Human | 973 | |
| SRC | Src | TK | 9irl | A | | (2~{r})-2-[3,5-bis(fluoranyl)phenyl]-2-[2-chloranylethanoyl(cyclopropyl)amino]-~{n}-cyclopentyl-ethanamide | Human | 15614 | |
| MET | Met | TK | 4knb | B | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3007 | |
| MET | Met | TK | 6sde | A | | volitinib | Human | 11535 | |
| MET | Met | TK | 4xyf | A | A | 6-{(1s)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline | Human | 2986 | |
| SRC | Src | TK | 6e6e | E | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11490 | |
| SRC | Src | TK | 9ns0 | A | 14 | - | Human | 15622 | |
| SRC | Src | TK | 9ns1 | A | 16 | - | Human | 15623 | |
| SRC | Src | TK | 8jn9 | A | | n-[(1r)-1-[3,5-bis(fluoranyl)phenyl]-2-(cyclopentylamino)-2-oxidanylidene-ethyl]-n-cyclopropyl-prop-2-enamide | Human | 15313 | |
| SRC | Src | TK | 9ns0 | A | 9 | - | Human | 15625 | |
| MET | Met | TK | 7b43 | A | | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13189 | |
| TEK (TIE2) | Tie | TK | 2wqb | A | | 2-[3-(cyclohexylmethyl)-5-phenyl-imidazol-4-yl]-[1,3]thiazolo[4,5-e]pyrimidin-7-amine | Human | 5553 | |
| MET | Met | TK | 4r1v | A | A | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 3004 | |
| MET | Met | TK | 4deh | A | | 5-phenyl-3-(quinolin-6-ylmethyl)-3,5,6,7-tetrahydro-4h-[1,2,3]triazolo[4,5-c]pyridin-4-one | Human | 2963 | |
| MET | Met | TK | 7b42 | A | | 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13190 | |
| MET | Met | TK | 7b3v | A | B | 3-(3-methyl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13194 | |
| MET | Met | TK | 3u6h | A | B | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 2965 | |
| JAK2 | JakA | TK | 6vnb | A | | (3s)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13298 | |
| MET | Met | TK | 3a4p | A | | (2e)-3-{6-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]quinolin-3-yl}-n-methylprop-2-enamide | Human | 3005 | |
| ITK | Tec | TK | 4ppc | B | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 78 | |
| ITK | Tec | TK | 4mf1 | B | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 12 | |
| ITK | Tec | TK | 3miy | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 46 | |
| ITK | Tec | TK | 3v5l | A | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 30 | |
| ITK | Tec | TK | 4kio | B | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 36 | |
| MET | Met | TK | 7b3t | A | B | 3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13191 | |
| ITK | Tec | TK | 3t9t | A | B | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 83 | |
| JAK2 | JakA | TK | 6vsn | D | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13343 | |
| ITK | Tec | TK | 4kio | C | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 75 | |
| PTK6 (BRK) | Src | TK | 5h2u | C | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7342 | |
| PTK6 (BRK) | Src | TK | 5da3 | A | B | (2-chloro-4-{[6-cyclopropyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | Human | 6988 | |
| PTK6 (BRK) | Src | TK | 6cz2 | A | B | - | Human | 10031 | |
| PTK6 (BRK) | Src | TK | 5d7v | B | B | - | Human | 6951 | |
| PTK6 (BRK) | Src | TK | 5d7v | C | B | - | Human | 6954 | |
| ITK | Tec | TK | 4mf1 | A | A | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 41 | |
| ITK | Tec | TK | 4ppc | A | A | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 53 | |
| PTK6 (BRK) | Src | TK | 6cz3 | A | A | (3-fluoro-4-{[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | Human | 10001 | |
| PTK6 (BRK) | Src | TK | 5da3 | A | A | (2-chloro-4-{[6-cyclopropyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | Human | 6989 | |
| PTK6 (BRK) | Src | TK | 6cz2 | A | A | - | Human | 10030 | |
| PTK6 (BRK) | Src | TK | 6cz4 | A | A | 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide | Human | 9998 | |
| PTK6 (BRK) | Src | TK | 5h2u | C | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7341 | |
| TYK2-b | JakB | TK | 8s99 | A | A | (8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14847 | |
| ITK | Tec | TK | 3v8t | A | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 55 | |
| ITK | Tec | TK | 4kio | A | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 79 | |
| ITK | Tec | TK | 3miy | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 8 | |
| ITK | Tec | TK | 3qgw | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 11 | |
| NTRK1 (TRKA) | Trk | TK | 5kmj | A | A | ~{n}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide | Human | 7334 | |
| NTRK1 (TRKA) | Trk | TK | 6pl1 | A | A | n-(5-{[(7-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-n'-[3-(trifluoromethyl)phenyl]urea | Human | 11722 | |
| TYK2-b | JakB | TK | 8s98 | A | B | (8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14846 | |
| TYK2-b | JakB | TK | 8s9a | A | A | (8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14848 | |
| TYK2-b | JakB | TK | 8s98 | A | A | (8s)-n-cyclopropyl-5-[(2-methoxypyridin-3-yl)amino]-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14849 | |
| JAK2 | JakA | TK | 6vng | B | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13341 | |
| JAK1-b | JakB | TK | 4l01 | A | A | - | Human | 1424 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | D | | - | Human | 9324 | |
| JAK2 | JakA | TK | 6vnf | B | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13352 | |
| TYK2 | JakA | TK | 4gii | A | | 2,6-dichloro-4-cyano-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3331 | |
| TYK2 | JakA | TK | 6dbk | A | | 4-({4-[(1s,4s)-5-(cyanoacetyl)-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyrimidin-2-yl}amino)-n-ethylbenzamide | Human | 10490 | |
| TYK2 | JakA | TK | 6vnv | A | | (1s,2s)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12138 | |
| TYK2 | JakA | TK | 6vns | A | A | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12139 | |
| TYK2 | JakA | TK | 6x8f | A | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13159 | |
| TYK2 | JakA | TK | 5f1z | A | B | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6357 | |
| FGFR1 | FGFR | TK | 5uq0 | A | A | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide | Human | 7456 | |
| FGFR1 | FGFR | TK | 4rwl | B | | 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl}oxy)-n-methylnaphthalene-1-carboxamide | Human | 3596 | |
| FGFR1 | FGFR | TK | 6mzw | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11165 | |
| FGFR1 | FGFR | TK | 3rhx | B | | (6s)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | Human | 3522 | |
| FGFR1 | FGFR | TK | 4zsa | A | A | 4-(4-ethylpiperazin-1-yl)-n-[6-(3-methoxyphenyl)-2h-indazol-3-yl]benzamide | Human | 3491 | |
| FGFR1 | FGFR | TK | 6c1b | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11167 | |
| FGFR1 | FGFR | TK | 4rwj | B | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3559 | |
| FGFR1 | FGFR | TK | 4v05 | A | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3593 | |
| FGFR1 | FGFR | TK | 5z0s | B | B | 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[4,3-b]pyridine | Human | 10814 | |
| FGFR1 | FGFR | TK | 44ad | A | B | 2-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1~{h}-pyrazol-3-yl]-6-(4-methylpiperazin-1-yl)-1~{h}-benzimidazole | Human | 15672 | |
| FGFR1 | FGFR | TK | 3tt0 | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | Human | 3547 | |
| FGFR1 | FGFR | TK | 1agw | B | B | 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone | Human | 3510 | |
| FGFR1 | FGFR | TK | 8jqi | B | | - | Human | 15678 | |
| FGFR1 | FGFR | TK | 5vnd | B | A | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide | Human | 7647 | |
| FGFR1 | FGFR | TK | 7ozd | A | A | n-[6-(4-hydroxyphenyl)-1h-indazol-3-yl]benzamide | Human | 14007 | |
| FGFR1 | FGFR | TK | 5am7 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3533 | |
| FGFR1 | FGFR | TK | 6mzq | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11171 | |
| FGFR1 | FGFR | TK | 6nvl | D | B | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11398 | |
| FGFR1 | FGFR | TK | 6p69 | B | A | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide | Human | 11331 | |
| FGFR1 | FGFR | TK | 5zv2 | B | | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 10054 | |
| FGFR1 | FGFR | TK | 4v04 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3542 | |
| FGFR1 | FGFR | TK | 4uwy | A | B | - | Human | 3582 | |
| FGFR1 | FGFR | TK | 5a46 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3526 | |
| FGFR1 | FGFR | TK | 4f65 | B | A | 5-bromo-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[3-(2-phenylethyl)-1h-pyrazol-5-yl]pyrimidine-2,4-diamine | Human | 3545 | |
| FGFR1 | FGFR | TK | 1fgk | B | A | - | Human | 3513 | |
| FGFR1 | FGFR | TK | 6c18 | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11168 | |
| FGFR1 | FGFR | TK | 1agw | A | A | 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone | Human | 3520 | |
| FGFR1 | FGFR | TK | 5a4c | A | A | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | Human | 3543 | |
| FGFR1 | FGFR | TK | 4nk9 | B | | n~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3535 | |
| FGFR1 | FGFR | TK | 7ozb | A | B | 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1h-indazol-6-yl]phenol | Human | 14008 | |
| FGFR1 | FGFR | TK | 5ur1 | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 7971 | |
| FGFR1 | FGFR | TK | 4uwy | B | A | - | Human | 3537 | |
| FGFR1 | FGFR | TK | 4f64 | B | A | 5-bromo-n~4~-[3-(3-methoxypropyl)-1h-pyrazol-5-yl]-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3576 | |
| FGFR1 | FGFR | TK | 4rwk | A | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3517 | |
| FGFR1 | FGFR | TK | 1fgi | A | A | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3555 | |
| FGFR1 | FGFR | TK | 3c4f | A | A | 3-(3-methoxybenzyl)-1h-pyrrolo[2,3-b]pyridine | Human | 3515 | |
| FGFR1 | FGFR | TK | 5uq0 | B | A | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide | Human | 7459 | |
| KDR | VEGFR | TK | 4agc | A | | axitinib | Human | 5343 | |
| FGFR1 | FGFR | TK | 6c19 | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11163 | |
| FGFR1 | FGFR | TK | 3ky2 | A | | - | Human | 3534 | |
| FGFR1 | FGFR | TK | 5am6 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3521 | |
| FGFR1 | FGFR | TK | 5o4a | A | A | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | Human | 9554 | |
| FGFR1 | FGFR | TK | 4rwi | B | B | - | Human | 3527 | |
| FGFR1 | FGFR | TK | 5flf | C | B | - | Human | 6466 | |
| FGFR1 | FGFR | TK | 5a4c | B | B | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | Human | 3540 | |
| FGFR1 | FGFR | TK | 5o4a | A | B | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | Human | 9558 | |
| FGFR1 | FGFR | TK | 6c1o | A | A | n-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)prop-2-enamide | Human | 11159 | |
| FGFR1 | FGFR | TK | 5b7v | A | | [5-amino-1-(2-methyl-1h-benzimidazol-6-yl)-1h-pyrazol-4-yl](1h-indol-2-yl)methanone | Human | 6705 | |
| FGFR1 | FGFR | TK | 4nka | A | | n~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3501 | |
| FGFR1 | FGFR | TK | 4zsa | B | B | 4-(4-ethylpiperazin-1-yl)-n-[6-(3-methoxyphenyl)-2h-indazol-3-yl]benzamide | Human | 3512 | |
| FGFR1 | FGFR | TK | 6mzw | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11157 | |
| FGFR1 | FGFR | TK | 6mzq | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11156 | |
| FGFR1 | FGFR | TK | 6itj | B | A | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{h}-pyrazolo[3,4-d]pyridazin-7-one | Human | 11775 | |
| FGFR1 | FGFR | TK | 4f64 | A | B | 5-bromo-n~4~-[3-(3-methoxypropyl)-1h-pyrazol-5-yl]-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3589 | |
| FGFR1 | FGFR | TK | 4uwc | A | A | 3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide | Human | 6019 | |
| FGFR1 | FGFR | TK | 3tt0 | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | Human | 3581 | |
| FGFR1 | FGFR | TK | 4rwl | A | | - | Human | 3516 | |
| FGFR1 | FGFR | TK | 3c4f | A | B | 3-(3-methoxybenzyl)-1h-pyrrolo[2,3-b]pyridine | Human | 3564 | |
| PTK2 (FAK) | FAK | TK | 4ebv | A | A | - | Human | 237 | |
| FGFR1 | FGFR | TK | 5am6 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3494 | |
| FGFR1 | FGFR | TK | 6mzw | B | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10857 | |
| FGFR1 | FGFR | TK | 5am7 | B | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3531 | |
| FGFR1 | FGFR | TK | 6itj | A | A | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{h}-pyrazolo[3,4-d]pyridazin-7-one | Human | 11773 | |
| FGFR1 | FGFR | TK | 6c19 | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10859 | |
| FGFR1 | FGFR | TK | 5flf | C | A | - | Human | 6469 | |
| FGFR1 | FGFR | TK | 6nvl | B | A | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11403 | |
| FGFR1 | FGFR | TK | 7ozb | A | A | 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1h-indazol-6-yl]phenol | Human | 14010 | |
| FGFR1 | FGFR | TK | 5ur1 | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 7970 | |
| FGFR1 | FGFR | TK | 6c1b | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11169 | |
| FGFR1 | FGFR | TK | 3gqi | A | | phosphomethylphosphonic acid adenylate ester | Human | 3566 | |
| FGFR1 | FGFR | TK | 4v05 | B | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3518 | |
| FGFR1 | FGFR | TK | 7ozf | A | A | n-[6-(3-ethoxyphenyl)-1h-indazol-3-yl]benzamide | Human | 14011 | |
| FGFR1 | FGFR | TK | 4rwi | A | B | - | Human | 3551 | |
| FGFR1 | FGFR | TK | 6nvl | A | B | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11401 | |
| EPHB4 (EphB4) | Eph | TK | 6fnl | A | B | - | Human | 10335 | |
| EPHB4 (EphB4) | Eph | TK | 6fnk | A | B | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10337 | |
| EPHB4 (EphB4) | Eph | TK | 4bb4 | A | B | n-(2-methoxyethyl)-4-[(6-pyridin-4-ylquinazolin-2-yl)amino]benzamide | Human | 366 | |
| EPHB4 (EphB4) | Eph | TK | 3zew | A | A | staurosporine | Human | 373 | |
| BMX | Tec | TK | 8x2a | A | B | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 15130 | |
| BMX | Tec | TK | 8x2a | A | A | 4-[(3s)-3-{[(2e)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1h-indole-7-carboxamide | Human | 15131 | |
| CSF1R (FMS) | PDGFR | TK | 2ogv | A | | - | Human | 1243 | |
| CSF1R (FMS) | PDGFR | TK | 7mfc | A | B | vimseltinib | Human | 13989 | |
| CSF1R (FMS) | PDGFR | TK | 7mfc | A | A | vimseltinib | Human | 13990 | |
| CSF1R (FMS) | PDGFR | TK | 6n33 | A | | 6-fluoro-n-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine | Human | 11634 | |
| CSF1R (FMS) | PDGFR | TK | 3krj | A | A | 4-cyano-n-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1h-imidazole-2-carboxamide | Human | 2302 | |
| CSF1R (FMS) | PDGFR | TK | 6ig8 | A | A | (3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2s)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone | Human | 11519 | |
| FGFR1 | FGFR | TK | 3gql | A | | (e)-[4-(3,5-difluorophenyl)-3h-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | Human | 3509 | |
| FGFR1 | FGFR | TK | 6c19 | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10855 | |
| EPHA2 (EphA2) | Eph | TK | 8xpv | A | B | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 15135 | |
| EGFR | EGFR | TK | 8fv3 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 15167 | |
| EGFR | EGFR | TK | 8fv4 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 15166 | |
| EGFR | EGFR | TK | 8fv3 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 15168 | |
| FES | Fer | TK | 3bkb | A | C | staurosporine | Human | 2812 | |
| INSR | InsR | TK | 4ibm | A | A | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one | Human | 589 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bce | C | | - | Human | 2824 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6joi | A | | 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1h-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine | Human | 12102 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqi | A | B | (1~{s})-~{n}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15104 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqj | A | B | - | Human | 15105 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | B | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9478 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqk | A | A | - | Human | 15110 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6jok | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 12105 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5k5x | A | | - | Human | 6962 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 9sxg | A | | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | 15731 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6a32 | A | | - | Human | 11327 | |
| INSR | InsR | TK | 7bw7 | C | | - | Human | 13505 | |
| NTRK1 (TRKA) | Trk | TK | 6dkw | B | A | 5-(1-methyl-1h-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide | Human | 10062 | |
| NTRK1 (TRKA) | Trk | TK | 4yps | A | | 4-{6-[(3r)-3-(3-fluorophenyl)morpholin-4-yl]imidazo[1,2-b]pyridazin-3-yl}benzonitrile | Human | 3615 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | B | B | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3604 | |
| NTRK1 (TRKA) | Trk | TK | 6j5l | A | A | n-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1h-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide | Human | 11436 | |
| NTRK1 (TRKA) | Trk | TK | 5kmm | A | | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-naphthalen-1-yl-urea | Human | 7331 | |
| NTRK1 (TRKA) | Trk | TK | 6nsp | A | B | n-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4h-1,4-benzothiazin-4-yl)acetamide | Human | 11175 | |
| JAK2 | JakA | TK | 5aep | A | B | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3686 | |
| ABL1 | Abl | TK | 6xrg | A | 19 | - | Human | 12886 | |
| FGFR1 | FGFR | TK | 6c1b | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10861 | |
| KIT | PDGFR | TK | 8pqd | A | A | ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]ethanamide | Human | 15113 | |
| KIT | PDGFR | TK | 6gqj | A | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10354 | |
| KIT | PDGFR | TK | 4u0i | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 405 | |
| KIT | PDGFR | TK | 7khg | A | A | 5-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-{[6-(trifluoromethyl)pyridin-3-yl]methyl}pyridin-2-amine | Human | 13786 | |
| KIT | PDGFR | TK | 3g0e | A | A | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 401 | |
| KIT | PDGFR | TK | 8pqg | A | A | (1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15114 | |
| KIT | PDGFR | TK | 6itv | A | A | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11822 | |
| KIT | PDGFR | TK | 8pqa | A | B | 6-(1-methylpyrazol-4-yl)-4-(4-pyrimidin-2-ylpiperazin-1-yl)pyrrolo[2,1-f][1,2,4]triazine | Human | 15115 | |
| KIT | PDGFR | TK | 6gqj | A | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10364 | |
| KIT | PDGFR | TK | 6xvb | A | | ~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12279 | |
| KIT | PDGFR | TK | 1pkg | B | | adenosine-5'-diphosphate | Human | 402 | |
| KIT | PDGFR | TK | 7zw8 | A | A | ~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | Human | 14622 | |
| ABL1 | Abl | TK | 6xrg | A | 18 | - | Human | 12880 | |
| KIT | PDGFR | TK | 7khj | A | | 2-phenyl-5-(1h-pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine | Human | 13789 | |
| KIT | PDGFR | TK | 6gqm | A | | ~{n}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10359 | |
| KIT | PDGFR | TK | 8s16 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 15759 | |
| KIT | PDGFR | TK | 4hvs | A | | 5-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-n-[4-(trifluoromethyl)benzyl]pyridin-2-amine | Human | 403 | |
| KIT | PDGFR | TK | 9sxe | A | | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | 15760 | |
| KIT | PDGFR | TK | 6itt | A | B | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11824 | |
| KIT | PDGFR | TK | 6xv9 | B | | ~{n}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12283 | |
| KIT | PDGFR | TK | 6kla | A | A | n-[6-(4-ethylpiperazin-1-yl)-2-methyl-pyrimidin-4-yl]-5-pyridin-4-yl-1,3-thiazol-2-amine | Human | 11825 | |
| KIT | PDGFR | TK | 6xva | A | | ~{n}-[[3-[2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanoylamino]-5-methyl-phenyl]methyl]propanamide | Human | 12284 | |
| EGFR | EGFR | TK | 7jxk | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 13876 | |
| ABL1 | Abl | TK | 7w7x | A | | 5-[5-(dimethylcarbamoyl)pyridin-3-yl]-3-(5-fluorosulfonyloxy-2-methoxy-phenyl)-1h-pyrrolo[2,3-b]pyridine | Human | 14196 | |
| ABL1 | Abl | TK | 6xr7 | A | 15 | - | Human | 12913 | |
| HCK | Src | TK | 5h0g | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-~{n},4-dimethyl-pentanamide | Human | 8536 | |
| FGFR1 | FGFR | TK | 6p69 | A | B | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide | Human | 11330 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | D | | - | Human | 552 | |
| EPHB1 (EphB1) | Eph | TK | 7kpm | A | B | adenosine-5'-diphosphate | Human | 13382 | |
| DDR2 | DDR | TK | 6fer | F | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10732 | |
| LCK | Src | TK | 2pl0 | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 2290 | |
| IGF1R | InsR | TK | 3d94 | A | A | 3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine | Human | 6759 | |
| IGF1R | InsR | TK | 3f5p | D | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1015 | |
| IGF1R | InsR | TK | 3f5p | J | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1040 | |
| IGF1R | InsR | TK | 3f5p | T | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1037 | |
| IGF1R | InsR | TK | 3f5p | E | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1042 | |
| IGF1R | InsR | TK | 2zm3 | B | | (4z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2h,4h)-dione | Human | 1000 | |
| IGF1R | InsR | TK | 3nw6 | A | | n-(5-cyclopropyl-1h-pyrazol-3-yl)-2-{(2s)-1-[(6-fluoropyridin-3-yl)carbonyl]pyrrolidin-2-yl}pyrrolo[2,1-f][1,2,4]triazin-4-amine | Human | 1043 | |
| IGF1R | InsR | TK | 3f5p | L | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1039 | |
| RET | Ret | TK | 7du8 | A | A | selpercatinib | Human | 14096 | |
| RET | Ret | TK | 2ivs | B | A | (3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide | Human | 3357 | |
| RET | Ret | TK | 7ju5 | B | B | pralsetinib | Human | 13108 | |
| FGFR4 | FGFR | TK | 8kh9 | A | | 1-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea | Human | 15284 | |
| FGFR4 | FGFR | TK | 8kh7 | A | | 1-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea | Human | 15286 | |
| FGFR4 | FGFR | TK | 8kh6 | A | | 1-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[5-bromanyl-6-(hydroxymethyl)-3-methoxy-pyridin-2-yl]urea | Human | 15287 | |
| FGFR4 | FGFR | TK | 8w5c | A | | n-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 15288 | |
| RET | Ret | TK | 4cki | A | C | adenosine | Human | 3368 | |
| RET | Ret | TK | 7ju5 | A | B | pralsetinib | Human | 13109 | |
| FGFR4 | FGFR | TK | 4tyj | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 925 | |
| EGFR | EGFR | TK | 4r3p | A | | - | Human | 827 | |
| EGFR | EGFR | TK | 6v6k | E | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12187 | |
| EGFR | EGFR | TK | 7sz7 | A | | - | Human | 14016 | |
| EGFR | EGFR | TK | 7a6k | A | A | propan-2-yl 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]-2-methoxy-5-(propanoylamino)phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14111 | |
| EGFR | EGFR | TK | 6s9d | A | | 8-oxa-14,21,23,28-tetraazapentacyclo[23.3.1.02,7.014,22.015,20]nonacosa-1(28),2(7),3,5,15,17,19,21,25(29),26-decaen-24-one | Human | 11803 | |
| EGFR | EGFR | TK | 6v6o | C | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12188 | |
| EGFR | EGFR | TK | 4lrm | D | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 786 | |
| EGFR | EGFR | TK | 6tg1 | B | B | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12824 | |
| EGFR | EGFR | TK | 5j9z | A | | (r)-1-(3-(4-amino-3-(1-methyl-1h-indol-3-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6947 | |
| EGFR | EGFR | TK | 9mss | A | | limertinib. bound form | Human | 15859 | |
| EGFR | EGFR | TK | 6v6o | G | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12189 | |
| EGFR | EGFR | TK | 5x2a | A | C | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9539 | |
| EGFR | EGFR | TK | 5ugb | A | | 4-(4-{[2-{[(3s)-1-acetylpyrrolidin-3-yl]amino}-9-(propan-2-yl)-9h-purin-6-yl]amino}phenyl)-1-methylpiperazin-1-ium | Human | 7515 | |
| EGFR | EGFR | TK | 5czh | A | | - | Human | 6111 | |
| EGFR | EGFR | TK | 3ika | B | B | - | Human | 868 | |
| EGFR | EGFR | TK | 5cap | A | A | 2-methyl-n-[2-(2-methyl-2-methylsulfonyl-propoxy)pyrimidin-4-yl]-1-propan-2-yl-imidazo[4,5-c]pyridin-6-amine | Human | 6200 | |
| EGFR | EGFR | TK | 7k1h | A | | (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2h-isoindol-2-yl}-n-(1,3-thiazol-2-yl)acetamide | Human | 13902 | |
| EGFR | EGFR | TK | 6wa2 | A | A | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13434 | |
| EGFR | EGFR | TK | 6v6k | H | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12190 | |
| EGFR | EGFR | TK | 5fed | A | | ~{n}-[7-methyl-1-[(3~{r})-1-propanoylazepan-3-yl]benzimidazol-2-yl]-3-(trifluoromethyl)benzamide | Human | 6882 | |
| EGFR | EGFR | TK | 3ug1 | A | A | - | Human | 864 | |
| EPHA3 (EphA3) | Eph | TK | 4p5q | A | A | 2-amino-1-(2-chlorophenyl)-n-(3-ethoxypropyl)-1h-pyrrolo[2,3-b]quinoxaline-3-carboxamide | Human | 2892 | |
| EGFR | EGFR | TK | 7jxp | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13874 | |
| EPHA2 (EphA2) | Eph | TK | 8boi | A | A | 4-methyl-~{n}-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14645 | |
| EPHA2 (EphA2) | Eph | TK | 5nkc | A | B | (3~{s})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidine-3-carboxylic acid | Human | 8072 | |
| EPHA2 (EphA2) | Eph | TK | 8bod | A | B | ~{n}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14646 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | C | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14512 | |
| EPHA2 (EphA2) | Eph | TK | 7kja | A | A | phosphomethylphosphonic acid adenylate ester | Human | 13250 | |
| EPHA2 (EphA2) | Eph | TK | 5nki | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]-1,3-thiazole-5-carboxamide | Human | 8084 | |
| EPHA2 (EphA2) | Eph | TK | 6het | A | C | - | Human | 11562 | |
| EGFR | EGFR | TK | 5x2a | D | B | phosphoaminophosphonic acid-adenylate ester | Human | 9532 | |
| EGFR | EGFR | TK | 5c8n | A | | n-{2-[4-(2-aminoethyl)-4-methoxypiperidin-1-yl]pyrimidin-4-yl}-2-methyl-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-amine | Human | 6199 | |
| EGFR | EGFR | TK | 5y25 | A | | (2r)-n-[4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]-1-(2-fluoranylethanoyl)pyrrolidine-2-carboxamide | Human | 10373 | |
| EGFR | EGFR | TK | 4wd5 | A | | n-{2-methyl-5-[2-oxo-9-(1h-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1(2h)-yl]phenyl}propanamide | Human | 6594 | |
| EGFR | EGFR | TK | 9gc5 | A | | 1-[2-[5-(1,3-benzoxazol-4-yl)-2,4-bis(fluoranyl)phenyl]-3-pyrimidin-4-yl-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | Human | 15863 | |
| EGFR | EGFR | TK | 6p1d | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 11873 | |
| EGFR | EGFR | TK | 9kl4 | A | | n-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide | Human | 15864 | |
| EGFR | EGFR | TK | 6v6o | H | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12194 | |
| EGFR | EGFR | TK | 5gty | G | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8355 | |
| EGFR | EGFR | TK | 5cnn | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 902 | |
| EGFR | EGFR | TK | 6p1l | A | | phosphoaminophosphonic acid-adenylate ester | Human | 11878 | |
| EGFR | EGFR | TK | 6v6k | G | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12195 | |
| EGFR | EGFR | TK | 5x27 | A | | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9534 | |
| EGFR | EGFR | TK | 5c8m | A | | 2-methyl-n-{2-[4-(methylsulfonyl)piperidin-1-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-amine | Human | 6202 | |
| EGFR | EGFR | TK | 6p1d | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 11872 | |
| EGFR | EGFR | TK | 4g5j | A | A | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 794 | |
| EGFR | EGFR | TK | 9vox | A | | tas-2913 | Human | 15865 | |
| EGFR | EGFR | TK | 6v5n | A | A | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12170 | |
| EGFR | EGFR | TK | 5hcy | A | | 6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]-~{n}-(oxan-4-yl)-1-propan-2-yl-pyrrolo[3,2-c]pyridine-3-carboxamide | Human | 7039 | |
| EGFR | EGFR | TK | 7aei | A | | 5-chloranyl-~{n}2-[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-5-(1-methylpyrazol-4-yl)phenyl]-~{n}4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine | Human | 13619 | |
| EGFR | EGFR | TK | 2itp | A | A | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 880 | |
| EGFR | EGFR | TK | 9nm0 | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-5-{[4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 15866 | |
| EGFR | EGFR | TK | 9by4 | A | | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15867 | |
| EGFR | EGFR | TK | 5cau | A | | (1r)-1-{6-({2-[(3s,4r)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2s)-1,1,1-trifluoropropan-2-yl]-1h-imidazo[4,5-c]pyridin-2-yl}ethanol | Human | 6196 | |
| EGFR | EGFR | TK | 4g5p | B | | - | Human | 788 | |
| EGFR | EGFR | TK | 6tfv | A | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12828 | |
| EGFR | EGFR | TK | 8hv7 | A | | ~{n}-[7-(dimethylamino)-2-methyl-pyrazolo[1,5-a]pyrimidin-5-yl]prop-2-enamide | Human | 15066 | |
| EGFR | EGFR | TK | 6duk | C | A | phosphoaminophosphonic acid-adenylate ester | Human | 11061 | |
| EGFR | EGFR | TK | 3vjo | A | | phosphoaminophosphonic acid-adenylate ester | Human | 777 | |
| EGFR | EGFR | TK | 6p8q | B | B | adenosine monophosphate | Human | 11874 | |
| EGFR | EGFR | TK | 8fv4 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 15165 | |
| EGFR | EGFR | TK | 9vv1 | A | | (4-fluorophenyl)-[4-[[4-(hydroxymethyl)cyclohexyl]amino]-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]methanone | Human | 15875 | |
| EGFR | EGFR | TK | 5gty | B | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8360 | |
| EGFR | EGFR | TK | 6v6k | C | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12207 | |
| EGFR | EGFR | TK | 8hv2 | A | B | ~{n}-pyridin-2-ylprop-2-enamide | Human | 15068 | |
| EGFR | EGFR | TK | 8a2d | A | B | (2r)-2-[4-[bis(fluoranyl)methyl]-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-n-(1,3-thiazol-2-yl)ethanamide | Human | 14461 | |
| EGFR | EGFR | TK | 5jeb | A | | 3-(furan-2-yl)-n-[5-(furan-2-yl)-2-methoxyphenyl]-1h-pyrazolo[3,4-d]pyrimidin-4-amine
| Human | 7038 | |
| EGFR | EGFR | TK | 4zau | A | | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 6221 | |
| EGFR | EGFR | TK | 8a27 | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14462 | |
| EGFR | EGFR | TK | 3w2r | A | B | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 885 | |
| EGFR | EGFR | TK | 3gt8 | C | | phosphoaminophosphonic acid-adenylate ester | Human | 882 | |
| EGFR | EGFR | TK | 7jxw | A | B | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 13877 | |
| EGFR | EGFR | TK | 2eb2 | A | | - | Human | 787 | |
| EGFR | EGFR | TK | 1m17 | A | B | [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine | Human | 905 | |
| EGFR | EGFR | TK | 4rj8 | A | | 1-cyclopentyl-n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1h-pyrrolo[3,2-c]pyridin-6-amine | Human | 899 | |
| EGFR | EGFR | TK | 4li5 | A | B | n-(3-{[5-chloro-4-(1h-indol-3-yl)pyrimidin-2-yl]amino}-4-methoxyphenyl)propanamide | Human | 797 | |
| EGFR | EGFR | TK | 5gty | A | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8363 | |
| EGFR | EGFR | TK | 5ugc | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7518 | |
| EGFR | EGFR | TK | 8hv5 | A | A | ~{n}-(1-methylbenzimidazol-4-yl)prop-2-enamide | Human | 15069 | |
| EGFR | EGFR | TK | 6p1d | C | A | 10-benzyl-8-fluoro-5,10-dihydro-11h-dibenzo[b,e][1,4]diazepin-11-one | Human | 11880 | |
| EGFR | EGFR | TK | 9ght | A | A | (20r)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15h,17h-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6h)-one | Human | 15884 | |
| EGFR | EGFR | TK | 6z4b | A | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 12975 | |
| EGFR | EGFR | TK | 8sc7 | A | A | n-[(5p)-2-chloro-5-(4-{[(1r)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide | Human | 15325 | |
| EGFR | EGFR | TK | 5cas | A | | (1r)-1-{6-({2-[(3r,4s)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2s)-1,1,1-trifluoropropan-2-yl]-1h-imidazo[4,5-c]pyridin-2-yl}ethanol | Human | 6205 | |
| EGFR | EGFR | TK | 1m14 | A | | - | Human | 826 | |
| EGFR | EGFR | TK | 6wak | C | B | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-[(1-oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]benzamide | Human | 13441 | |
| EGFR | EGFR | TK | 2jiv | B | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 812 | |
| EGFR | EGFR | TK | 5cnn | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 791 | |
| EGFR | EGFR | TK | 8a2b | A | A | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14464 | |
| EGFR | EGFR | TK | 6jxt | A | B | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12239 | |
| EGFR | EGFR | TK | 4jrv | A | | 4-(dimethylamino)-n-[3-(4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]butanamide | Human | 857 | |
| EGFR | EGFR | TK | 6jrk | A | | 6-(2-chloranyl-3-fluoranyl-phenyl)-5-methyl-2-[[3-methyl-4-(4-methylpiperazin-1-yl)phenyl]amino]-8-[(3s)-1-propanoylpiperidin-3-yl]pyrido[2,3-d]pyrimidin-7-one | Human | 12159 | |
| EGFR | EGFR | TK | 3lzb | C | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 808 | |
| EGFR | EGFR | TK | 2itt | A | B | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 891 | |
| EGFR | EGFR | TK | 5gty | C | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8358 | |
| EGFR | EGFR | TK | 4zse | D | B | phosphoaminophosphonic acid-adenylate ester | Human | 6700 | |
| EGFR | EGFR | TK | 3lzb | A | | n-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Human | 800 | |
| EGFR | EGFR | TK | 9d3v | A | | (4s)-n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-methyl-1-(propan-2-yl)-1h-imidazo[1,2-b]pyrazol-6-amine | Human | 15886 | |
| EGFR | EGFR | TK | 9ght | A | B | (20r)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15h,17h-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6h)-one | Human | 15887 | |
| EGFR | EGFR | TK | 9mst | A | | befotertinib, bound form | Human | 15888 | |
| EGFR | EGFR | TK | 5x2c | A | B | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9567 | |
| EGFR | EGFR | TK | 6p8q | B | A | adenosine monophosphate | Human | 11867 | |
| EGFR | EGFR | TK | 9h47 | A | | 2-[[4-[2-(dimethylamino)ethyl-methyl-amino]phenyl]amino]-8-phenyl-pyrido[2,3-d]pyrimidin-7-one | Human | 15891 | |
| EGFR | EGFR | TK | 6p1d | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 11883 | |
| EGFR | EGFR | TK | 6jxt | A | A | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 12240 | |
| EGFR | EGFR | TK | 9ewt | A | | 1-[2-[3-[(e)-2-(5-cyclopropyl-1,3-oxazol-2-yl)ethenyl]phenyl]-3-pyridin-4-yl-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | Human | 15900 | |
| EGFR | EGFR | TK | 7a6j | A | A | 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one | Human | 14125 | |
| EGFR | EGFR | TK | 5em7 | A | A | 4-[(2-methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6304 | |
| EGFR | EGFR | TK | 2itp | A | B | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 871 | |
| EGFR | EGFR | TK | 6vh4 | A | | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12183 | |
| EGFR | EGFR | TK | 2jit | A | | - | Human | 888 | |
| EGFR | EGFR | TK | 6p8q | C | A | adenosine monophosphate | Human | 11881 | |
| EGFR | EGFR | TK | 6v6o | B | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12198 | |
| EPHA2 (EphA2) | Eph | TK | 8xpv | A | A | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 15134 | |
| FGFR4 | FGFR | TK | 5xfj | A | | 2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | Human | 10376 | |
| FGFR4 | FGFR | TK | 6nvh | A | B | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11393 | |
| FGFR2 | FGFR | TK | 3ri1 | A | | (6s)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | Human | 503 | |
| FGFR2 | FGFR | TK | 8stg | A | | n-{4-[(5p)-4-amino-5-{3-fluoro-4-[(4-methylpyrimidin-2-yl)oxy]phenyl}-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}-2-methylprop-2-enamide | Human | 14762 | |
| FGFR2 | FGFR | TK | 4j98 | A | A | - | Human | 500 | |
| EPHA2 (EphA2) | Eph | TK | 5i9x | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 7177 | |
| ERBB2 (ErbB2) | EGFR | TK | 8u8x | A | A | 1-{(1r,3r,5s)-3-[(3m)-4-methyl-3-{3-methyl-4-[(1-methyl-1h-benzimidazol-5-yl)oxy]phenyl}-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-8-azabicyclo[3.2.1]octan-8-yl}propan-1-one | Human | 15345 | |
| MST1R (RON) | Met | TK | 8zkd | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 15346 | |
| JAK2 | JakA | TK | 3krr | A | B | 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1h-pyrazol-4-yl)quinoxaline | Human | 3695 | |
| HCK | Src | TK | 3vrz | B | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea | Human | 2661 | |
| SRC | Src | TK | 1yi6 | B | | - | Human | 991 | |
| EGFR | EGFR | TK | 5gty | F | A | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8354 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | A | B | alisertib | Human | 7171 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | C | A | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10415 | |
| EPHA2 (EphA2) | Eph | TK | 5nkf | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)-5-(trifluoromethyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8071 | |
| EPHA2 (EphA2) | Eph | TK | 5nk4 | A | B | 2-[[3-[[(4~{r})-3,3-bis(fluoranyl)piperidin-4-yl]carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8076 | |
| EPHA2 (EphA2) | Eph | TK | 6q7c | A | A | 3-[[4-imidazol-1-yl-6-[(3~{s})-3-oxidanylpiperidin-1-yl]-1,3,5-triazin-2-yl]amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11931 | |
| EPHA2 (EphA2) | Eph | TK | 5nkg | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-ethyl-5-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8090 | |
| EPHA2 (EphA2) | Eph | TK | 6q7f | A | A | 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11929 | |
| EPHA2 (EphA2) | Eph | TK | 6hex | A | B | 4-methyl-3-[(1-methyl-6-pyrazin-2-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11555 | |
| EPHA2 (EphA2) | Eph | TK | 5i9w | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 7187 | |
| EPHB4 (EphB4) | Eph | TK | 2x9f | A | B | n^4^-1h-indazol-4-yl-n^2^-[3-(methylsulfonyl)phenyl]pyrimidine-2,4-diamine | Human | 359 | |
| EPHB4 (EphB4) | Eph | TK | 2vwu | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine | Human | 370 | |
| EPHA2 (EphA2) | Eph | TK | 8bod | A | A | ~{n}-[3,5-bis(chloranyl)phenyl]-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14657 | |
| EPHA2 (EphA2) | Eph | TK | 8bom | A | A | ~{n}-(3-methoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14658 | |
| EPHA2 (EphA2) | Eph | TK | 5ia3 | A | B | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Human | 7184 | |
| EPHA2 (EphA2) | Eph | TK | 5nk9 | A | B | (2~{z})-~{n}-(2-chloranyl-6-methyl-phenyl)-2-[3-[(4-methyl-4-oxidanyl-cyclohexyl)carbamoyl]phenyl]imino-1,3-thiazolidine-5-carboxamide | Human | 8067 | |
| EPHA2 (EphA2) | Eph | TK | 8bok | A | B | ~{n}-(3,5-dimethoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14659 | |
| EPHA2 (EphA2) | Eph | TK | 5nk5 | A | A | 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8068 | |
| JAK2-b | JakB | TK | 5win | A | | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 10378 | |
| EGFR | EGFR | TK | 7lgs | D | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15370 | |
| EGFR | EGFR | TK | 7lgs | C | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15371 | |
| BTK | Tec | TK | 5fbn | D | A | 4-[8-azanyl-3-[(3~{r})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{n}-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 6384 | |
| EGFR | EGFR | TK | 7lgs | B | A | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15372 | |
| EGFR | EGFR | TK | 7lgs | B | B | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15373 | |
| EPHA2 (EphA2) | Eph | TK | 7kjc | B | A | phosphomethylphosphonic acid adenylate ester | Human | 13252 | |
| EGFR | EGFR | TK | 5gnk | A | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(1-methylimidazol-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 7524 | |
| EPHA2 (EphA2) | Eph | TK | 5i9u | A | A | - | Human | 7190 | |
| EPHA2 (EphA2) | Eph | TK | 7kjb | A | | - | Human | 13253 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | B | B | alisertib | Human | 7179 | |
| EPHA2 (EphA2) | Eph | TK | 5nk3 | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{s})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8080 | |
| MET | Met | TK | 9c1r | A | A | n-(2,5-difluoro-4-{[(1s,3s)-3-(1-methyl-1h-pyrazol-3-yl)cyclobutyl][(8r)-pyrazolo[1,5-a]pyrazin-4-yl]amino}phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide | Human | 15368 | |
| MET | Met | TK | 3efj | B | | 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3h)-one | Human | 2957 | |
| MET | Met | TK | 9c1r | A | B | n-(2,5-difluoro-4-{[(1s,3s)-3-(1-methyl-1h-pyrazol-3-yl)cyclobutyl][(8r)-pyrazolo[1,5-a]pyrazin-4-yl]amino}phenyl)-2-(5-fluoropyridin-2-yl)-3-oxo-2,3-dihydropyridazine-4-carboxamide | Human | 15369 | |
| NTRK1 (TRKA) | Trk | TK | 5h3q | A | A | 1-[(3s,4r)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea | Human | 7461 | |
| TYK2-b | JakB | TK | 5tkd | B | B | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7324 | |
| EPHB1 (EphB1) | Eph | TK | 7kpm | A | A | adenosine-5'-diphosphate | Human | 13385 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bbt | D | | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine | Human | 2819 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bbw | B | | - | Human | 2817 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | A | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13313 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | D | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13314 | |
| PTK2 (FAK) | FAK | TK | 6yvy | C | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13268 | |
| PTK2 (FAK) | FAK | TK | 6yvy | D | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13273 | |
| PTK2 (FAK) | FAK | TK | 2etm | A | | 7-pyridin-2-yl-n-(3,4,5-trimethoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 246 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | B | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13328 | |
| PTK2 (FAK) | FAK | TK | 6yxv | B | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13329 | |
| PTK2 (FAK) | FAK | TK | 3pxk | B | | 6-(4,4-dimethylpent-2-yn-1-yl)-1lambda~4~-pyrrolo[2,3-d][1,3]thiazole | Human | 236 | |
| PTK2 (FAK) | FAK | TK | 4ebw | A | C | - | Human | 235 | |
| ALK | ALK | TK | 8arj | A | A | 3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{h}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one | Human | 14366 | |
| ALK | ALK | TK | 3aox | A | B | 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile | Human | 5370 | |
| ALK | ALK | TK | 5iug | A | B | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6639 | |
| ALK | ALK | TK | 4mkc | A | B | 5-chloro-n~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine | Human | 5386 | |
| ALK | ALK | TK | 4dce | B | | (3s)-n-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | Human | 5372 | |
| ALK | ALK | TK | 4fny | A | | n-(4-chlorophenyl)-5-[(6,7-dimethoxyquinolin-4-yl)oxy]-1,3-benzoxazol-2-amine | Human | 5367 | |
| ALK | ALK | TK | 4tt7 | A | A | - | Human | 5406 | |
| ALK | ALK | TK | 5iui | A | B | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6642 | |
| ALK | ALK | TK | 4tt7 | A | B | - | Human | 5382 | |
| ALK | ALK | TK | 4fod | A | B | 4-fluoro-n-{(2e)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2h-benzimidazol-2-ylidene}benzamide | Human | 5404 | |
| ALK | ALK | TK | 2yjr | A | A | - | Human | 5399 | |
| ALK | ALK | TK | 4clj | A | | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 5369 | |
| ALK | ALK | TK | 5iuh | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[3-methyl-4-({[5-(propan-2-yl)-1,2-oxazol-3-yl]carbamoyl}amino)phenyl]-1h-pyrazol-5-yl}benzamide | Human | 6638 | |
| ALK | ALK | TK | 5ftq | A | B | n-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamide | Human | 6518 | |
| ALK | ALK | TK | 4fod | A | A | 4-fluoro-n-{(2e)-6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[cis-4-(propan-2-ylcarbamoyl)cyclohexyl]-1,3-dihydro-2h-benzimidazol-2-ylidene}benzamide | Human | 5383 | |
| ALK | ALK | TK | 8arj | A | B | 3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{h}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one | Human | 14367 | |
| ALK | ALK | TK | 4joa | A | A | 3-[1-(2,5-difluorobenzyl)-1h-pyrazol-4-yl]-5-(1-methyl-1h-pyrazol-4-yl)-1h-pyrrolo[2,3-b]pyridine | Human | 5389 | |
| PTK2B (PYK2) | FAK | TK | 8xox | A | A | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 15171 | |
| PTK2B (PYK2) | FAK | TK | 5to8 | A | | 25-(methylsulfonyl)-8-(trifluoromethyl)-5,17,18,21,22,23,24,25-octahydro-12h-7,11-(azeno)-16,13-(metheno)pyrido[3,2-i]pyrrolo[1,2-q][1,3,7,11,17]pentaazacyclohenicosin-20(6h)-one | Human | 7316 | |
| PTK2B (PYK2) | FAK | TK | 3fzo | A | | - | Human | 95 | |
| PTK2B (PYK2) | FAK | TK | 5tob | A | | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 8686 | |
| PTK2B (PYK2) | FAK | TK | 4h1j | A | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(4-methoxy-2-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 91 | |
| ITK | Tec | TK | 4m12 | A | A | - | Human | 22 | |
| ITK | Tec | TK | 4m0y | A | B | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 70 | |
| ITK | Tec | TK | 1snu | A | | staurosporine | Human | 82 | |
| ITK | Tec | TK | 4m0z | A | B | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 47 | |
| ITK | Tec | TK | 4m12 | A | B | - | Human | 51 | |
| ITK | Tec | TK | 3mj2 | A | | n-[5-({5-[(4-acetylpiperazin-1-yl)carbonyl]-4-methoxy-2-methylphenyl}sulfanyl)-1,3-thiazol-2-yl]-4-({[(1s)-1,2,2-trimethylpropyl]amino}methyl)benzamide | Human | 67 | |
| ITK | Tec | TK | 4ppb | A | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 29 | |
| ITK | Tec | TK | 3v5l | D | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 56 | |
| ITK | Tec | TK | 3v8t | B | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 49 | |
| ITK | Tec | TK | 4kio | B | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 48 | |
| ITK | Tec | TK | 4pp9 | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 40 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | C | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9323 | |
| ERBB2 (ErbB2) | EGFR | TK | 9qbg | A | | - | Human | 16006 | |
| JAK2 | JakA | TK | 4f08 | A | | 1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3662 | |
| CSF1R (FMS) | PDGFR | TK | 6wxj | A | | 4-(3-{[(2s)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3h-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine | Human | 13337 | |
| SYK | Syk | TK | 4gfg | A | | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 1188 | |
| INSR | InsR | TK | 1p14 | A | | - | Human | 593 | |
| INSR | InsR | TK | 1gag | A | | - | Human | 586 | |
| INSR | InsR | TK | 4ibm | B | A | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one | Human | 604 | |
| INSR | InsR | TK | 7bw8 | A | | - | Human | 13502 | |
| INSR | InsR | TK | 8xkm | A | | - | Human | 16054 | |
| INSR | InsR | TK | 5e1s | A | A | (5r)-n-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1h-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5h-pyrazolo[3,4-h]quinazolin-2-amine | Human | 6146 | |
| INSR | InsR | TK | 3ekn | A | B | 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide | Human | 594 | |
| INSR | InsR | TK | 8xkr | E | | - | Human | 16055 | |
| INSR | InsR | TK | 7bw8 | C | | - | Human | 13503 | |
| INSR | InsR | TK | 2auh | A | | - | Human | 584 | |
| INSR | InsR | TK | 3bu3 | A | | - | Human | 591 | |
| INSR | InsR | TK | 9dni | C | | - | Human | 16056 | |
| INSR | InsR | TK | 3eta | B | B | 1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea | Human | 600 | |
| INSR | InsR | TK | 6pxw | A | | - | Human | 11593 | |
| INSR | InsR | TK | 3ekk | A | A | 2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamide | Human | 578 | |
| FGFR1 | FGFR | TK | 4v01 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3590 | |
| MET | Met | TK | 3dkc | A | A | adenosine-5'-triphosphate | Human | 2997 | |
| MET | Met | TK | 3vw8 | A | | n-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamothioyl)-2-phenylacetamide | Human | 2985 | |
| PTK6 (BRK) | Src | TK | 5d7v | C | A | - | Human | 6949 | |
| PTK6 (BRK) | Src | TK | 5h2u | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7343 | |
| NTRK1 (TRKA) | Trk | TK | 6pl1 | A | B | n-(5-{[(7-methyl-4-oxo-4h-pyrido[1,2-a]pyrimidin-2-yl)methyl]sulfanyl}-1,3,4-thiadiazol-2-yl)-n'-[3-(trifluoromethyl)phenyl]urea | Human | 11723 | |
| NTRK1 (TRKA) | Trk | TK | 4pmt | A | B | n~4~-[4-(morpholin-4-yl)phenyl]-n~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine | Human | 3612 | |
| NTRK1 (TRKA) | Trk | TK | 6nsp | A | A | n-(8-methyl-2-phenylimidazo[1,2-a]pyridin-3-yl)-2-(3-oxo-2,3-dihydro-4h-1,4-benzothiazin-4-yl)acetamide | Human | 11173 | |
| NTRK1 (TRKA) | Trk | TK | 4gt5 | A | A | - | Human | 3616 | |
| NTRK1 (TRKA) | Trk | TK | 6dkg | A | B | 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-4-(2-hydroxy-2-methylpropoxy)benzamide | Human | 10063 | |
| NTRK1 (TRKA) | Trk | TK | 6pl3 | A | A | 2-[(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)amino]-2-oxoethyl 4-(1h-tetrazol-1-yl)benzoate | Human | 11599 | |
| NTRK1 (TRKA) | Trk | TK | 6d1y | A | B | 2,4-dichloro-n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)benzamide | Human | 9871 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | B | B | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 12000 | |
| NTRK1 (TRKA) | Trk | TK | 5kmo | A | | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-pyridin-2-yl-urea | Human | 7329 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | A | B | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 12005 | |
| NTRK1 (TRKA) | Trk | TK | 4pmm | A | A | n-(3-cyclopropyl-1-phenyl-1h-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]-1h-1,2,3-triazol-1-yl}acetamide | Human | 3618 | |
| NTRK1 (TRKA) | Trk | TK | 5jfv | A | A | n-{5-[4-amino-7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide | Human | 7504 | |
| FLT3 | PDGFR | TK | 6il3 | A | A | 7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)-3-(pyridin-2-yl)imidazo[1,2-a]pyridine | Human | 10785 | |
| FLT3 | PDGFR | TK | 4rt7 | A | B | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea | Human | 627 | |
| FLT3 | PDGFR | TK | 4xuf | B | | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea | Human | 623 | |
| FLT3 | PDGFR | TK | 8xb1 | A | | 3^3-ethyl-5^4-morpholino-6,9-dioxa-2,4-diaza-3(2,6)-pyrazina-1(4,1)-piperidina-5(1,3)-benzenacycloundecaphane-3^5-carboxamide | Human | 16140 | |
| FLT3 | PDGFR | TK | 5x02 | A | | n-[(2s)-1-[5-[2-[(4-cyanophenyl)amino]-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxidanylidene-propan-2-yl]-4-(dimethylamino)-n-methyl-but-2-enamide | Human | 9522 | |
| FLT3 | PDGFR | TK | 6il3 | A | B | 7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)-3-(pyridin-2-yl)imidazo[1,2-a]pyridine | Human | 10786 | |
| FLT3 | PDGFR | TK | 4rt7 | A | A | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea | Human | 626 | |
| FLT3 | PDGFR | TK | 4xuf | A | | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea | Human | 624 | |
| BTK | Tec | TK | 8yvv | A | A | - | Human | 15353 | |
| BTK | Tec | TK | 7kxq | A | A | 3-tert-butyl-n-[(5r)-2-{2-[3,5-dimethyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-6,7,8,9-tetrahydro-5h-benzo[7]annulen-5-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13562 | |
| BTK | Tec | TK | 8tu3 | A | B | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15354 | |
| BTK | Tec | TK | 7n5x | A | B | 5-(1-ethoxyisoquinolin-3-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13889 | |
| BTK | Tec | TK | 6aub | A | B | 4-tert-butyl-n-[2-methyl-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]benzamide | Human | 10475 | |
| BTK | Tec | TK | 5p9g | A | A | 6-cyclopropyl-8-fluoranyl-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridin-3-yl]phenyl]isoquinolin-1-one | Human | 7635 | |
| BTK | Tec | TK | 6di0 | A | B | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10626 | |
| BTK | Tec | TK | 5p9i | A | A | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7627 | |
| BTK | Tec | TK | 3pix | A | | 7-(4-methylpiperazin-1-yl)-4-[(5-methyl-1h-pyrazol-3-yl)amino]-2-(propan-2-yl)phthalazin-1(2h)-one | Human | 2927 | |
| BTK | Tec | TK | 7kxm | A | B | 4-tert-butyl-n-(2-methyl-3-{2-[4-(morpholine-4-carbonyl)phenyl]-1h-imidazo[4,5-b]pyridin-7-yl}phenyl)benzamide | Human | 13564 | |
| BTK | Tec | TK | 9y56 | A | | 1-{4-[(5-fluoro-2-methoxybenzamido)methyl]phenyl}-4-({6-[(1s)-1-methoxyethyl]-5-[4-(2-methoxyethyl)piperazin-1-yl]pyridin-2-yl}amino)-1h-pyrazole-5-carboxamide | Human | 16160 | |
| BTK | Tec | TK | 6s90 | A | | 4-~{tert}-butyl-~{n}-[2-methyl-3-[6-[4-(4-methylpiperazin-1-yl)carbonylphenyl]-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]benzamide | Human | 11636 | |
| BTK | Tec | TK | 5p9m | A | B | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7639 | |
| BTK | Tec | TK | 3gen | A | A | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2928 | |
| BTK | Tec | TK | 5p9k | A | C | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7626 | |
| BTK | Tec | TK | 4yhf | B | A | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2897 | |
| BTK | Tec | TK | 4rfz | A | | 6-(dimethylamino)-8-fluoro-2-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridin-3-yl)phenyl]isoquinolin-1(2h)-one | Human | 2925 | |
| BTK | Tec | TK | 5p9f | A | A | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 7632 | |
| BTK | Tec | TK | 5p9k | A | A | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7633 | |
| BTK | Tec | TK | 5p9j | A | C | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7640 | |
| BTK | Tec | TK | 6bik | A | B | 4-tert-butyl-n-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide | Human | 10678 | |
| BTK | Tec | TK | 5p9j | A | A | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7637 | |
| BTK | Tec | TK | 5zz4 | D | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10478 | |
| BTK | Tec | TK | 8tu5 | A | A | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15363 | |
| BTK | Tec | TK | 6di5 | A | A | 2-(4-phenoxyphenoxy)-6-[(1s,4s)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]pyridine-3-carboxamide | Human | 10471 | |
| BTK | Tec | TK | 5p9i | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 7642 | |
| BTK | Tec | TK | 7n5o | A | A | 5-(1h-benzimidazol-2-yl)-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 13896 | |
| JAK1 | JakA | TK | 4fk6 | A | B | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1460 | |
| JAK1 | JakA | TK | 6rsc | A | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12468 | |
| JAK1 | JakA | TK | 3eyg | A | A | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1445 | |
| JAK1 | JakA | TK | 4i5c | A | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1446 | |
| JAK1 | JakA | TK | 4ivb | B | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1444 | |
| JAK1 | JakA | TK | 6rsc | B | B | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12469 | |
| JAK1 | JakA | TK | 6smb | B | A | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12244 | |
| JAK1 | JakA | TK | 4fk6 | B | A | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1487 | |
| JAK1 | JakA | TK | 6n7a | A | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11017 | |
| JAK1 | JakA | TK | 4i5c | A | B | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1471 | |
| JAK1 | JakA | TK | 6rsc | A | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12477 | |
| JAK1 | JakA | TK | 6c7y | A | A | adenosine-5'-diphosphate | Human | 9866 | |
| JAK1 | JakA | TK | 6elr | B | B | [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol | Human | 10617 | |
| JAK1 | JakA | TK | 6rsd | A | B | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12478 | |
| JAK1 | JakA | TK | 6rsb | B | | 1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12479 | |
| LCK | Src | TK | 3lck | A | B | - | Human | 2301 | |
| IGF1R | InsR | TK | 3qqu | D | | n~2~-[3-methoxy-4-(morpholin-4-yl)phenyl]-n~4~-(quinolin-3-yl)pyrimidine-2,4-diamine | Human | 997 | |
| ABL1 | Abl | TK | 9yub | A | B | (1s,2s)-n-[2-(4,6-dimethoxypyrimidin-5-yl)-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 16253 | |
| ABL1 | Abl | TK | 9yu9 | A | | (1s,2s)-n-[2-(4,6-dimethoxypyrimidin-5-yl)-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 16254 | |
| ABL1 | Abl | TK | 9yub | A | A | (1s,2s)-n-[2-(4,6-dimethoxypyrimidin-5-yl)-1-methyl-1h-pyrrolo[2,3-c]pyridin-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 16255 | |
| IGF1R | InsR | TK | 3f5p | M | | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile | Human | 1001 | |
| ROR1 | Ror | TK | 6tu9 | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11945 | |
| ROR1 | Ror | TK | 6tu9 | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 11944 | |
| FGFR4 | FGFR | TK | 7yc1 | A | | ~{n}-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-1-propyl-pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 14498 | |
| FGFR4 | FGFR | TK | 7ybx | A | | ~{n}-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-6-bromanyl-5-(hydroxymethyl)-1-(2-morpholin-4-ylethyl)pyrrolo[3,2-b]pyridine-3-carboxamide | Human | 14502 | |
| FGFR4 | FGFR | TK | 6v9c | A | B | n-[(3r,4s)-4-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl]amino}oxolan-3-yl]prop-2-enamide | Human | 12095 | |
| FGFR4 | FGFR | TK | 9k0i | A | | (2~{s})-~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-2-cyano-3-cyclopropyl-propanamide | Human | 15405 | |
| FGFR4 | FGFR | TK | 4xcu | A | A | n-(2-{[6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino}-3-methylphenyl)prop-2-enamide | Human | 928 | |
| FGFR4 | FGFR | TK | 7wct | A | | ~{n}-[2-[[5-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1~{h}-indazol-3-yl]amino]-3-fluoranyl-5-(4-morpholin-4-ylpiperidin-1-yl)phenyl]propanamide | Human | 14167 | |
| FGFR4 | FGFR | TK | 5xff | A | | 2-[4-[e-2-[5-[(1r)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1h-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol | Human | 10375 | |
| FGFR2 | FGFR | TK | 7kia | B | A | 1-[4-(4-{4-(4-methylpiperazin-1-yl)-6-[(3-methyl-1h-pyrazol-5-yl)amino]pyrimidin-2-yl}phenyl)piperidin-1-yl]prop-2-en-1-one | Human | 13281 | |
| FGFR2 | FGFR | TK | 1oec | A | | 4-aryl-2-phenylamino pyrimidine | Human | 479 | |
| FGFR2 | FGFR | TK | 4j95 | C | B | phosphomethylphosphonic acid adenylate ester | Human | 502 | |
| FGFR2 | FGFR | TK | 2py3 | A | | phosphomethylphosphonic acid adenylate ester | Human | 509 | |
| FGFR2 | FGFR | TK | 3cly | A | | phosphomethylphosphonic acid adenylate ester | Human | 522 | |
| FGFR2 | FGFR | TK | 7ozy | A | B | 4-[3-(4-piperazin-4-ium-1-ylphenyl)-1h-indazol-6-yl]phenol | Human | 13998 | |
| FGFR2 | FGFR | TK | 4j99 | C | A | phosphomethylphosphonic acid adenylate ester | Human | 505 | |
| FGFR2 | FGFR | TK | 4j99 | D | C | phosphomethylphosphonic acid adenylate ester | Human | 480 | |
| FGFR2 | FGFR | TK | 4j99 | B | C | phosphomethylphosphonic acid adenylate ester | Human | 491 | |
| FGFR2 | FGFR | TK | 2psq | A | | - | Human | 515 | |
| FGFR2 | FGFR | TK | 2pzr | B | | phosphomethylphosphonic acid adenylate ester | Human | 508 | |
| FGFR2 | FGFR | TK | 5ui0 | A | A | - | Human | 7446 | |
| FGFR2 | FGFR | TK | 4j97 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 527 | |
| FGFR2 | FGFR | TK | 8swe | A | B | n-{4-[4-amino-5-(4-methoxyphenyl)-7-methyl-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl}prop-2-enamide | Human | 15201 | |
| FGFR2 | FGFR | TK | 4j99 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 494 | |
| FGFR2 | FGFR | TK | 5ui0 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 7453 | |
| FGFR2 | FGFR | TK | 3b2t | B | | 5'-o-[(s)-hydroxy{[(s)-hydroxy(methyl)phosphoryl]oxy}phosphoryl]adenosine | Human | 517 | |
| FGFR2 | FGFR | TK | 8w3b | A | B | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 15412 | |
| FGFR2 | FGFR | TK | 4j97 | C | B | phosphomethylphosphonic acid adenylate ester | Human | 487 | |
| FGFR2 | FGFR | TK | 4j97 | D | C | phosphomethylphosphonic acid adenylate ester | Human | 514 | |
| FGFR2 | FGFR | TK | 10oo | A | | (4p)-n-[4-(4-aminopiperidin-1-yl)-2-methoxyphenyl]-5-chloro-4-(1h-indol-3-yl)pyrimidin-2-amine | Human | 15414 | |
| FLT1 | VEGFR | TK | 3hng | A | B | n-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide | Human | 3838 | |
| FLT1 | VEGFR | TK | 3hng | A | A | n-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide | Human | 3837 | |
| EPHA3 (EphA3) | Eph | TK | 2qof | A | A | - | Human | 2888 | |
| EPHA3 (EphA3) | Eph | TK | 2qo2 | A | A | - | Human | 2880 | |
| EPHA3 (EphA3) | Eph | TK | 3fy2 | A | A | - | Human | 2851 | |
| EPHA3 (EphA3) | Eph | TK | 4p5q | A | B | 2-amino-1-(2-chlorophenyl)-n-(3-ethoxypropyl)-1h-pyrrolo[2,3-b]quinoxaline-3-carboxamide | Human | 2878 | |
| EPHA3 (EphA3) | Eph | TK | 4g2f | A | A | 1-amino-5-(5-hydroxy-2-methylphenyl)-7,8,9,10-tetrahydropyrimido[4,5-c]isoquinolin-6(5h)-one | Human | 2843 | |
| EPHA3 (EphA3) | Eph | TK | 4two | A | A | 5-{[3-carbamoyl-4-(3,4-dimethylphenyl)-5-methylthiophen-2-yl]amino}-5-oxopentanoic acid | Human | 2893 | |
| EPHA3 (EphA3) | Eph | TK | 2qol | A | D | - | Human | 2877 | |
| EPHA3 (EphA3) | Eph | TK | 2qo2 | A | B | - | Human | 2886 | |
| EPHA3 (EphA3) | Eph | TK | 2qo9 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 2864 | |
| EPHA3 (EphA3) | Eph | TK | 2qok | A | A | - | Human | 2873 | |
| EPHA3 (EphA3) | Eph | TK | 2qoc | A | C | - | Human | 2871 | |
| EPHA3 (EphA3) | Eph | TK | 2qoi | A | B | - | Human | 2891 | |
| EPHA3 (EphA3) | Eph | TK | 2qoc | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 2882 | |
| EPHA3 (EphA3) | Eph | TK | 2qok | A | C | - | Human | 2884 | |
| EPHA3 (EphA3) | Eph | TK | 2qoo | A | A | - | Human | 2847 | |
| EPHA3 (EphA3) | Eph | TK | 2qok | A | B | - | Human | 2876 | |
| EPHA3 (EphA3) | Eph | TK | 3dzq | A | B | n-[2-methyl-5-({[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide | Human | 2868 | |
| EPHA3 (EphA3) | Eph | TK | 2qof | A | B | - | Human | 2859 | |
| EPHA3 (EphA3) | Eph | TK | 4twn | A | A | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 2846 | |
| EPHA3 (EphA3) | Eph | TK | 4gk4 | A | B | 8-butyl-1-methyl-7-(5-methyl-1h-indazol-4-yl)-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2840 | |
| EPHA3 (EphA3) | Eph | TK | 2qoq | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 2849 | |
| EPHA3 (EphA3) | Eph | TK | 2qoi | A | A | - | Human | 2855 | |
| EPHA3 (EphA3) | Eph | TK | 2qob | A | B | - | Human | 2872 | |
| EPHA3 (EphA3) | Eph | TK | 4gk3 | A | A | 8-butyl-1-methyl-7-(2-methylphenyl)-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 2844 | |
| EPHA3 (EphA3) | Eph | TK | 2gsf | A | | - | Human | 2861 | |
| EPHA3 (EphA3) | Eph | TK | 3fxx | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 2883 | |
| EPHA3 (EphA3) | Eph | TK | 2qol | A | A | - | Human | 2863 | |
| EPHA3 (EphA3) | Eph | TK | 2qol | A | C | - | Human | 2845 | |
| EPHA3 (EphA3) | Eph | TK | 2qod | A | B | - | Human | 2842 | |
| EPHA2 (EphA2) | Eph | TK | 6het | A | A | ~{n}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 11564 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | C | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11934 | |
| EPHA2 (EphA2) | Eph | TK | 6q7g | A | B | 3-[(4-imidazol-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11938 | |
| EPHA2 (EphA2) | Eph | TK | 6hex | A | A | 4-methyl-3-[(1-methyl-6-pyrazin-2-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11559 | |
| EPHA2 (EphA2) | Eph | TK | 5nk2 | A | B | - | Human | 8060 | |
| EPHA2 (EphA2) | Eph | TK | 5nk8 | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8062 | |
| EPHA2 (EphA2) | Eph | TK | 4pdo | B | | - | Human | 2087 | |
| EPHA2 (EphA2) | Eph | TK | 5ia5 | A | A | golvatinib | Human | 7192 | |
| EPHA2 (EphA2) | Eph | TK | 6fng | A | A | 4-methyl-3-[(2-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 10414 | |
| EPHA2 (EphA2) | Eph | TK | 5njz | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8093 | |
| EPHA2 (EphA2) | Eph | TK | 5nk3 | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{s})-pyrrolidin-3-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8092 | |
| EPHA2 (EphA2) | Eph | TK | 8qqy | A | A | 6-(4-fluoranyl-3-methoxy-phenyl)-13$l^{6}-thia-2,4,8,12,19-pentazatricyclo[12.3.1.1^{3,7}]nonadeca-1(18),3,5,7(19),14,16-hexaene 13,13-dioxide | Human | 15001 | |
| EPHA2 (EphA2) | Eph | TK | 5nk2 | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{r},4~{r})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8100 | |
| EPHA2 (EphA2) | Eph | TK | 5nk2 | A | C | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{r},4~{r})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8065 | |
| EPHA2 (EphA2) | Eph | TK | 1mqb | B | | phosphoaminophosphonic acid-adenylate ester | Human | 2089 | |
| EPHA2 (EphA2) | Eph | TK | 8bom | A | B | ~{n}-(3-methoxyphenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 14653 | |
| EPHA2 (EphA2) | Eph | TK | 5i9v | A | A | phosphothiophosphoric acid-adenylate ester | Human | 7188 | |
| EPHA2 (EphA2) | Eph | TK | 5i9u | A | B | - | Human | 7185 | |
| EPHA2 (EphA2) | Eph | TK | 5ia2 | A | A | 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1h-imidazo[2,1-f]purine-2,4(3h,8h)-dione | Human | 7170 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | B | A | alisertib | Human | 7174 | |
| EPHA2 (EphA2) | Eph | TK | 6heu | A | A | 3-[(4,6-dipyridin-4-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11563 | |
| EPHA2 (EphA2) | Eph | TK | 6hev | A | A | 4-methyl-3-[(2-pyridin-3-ylpyrido[2,3-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11561 | |
| EPHA2 (EphA2) | Eph | TK | 6hey | A | A | 3-[(4,6-dipyridin-3-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11557 | |
| EPHA2 (EphA2) | Eph | TK | 7kjc | B | B | phosphomethylphosphonic acid adenylate ester | Human | 13254 | |
| EPHA2 (EphA2) | Eph | TK | 5ia3 | A | A | 6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-one | Human | 7193 | |
| EPHA2 (EphA2) | Eph | TK | 5njz | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-(piperidin-4-ylcarbamoyl)phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8085 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | A | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14514 | |
| EPHA2 (EphA2) | Eph | TK | 6fnh | A | B | 1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 10418 | |
| EPHA2 (EphA2) | Eph | TK | 5ia5 | A | B | golvatinib | Human | 7183 | |
| EPHA2 (EphA2) | Eph | TK | 8bin | A | B | 8-(4-azanylbutyl)-6-(2-chlorophenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one | Human | 14515 | |
| EPHA2 (EphA2) | Eph | TK | 6hew | A | B | 4-methyl-3-[(1-methyl-6-pyrimidin-5-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11556 | |
| EPHA2 (EphA2) | Eph | TK | 5ia0 | A | A | alisertib | Human | 7169 | |
| EPHA2 (EphA2) | Eph | TK | 5nki | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]-1,3-thiazole-5-carboxamide | Human | 8069 | |
| EPHA2 (EphA2) | Eph | TK | 5nkb | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[(3,5-dimorpholin-4-ylphenyl)amino]-1,3-thiazole-5-carboxamide | Human | 8097 | |
| EPHA2 (EphA2) | Eph | TK | 5nkd | A | A | 2-[(3~{r})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidin-3-yl]ethanoic acid | Human | 8058 | |
| EPHA2 (EphA2) | Eph | TK | 5i9v | A | B | phosphothiophosphoric acid-adenylate ester | Human | 7173 | |
| EPHA2 (EphA2) | Eph | TK | 7kjc | A | B | phosphomethylphosphonic acid adenylate ester | Human | 13256 | |
| EPHA2 (EphA2) | Eph | TK | 5nkb | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[(3,5-dimorpholin-4-ylphenyl)amino]-1,3-thiazole-5-carboxamide | Human | 8098 | |
| EPHA2 (EphA2) | Eph | TK | 5nk8 | A | B | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[(2,2,6,6-tetramethyl-1-oxidanyl-piperidin-4-yl)carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8088 | |
| EPHA2 (EphA2) | Eph | TK | 5ek7 | A | | - | Human | 6322 | |
| EPHA2 (EphA2) | Eph | TK | 6q7f | A | B | 3-[(4-imidazol-1-yl-6-piperazin-1-yl-1,3,5-triazin-2-yl)amino]-4-methyl-~{n}-[3-(trifluoromethyl)phenyl]benzamide | Human | 11936 | |
| EPHA2 (EphA2) | Eph | TK | 6het | A | B | ~{n}-(3-chlorophenyl)-4-methyl-3-[(1-methyl-6-pyridin-3-yl-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide | Human | 11560 | |
| EPHA2 (EphA2) | Eph | TK | 5nk5 | A | B | 2-[[3-[(3-aminophenyl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8066 | |
| EPHA2 (EphA2) | Eph | TK | 5nkc | A | A | (3~{s})-1-[3-[[5-[(2-chloranyl-6-methyl-phenyl)carbamoyl]-1,3-thiazol-2-yl]amino]phenyl]carbonylpyrrolidine-3-carboxylic acid | Human | 8099 | |
| EPHA2 (EphA2) | Eph | TK | 5nk1 | A | B | 2-[[3-[(4-azanyl-6-methyl-1,3,5-triazin-2-yl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8059 | |
| EPHA2 (EphA2) | Eph | TK | 7kjc | A | A | phosphomethylphosphonic acid adenylate ester | Human | 13257 | |
| EPHA2 (EphA2) | Eph | TK | 5nk7 | A | A | ~{n}-(2-chloranyl-6-methyl-phenyl)-2-[[3-[[(3~{r},4~{r})-3-fluoranylpiperidin-4-yl]carbamoyl]phenyl]amino]-1,3-thiazole-5-carboxamide | Human | 8089 | |
| EPHA2 (EphA2) | Eph | TK | 4pdo | A | | - | Human | 2086 | |
| EPHA2 (EphA2) | Eph | TK | 5nk0 | A | A | 2-[[3-[(3-azanyl-2,2-dimethyl-propyl)carbamoyl]phenyl]amino]-~{n}-(2-chloranyl-6-methyl-phenyl)-1,3-thiazole-5-carboxamide | Human | 8095 | |
| MERTK (MER) | Axl | TK | 5u6c | A | A | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8251 | |
| MERTK (MER) | Axl | TK | 7aay | A | B | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 12935 | |
| MERTK (MER) | Axl | TK | 7ab2 | A | B | 4-[2-(butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol | Human | 12936 | |
| MERTK (MER) | Axl | TK | 7olv | A | | 4-[4-[5-[imidazo[1,2-a]pyridin-6-ylmethyl(methyl)amino]-1,3,4-oxadiazol-2-yl]-3-methyl-phenyl]-2,5-dimethyl-pyrazole-3-carbonitrile | Human | 13898 | |
| MERTK (MER) | Axl | TK | 3bpr | C | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 276 | |
| MERTK (MER) | Axl | TK | 3bpr | B | A | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 281 | |
| MERTK (MER) | Axl | TK | 3brb | B | A | adenosine-5'-diphosphate | Human | 267 | |
| MERTK (MER) | Axl | TK | 5u6c | A | B | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8253 | |
| MERTK (MER) | Axl | TK | 3tcp | B | | 1-[(trans-4-aminocyclohexyl)methyl]-n-butyl-3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-6-amine | Human | 285 | |
| MERTK (MER) | Axl | TK | 7aax | A | A | ~{n}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide | Human | 12938 | |
| MERTK (MER) | Axl | TK | 7ab0 | A | B | - | Human | 12939 | |
| MERTK (MER) | Axl | TK | 7avx | B | | 1-(4-fluorophenyl)-n-[3-fluoro-4-[(3-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide | Human | 13375 | |
| MERTK (MER) | Axl | TK | 5u6c | B | A | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8250 | |
| MERTK (MER) | Axl | TK | 7aay | A | A | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 12940 | |
| MERTK (MER) | Axl | TK | 7aw4 | B | A | 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)-n-((r)-1-(((r)-3-(methylamino)-3-oxo-1-(4-(trifluoromethyl)phenyl)propyl)amino)-1-oxo-4-phenylbutan-2-yl)isoxazole-4-carboxamide | Human | 13376 | |
| MERTK (MER) | Axl | TK | 7aw2 | A | | 5-(2'-chloro-[1,1'-biphenyl]-4-yl)-n-(imidazo[1,2-a]pyridin-6-ylmethyl)-n-methyl-1,3,4-oxadiazol-2-amine | Human | 13377 | |
| MERTK (MER) | Axl | TK | 5td2 | B | B | - | Human | 7382 | |
| MERTK (MER) | Axl | TK | 3tcp | A | | 1-[(trans-4-aminocyclohexyl)methyl]-n-butyl-3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-6-amine | Human | 272 | |
| MERTK (MER) | Axl | TK | 7ols | A | | 5-[4-(1,5-dimethylpyrazol-4-yl)-2-methyl-phenyl]-~{n}-(imidazo[1,2-a]pyridin-6-ylmethyl)-~{n}-methyl-1,3,4-oxadiazol-2-amine | Human | 13899 | |
| MERTK (MER) | Axl | TK | 6mep | B | | cis-4-[(2-[(4-{[4-(1,3-dioxolan-2-yl)pyridin-2-yl]ethynyl}phenyl)amino]-5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}pyrimidin-4-yl)amino]cyclohexan-1-ol | Human | 11601 | |
| MERTK (MER) | Axl | TK | 7aax | A | B | ~{n}-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluoranyl-phenyl]-4-ethoxy-1-(4-fluoranyl-2-methyl-phenyl)pyrazole-3-carboxamide | Human | 12941 | |
| MERTK (MER) | Axl | TK | 3bpr | A | B | 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine | Human | 263 | |
| EPHB4 (EphB4) | Eph | TK | 2vwx | A | B | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide | Human | 350 | |
| EPHB4 (EphB4) | Eph | TK | 3zew | A | B | staurosporine | Human | 377 | |
| EPHB4 (EphB4) | Eph | TK | 2vwv | A | A | n'-(3-chloro-4-methoxy-phenyl)-n-(3,4,5-trimethoxyphenyl)-1,3,5-triazine-2,4-diamine | Human | 365 | |
| EPHB4 (EphB4) | Eph | TK | 3zew | B | B | staurosporine | Human | 357 | |
| EPHB4 (EphB4) | Eph | TK | 2vx1 | A | A | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzamide | Human | 371 | |
| EPHB4 (EphB4) | Eph | TK | 2vww | A | A | n'-(5-chloro-1,3-benzodioxol-4-yl)-n-(3,4,5- trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 356 | |
| JAK2-b | JakB | TK | 5wil | A | | 5-(3-fluorophenyl)-n-[(3s)-3-piperidyl]-3-ureido-thiophene-2-carboxamide | Human | 10379 | |
| JAK2-b | JakB | TK | 5ut6 | A | A | 4-({4-amino-6-[3-(hydroxymethyl)-1h-pyrazol-1-yl]pyrimidin-2-yl}amino)benzonitrile | Human | 8036 | |
| JAK2-b | JakB | TK | 5i4n | A | A | adenosine-5'-triphosphate | Human | 6525 | |
| JAK2-b | JakB | TK | 6g3c | B | A | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10977 | |
| JAK2-b | JakB | TK | 6bs0 | A | A | 4-(5-aminopyrazin-2-yl)-1h-pyrrolo[2,3-b]pyridin-6-amine | Human | 10380 | |
| JAK2-b | JakB | TK | 6bs0 | A | B | 4-(5-aminopyrazin-2-yl)-1h-pyrrolo[2,3-b]pyridin-6-amine | Human | 10381 | |
| JAK2-b | JakB | TK | 5ut1 | A | A | (7s)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5h)-one | Human | 8046 | |
| JAK2-b | JakB | TK | 6d2i | A | | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}urea | Human | 10967 | |
| JAK2-b | JakB | TK | 6g3c | B | B | 2-[[3,5-bis(fluoranyl)-4-oxidanyl-phenyl]amino]-5,7,7-trimethyl-8-(3-methylbutyl)pteridin-6-one | Human | 10975 | |
| JAK2-b | JakB | TK | 6d2i | B | | 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1h-benzimidazol-2-yl]-1h-pyrazol-4-yl}urea | Human | 10966 | |
| JAK2-b | JakB | TK | 6obb | A | | 5-amino-n-phenyl-3-[(4-sulfamoylphenyl)amino]-1h-1,2,4-triazole-1-carboxamide | Human | 12097 | |
| JAK2-b | JakB | TK | 4fvp | A | | - | Human | 1222 | |
| FES | Fer | TK | 4e93 | A | B | 5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine | Human | 2809 | |
| EGFR | EGFR | TK | 4lrm | A | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 901 | |
| EGFR | EGFR | TK | 4g5p | A | | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 809 | |
| FGFR3 | FGFR | TK | 8udu | A | A | 3-[(6-chloro-1-cyclopropyl-1h-benzimidazol-5-yl)ethynyl]-1-[(3s,5s)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15205 | |
| FGFR3 | FGFR | TK | 8udt | A | | 3-[(1-cyclopropyl-4,6-difluoro-1h-benzimidazol-5-yl)ethynyl]-1-[(3r,5r)-5-(methoxymethyl)-1-propanoylpyrrolidin-3-yl]-5-(methylamino)-1h-pyrazole-4-carboxamide | Human | 15206 | |
| NTRK2 (TRKB) | Trk | TK | 4at4 | A | | 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea | Human | 3598 | |
| NTRK2 (TRKB) | Trk | TK | 4at5 | A | | 5-{3-methoxy-4-[(4-methoxybenzyl)oxy]benzyl}pyrimidine-2,4-diamine | Human | 3597 | |
| JAK3 | JakA | TK | 6db4 | A | B | n-[(1s)-6-(5-phenyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10721 | |
| JAK3 | JakA | TK | 6gl9 | A | B | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10016 | |
| JAK3 | JakA | TK | 9r5z | A | | 3-(3-cyclohexyl-3,8,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-5-yl)benzenesulfonyl fluoride | Human | 15522 | |
| JAK3 | JakA | TK | 5w86 | C | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8550 | |
| JAK3 | JakA | TK | 6dud | A | A | n-[(1s)-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]imidoformamide | Human | 10722 | |
| JAK3 | JakA | TK | 6hzv | C | A | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11752 | |
| JAK3 | JakA | TK | 6gla | A | B | (~{e})-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | Human | 10012 | |
| JAK3 | JakA | TK | 7apg | A | A | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13134 | |
| JAK3 | JakA | TK | 6glb | A | A | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10020 | |
| JAK3 | JakA | TK | 4qps | A | A | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 453 | |
| JAK3 | JakA | TK | 6glb | B | B | 3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)furan-2-yl]propanenitrile | Human | 10015 | |
| JAK3 | JakA | TK | 5lwm | A | A | 2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-~{n},~{n}-dimethyl-prop-2-enamide | Human | 7115 | |
| JAK3 | JakA | TK | 7q6h | A | B | 1-[4-[[2-[(1-methylpyrazol-4-yl)amino]quinazolin-8-yl]amino]piperidin-1-yl]ethanone | Human | 14082 | |
| JAK3 | JakA | TK | 4qps | C | A | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 435 | |
| JAK3 | JakA | TK | 1yvj | A | B | 1,2,3,4-tetrahydrogen-staurosporine | Human | 451 | |
| JAK3 | JakA | TK | 4qt1 | A | | 1-{(3s)-1-[(2-methylpropyl)sulfonyl]piperidin-3-yl}-3-(5h-pyrrolo[2,3-b]pyrazin-2-yl)urea | Human | 452 | |
| JAK3 | JakA | TK | 6gl9 | B | B | (~{e})-3-[3-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2(6),4,7,11-pentaen-4-yl)phenyl]prop-2-enenitrile | Human | 10013 | |
| JAK3 | JakA | TK | 7apf | B | A | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13137 | |
| JAK3 | JakA | TK | 4hvd | A | | 2-cyclopropyl-n-[(2s)-3,3-dimethylbutan-2-yl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 431 | |
| JAK3 | JakA | TK | 4qps | C | B | n-{1-[6-(phenylamino)pyrazin-2-yl]-1h-benzimidazol-6-yl}prop-2-enamide | Human | 455 | |
| JAK3 | JakA | TK | 3zep | A | A | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 448 | |
| JAK3 | JakA | TK | 4v0g | B | B | n-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1h-pyrazol-4-yl]pyrazin-2-yl}-1h-benzimidazol-1-yl)phenyl]propanamide | Human | 6345 | |
| JAK3 | JakA | TK | 4z16 | B | | n-(3-{[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]methyl}phenyl)prop-2-enamide | Human | 6396 | |
| JAK3 | JakA | TK | 6db3 | A | B | [(1s)-1-methyl-6-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1h-inden-1-yl]cyanamide | Human | 10719 | |
| JAK3 | JakA | TK | 7c3n | A | C | 3-[(3s,4r)-3-methyl-7-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1,7-diazaspiro[3.4]octan-1-yl]-3-oxidanylidene-propanenitrile | Human | 12390 | |
| JAK3 | JakA | TK | 5ttv | A | B | n-[3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]propanamide | Human | 7436 | |
| JAK3 | JakA | TK | 8rpn | A | | 3-[4-[[(3~{r})-1-(2-cyanoethanoyl)piperidin-3-yl]amino]pyrimidin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 15523 | |
| JAK3 | JakA | TK | 7apg | C | B | ~{n}-[3-(1~{h}-pyrrolo[2,3-b]pyridin-3-yl)phenyl]propanamide | Human | 13139 | |
| JAK3 | JakA | TK | 5w86 | D | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8548 | |
| JAK3 | JakA | TK | 5w86 | A | A | 4-(benzylamino)-6-({4-[(1-methylpiperidin-4-yl)carbamoyl]phenyl}amino)pyridine-3-carboxamide | Human | 8549 | |
| JAK3 | JakA | TK | 7apf | A | A | 3-[3-(propanoylamino)phenyl]-1~{h}-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 13141 | |
| JAK3 | JakA | TK | 3zep | D | B | 2-[[(3r)-3-acetamido-2,3-dihydro-1h-inden-5-yl]oxy]-n-[(1s)-1-cyclopropylethyl]-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 457 | |
| JAK3 | JakA | TK | 3zc6 | B | A | n-[(2r)-1-(3-cyanoazetidin-1-yl)-1-oxidanylidene-propan-2-yl]-2-(6-fluoranyl-1-methyl-indazol-3-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 449 | |
| JAK3 | JakA | TK | 6hzv | A | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11751 | |
| JAK3 | JakA | TK | 6hzv | D | B | 3-[7-(2-hydroxyethyl)-9-(oxan-4-yl)-8-oxidanylidene-purin-2-yl]imidazo[1,2-a]pyridine-6-carbonitrile | Human | 11750 | |
| TNK2 (ACK) | Ack | TK | 1u46 | B | | - | Human | 3408 | |
| TNK2 (ACK) | Ack | TK | 1u54 | B | | phosphomethylphosphonic acid adenylate ester | Human | 3397 | |
| TNK2 (ACK) | Ack | TK | 4hzr | A | A | - | Human | 3394 | |
| DDR1 | DDR | TK | 6fex | A | B | 2-[4-bromanyl-2-oxidanylidene-1'-(1~{h}-pyrazolo[4,3-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10744 | |
| DDR1 | DDR | TK | 5bvw | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 3254 | |
| DDR1 | DDR | TK | 6gwr | B | A | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10486 | |
| DDR1 | DDR | TK | 4ckr | A | B | 4-[(4-ethylpiperazin-1-yl)methyl]-n-{4-methyl-3-[(2-oxo-2,3-dihydro-1h-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide | Human | 3252 | |
| DDR1 | DDR | TK | 5sax | A | B | 2-{3-[(pyridin-3-yl)ethynyl]phenyl}-n-[3-(trifluoromethyl)phenyl]acetamide | Human | 14263 | |
| DDR1 | DDR | TK | 6gwr | A | A | 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{n}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide | Human | 10485 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | I | | - | Human | 559 | |
| EPHB1 (EphB1) | Eph | TK | 6umw | A | B | 7-chlorotetracycline | Human | 12923 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | C | | - | Human | 557 | |
| EPHB1 (EphB1) | Eph | TK | 5mjb | B | | 2-chloranyl-~{n}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide | Human | 7585 | |
| EPHB1 (EphB1) | Eph | TK | 5mja | A | | 2-chloranyl-~{n}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide | Human | 7582 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | H | | - | Human | 556 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | B | | - | Human | 558 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | E | | - | Human | 555 | |
| EPHB1 (EphB1) | Eph | TK | 3zfx | F | | - | Human | 553 | |
| ROR2 | Ror | TK | 4gt4 | A | B | - | Human | 409 | |
| ROR2 | Ror | TK | 4gt4 | B | A | - | Human | 413 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bbw | A | | - | Human | 2820 | |
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | B | B | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2823 | |
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | A | B | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2827 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bce | A | | - | Human | 2821 | |
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | B | A | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2818 | |
| ERBB4 (ErbB4) | EGFR | TK | 3bce | B | | - | Human | 2826 | |
| ERBB4 (ErbB4) | EGFR | TK | 2r4b | A | A | n-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-ethylthieno[3,2-d]pyrimidin-4-amine | Human | 2822 | |
| ALK | ALK | TK | 4fnz | A | | (3s)-n-[3-(trifluoromethoxy)benzyl]-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | Human | 5397 | |
| ALK | ALK | TK | 5aaa | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6683 | |
| ALK | ALK | TK | 4cmt | A | | 3-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}-5-[3-(methylsulfonyl)phenyl]pyridin-2-amine | Human | 5371 | |
| ALK | ALK | TK | 5aab | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6681 | |
| ALK | ALK | TK | 4fnw | A | | - | Human | 5403 | |
| ALK | ALK | TK | 5fto | A | A | entrectinib | Human | 6520 | |
| ALK | ALK | TK | 4ctc | A | | (10r)-7-amino-3-cyclopropyl-12-fluoro-1,10,16-trimethyl-16,17-dihydro-1h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 5364 | |
| ALK | ALK | TK | 3l9p | A | B | - | Human | 5375 | |
| ALK | ALK | TK | 4mkc | A | A | 5-chloro-n~2~-[5-methyl-4-(piperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]pyrimidine-2,4-diamine | Human | 5401 | |
| ALK | ALK | TK | 4cmo | A | | 2-[(1r)-1-{[3-amino-6-(2-methoxypyridin-3-yl)pyrazin-2-yl]oxy}ethyl]-4-fluoro-n-methylbenzamide | Human | 5391 | |
| ABL1 | Abl | TK | 6xr7 | A | 5 | - | Human | 12857 | |
| ABL1 | Abl | TK | 6xr6 | A | 5 | - | Human | 12858 | |
| ABL1 | Abl | TK | 2hz4 | B | | 1,2,3,4-tetrahydrogen-staurosporine | Human | 1058 | |
| ABL1 | Abl | TK | 2hz0 | B | B | 2-{[(6-oxo-1,6-dihydropyridin-3-yl)methyl]amino}-n-[4-propyl-3-(trifluoromethyl)phenyl]benzamide | Human | 1109 | |
| ABL1 | Abl | TK | 6xr7 | A | 16 | - | Human | 12859 | |
| ABL1 | Abl | TK | 6xr7 | A | 12 | - | Human | 12860 | |
| ABL1 | Abl | TK | 3cs9 | B | B | nilotinib | Human | 1112 | |
| ABL1 | Abl | TK | 2hz0 | A | B | 2-{[(6-oxo-1,6-dihydropyridin-3-yl)methyl]amino}-n-[4-propyl-3-(trifluoromethyl)phenyl]benzamide | Human | 1083 | |
| ABL1 | Abl | TK | 6npv | B | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10949 | |
| ABL1 | Abl | TK | 2hyy | C | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1048 | |
| ABL1 | Abl | TK | 6npv | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10948 | |
| ABL1 | Abl | TK | 3pyy | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1098 | |
| ABL1 | Abl | TK | 3pyy | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1071 | |
| ABL1 | Abl | TK | 6bl8 | B | A | purvalanol b | Human | 9701 | |
| ABL1 | Abl | TK | 6xr7 | A | 8 | - | Human | 12863 | |
| ABL1 | Abl | TK | 6xrg | A | 8 | - | Human | 12864 | |
| ABL1 | Abl | TK | 6xr6 | A | 12 | - | Human | 12871 | |
| ABL1 | Abl | TK | 3qri | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1103 | |
| ABL1 | Abl | TK | 2hyy | B | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1078 | |
| ABL1 | Abl | TK | 2hzi | B | A | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1108 | |
| ABL1 | Abl | TK | 6xr6 | A | 17 | - | Human | 12874 | |
| ABL1 | Abl | TK | 6npv | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10950 | |
| ABL1 | Abl | TK | 3qri | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1051 | |
| ABL1 | Abl | TK | 6xrg | A | 14 | - | Human | 12875 | |
| ABL1 | Abl | TK | 6bl8 | B | B | purvalanol b | Human | 9700 | |
| ABL1 | Abl | TK | 6xrg | A | 6 | - | Human | 12876 | |
| ABL1 | Abl | TK | 2v7a | A | | n-[(3e)-5-[(2r)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5h)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide | Human | 1088 | |
| ABL1 | Abl | TK | 6xr6 | A | 2 | - | Human | 12878 | |
| ABL1 | Abl | TK | 7w7y | A | | 5-[3-(5-methanoyl-2-methoxy-4-oxidanyl-phenyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-~{n},~{n}-dimethyl-pyridine-3-carboxamide | Human | 14195 | |
| ABL1 | Abl | TK | 2g2i | B | | adenosine-5'-diphosphate | Human | 1075 | |
| ABL1 | Abl | TK | 2hiw | A | | 7-amino-1-methyl-3-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium | Human | 1069 | |
| ABL1 | Abl | TK | 6xr7 | A | 19 | - | Human | 12879 | |
| ABL1 | Abl | TK | 2g2h | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1106 | |
| ABL1 | Abl | TK | 2g1t | D | | - | Human | 1096 | |
| ABL1 | Abl | TK | 6npe | B | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10945 | |
| ABL1 | Abl | TK | 6xr6 | A | 7 | - | Human | 12881 | |
| ABL1 | Abl | TK | 2hz4 | C | | - | Human | 1067 | |
| ABL1 | Abl | TK | 4zog | A | | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 7043 | |
| ABL1 | Abl | TK | 2g1t | B | | - | Human | 1105 | |
| ABL1 | Abl | TK | 5hu9 | A | B | 4-[(4-methylpiperazin-1-yl)methyl]-n-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide | Human | 6755 | |
| ABL1 | Abl | TK | 2hz0 | A | A | 2-{[(6-oxo-1,6-dihydropyridin-3-yl)methyl]amino}-n-[4-propyl-3-(trifluoromethyl)phenyl]benzamide | Human | 1052 | |
| ABL1 | Abl | TK | 6xr7 | A | 4 | - | Human | 12894 | |
| ABL1 | Abl | TK | 6xrg | A | 2 | - | Human | 12895 | |
| ABL1 | Abl | TK | 4zog | B | | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 7042 | |
| ABL1 | Abl | TK | 6xr6 | A | 6 | - | Human | 12896 | |
| ABL1 | Abl | TK | 6xr7 | A | 6 | - | Human | 12897 | |
| ABL1 | Abl | TK | 3cs9 | A | A | nilotinib | Human | 1080 | |
| ABL1 | Abl | TK | 6xr6 | A | 4 | - | Human | 12898 | |
| ABL1 | Abl | TK | 2hyy | D | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1068 | |
| ABL1 | Abl | TK | 6xr6 | A | 10 | - | Human | 12901 | |
| ABL1 | Abl | TK | 2hiw | B | | 7-amino-1-methyl-3-(2-methyl-5-{[3-(trifluoromethyl)benzoyl]amino}phenyl)-2-oxo-2,3-dihydropyrimido[4,5-d]pyrimidin-1-ium | Human | 1110 | |
| ABL1 | Abl | TK | 7n9g | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 14197 | |
| ABL1 | Abl | TK | 4yc8 | A | | 2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-n-(4-phenoxyphenyl)-1,3-thiazole-5-carboxamide | Human | 6419 | |
| ABL1 | Abl | TK | 3qrj | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1099 | |
| ABL1 | Abl | TK | 6xr6 | A | 16 | - | Human | 12902 | |
| ABL1 | Abl | TK | 6xr7 | A | 10 | - | Human | 12903 | |
| ABL1 | Abl | TK | 3qrj | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1085 | |
| ABL1 | Abl | TK | 6npe | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10943 | |
| ABL1 | Abl | TK | 2gqg | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1060 | |
| ABL1 | Abl | TK | 6bl8 | A | B | purvalanol b | Human | 9698 | |
| ABL1 | Abl | TK | 6xr6 | A | 8 | - | Human | 12906 | |
| ABL1 | Abl | TK | 2g2i | A | | adenosine-5'-diphosphate | Human | 1111 | |
| ABL1 | Abl | TK | 2gqg | B | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 1084 | |
| ABL1 | Abl | TK | 1opl | B | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1086 | |
| ABL1 | Abl | TK | 2g1t | A | | - | Human | 1045 | |
| ABL1 | Abl | TK | 2hzi | B | B | 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1055 | |
| ABL1 | Abl | TK | 8h7f | A | | 1-[6-(6-methoxyisoquinolin-7-yl)-1,3-benzothiazol-2-yl]-3-(2-oxidanylideneethyl)urea | Human | 14632 | |
| ABL1 | Abl | TK | 6npe | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 10946 | |
| ABL1 | Abl | TK | 6xr7 | A | 13 | - | Human | 12910 | |
| ABL1 | Abl | TK | 6xrg | A | 15 | - | Human | 12911 | |
| ABL1 | Abl | TK | 2v7a | B | | n-[(3e)-5-[(2r)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3(5h)-ylidene]-4-(4-methylpiperazin-1-yl)benzamide | Human | 1072 | |
| ABL1 | Abl | TK | 1opl | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1104 | |
| ABL1 | Abl | TK | 2fo0 | A | | 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-one | Human | 1073 | |
| ABL1 | Abl | TK | 6xr7 | A | 20 | - | Human | 12914 | |
| ABL1 | Abl | TK | 6xr7 | A | 9 | - | Human | 12915 | |
| ABL1 | Abl | TK | 6xrg | A | 17 | - | Human | 12916 | |
| ABL1 | Abl | TK | 3qri | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1047 | |
| ABL1 | Abl | TK | 3qri | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 1076 | |
| ABL1 | Abl | TK | 2hz0 | B | A | 2-{[(6-oxo-1,6-dihydropyridin-3-yl)methyl]amino}-n-[4-propyl-3-(trifluoromethyl)phenyl]benzamide | Human | 1095 | |
| KDR | VEGFR | TK | 3b8q | A | | n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5332 | |
| KDR | VEGFR | TK | 6xvk | A | | ~{n}-(4,4-dimethyl-2-prop-1-ynyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12273 | |
| KDR | VEGFR | TK | 3b8q | B | | n-(4-chlorophenyl)-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide | Human | 5319 | |
| KDR | VEGFR | TK | 2rl5 | A | | n-(4-chlorophenyl)-7-[(6,7-dimethoxyquinolin-4-yl)oxy]-2,3-dihydro-1,4-benzoxazine-4-carboxamide | Human | 5348 | |
| KDR | VEGFR | TK | 3vo3 | A | B | n-[3-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)phenyl]-1,3-dimethyl-1h-pyrazole-5-carboxamide | Human | 5321 | |
| KDR | VEGFR | TK | 3cpb | B | | n'-(6-aminopyridin-3-yl)-n-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide | Human | 6793 | |
| KDR | VEGFR | TK | 3u6j | A | | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 5318 | |
| KDR | VEGFR | TK | 3cpb | A | | n'-(6-aminopyridin-3-yl)-n-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide | Human | 6787 | |
| KDR | VEGFR | TK | 6gqp | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10584 | |
| KDR | VEGFR | TK | 3dtw | A | | 6-chloro-n-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide | Human | 5313 | |
| KDR | VEGFR | TK | 2oh4 | A | A | methyl (5-{4-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-1h-benzimidazol-2-yl)carbamate | Human | 5347 | |
| KDR | VEGFR | TK | 3cjg | A | B | n~4~-methyl-n~4~-(3-methyl-1h-indazol-6-yl)-n~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine | Human | 6788 | |
| KDR | VEGFR | TK | 2p2i | B | | n-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide | Human | 5315 | |
| KDR | VEGFR | TK | 1ywn | A | | n-{4-[4-amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-n'-[2-fluoro-5-(trifluoromethyl)phenyl]urea | Human | 5314 | |
| KDR | VEGFR | TK | 6gqo | A | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10580 | |
| ZAP70 | Syk | TK | 2ozo | A | | phosphoaminophosphonic acid-adenylate ester | Human | 2735 | |
| ZAP70 | Syk | TK | 4k2r | A | | phosphoaminophosphonic acid-adenylate ester | Human | 2732 | |
| JAK2 | JakA | TK | 6wtq | A | A | n-methyl-4-{[4-(1-propyl-1h-pyrazol-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl]amino}benzamide | Human | 13535 | |
| JAK2 | JakA | TK | 4bbe | D | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3726 | |
| JAK2 | JakA | TK | 3kck | A | A | 3-chloro-4-(4h-3,4,7-triazadibenzo[cd,f]azulen-6-yl)phenol | Human | 3683 | |
| JAK2 | JakA | TK | 29rx | A | A | adenosine-5'-diphosphate | Human | 15571 | |
| JAK2 | JakA | TK | 5cf8 | B | B | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5983 | |
| JAK2 | JakA | TK | 4bbe | C | | n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide | Human | 3649 | |
| JAK2 | JakA | TK | 7ll4 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14035 | |
| JAK2 | JakA | TK | 4ytf | A | B | n~2~-[2-(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-n-(2,2,2-trifluoroethyl)-l-alaninamide | Human | 3693 | |
| JAK2 | JakA | TK | 7ree | A | A | [3-(4-{2-[3,5-difluoro-4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)anilino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}-1h-pyrazol-1-yl)-1-(ethanesulfonyl)azetidin-3-yl]acetonitrile | Human | 13855 | |
| JAK2 | JakA | TK | 6vgl | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13221 | |
| JAK2 | JakA | TK | 4e6d | B | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3647 | |
| JAK2 | JakA | TK | 5tq3 | A | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7356 | |
| JAK2 | JakA | TK | 2xa4 | B | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3707 | |
| JAK2 | JakA | TK | 4bbf | C | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3644 | |
| JAK2 | JakA | TK | 8bm2 | A | B | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | Human | 15035 | |
| JAK2 | JakA | TK | 4e6d | A | A | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3689 | |
| JAK2 | JakA | TK | 6vnh | A | | n-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-2-methylpropane-2-sulfonamide | Human | 13344 | |
| JAK2 | JakA | TK | 5cf8 | A | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5978 | |
| JAK2 | JakA | TK | 4p7e | A | | n-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide | Human | 3682 | |
| JAK2 | JakA | TK | 3lpb | B | B | n-methyl-4-[3-(3,4,5-trimethoxyphenyl)quinoxalin-5-yl]benzenesulfonamide | Human | 3681 | |
| JAK2 | JakA | TK | 3zmm | A | A | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3674 | |
| JAK2 | JakA | TK | 6vnk | D | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13292 | |
| JAK2 | JakA | TK | 4ji9 | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3724 | |
| JAK2 | JakA | TK | 4zim | B | A | 3-(3,4-dichlorophenyl)-6-(morpholin-4-ylcarbonyl)-9h-carbazole-1-carboxamide | Human | 3660 | |
| JAK2 | JakA | TK | 3e64 | A | B | 4-(3-amino-1h-indazol-5-yl)-n-tert-butylbenzenesulfonamide | Human | 3653 | |
| JAK2 | JakA | TK | 8bpw | A | B | lestaurtinib | Human | 15039 | |
| JAK2 | JakA | TK | 4e6q | B | | 1-(1-benzylpiperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3671 | |
| JAK2 | JakA | TK | 5tq3 | B | B | 4-[3-(1h-benzimidazol-2-yl)-1h-indazol-6-yl]-3-ethylphenol | Human | 7352 | |
| JAK2 | JakA | TK | 6vni | A | | 2-{5-[(2-{[3,5-difluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]-2-fluorophenyl}-1lambda~6~,2-thiazolidine-1,1-dione | Human | 13294 | |
| JAK2 | JakA | TK | 7uyw | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14334 | |
| JAK2 | JakA | TK | 4e6d | A | B | 3-[(3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl]-3-oxopropanenitrile | Human | 3656 | |
| JAK2 | JakA | TK | 3tjc | A | | 4-amino-n-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide | Human | 3685 | |
| JAK2 | JakA | TK | 2w1i | A | | 4-[(2-{4-[(cyclopropylcarbamoyl)amino]-1h-pyrazol-3-yl}-1h-benzimidazol-6-yl)methyl]morpholin-4-ium | Human | 3652 | |
| JAK2 | JakA | TK | 3tjd | A | | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-n-methylthieno[3,2-c]pyridine-7-carboxamide | Human | 3677 | |
| JAK2 | JakA | TK | 3e63 | A | B | 5-phenyl-1h-indazol-3-amine | Human | 3711 | |
| JAK2 | JakA | TK | 4yti | A | B | (2r)-2-methyl-2-[[2-(1h-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-n-[2,2,2-tris(fluoranyl)ethyl]butanamide | Human | 3657 | |
| JAK2 | JakA | TK | 6vgl | A | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13223 | |
| JAK2 | JakA | TK | 3iok | A | A | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3694 | |
| JAK2 | JakA | TK | 7q7k | A | B | 4-(2-azanyl-8-methoxy-quinazolin-6-yl)phenol | Human | 14086 | |
| JAK2 | JakA | TK | 8bpv | A | A | 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene | Human | 15040 | |
| JAK2 | JakA | TK | 4e4m | B | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3712 | |
| JAK2 | JakA | TK | 7rn6 | A | B | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13955 | |
| JAK2 | JakA | TK | 6vsn | C | | (3s)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13350 | |
| JAK2 | JakA | TK | 6wtp | A | A | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13541 | |
| JAK2 | JakA | TK | 6vnl | B | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13299 | |
| JAK2 | JakA | TK | 7q7l | A | B | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14090 | |
| JAK2 | JakA | TK | 4gfm | A | B | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3705 | |
| JAK2 | JakA | TK | 4e4m | E | | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 3637 | |
| JAK2 | JakA | TK | 4d1s | A | A | 2-(5-chloro-2-methylphenyl)-1-methyl-5-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1h-pyrrole-3-carboxamide | Human | 3634 | |
| JAK2 | JakA | TK | 4d0x | A | A | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3699 | |
| JAK2 | JakA | TK | 5cf8 | B | A | n,n-dicyclopropyl-4-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5985 | |
| JAK2 | JakA | TK | 6vnm | A | | 4-[1-(but-3-en-1-yl)-1h-pyrazol-4-yl]-n-[4-(piperidin-4-yl)phenyl]-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 13354 | |
| JAK2 | JakA | TK | 5hez | B | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7255 | |
| JAK2 | JakA | TK | 6vnl | C | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13300 | |
| JAK2 | JakA | TK | 5wev | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8376 | |
| JAK2 | JakA | TK | 4hge | A | A | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3703 | |
| JAK2 | JakA | TK | 4bbf | B | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3717 | |
| JAK2 | JakA | TK | 3zmm | B | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3678 | |
| JAK2 | JakA | TK | 7rn6 | A | A | 5-{[6-(acetylamino)pyrimidin-4-yl]oxy}-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-2,3-dihydro-1h-indole-1-carboxamide | Human | 13956 | |
| JAK2 | JakA | TK | 2xa4 | B | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3628 | |
| JAK2 | JakA | TK | 3fup | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3721 | |
| JAK2 | JakA | TK | 4bbf | A | | (2r)-n-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | Human | 3723 | |
| JAK2 | JakA | TK | 5aep | A | A | 1-(5-chloro-2-methylphenyl)-4-(pyrrolo[2,1-f][1,2,4]triazin-4-yl)-1h-pyrrole-2-carboxamide | Human | 3629 | |
| JAK2 | JakA | TK | 2xa4 | A | B | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3623 | |
| JAK2 | JakA | TK | 2xa4 | A | A | 5-chloro-n2-[(1s)-1-(5-fluoropyrimidin-2-yl)ethyl]-n4-(5-methyl-1h-pyrazol-3-yl)pyrimidine-2,4-diamine | Human | 3664 | |
| JAK2 | JakA | TK | 2b7a | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3708 | |
| JAK2 | JakA | TK | 3zmm | A | B | 5-fluoro-4-[(1s)-1-(5-fluoropyrimidin-2-yl)ethoxy]-n-(5-methyl-1h-pyrazol-3-yl)-6-morpholino-pyrimidin-2-amine | Human | 3667 | |
| JAK2 | JakA | TK | 3e62 | A | B | 5-bromo-1h-indazol-3-amine | Human | 3630 | |
| JAK2 | JakA | TK | 3iok | A | B | 3-(6-{[(1s)-1-(4-fluorophenyl)ethyl]amino}pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | Human | 3718 | |
| JAK2 | JakA | TK | 5hez | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 7254 | |
| JAK2 | JakA | TK | 6x8e | B | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13155 | |
| JAK2 | JakA | TK | 6vne | B | | n-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide | Human | 13302 | |
| JAK2 | JakA | TK | 3rvg | A | | 1-(cyclohexylamino)-7-(1-methyl-1h-pyrazol-4-yl)-5h-pyrido[4,3-b]indole-4-carboxamide | Human | 3638 | |
| JAK2 | JakA | TK | 4d0w | A | B | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3650 | |
| JAK2 | JakA | TK | 7ll5 | A | A | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14036 | |
| JAK2 | JakA | TK | 6aaj | B | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10514 | |
| JAK2 | JakA | TK | 8bpw | A | A | lestaurtinib | Human | 15044 | |
| JAK2 | JakA | TK | 6vnl | A | | 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{n}-(1-methylpiperidin-4-yl)benzamide | Human | 13303 | |
| JAK2 | JakA | TK | 6vnk | C | | (3r)-3-cyclopentyl-3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13304 | |
| JAK2 | JakA | TK | 6vnf | A | B | n~4~-[1-(tert-butylsulfonyl)-2,3-dihydro-1h-indol-6-yl]-n~2~-[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]-5-methylpyrimidine-2,4-diamine | Human | 13357 | |
| JAK2 | JakA | TK | 5cf5 | A | | n,n-dicyclopropyl-4-[(4,5-dimethyl-1,3-thiazol-2-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5984 | |
| JAK2 | JakA | TK | 5cf6 | A | | n,n-dicyclopropyl-6-[(2s)-2,3-dihydroxypropyl]-1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide | Human | 5979 | |
| JAK2 | JakA | TK | 4hge | B | B | n-[1-(3-chlorophenyl)-3-methyl-1h-pyrazol-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 3715 | |
| JAK2 | JakA | TK | 7q7l | A | A | 4-[2-azanyl-8-[[(2~{s})-1-oxidanylpropan-2-yl]amino]quinazolin-6-yl]-5-ethyl-2-fluoranyl-phenol | Human | 14092 | |
| JAK2 | JakA | TK | 7ll4 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14037 | |
| RET | Ret | TK | 7run | A | | 1-(4-{(1s,3s)-3-[4-amino-5-(3-amino-4-chlorophenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl}piperazin-1-yl)ethan-1-one | Human | 14072 | |
| RET | Ret | TK | 6ne7 | A | A | adenosine monophosphate | Human | 11149 | |
| RET | Ret | TK | 2x2m | A | | (3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3366 | |
| RET | Ret | TK | 7dua | A | C | 4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide | Human | 14046 | |
| RET | Ret | TK | 7ju6 | A | A | selpercatinib | Human | 13103 | |
| RET | Ret | TK | 6i82 | B | B | ~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine | Human | 12053 | |
| RET | Ret | TK | 2ivt | A | B | adenosine monophosphate | Human | 3365 | |
| RET | Ret | TK | 2x2m | B | | (3z)-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3375 | |
| RET | Ret | TK | 6ne7 | A | C | adenosine monophosphate | Human | 11152 | |
| RET | Ret | TK | 7ju6 | B | B | selpercatinib | Human | 13104 | |
| RET | Ret | TK | 7ju5 | B | A | pralsetinib | Human | 13105 | |
| RET | Ret | TK | 6fek | A | A | adenosine | Human | 9604 | |
| RET | Ret | TK | 7du8 | A | B | selpercatinib | Human | 14095 | |
| RET | Ret | TK | 4ckj | A | A | adenosine | Human | 3359 | |
| RET | Ret | TK | 7nzn | A | | 2-[4-[[4-[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]-6-[(3-methyl-1~{h}-pyrazol-5-yl)amino]pyrimidin-2-yl]amino]phenyl]-~{n}-(3-fluorophenyl)ethanamide | Human | 14105 | |
| RET | Ret | TK | 4ckj | A | B | adenosine | Human | 3376 | |
| RET | Ret | TK | 2ivs | A | A | (3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide | Human | 3372 | |
| RET | Ret | TK | 6i82 | B | A | ~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine | Human | 12052 | |
| RET | Ret | TK | 6nja | A | A | adenine | Human | 11146 | |
| RET | Ret | TK | 2x2l | A | A | (3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3363 | |
| RET | Ret | TK | 6i82 | A | A | ~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine | Human | 12050 | |
| RET | Ret | TK | 7du9 | A | B | pralsetinib | Human | 14047 | |
| RET | Ret | TK | 5amn | A | | 4-[3-hydroxyanilino]-6,7-dimethoxyquinazoline | Human | 6412 | |
| RET | Ret | TK | 6nja | A | B | adenine | Human | 11145 | |
| RET | Ret | TK | 7ju5 | A | A | pralsetinib | Human | 13106 | |
| JAK2 | JakA | TK | 6vng | A | | n-{2-fluoro-5-[(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-5-methylpyrimidin-4-yl)amino]phenyl}-2-methylpropane-2-sulfonamide | Human | 13358 | |
| JAK2 | JakA | TK | 7ll5 | A | B | {1-(ethylsulfonyl)-3-[4-(2-{[4-(1-methylpiperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]azetidin-3-yl}acetonitrile | Human | 14038 | |
| JAK2 | JakA | TK | 2w1i | B | | - | Human | 3648 | |
| JAK2 | JakA | TK | 8bxh | A | B | momelotinib | Human | 15045 | |
| JAK2 | JakA | TK | 4ji9 | A | | n-tert-butyl-3-[(5-methyl-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]benzenesulfonamide | Human | 3692 | |
| JAK2 | JakA | TK | 6vnc | A | | (3r)-3-cyclopentyl-3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13359 | |
| JAK2 | JakA | TK | 4ytc | A | A | n~3~-phenyl-1-[6-(phenylamino)pyrimidin-4-yl]-1h-1,2,4-triazole-3,5-diamine | Human | 3633 | |
| JAK2 | JakA | TK | 4d0x | A | B | 5-(2-aminopyrimidin-4-yl)-2-[2-chloro-5-(trifluoromethyl)phenyl]-1h-pyrrole-3-carboxamide | Human | 3642 | |
| JAK2 | JakA | TK | 4d0w | A | A | 5-(2-aminopyrimidin-4-yl)-2-(5-chloro-2-methylphenyl)-1h-pyrrole-3-carboxamide | Human | 3666 | |
| JAK2 | JakA | TK | 6wtp | A | B | tert-butyl 4-[(4-{1-[3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl]-1h-pyrazol-4-yl}-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino]benzoate | Human | 13542 | |
| SYK | Syk | TK | 4px6 | A | B | 7-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3h)-one | Human | 1204 | |
| SYK | Syk | TK | 6vov | A | | 6-(6-aminopyrazin-2-yl)-n-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine | Human | 12041 | |
| SYK | Syk | TK | 4fl3 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 1170 | |
| SYK | Syk | TK | 6zcr | A | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 13630 | |
| SYK | Syk | TK | 5tt7 | A | B | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 7283 | |
| SYK | Syk | TK | 8x5k | A | B | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 15102 | |
| SYK | Syk | TK | 3fqs | A | B | 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one | Human | 1202 | |
| SYK | Syk | TK | 4yjt | A | B | n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine | Human | 6118 | |
| SYK | Syk | TK | 6zcr | A | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 13631 | |
| SYK | Syk | TK | 4rss | A | B | 1-[(3-methyl-1-{2-[(1,2,3-trimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6170 | |
| SYK | Syk | TK | 3vf8 | A | | 3-[5-(5-ethoxy-6-fluoro-1h-benzimidazol-2-yl)-1h-pyrazol-4-yl]-1,1-diethylurea | Human | 1187 | |
| SYK | Syk | TK | 4i0s | A | A | 2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1157 | |
| SYK | Syk | TK | 6zcp | A | | 7-[[4-[4-[(dimethylamino)methyl]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{n},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide | Human | 13632 | |
| SYK | Syk | TK | 4rx9 | A | A | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 1190 | |
| SYK | Syk | TK | 3fqh | A | | n-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indole-5-carboxamide | Human | 1203 | |
| SYK | Syk | TK | 4fyo | A | B | 4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid | Human | 1205 | |
| SYK | Syk | TK | 6hm7 | A | A | 7-[2-methoxy-6-[(4-methylpyridin-2-yl)methoxy]phenyl]-2,3,4,5-tetrahydro-1~{h}-3-benzazepine | Human | 10612 | |
| SYK | Syk | TK | 4xg7 | A | A | 1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6316 | |
| SYK | Syk | TK | 4rx7 | A | A | 3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide | Human | 1189 | |
| SYK | Syk | TK | 6zcq | A | | 7-[[4-[4-[[(3~{r},4~{r})-3-azanyloxan-4-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]-~{n},3-dimethyl-imidazo[1,5-a]pyridine-1-carboxamide | Human | 13633 | |
| SYK | Syk | TK | 4fz6 | A | A | n-{6-[(2s)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine | Human | 1173 | |
| SYK | Syk | TK | 4rx9 | A | B | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 1194 | |
| SYK | Syk | TK | 3fqs | A | A | 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2h-pyrido[3,2-b][1,4]oxazin-3(4h)-one | Human | 1169 | |
| SYK | Syk | TK | 5tr6 | A | A | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-7-fluoro-4-(1-methyl-1h-pyrazol-4-yl)-1,2-dihydro-3h-pyrrolo[3,4-c]pyridin-3-one | Human | 7282 | |
| SYK | Syk | TK | 5t68 | B | | n~4~-cyclopropyl-n~2~-(3-methyl-1h-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine | Human | 7120 | |
| SYK | Syk | TK | 5y5u | A | | 4-[(1-methylindazol-5-yl)amino]-2-(4-oxidanylpiperidin-1-yl)-8h-pyrido[4,3-d]pyrimidin-5-one | Human | 10027 | |
| SYK | Syk | TK | 6zcy | A | A | ~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | Human | 13634 | |
| SYK | Syk | TK | 1xbb | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1196 | |
| SYK | Syk | TK | 4fz7 | A | B | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 1177 | |
| SYK | Syk | TK | 4yju | A | A | n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-n~4~-(1h-indazol-4-yl)-n~4~-methylpyrimidine-2,4-diamine | Human | 6112 | |
| SYK | Syk | TK | 5lmb | B | A | 7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | Human | 7045 | |
| SYK | Syk | TK | 4fyn | A | B | 3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol | Human | 1197 | |
| SYK | Syk | TK | 3fqe | A | | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide | Human | 1155 | |
| SYK | Syk | TK | 6zc0 | A | | ~{n},~{n}-dimethyl-1-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]methanamine | Human | 13636 | |
| SYK | Syk | TK | 5tt7 | A | A | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]-6,7-dihydro-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 7281 | |
| SYK | Syk | TK | 4i0s | A | B | 2-(6-chloro-1-methyl-1h-indazol-3-yl)-n-(propan-2-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1166 | |
| SYK | Syk | TK | 4yjp | A | | 2-[{2-[(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)amino]pyrimidin-4-yl}(1h-indazol-4-yl)amino]ethanol | Human | 6115 | |
| SYK | Syk | TK | 4xg8 | C | | 1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6310 | |
| SYK | Syk | TK | 4yjt | A | C | n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-5-fluoro-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine | Human | 6124 | |
| SYK | Syk | TK | 5lmb | B | B | 7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | Human | 7048 | |
| SYK | Syk | TK | 6zcx | A | B | ~{n},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{r})-piperidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide | Human | 13637 | |
| SYK | Syk | TK | 3fqh | B | | n-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indole-5-carboxamide | Human | 1171 | |
| SYK | Syk | TK | 5tiu | A | B | 5-{[(2s)-2-aminopropyl]amino}-3-(1h-indol-2-yl)pyrazine-2-carboxamide | Human | 7349 | |
| SYK | Syk | TK | 5c26 | A | | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide | Human | 6131 | |
| SYK | Syk | TK | 4xg2 | A | | - | Human | 6309 | |
| SYK | Syk | TK | 4fyo | A | A | 4-{[(3s)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid | Human | 1180 | |
| SYK | Syk | TK | 4yju | A | B | n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-5-fluoro-n~4~-(1h-indazol-4-yl)-n~4~-methylpyrimidine-2,4-diamine | Human | 6121 | |
| SYK | Syk | TK | 3tud | A | | n-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide | Human | 1176 | |
| SYK | Syk | TK | 4i0t | A | A | n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1198 | |
| SYK | Syk | TK | 4rx7 | A | B | 3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}-1,2,4-triazine-6-carboxamide | Human | 1182 | |
| SYK | Syk | TK | 4i0r | A | A | n-(propan-2-yl)-2-(3,4,5-trimethoxyphenyl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1192 | |
| SYK | Syk | TK | 4fz7 | A | A | 6-{[(1r,2s)-2-aminocyclohexyl]amino}-4-[(6-ethylpyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 1186 | |
| SYK | Syk | TK | 4fl1 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 1167 | |
| SYK | Syk | TK | 4yjr | A | B | 3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol | Human | 6116 | |
| SYK | Syk | TK | 5cxz | A | A | n-{7-[4-(dimethylamino)phenyl]-1,6-naphthyridin-5-yl}propane-1,3-diamine | Human | 6040 | |
| SYK | Syk | TK | 4fl1 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 1160 | |
| SYK | Syk | TK | 4xg9 | B | | 1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6315 | |
| INSR | InsR | TK | 5hhw | A | B | 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6522 | |
| INSR | InsR | TK | 4ibm | A | B | 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3h-pyrazolo[3,4-c]pyridazin-3-one | Human | 598 | |
| INSR | InsR | TK | 7pg4 | A | | - | Human | 14100 | |
| SYK | Syk | TK | 5cxh | A | | (4r)-4-[(1r)-1-{[6-(3,4-dimethoxyphenyl)[1,3]thiazolo[5,4-c]pyridin-4-yl]oxy}ethyl]pyrrolidin-2-one | Human | 6057 | |
| SYK | Syk | TK | 4dfn | A | B | 3-amino-6-[3-(1-methyl-1h-pyrazol-4-yl)phenyl]-n-[(1r,2r,3s,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide | Human | 1199 | |
| SYK | Syk | TK | 4px6 | A | A | 7-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3h)-one | Human | 1200 | |
| SYK | Syk | TK | 6zcu | A | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 13640 | |
| SYK | Syk | TK | 4xg9 | A | | 1-[(1-{2-[(3-chloro-1,2-dimethyl-1h-indol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6311 | |
| SYK | Syk | TK | 5c27 | A | | 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-n-[4-(methylcarbamoyl)phenyl]benzamide | Human | 6132 | |
| SYK | Syk | TK | 4fz6 | A | B | n-{6-[(2s)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine | Human | 1185 | |
| SYK | Syk | TK | 4dfl | A | | 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-n-(piperidin-4-ylmethyl)pyrazine-2-carboxamide | Human | 1152 | |
| SYK | Syk | TK | 6zcs | A | B | (3~{r},4~{r})-~{n}4-[1-[2-(1-methylindol-4-yl)-3~{h}-imidazo[4,5-b]pyridin-7-yl]pyrazol-4-yl]oxane-3,4-diamine | Human | 13641 | |
| SYK | Syk | TK | 5lma | A | A | ~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine | Human | 7047 | |
| SYK | Syk | TK | 3vf9 | A | | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 1159 | |
| SYK | Syk | TK | 4xg3 | B | | 4-{[5-fluoro-4-(3-{[(3r)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1h-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate | Human | 6314 | |
| SYK | Syk | TK | 4xg6 | A | | 1-[(1-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6312 | |
| SYK | Syk | TK | 4xg8 | A | | 1-[(1-{2-[(3-chloro-1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6317 | |
| SYK | Syk | TK | 4xg7 | A | B | 1-[(3-methyl-1-{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}-1h-pyrazol-4-yl)methyl]azetidin-3-ol | Human | 6318 | |
| SYK | Syk | TK | 3emg | A | | 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-n-[(1s)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide | Human | 1183 | |
| SYK | Syk | TK | 5tiu | A | A | 5-{[(2s)-2-aminopropyl]amino}-3-(1h-indol-2-yl)pyrazine-2-carboxamide | Human | 7350 | |
| SYK | Syk | TK | 5lma | A | C | ~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine | Human | 7044 | |
| SYK | Syk | TK | 4yjr | A | C | 3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol | Human | 6122 | |
| SYK | Syk | TK | 4yjr | A | A | 3-(1h-indazol-4-yl{2-[(1-methyl-1h-indazol-5-yl)amino]pyrimidin-4-yl}amino)propan-1-ol | Human | 6113 | |
| SYK | Syk | TK | 1xbb | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 1184 | |
| SYK | Syk | TK | 3srv | A | A | 2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | Human | 1154 | |
| SYK | Syk | TK | 4yjq | A | B | 3-[1h-indazol-4-yl(2-{[3-(4-methyl-1,3-oxazol-5-yl)phenyl]amino}pyrimidin-4-yl)amino]propan-1-ol | Human | 6123 | |
| SYK | Syk | TK | 4pv0 | A | | 4-[(3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzoyl)amino]benzoic acid | Human | 1161 | |
| SYK | Syk | TK | 4fyn | A | A | 3-[8-({4-[ethyl(2-hydroxyethyl)amino]phenyl}amino)imidazo[1,2-a]pyrazin-5-yl]phenol | Human | 1174 | |
| SYK | Syk | TK | 3srv | B | B | 2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | Human | 1206 | |
| SYK | Syk | TK | 5ghv | B | | 1-({1-[2-({3,5-dimethyl-4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]-4-methyl-1h-pyrrol-3-yl}methyl)azetidin-3-ol | Human | 6742 | |
| SYK | Syk | TK | 5lmb | A | B | 7-[6-(dimethylamino)pyridin-3-yl]-~{n}-[[(3~{s})-piperidin-3-yl]methyl]pyrido[3,4-b]pyrazin-5-amine | Human | 7046 | |
| SYK | Syk | TK | 5lma | A | B | ~{n}'-[7-(4-methylphenyl)pyrido[3,4-b]pyrazin-5-yl]butane-1,4-diamine | Human | 7049 | |
| SYK | Syk | TK | 4fl2 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1191 | |
| SYK | Syk | TK | 3srv | B | A | 2-{[(3r,4r)-3-aminotetrahydro-2h-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide | Human | 1181 | |
| SYK | Syk | TK | 4rx8 | A | A | 3-{[(1r,2s)-2-aminocyclohexyl]amino}-5-(1h-indol-7-ylamino)-1,2,4-triazine-6-carboxamide | Human | 1158 | |
| HCK | Src | TK | 2c0i | A | A | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2662 | |
| HCK | Src | TK | 3vs0 | A | | n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | Human | 2633 | |
| HCK | Src | TK | 3vs1 | B | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | Human | 2636 | |
| HCK | Src | TK | 2c0o | B | A | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2663 | |
| HCK | Src | TK | 2hck | A | | 3,5,7,3',4'-pentahydroxyflavone | Human | 9481 | |
| HCK | Src | TK | 2c0i | B | A | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2650 | |
| HCK | Src | TK | 3vs4 | A | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2654 | |
| HCK | Src | TK | 3vs0 | B | | n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide | Human | 2644 | |
| HCK | Src | TK | 2c0i | B | B | n-(4-{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2640 | |
| HCK | Src | TK | 3vs2 | B | | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2632 | |
| HCK | Src | TK | 3vs5 | B | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2669 | |
| HCK | Src | TK | 3vs2 | A | | 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2651 | |
| HCK | Src | TK | 2c0t | A | B | n-(4-{4-amino-1-[1-(tetrahydro-2h-pyran-4-yl)piperidin-4-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2667 | |
| HCK | Src | TK | 3vs6 | B | | tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate | Human | 2656 | |
| HCK | Src | TK | 3vs7 | A | | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 2659 | |
| HCK | Src | TK | 3vs5 | A | | 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2645 | |
| HCK | Src | TK | 1qcf | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 2641 | |
| HCK | Src | TK | 3vs7 | B | | 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 2648 | |
| HCK | Src | TK | 4lue | A | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2655 | |
| HCK | Src | TK | 3vry | A | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2647 | |
| HCK | Src | TK | 3vs1 | A | | 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea | Human | 2635 | |
| HCK | Src | TK | 1ad5 | B | | phosphoaminophosphonic acid-adenylate ester | Human | 9483 | |
| HCK | Src | TK | 5h0e | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]amino]-4-methyl-pentanamide | Human | 8538 | |
| HCK | Src | TK | 4lud | B | | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole | Human | 2637 | |
| HCK | Src | TK | 3vry | B | | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2646 | |
| HCK | Src | TK | 2c0o | B | B | n-(4-{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-2-methoxyphenyl)-1-methyl-1h-indole-2-carboxamide | Human | 2657 | |
| HCK | Src | TK | 5h0b | A | | (2~{s})-2-[[4-[4-azanyl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexyl]azaniumyl]-4-methyl-pentanoate | Human | 8567 | |
| HCK | Src | TK | 5zj6 | B | | 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9988 | |
| HCK | Src | TK | 3vs4 | B | | 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 2638 | |
| HCK | Src | TK | 1ad5 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 9480 | |
| SRC | Src | TK | 6e6e | D | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11494 | |
| SRC | Src | TK | 8haq | A | | 4-[(~{e})-(7-oxidanyl-6~{h}-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-~{n}-pyridin-2-yl-benzenesulfonamide | Human | 14883 | |
| SRC | Src | TK | 1fmk | A | | - | Human | 981 | |
| SRC | Src | TK | 4mxy | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 982 | |
| SRC | Src | TK | 6e6e | F | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11487 | |
| SRC | Src | TK | 1yol | B | | 1-{4-[4-amino-5-(3-methoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]benzyl}piperidin-4-ol | Human | 966 | |
| SRC | Src | TK | 6e6e | A | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11485 | |
| SRC | Src | TK | 6e6e | H | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11481 | |
| SRC | Src | TK | 6e6e | C | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11488 | |
| SRC | Src | TK | 1y57 | A | | 4-[(4-methylpiperazin-1-yl)methyl]-n-{3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide | Human | 986 | |
| SRC | Src | TK | 6e6e | G | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11477 | |
| SRC | Src | TK | 1yoj | B | | - | Human | 974 | |
| SRC | Src | TK | 6e6e | F | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11472 | |
| SRC | Src | TK | 8jn8 | A | | (2r)-n-cyclopentyl-2-[cyclopropyl(ethanoyl)amino]-2-(4-fluorophenyl)ethanamide | Human | 15312 | |
| SRC | Src | TK | 4k11 | A | A | 1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 983 | |
| SRC | Src | TK | 6e6e | D | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11489 | |
| SRC | Src | TK | 6e6e | B | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11480 | |
| SRC | Src | TK | 4mxy | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 972 | |
| SRC | Src | TK | 4mxz | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 969 | |
| SRC | Src | TK | 6e6e | B | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11484 | |
| SRC | Src | TK | 9ns0 | A | 7 | - | Human | 15612 | |
| SRC | Src | TK | 2bdj | A | | 3-[2-(2-cyclopentyl-6-{[4-(dimethylphosphoryl)phenyl]amino}-9h-purin-9-yl)ethyl]phenol | Human | 971 | |
| SRC | Src | TK | 4mxz | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 988 | |
| SRC | Src | TK | 9ns1 | A | 8 | - | Human | 15615 | |
| SRC | Src | TK | 2h8h | A | A | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 970 | |
| SRC | Src | TK | 9ns1 | A | 14 | - | Human | 15616 | |
| SRC | Src | TK | 6e6e | C | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11492 | |
| SRC | Src | TK | 9ns0 | A | 10 | - | Human | 15617 | |
| SRC | Src | TK | 6e6e | H | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11483 | |
| SRC | Src | TK | 9ns1 | A | 4 | - | Human | 15618 | |
| SRC | Src | TK | 4mxx | B | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 976 | |
| SRC | Src | TK | 4mxo | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 990 | |
| SRC | Src | TK | 6e6e | C | A | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11471 | |
| SRC | Src | TK | 6e6e | D | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11473 | |
| SRC | Src | TK | 1yol | A | | 1-{4-[4-amino-5-(3-methoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl]benzyl}piperidin-4-ol | Human | 968 | |
| SRC | Src | TK | 6e6e | F | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11486 | |
| SRC | Src | TK | 9ns0 | A | 11 | - | Human | 15619 | |
| SRC | Src | TK | 9ns1 | A | 5 | - | Human | 15620 | |
| SRC | Src | TK | 6e6e | G | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11474 | |
| SRC | Src | TK | 2h8h | A | B | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 992 | |
| SRC | Src | TK | 9ns0 | A | 19 | - | Human | 15621 | |
| SRC | Src | TK | 6e6e | A | C | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11491 | |
| SRC | Src | TK | 6e6e | A | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11482 | |
| SRC | Src | TK | 1yi6 | A | | - | Human | 967 | |
| SRC | Src | TK | 9ns0 | A | 17 | - | Human | 15626 | |
| SRC | Src | TK | 9ns1 | A | 3 | - | Human | 15627 | |
| SRC | Src | TK | 9ns1 | A | 19 | - | Human | 15628 | |
| SRC | Src | TK | 6e6e | B | B | n-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino)phenyl]amino}pyrimidine-5-carboxamide | Human | 11476 | |
| SRC | Src | TK | 1yoj | A | | - | Human | 984 | |
| SRC | Src | TK | 1ksw | A | | n6-benzyl adenosine-5'-diphosphate | Human | 985 | |
| SRC | Src | TK | 9ns1 | A | 7 | - | Human | 15629 | |
| SRC | Src | TK | 9ns1 | A | 9 | - | Human | 15630 | |
| SRC | Src | TK | 7ote | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 14240 | |
| SRC | Src | TK | 4k11 | A | B | 1-tert-butyl-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 977 | |
| SRC | Src | TK | 9ns1 | A | 18 | - | Human | 15631 | |
| SRC | Src | TK | 4mxx | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 989 | |
| SRC | Src | TK | 1yom | B | | 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9h-purin-2-yl}amino)-3-methylbutan-1-ol | Human | 987 | |
| SRC | Src | TK | 9ns1 | A | 20 | - | Human | 15632 | |
| SRC | Src | TK | 9ns0 | A | 12 | - | Human | 15633 | |
| SRC | Src | TK | 2src | A | | phosphoaminophosphonic acid-adenylate ester | Human | 979 | |
| SRC | Src | TK | 9ns0 | A | 4 | - | Human | 15634 | |
| TYK2 | JakA | TK | 6vns | A | B | (1r,2r)-2-cyano-n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12137 | |
| TYK2 | JakA | TK | 6ova | A | B | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | 11981 | |
| TYK2 | JakA | TK | 4gj3 | A | | 2,6-dichloro-4-cyano-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3345 | |
| TYK2 | JakA | TK | 7uyr | A | B | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | 14335 | |
| TYK2 | JakA | TK | 4gfo | A | A | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3336 | |
| TYK2 | JakA | TK | 6dbm | A | B | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10488 | |
| TYK2 | JakA | TK | 6x8f | C | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13156 | |
| TYK2 | JakA | TK | 7uys | A | B | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 14336 | |
| TYK2 | JakA | TK | 6x8f | A | A | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13157 | |
| TYK2 | JakA | TK | 4gfo | A | B | 2,6-dichloro-n-(2-oxo-2,5-dihydropyridin-4-yl)benzamide | Human | 3338 | |
| TYK2 | JakA | TK | 6aam | A | | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10489 | |
| TYK2 | JakA | TK | 6ova | A | A | 6-({4-[(3s)-3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl]pyridin-2-yl}amino)-n,n-dimethylpyridine-3-carboxamide | Human | 11980 | |
| TYK2 | JakA | TK | 6dbm | A | A | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10491 | |
| TYK2 | JakA | TK | 6vnx | A | | (1s)-2,2-difluoro-n-[(1s,5r,6r)-3-{5-fluoro-2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-6-methyl-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropane-1-carboxamide | Human | 12136 | |
| TYK2 | JakA | TK | 5wal | A | B | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8374 | |
| TYK2 | JakA | TK | 3lxn | A | | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 3337 | |
| TYK2 | JakA | TK | 3lxp | A | | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3340 | |
| TYK2 | JakA | TK | 4gvj | A | | adenosine-5'-diphosphate | Human | 3334 | |
| TYK2 | JakA | TK | 6x8g | A | A | trans-3-(cyanomethyl)-3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}cyclobutane-1-carbonitrile | Human | 12992 | |
| TYK2 | JakA | TK | 6vny | A | | n-[(1s,5r)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1h-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide | Human | 12135 | |
| TYK2 | JakA | TK | 4gih | A | A | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3339 | |
| TYK2 | JakA | TK | 4gj2 | A | | 2,6-dichloro-n-[2-({[(1r,2r)-2-fluorocyclopropyl]carbonyl}amino)pyridin-4-yl]benzamide | Human | 3344 | |
| TYK2 | JakA | TK | 7uyu | A | A | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14337 | |
| TYK2 | JakA | TK | 4gih | A | B | 2,6-dichloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 3332 | |
| TYK2 | JakA | TK | 6x8f | C | B | [3-{4-[6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]-1h-pyrazol-1-yl}-1-(2,2,2-trifluoroethyl)azetidin-3-yl]acetonitrile | Human | 13158 | |
| TYK2 | JakA | TK | 7uyr | A | A | 2-(4-{[2-(2,6-difluorophenyl)-5-oxo-5h-pyrrolo[3,4-d]pyrimidin-4-yl]amino}phenyl)-n-ethylacetamide | Human | 14338 | |
| TYK2 | JakA | TK | 3nyx | A | A | n-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | Human | 3341 | |
| TYK2 | JakA | TK | 4py1 | A | | 6-[(2,5-dimethoxyphenyl)sulfanyl]-3-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazine | Human | 3333 | |
| TYK2 | JakA | TK | 7uys | A | A | 2-(2,6-difluorophenyl)-4-(4-methoxyanilino)-5h-pyrrolo[3,4-d]pyrimidin-5-one | Human | 14339 | |
| TYK2 | JakA | TK | 3nyx | A | B | n-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | Human | 3343 | |
| TYK2 | JakA | TK | 7uyt | A | B | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14340 | |
| TYK2 | JakA | TK | 7uyu | A | B | 2-(2,6-difluorophenyl)-4-[4-(pyrrolidine-1-carbonyl)anilino]-5h-pyrrolo[3,4-b]pyridin-5-one | Human | 14341 | |
| TYK2 | JakA | TK | 5f1z | A | A | 3-azanyl-5-[(2~{s})-3-methylbutan-2-yl]-7-[1-methyl-5-(2-oxidanylpropan-2-yl)pyrazol-3-yl]-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6356 | |
| TYK2 | JakA | TK | 5wal | A | A | n-[2-(2,6-dichlorophenyl)-1h-imidazo[4,5-c]pyridin-4-yl]cyclopropanecarboxamide | Human | 8375 | |
| TYK2 | JakA | TK | 7uyt | A | A | 6-{[(2m)-2-(2-chloro-6-fluorophenyl)-5-oxo-5h-pyrrolo[3,4-b]pyridin-4-yl]amino}-n-ethylpyridine-3-carboxamide | Human | 14342 | |
| TYK2 | JakA | TK | 3nz0 | A | A | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3342 | |
| TYK2 | JakA | TK | 3nz0 | A | B | 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-one | Human | 3335 | |
| TYK2 | JakA | TK | 5f20 | A | | 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{h}-pyrazolo[4,3-c]pyridin-4-one | Human | 6355 | |
| MUSK | Musk | TK | 9sn0 | A | | - | Human | 15669 | |
| MUSK | Musk | TK | 9snu | A | | - | Human | 15670 | |
| FGFR1 | FGFR | TK | 6nvl | C | A | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11404 | |
| FGFR1 | FGFR | TK | 4wun | A | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3595 | |
| FGFR1 | FGFR | TK | 4nks | B | A | n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[5-(2-phenylethyl)-1h-pyrazol-3-yl]pyrimidine-2,4-diamine | Human | 3492 | |
| FGFR1 | FGFR | TK | 3kxx | D | | - | Human | 3503 | |
| FGFR1 | FGFR | TK | 44aa | A | B | (2~{r},3~{s},4~{r},5~{r})-2-[[(azanylidene-$l^{4}-azanylidene)amino]methyl]-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]oxolane-3,4-diol | Human | 15671 | |
| FGFR1 | FGFR | TK | 5o4a | B | B | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | Human | 9555 | |
| FGFR1 | FGFR | TK | 5z0s | B | A | 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[4,3-b]pyridine | Human | 10812 | |
| FGFR1 | FGFR | TK | 6nvl | A | A | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11400 | |
| FGFR1 | FGFR | TK | 5b7v | B | | [5-amino-1-(2-methyl-1h-benzimidazol-6-yl)-1h-pyrazol-4-yl](1h-indol-2-yl)methanone | Human | 6704 | |
| FGFR1 | FGFR | TK | 7ozf | A | B | n-[6-(3-ethoxyphenyl)-1h-indazol-3-yl]benzamide | Human | 14006 | |
| FGFR1 | FGFR | TK | 4v05 | B | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3493 | |
| FGFR1 | FGFR | TK | 4v01 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3556 | |
| FGFR1 | FGFR | TK | 5am7 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3588 | |
| FGFR1 | FGFR | TK | 5flf | B | B | - | Human | 6467 | |
| FGFR1 | FGFR | TK | 6p68 | A | | n-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1h-pyrazol-4-yl}prop-2-enamide | Human | 11336 | |
| FGFR1 | FGFR | TK | 5flf | E | A | - | Human | 6473 | |
| FGFR1 | FGFR | TK | 4rwk | A | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3500 | |
| FGFR1 | FGFR | TK | 5am6 | B | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3587 | |
| FGFR1 | FGFR | TK | 6mzq | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 10860 | |
| FGFR1 | FGFR | TK | 3js2 | B | | 5-(2-thienyl)nicotinic acid | Human | 3504 | |
| FGFR1 | FGFR | TK | 5o49 | B | B | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate | Human | 9557 | |
| FGFR1 | FGFR | TK | 6p68 | C | | n-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1h-pyrazol-4-yl}prop-2-enamide | Human | 11332 | |
| FGFR1 | FGFR | TK | 4rwk | B | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3591 | |
| FGFR1 | FGFR | TK | 5ew8 | B | A | ~{n}'-(3,5-dimethoxyphenyl)-~{n}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{n}-propan-2-yl-ethane-1,2-diamine | Human | 6474 | |
| FGFR1 | FGFR | TK | 5am6 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3514 | |
| FGFR1 | FGFR | TK | 5o49 | A | A | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate | Human | 9560 | |
| FGFR1 | FGFR | TK | 4f65 | A | A | 5-bromo-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[3-(2-phenylethyl)-1h-pyrazol-5-yl]pyrimidine-2,4-diamine | Human | 3558 | |
| FGFR1 | FGFR | TK | 4nk9 | A | | n~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-3-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3550 | |
| FGFR1 | FGFR | TK | 5flf | A | A | - | Human | 6462 | |
| FGFR1 | FGFR | TK | 9vlj | A | | ~{n}-[3-[2-[[3-[2-(dimethylamino)ethylsulfamoylmethyl]phenyl]amino]pyrimidin-4-yl]-1-methyl-indol-6-yl]propanamide | Human | 15673 | |
| FGFR1 | FGFR | TK | 3kxx | B | | - | Human | 3575 | |
| FGFR1 | FGFR | TK | 5o4a | B | A | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | Human | 9559 | |
| FGFR1 | FGFR | TK | 4uwb | A | B | n-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamide | Human | 6023 | |
| FGFR1 | FGFR | TK | 43xk | A | A | ~{n}-[[(2~{r},3~{s},4~{r},5~{r})-5-[4-azanyl-5-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)thiolan-2-yl]methyl]prop-2-enamide | Human | 15674 | |
| FGFR1 | FGFR | TK | 1fgk | A | A | - | Human | 3592 | |
| FGFR1 | FGFR | TK | 6nvl | B | B | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11399 | |
| FGFR1 | FGFR | TK | 6mzq | B | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11161 | |
| FGFR1 | FGFR | TK | 6c19 | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(methylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10862 | |
| FGFR1 | FGFR | TK | 9u7g | A | | (e)-4-methyl-17-(1-methyl-1h-pyrazol-4-yl)-7,10-dioxa-4-aza-1(3,6)-imidazo[1,2-b]pyridazina-2(3,5)-pyridinacyclodecaphan-3-one | Human | 15675 | |
| FGFR1 | FGFR | TK | 5a4c | A | B | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | Human | 3498 | |
| FGFR1 | FGFR | TK | 6c1o | B | A | n-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)prop-2-enamide | Human | 11160 | |
| FGFR1 | FGFR | TK | 1fgi | B | A | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3586 | |
| FGFR1 | FGFR | TK | 6c1c | B | B | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11158 | |
| FGFR1 | FGFR | TK | 6c18 | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10854 | |
| FGFR1 | FGFR | TK | 9uhc | A | | ~{n}-[1-methyl-3-[2-[1-(2-morpholin-4-ylethyl)pyrazol-4-yl]-5~{h}-pyrrolo[2,3-b]pyrazin-7-yl]indol-6-yl]propanamide | Human | 15676 | |
| FGFR1 | FGFR | TK | 44ah | A | B | derazantinib | Human | 15677 | |
| FGFR1 | FGFR | TK | 6c1c | A | A | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11164 | |
| FGFR1 | FGFR | TK | 5ew8 | A | A | ~{n}'-(3,5-dimethoxyphenyl)-~{n}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{n}-propan-2-yl-ethane-1,2-diamine | Human | 6470 | |
| FGFR1 | FGFR | TK | 4f64 | B | B | 5-bromo-n~4~-[3-(3-methoxypropyl)-1h-pyrazol-5-yl]-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3553 | |
| FGFR1 | FGFR | TK | 5zv2 | A | | 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide | Human | 10055 | |
| FGFR1 | FGFR | TK | 5o49 | A | B | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate | Human | 9556 | |
| FGFR1 | FGFR | TK | 4f63 | B | | 5-bromo-n~4~-(3-methyl-1h-pyrazol-5-yl)-n~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine | Human | 3574 | |
| FGFR1 | FGFR | TK | 3tt0 | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | Human | 3567 | |
| FGFR1 | FGFR | TK | 5o49 | B | A | [(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 3-fluorosulfonylbenzoate | Human | 9561 | |
| FGFR1 | FGFR | TK | 4wun | B | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3529 | |
| FGFR1 | FGFR | TK | 1fgi | A | B | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3552 | |
| FGFR1 | FGFR | TK | 4f64 | A | A | 5-bromo-n~4~-[3-(3-methoxypropyl)-1h-pyrazol-5-yl]-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3548 | |
| FGFR1 | FGFR | TK | 6c1o | B | B | n-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)prop-2-enamide | Human | 11154 | |
| FGFR1 | FGFR | TK | 5vnd | B | B | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide | Human | 7645 | |
| FGFR1 | FGFR | TK | 4uwb | B | A | n-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamide | Human | 6018 | |
| FGFR1 | FGFR | TK | 4f63 | A | | 5-bromo-n~4~-(3-methyl-1h-pyrazol-5-yl)-n~2~-[2-(pyridin-3-yl)ethyl]pyrimidine-2,4-diamine | Human | 3563 | |
| FGFR1 | FGFR | TK | 3js2 | A | | 5-(2-thienyl)nicotinic acid | Human | 3523 | |
| FGFR1 | FGFR | TK | 1agw | A | B | 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone | Human | 3528 | |
| FGFR1 | FGFR | TK | 6mzw | A | A | 1-[(3s)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1h-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | Human | 11162 | |
| FGFR1 | FGFR | TK | 1fgk | A | B | - | Human | 3546 | |
| FGFR1 | FGFR | TK | 4v04 | A | B | - | Human | 3571 | |
| FGFR1 | FGFR | TK | 4uwy | A | A | - | Human | 3489 | |
| FGFR1 | FGFR | TK | 6nvl | C | B | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11405 | |
| FGFR1 | FGFR | TK | 3ky2 | B | | - | Human | 3525 | |
| FGFR1 | FGFR | TK | 6p68 | B | | n-{3-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-1-(2-hydroxyethyl)-1h-pyrazol-4-yl}prop-2-enamide | Human | 11334 | |
| FGFR1 | FGFR | TK | 4rwj | A | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3519 | |
| FGFR1 | FGFR | TK | 5flf | E | B | - | Human | 6472 | |
| FGFR1 | FGFR | TK | 3c4f | B | A | 3-(3-methoxybenzyl)-1h-pyrrolo[2,3-b]pyridine | Human | 3573 | |
| FGFR1 | FGFR | TK | 4rwj | A | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3584 | |
| FGFR1 | FGFR | TK | 6c1b | B | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10856 | |
| FGFR1 | FGFR | TK | 4rwk | B | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3530 | |
| FGFR1 | FGFR | TK | 4zsa | A | B | 4-(4-ethylpiperazin-1-yl)-n-[6-(3-methoxyphenyl)-2h-indazol-3-yl]benzamide | Human | 3487 | |
| FGFR1 | FGFR | TK | 4v01 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3497 | |
| FGFR1 | FGFR | TK | 4uwb | B | B | n-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamide | Human | 6022 | |
| FGFR1 | FGFR | TK | 3tt0 | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-1-methylurea | Human | 3538 | |
| FGFR1 | FGFR | TK | 4nks | A | A | n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[5-(2-phenylethyl)-1h-pyrazol-3-yl]pyrimidine-2,4-diamine | Human | 3570 | |
| FGFR1 | FGFR | TK | 4nks | B | B | n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[5-(2-phenylethyl)-1h-pyrazol-3-yl]pyrimidine-2,4-diamine | Human | 3577 | |
| FGFR1 | FGFR | TK | 4uwc | B | A | 3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide | Human | 6021 | |
| FGFR1 | FGFR | TK | 4rwj | B | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3579 | |
| FGFR1 | FGFR | TK | 4zsa | B | A | 4-(4-ethylpiperazin-1-yl)-n-[6-(3-methoxyphenyl)-2h-indazol-3-yl]benzamide | Human | 3572 | |
| FGFR1 | FGFR | TK | 3kxx | A | | - | Human | 3495 | |
| FGFR1 | FGFR | TK | 4v04 | B | B | - | Human | 3496 | |
| FGFR1 | FGFR | TK | 1agw | B | A | 3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone | Human | 3568 | |
| FGFR1 | FGFR | TK | 4nks | A | B | n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[5-(2-phenylethyl)-1h-pyrazol-3-yl]pyrimidine-2,4-diamine | Human | 3561 | |
| FGFR1 | FGFR | TK | 5a4c | B | A | 1-tert-butyl-3-[2-[3-(diethylamino)propylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea | Human | 3585 | |
| FGFR1 | FGFR | TK | 5vnd | A | B | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide | Human | 7648 | |
| FGFR1 | FGFR | TK | 5z0s | A | A | 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[4,3-b]pyridine | Human | 10813 | |
| FGFR1 | FGFR | TK | 6c18 | B | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11170 | |
| FGFR1 | FGFR | TK | 5flf | A | B | - | Human | 6464 | |
| FGFR1 | FGFR | TK | 5z0s | A | B | 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1h-pyrazol-4-yl)-1h-pyrazolo[4,3-b]pyridine | Human | 10815 | |
| FGFR1 | FGFR | TK | 4nka | B | | n~4~-{3-[2-(3,4-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine | Human | 3539 | |
| FGFR1 | FGFR | TK | 4uwb | A | A | n-[4-(4-methylpiperazin-1-yl)phenyl]-1h-indazole-3-carboxamide | Human | 6020 | |
| FGFR1 | FGFR | TK | 5a46 | A | A | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3532 | |
| FGFR1 | FGFR | TK | 6c1o | A | B | n-(3-{[3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-{[4-(diethylamino)butyl]amino}-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2h)-yl]methyl}phenyl)prop-2-enamide | Human | 11166 | |
| FGFR1 | FGFR | TK | 3kxx | C | | - | Human | 3549 | |
| FGFR1 | FGFR | TK | 2fgi | A | | 1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea | Human | 3490 | |
| FGFR1 | FGFR | TK | 7ozd | A | B | n-[6-(4-hydroxyphenyl)-1h-indazol-3-yl]benzamide | Human | 14009 | |
| FGFR1 | FGFR | TK | 3gql | C | | (e)-[4-(3,5-difluorophenyl)-3h-pyrrolo[2,3-b]pyridin-3-ylidene](3-methoxyphenyl)methanol | Human | 3536 | |
| FGFR1 | FGFR | TK | 5ur1 | A | B | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 7972 | |
| FGFR1 | FGFR | TK | 1fgi | B | B | 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone | Human | 3580 | |
| FGFR1 | FGFR | TK | 4rwi | A | A | - | Human | 3499 | |
| FGFR1 | FGFR | TK | 6c1c | B | A | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10858 | |
| FGFR1 | FGFR | TK | 6p69 | A | A | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide | Human | 11333 | |
| FGFR1 | FGFR | TK | 6p69 | B | B | n-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl][3-(4-methylpiperazin-1-yl)propyl]amino}pyrimidin-4-yl)amino]phenyl}prop-2-enamide | Human | 11335 | |
| FGFR1 | FGFR | TK | 4v04 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3524 | |
| FGFR1 | FGFR | TK | 4v05 | A | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3560 | |
| FGFR1 | FGFR | TK | 4uwy | B | B | - | Human | 3583 | |
| FGFR1 | FGFR | TK | 5uq0 | B | B | 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-carboxamide | Human | 7457 | |
| FGFR1 | FGFR | TK | 4uwc | B | B | 3,4-dimethoxy-n-(5-phenyl-1h-pyrazol-3-yl)benzamide | Human | 6016 | |
| FGFR1 | FGFR | TK | 6c18 | A | A | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-7-[(propan-2-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 11155 | |
| FGFR1 | FGFR | TK | 4v01 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 3594 | |
| FGFR1 | FGFR | TK | 4f65 | B | B | 5-bromo-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[3-(2-phenylethyl)-1h-pyrazol-5-yl]pyrimidine-2,4-diamine | Human | 3502 | |
| FGFR1 | FGFR | TK | 7wcl | A | A | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one | Human | 14364 | |
| FGFR1 | FGFR | TK | 5a46 | A | B | 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]quinolin-2(1h)-one | Human | 3505 | |
| FGFR1 | FGFR | TK | 6c1c | A | B | 7-(cyclohexylamino)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{(3s)-1-[(2e)-4-(dimethylamino)but-2-enoyl]pyrrolidin-3-yl}-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 10853 | |
| FGFR1 | FGFR | TK | 4wun | A | A | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3511 | |
| MET | Met | TK | 5t3q | A | | n-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 7413 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8xrr | A | | rh140 | Human | 15730 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqh | A | | (1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15107 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 8pqk | A | B | - | Human | 15108 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6joj | A | | 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1h-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine | Human | 12104 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 5grn | A | A | n-[2-(dimethylamino)ethyl]-n-[[4-[[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]carbamoyl]phenyl]methyl]pyridine-3-carboxamide | Human | 9479 | |
| PDGFRA (PDGFRa) | PDGFR | TK | 6jol | A | | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 12103 | |
| EGFR | EGFR | TK | 3w2q | A | B | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 874 | |
| KIT | PDGFR | TK | 6hh1 | A | B | ~{n}-(2,3-dimethylphenyl)-5-(4-pyridin-4-yloxyphenyl)-4~{h}-1,2,4-triazol-3-amine | Human | 11628 | |
| KIT | PDGFR | TK | 6xvb | B | | ~{n}-(4,4-dimethyl-2-propyl-3,1-benzoxazin-6-yl)-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12280 | |
| KIT | PDGFR | TK | 7zy6 | A | | 5-imidazo[1,2-a]pyridin-3-yl-~{n}-[(1~{r})-1-(6-pyrrolidin-1-ylpyridin-3-yl)ethyl]pyridin-3-amine | Human | 14623 | |
| KIT | PDGFR | TK | 6gql | B | | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide | Human | 10357 | |
| KIT | PDGFR | TK | 8pqf | A | A | methyl ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]carbamate | Human | 15116 | |
| KIT | PDGFR | TK | 6itt | B | A | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11821 | |
| KIT | PDGFR | TK | 1t45 | A | A | - | Human | 399 | |
| KIT | PDGFR | TK | 6gqj | B | B | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10356 | |
| KIT | PDGFR | TK | 6xv9 | A | | ~{n}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12282 | |
| KIT | PDGFR | TK | 6itt | B | B | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11820 | |
| KIT | PDGFR | TK | 6gqk | A | B | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10353 | |
| KIT | PDGFR | TK | 3g0e | A | B | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 398 | |
| KIT | PDGFR | TK | 1t45 | A | B | - | Human | 394 | |
| KIT | PDGFR | TK | 6mob | A | B | n-{4-chloro-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-n'-phenylurea | Human | 11470 | |
| KIT | PDGFR | TK | 6gqk | B | A | ~{n}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide | Human | 10363 | |
| KIT | PDGFR | TK | 8pqb | A | A | (1~{s})-1-(4-fluorophenyl)-~{n},~{n}-dimethyl-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15121 | |
| KIT | PDGFR | TK | 1t46 | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 393 | |
| KIT | PDGFR | TK | 8pq9 | A | B | (1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | Human | 15125 | |
| KIT | PDGFR | TK | 8pqd | A | B | ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]ethanamide | Human | 15126 | |
| KIT | PDGFR | TK | 6itv | A | B | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11827 | |
| KIT | PDGFR | TK | 8dfq | A | | - | Human | 14679 | |
| KIT | PDGFR | TK | 3g0f | B | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 400 | |
| KIT | PDGFR | TK | 6itt | A | A | n-(5-ethyl-1,2-oxazol-3-yl)-n'-[4-(2-{[6-(4-ethylpyrazin-1(4h)-yl)pyrimidin-4-yl]amino}-1,3-thiazol-5-yl)phenyl]urea | Human | 11826 | |
| KIT | PDGFR | TK | 4u0i | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 396 | |
| KIT | PDGFR | TK | 6gqj | B | A | 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{n}-(1-propan-2-ylpyrazol-4-yl)ethanamide | Human | 10358 | |
| KIT | PDGFR | TK | 8pqf | A | B | methyl ~{n}-[(1~{s})-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethyl]carbamate | Human | 15127 | |
| KIT | PDGFR | TK | 3g0f | A | | n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1,2-dihydro-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide | Human | 395 | |
| KIT | PDGFR | TK | 8s1b | A | B | ~{n}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | Human | 15761 | |
| KIT | PDGFR | TK | 8s1a | A | B | 1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1h-benzimidazol-1-yl}quinolin-8-yl)piperidin-4-amine | Human | 15762 | |
| EGFR | EGFR | TK | 2rfd | B | | - | Human | 840 | |
| EGFR | EGFR | TK | 9u91 | A | | n-[6-[[2-[[5-ethyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino]quinoxalin-5-yl]-n-methyl-methanesulfonamide | Human | 15892 | |
| EGFR | EGFR | TK | 5cav | A | | (1r)-1-{6-({2-[(3r,4s)-3-fluoro-4-methoxypiperidin-1-yl]pyrimidin-4-yl}amino)-1-[(2s)-1,1,1-trifluoropropan-2-yl]-1h-imidazo[4,5-c]pyridin-2-yl}ethanol | Human | 6197 | |
| EGFR | EGFR | TK | 9os6 | A | | canertinib | Human | 15893 | |
| EGFR | EGFR | TK | 6z4d | B | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 12979 | |
| EGFR | EGFR | TK | 6v6k | D | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12223 | |
| EGFR | EGFR | TK | 7jxk | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 13884 | |
| EGFR | EGFR | TK | 5x2f | C | A | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9527 | |
| EGFR | EGFR | TK | 9voy | A | | n-[(5p,8s,10r)-4-amino-6-methyl-5-(quinolin-3-yl)-8,9-dihydropyrimido[5,4-b]indolizin-8-yl]prop-2-enamide | Human | 15894 | |
| EGFR | EGFR | TK | 7jxi | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 13885 | |
| EGFR | EGFR | TK | 6v66 | D | B | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12224 | |
| EGFR | EGFR | TK | 5hib | A | | n-tert-butyl-5-{[(1-methyl-1h-pyrazol-5-yl)sulfonyl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6490 | |
| EGFR | EGFR | TK | 5edq | A | | ~{n}-(7-chloranyl-1~{h}-indazol-3-yl)-7,7-dimethyl-2-(1~{h}-pyrazol-4-yl)-5~{h}-furo[3,4-d]pyrimidin-4-amine | Human | 6253 | |
| EGFR | EGFR | TK | 3w2s | A | B | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 792 | |
| EGFR | EGFR | TK | 5x2a | D | C | phosphoaminophosphonic acid-adenylate ester | Human | 9533 | |
| EGFR | EGFR | TK | 6wa2 | C | A | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13447 | |
| EGFR | EGFR | TK | 6v6o | E | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12225 | |
| EGFR | EGFR | TK | 6duk | D | A | phosphoaminophosphonic acid-adenylate ester | Human | 11064 | |
| EGFR | EGFR | TK | 6v6o | A | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12181 | |
| EGFR | EGFR | TK | 6duk | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 11069 | |
| EGFR | EGFR | TK | 5hcz | A | | 2-[1-[1-[(2~{s})-butan-2-yl]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyrazolo[4,3-c]pyridin-3-yl]azetidin-3-yl]propan-2-ol | Human | 7041 | |
| EGFR | EGFR | TK | 5hg5 | A | B | n-{3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}propanamide | Human | 6376 | |
| EGFR | EGFR | TK | 6v6o | C | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12226 | |
| EGFR | EGFR | TK | 5ug8 | A | A | n-[(3r,4r)-4-fluoro-1-{6-[(1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7519 | |
| EGFR | EGFR | TK | 6p1l | C | | phosphoaminophosphonic acid-adenylate ester | Human | 11876 | |
| EGFR | EGFR | TK | 6duk | E | B | phosphoaminophosphonic acid-adenylate ester | Human | 11059 | |
| EGFR | EGFR | TK | 6duk | F | A | phosphoaminophosphonic acid-adenylate ester | Human | 11065 | |
| EGFR | EGFR | TK | 9h46 | A | | 5-ethyl-2-[(2-methoxyphenyl)amino]-8-phenyl-pyrido[2,3-d]pyrimidin-7-one | Human | 15895 | |
| EGFR | EGFR | TK | 5x2f | B | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9541 | |
| EGFR | EGFR | TK | 4riy | B | | adenosine-5'-diphosphate | Human | 806 | |
| EGFR | EGFR | TK | 6wak | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 13448 | |
| EGFR | EGFR | TK | 6tfy | B | A | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12847 | |
| ROS1 (ROS) | Sev | TK | 4uxl | A | | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 198 | |
| ROS1 (ROS) | Sev | TK | 3zbf | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 197 | |
| ROS1 (ROS) | Sev | TK | 7z5w | A | | ~{n}-[6-methyl-2-[(2~{s})-2-[3-(3-methylpyrazin-2-yl)-1,2-oxazol-5-yl]pyrrolidin-1-yl]pyrimidin-4-yl]-1,3-thiazol-2-amine | Human | 14326 | |
| AXL | Axl | TK | 5u6b | A | | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8258 | |
| AXL | Axl | TK | 5u6b | B | | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8260 | |
| AXL | Axl | TK | 5u6b | D | | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8259 | |
| AXL | Axl | TK | 5u6b | C | | (10r)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3,10,16-trimethyl-16,17-dihydro-1h-8,4-(azeno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 8257 | |
| DDR2 | DDR | TK | 7aym | A | A | n-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide | Human | 13071 | |
| DDR2 | DDR | TK | 6fer | C | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10731 | |
| DDR2 | DDR | TK | 6fer | B | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10736 | |
| DDR2 | DDR | TK | 6fer | D | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10730 | |
| DDR2 | DDR | TK | 6fer | K | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10725 | |
| DDR2 | DDR | TK | 6fer | I | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10735 | |
| DDR2 | DDR | TK | 6fer | A | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10729 | |
| DDR2 | DDR | TK | 6fer | J | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10728 | |
| DDR2 | DDR | TK | 6fer | H | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10727 | |
| DDR2 | DDR | TK | 7aym | A | B | n-[5-({[(3-fluorophenyl)carbamoyl]amino}methyl)-2-methylphenyl]imidazo[1,2-a]pyridine-3-carboxamide | Human | 13072 | |
| DDR2 | DDR | TK | 6fer | E | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10726 | |
| DDR2 | DDR | TK | 6fer | L | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10733 | |
| DDR2 | DDR | TK | 6fer | G | | 2-[4,5-bis(fluoranyl)-2-oxidanylidene-1'-(1~{h}-pyrazolo[3,4-b]pyridin-5-ylcarbonyl)spiro[indole-3,4'-piperidine]-1-yl]-~{n}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | Human | 10734 | |
| FGFR4 | FGFR | TK | 8kh8 | A | | 1-[4-[(1~{r})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea | Human | 15285 | |
| CSK | Csk | TK | 3d7u | C | | - | Human | 2944 | |
| CSK | Csk | TK | 3d7t | A | | staurosporine | Human | 2941 | |
| CSK | Csk | TK | 1byg | A | | staurosporine | Human | 2943 | |
| CSK | Csk | TK | 3d7u | A | | - | Human | 2942 | |
| ABL2 | Abl | TK | 2xyn | A | A | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 110 | |
| ABL2 | Abl | TK | 3gvu | A | B | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 109 | |
| ABL2 | Abl | TK | 2xyn | A | B | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 112 | |
| ABL2 | Abl | TK | 2xyn | B | B | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 113 | |
| ABL2 | Abl | TK | 2xyn | C | B | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 114 | |
| ABL2 | Abl | TK | 2xyn | C | A | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 116 | |
| ABL2 | Abl | TK | 2xyn | B | A | cyclopropanecarboxylic acid {4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2h-pyrazol-3-ylamino)-pyrimidin-2-ylsulfanyl]-phenyl}-amide | Human | 111 | |
| ABL2 | Abl | TK | 3hmi | A | A | 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-n-(2,6-difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide | Human | 115 | |
| ABL2 | Abl | TK | 3hmi | A | B | 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-n-(2,6-difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide | Human | 118 | |
| ABL2 | Abl | TK | 3gvu | A | A | 4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide | Human | 117 | |
| EPHA5 (EphA5) | Eph | TK | 2r2p | A | B | - | Human | 3413 | |
| KDR | VEGFR | TK | 6xvj | A | | ~{n}-[3-[(dimethylamino)methyl]-5-methyl-phenyl]-2-[3-methoxy-5-(7-methoxyquinolin-4-yl)oxy-pyridin-2-yl]ethanamide | Human | 12274 | |
| ZAP70 | Syk | TK | 1u59 | A | A | staurosporine | Human | 2734 | |
| JAK2 | JakA | TK | 6vnj | B | A | 3-[4-(2-{[4-(piperidin-4-yl)phenyl]amino}-6,7-dihydro-5h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]propanenitrile | Human | 13355 | |
| JAK2 | JakA | TK | 4iva | A | C | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 3714 | |
| JAK2 | JakA | TK | 5usy | A | B | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1h-1,2,4-triazol-3-yl}amino)benzenesulfonamide | Human | 8102 | |
| SYK | Syk | TK | 8bi2 | A | | 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one | Human | 14779 | |
| SYK | Syk | TK | 8x5k | A | A | 2-{[(1r,2s)-2-aminocyclohexyl]amino}-4-{[3-(2h-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide | Human | 15103 | |
| SYK | Syk | TK | 4i0t | A | B | n-tert-butyl-2-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-1-yl)-5h-pyrrolo[2,3-b]pyrazine-7-carboxamide | Human | 1164 | |
| SYK | Syk | TK | 4yjo | A | A | 5-chloro-n~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-n~4~-ethyl-n~4~-(1h-indazol-4-yl)pyrimidine-2,4-diamine | Human | 6120 | |
| EPHA5 (EphA5) | Eph | TK | 2r2p | A | A | - | Human | 3412 | |
| LCK | Src | TK | 1qpe | A | | 1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 2271 | |
| LCK | Src | TK | 3mpm | A | B | 4-{(6r,7r)-7-amino-3-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl}phenol | Human | 2295 | |
| LCK | Src | TK | 2ofv | A | | 3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 2280 | |
| LCK | Src | TK | 3b2w | A | | n-[5-({[2-fluoro-3-(trifluoromethyl)phenyl]amino}carbonyl)-2-methylphenyl]-4-methoxy-2-[(4-piperazin-1-ylphenyl)amino]pyrimidine-5-carboxamide | Human | 2299 | |
| LCK | Src | TK | 2ofu | A | | 2,6-dimethylphenyl 2-(3,5-dimethoxy-4-(3-(4-methylpiperazin-1-yl)propoxy)phenylamino)pyrimidin- 4-yl(2,4-dimethoxyphenyl)carbamate | Human | 2259 | |
| LCK | Src | TK | 6pdj | A | A | n-{4-[(6-methoxypyrazolo[1,5-a]pyridine-3-carbonyl)amino]-3-methylphenyl}-1-methyl-1h-indazole-3-carboxamide | Human | 11698 | |
| LCK | Src | TK | 3byo | A | | 6-(2,6-dimethylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimido[5',4':5,6]pyrimido[1,2-a]benzimidazol-5(6h)-one | Human | 2272 | |
| LCK | Src | TK | 3mpm | A | A | 4-{(6r,7r)-7-amino-3-[3-(4-methylpiperazin-1-yl)phenyl]-6,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl}phenol | Human | 2279 | |
| LCK | Src | TK | 2of4 | A | | 5,6-diphenyl-n-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine | Human | 2296 | |
| LCK | Src | TK | 3ac4 | A | | 5-[(2-amino-1,1-dimethylethyl)amino]-7-[(3,5-dimethoxyphenyl)amino][1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamide | Human | 2278 | |
| LCK | Src | TK | 3ac5 | A | | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-7-[(3,5-dimethoxyphenyl)amino]-2-(3-hydroxyphenyl)[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamide | Human | 2277 | |
| LCK | Src | TK | 1qpd | A | | staurosporine | Human | 2267 | |
| LCK | Src | TK | 2og8 | B | | n-{2-[(n,n-diethylglycyl)amino]-5-(trifluoromethyl)phenyl}-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide | Human | 2282 | |
| LCK | Src | TK | 1qpc | A | | phosphoaminophosphonic acid-adenylate ester | Human | 2291 | |
| LCK | Src | TK | 3bym | A | | n-phenyl-1-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}-1h-benzimidazol-2-amine | Human | 2264 | |
| LCK | Src | TK | 2of2 | A | | 2,3-diphenyl-n-(2-piperazin-1-ylethyl)furo[2,3-b]pyridin-4-amine | Human | 2261 | |
| FGFR1 | FGFR | TK | 6itj | A | B | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{h}-pyrazolo[3,4-d]pyridazin-7-one | Human | 11774 | |
| FGFR1 | FGFR | TK | 6nvl | D | A | n-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | Human | 11402 | |
| FGFR1 | FGFR | TK | 3rhx | A | | (6s)-6-phenyl-5,6-dihydrobenzo[h]quinazolin-2-amine | Human | 3554 | |
| FGFR1 | FGFR | TK | 5ew8 | A | B | ~{n}'-(3,5-dimethoxyphenyl)-~{n}'-[3-(1-methylpyrazol-4-yl)quinoxalin-6-yl]-~{n}-propan-2-yl-ethane-1,2-diamine | Human | 6461 | |
| FGFR1 | FGFR | TK | 4rwi | B | A | - | Human | 3569 | |
| FGFR1 | FGFR | TK | 5flf | D | B | - | Human | 6463 | |
| FGFR1 | FGFR | TK | 4f65 | A | B | 5-bromo-n~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]-n~4~-[3-(2-phenylethyl)-1h-pyrazol-5-yl]pyrimidine-2,4-diamine | Human | 3508 | |
| FGFR1 | FGFR | TK | 4wun | B | B | n-{3-[2-(3,5-dimethoxyphenyl)ethyl]-1h-pyrazol-5-yl}-4-[(3r,5s)-3,5-dimethylpiperazin-1-yl]benzamide | Human | 3565 | |
| LCK | Src | TK | 4c3f | A | B | n-phenyl-4-(5-phenyl-1h-pyrazol-4-yl)pyrimidin-2-amine | Human | 2297 | |
| LCK | Src | TK | 2zm4 | A | | n-(2-chloro-6-methylphenyl)-8-[(3s)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine | Human | 2262 | |
| LCK | Src | TK | 3ad5 | A | | 4-[4-(benzyloxy)phenyl]-5-{[2-(4-chlorophenyl)-2-oxoethyl]sulfanyl}-2,4-dihydro-3h-1,2,4-triazol-3-one | Human | 2270 | |
| LCK | Src | TK | 2og8 | A | | n-{2-[(n,n-diethylglycyl)amino]-5-(trifluoromethyl)phenyl}-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide | Human | 2286 | |
| LCK | Src | TK | 3lck | A | A | - | Human | 2263 | |
| LCK | Src | TK | 2zm1 | A | | n-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | Human | 2273 | |
| LCK | Src | TK | 3ac8 | A | | 7-[(2-amino-2-methylpropyl)amino]-5-cyclopropyl-2-[(3,5-dimethoxyphenyl)amino]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 2300 | |
| LCK | Src | TK | 4c3f | A | A | n-phenyl-4-(5-phenyl-1h-pyrazol-4-yl)pyrimidin-2-amine | Human | 2276 | |
| LCK | Src | TK | 3acj | A | | 7-(3,4-dimethoxyphenyl)-5-(ethylsulfanyl)imidazo[1,2-c]pyrimidine | Human | 2260 | |
| LCK | Src | TK | 3byu | A | | 2-methyl-n-{4-methyl-3-[(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)carbamoyl]phenyl}-3-(trifluoromethyl)benzamide | Human | 2288 | |
| LCK | Src | TK | 2zyb | A | | n-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | Human | 2275 | |
| LCK | Src | TK | 1qpj | A | | staurosporine | Human | 2283 | |
| LCK | Src | TK | 3ac1 | A | | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-3-[(3,5-dimethoxyphenyl)amino]pyrazine-2-carboxamide | Human | 2287 | |
| LCK | Src | TK | 3kxz | A | | 3-[7-[(3-hydroxyphenyl)amino]pyrazolo[1,5-a]pyrimidin-2-yl]-n-(1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-yl)benzamide | Human | 2281 | |
| LCK | Src | TK | 3ad6 | A | | 7-[(cyclopropylmethyl)amino]-2-[(4-methoxyphenyl)amino]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 2274 | |
| LCK | Src | TK | 3ac2 | A | | 7-[(2-amino-2-methylpropyl)amino]-2-[(3,5-dimethoxyphenyl)amino]-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 2266 | |
| LCK | Src | TK | 3ack | A | | 6-(5-methoxy-1-methyl-1h-indol-3-yl)-5h-pyrrolo[2,3-b]pyrazine | Human | 2284 | |
| INSRR (IRR) | InsR | TK | 7tym | A | | - | Human | 14611 | |
| INSRR (IRR) | InsR | TK | 7tyk | A | | - | Human | 14612 | |
| LCK | Src | TK | 3ac3 | A | | 2-[(3,5-dimethoxyphenyl)amino]-5-ethyl-7-[(2r)-2-(hydroxymethyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 2292 | |
| LCK | Src | TK | 2ofv | B | | 3-(2-aminoquinazolin-6-yl)-4-methyl-n-[3-(trifluoromethyl)phenyl]benzamide | Human | 2294 | |
| LCK | Src | TK | 3ad4 | A | | (4-chlorophenyl)(5-methoxy-1-benzofuran-2-yl)methanone | Human | 2268 | |
| LCK | Src | TK | 3bys | A | | 4-methyl-n~3~-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)-n~1~-[3-(trifluoromethyl)phenyl]benzene-1,3-dicarboxamide | Human | 2293 | |
| EGFR | EGFR | TK | 3w2p | A | B | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-4-(dimethylamino)butanamide | Human | 838 | |
| RET | Ret | TK | 2x2l | A | B | (3z)-5-amino-3-[(4-methoxyphenyl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3371 | |
| RET | Ret | TK | 2ivs | B | B | (3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide | Human | 3374 | |
| RET | Ret | TK | 6ne7 | A | B | adenosine monophosphate | Human | 11148 | |
| RET | Ret | TK | 7dua | A | A | 4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide | Human | 14048 | |
| RET | Ret | TK | 6i83 | A | | 4-[5-(pyridin-3-ylmethylamino)pyrazolo[1,5-a]pyrimidin-3-yl]benzamide | Human | 12051 | |
| RET | Ret | TK | 4cki | A | B | adenosine | Human | 3370 | |
| RET | Ret | TK | 6i82 | A | B | ~{n}-[3-(1,3-benzodioxol-5-yl)pyrazolo[1,5-a]pyrimidin-5-yl]-~{n}',~{n}'-dimethyl-propane-1,3-diamine | Human | 12054 | |
| RET | Ret | TK | 2ivv | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 3373 | |
| RET | Ret | TK | 2x2k | A | B | (3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3358 | |
| RET | Ret | TK | 7dua | A | B | 4-azanyl-7-(1-methylcyclopropyl)-~{n}-(5-methyl-1~{h}-pyrazol-3-yl)pyrrolo[2,3-d]pyrimidine-5-carboxamide | Human | 14049 | |
| RET | Ret | TK | 6nec | C | A | methyl (3z)-3-{[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}phenyl)amino](phenyl)methylidene}-2-oxo-2,3-dihydro-1h-indole-6-carboxylate | Human | 11147 | |
| RET | Ret | TK | 6fek | A | B | adenosine | Human | 9603 | |
| RET | Ret | TK | 2x2k | A | A | (3z)-5-amino-3-[(3,5-dimethyl-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3360 | |
| RET | Ret | TK | 7ju6 | A | B | selpercatinib | Human | 13107 | |
| RET | Ret | TK | 7ju6 | B | A | selpercatinib | Human | 13110 | |
| RET | Ret | TK | 6vhg | A | B | 3-(3,4-dimethoxyphenyl)-n~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine | Human | 11998 | |
| RET | Ret | TK | 5fm3 | A | | 1-ter-butyl-3-p-tolyl-1h-pyrazolo[3,4-d]pyrimidin-4-ylamine | Human | 7327 | |
| RET | Ret | TK | 7du9 | A | A | pralsetinib | Human | 14050 | |
| RET | Ret | TK | 6vhg | A | A | 3-(3,4-dimethoxyphenyl)-n~5~-(1-methylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine | Human | 11997 | |
| RET | Ret | TK | 2ivs | A | B | (3ar,4r,6r,6ar)-4-(6-amino-9h-purin-9-yl)-6-(hydroxymethyl)tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-2-ol 2-oxide | Human | 3369 | |
| RET | Ret | TK | 2ivu | A | | 4-bromo-2-fluoro-n-[(4e)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4(1h)-ylidene]aniline | Human | 3364 | |
| RET | Ret | TK | 2ivt | A | A | adenosine monophosphate | Human | 3361 | |
| RET | Ret | TK | 4cki | A | A | adenosine | Human | 3362 | |
| EGFR | EGFR | TK | 5yu9 | C | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9427 | |
| EGFR | EGFR | TK | 5caq | A | | n-[2-[(3r,4s)-3-fluoranyl-4-methoxy-piperidin-1-yl]pyrimidin-4-yl]-2-methyl-1-propan-2-yl-imidazo[4,5-c]pyridin-6-amine | Human | 6204 | |
| EGFR | EGFR | TK | 4zse | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 6699 | |
| EGFR | EGFR | TK | 2j6m | A | | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 900 | |
| EGFR | EGFR | TK | 6v66 | C | A | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12184 | |
| EGFR | EGFR | TK | 6v5n | B | B | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12185 | |
| EGFR | EGFR | TK | 6s9c | A | B | ~{n}-[1-(2-methyl-2-oxidanyl-propyl)benzimidazol-2-yl]-2-phenyl-pyridine-4-carboxamide | Human | 11804 | |
| EGFR | EGFR | TK | 2eb3 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 816 | |
| EGFR | EGFR | TK | 6v6o | E | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12191 | |
| EGFR | EGFR | TK | 5em5 | A | | 4-[2-(4-chlorophenyl)ethylamino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6307 | |
| EGFR | EGFR | TK | 5ug9 | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7513 | |
| EGFR | EGFR | TK | 4tks | A | | - | Human | 897 | |
| EGFR | EGFR | TK | 9df2 | A | | 3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[[(2s)-oxolan-2-yl]methoxy]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | Human | 15860 | |
| EGFR | EGFR | TK | 2jit | B | | - | Human | 805 | |
| EGFR | EGFR | TK | 9nis | A | | alflutinib, bound form | Human | 15861 | |
| EGFR | EGFR | TK | 6v5p | C | B | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12192 | |
| EGFR | EGFR | TK | 3gt8 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 908 | |
| EGFR | EGFR | TK | 6tg1 | A | A | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12826 | |
| EGFR | EGFR | TK | 6wak | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 13435 | |
| EGFR | EGFR | TK | 9wr8 | A | | alflutinib, bound form | Human | 15862 | |
| EGFR | EGFR | TK | 6v6k | E | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12193 | |
| EGFR | EGFR | TK | 6p8q | D | B | adenosine monophosphate | Human | 11877 | |
| EGFR | EGFR | TK | 8hv6 | A | B | ~{n}-quinolin-7-ylprop-2-enamide | Human | 15064 | |
| EGFR | EGFR | TK | 2rfe | B | | - | Human | 896 | |
| EGFR | EGFR | TK | 4rix | D | | adenosine-5'-diphosphate | Human | 909 | |
| EGFR | EGFR | TK | 5em7 | A | B | 4-[(2-methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6303 | |
| EGFR | EGFR | TK | 6duk | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 11066 | |
| EGFR | EGFR | TK | 8hv5 | A | B | ~{n}-(1-methylbenzimidazol-4-yl)prop-2-enamide | Human | 15065 | |
| EGFR | EGFR | TK | 8sc7 | A | B | n-[(5p)-2-chloro-5-(4-{[(1r)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide | Human | 15324 | |
| EGFR | EGFR | TK | 6tfv | B | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12827 | |
| EGFR | EGFR | TK | 5xdk | A | | n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | Human | 9065 | |
| EGFR | EGFR | TK | 9msr | A | | n-[4-(3-chloro-2-fluoroanilino)-7-{[(1s,5r)-3-methyl-3-azabicyclo[3.1.0]hexan-1-yl]ethynyl}quinazolin-6-yl]-4-(morpholin-4-yl)butanamide | Human | 15868 | |
| EGFR | EGFR | TK | 4zse | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 6697 | |
| EGFR | EGFR | TK | 6v5n | D | A | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12199 | |
| EGFR | EGFR | TK | 6z4d | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1h-pyrazol-4-yl)amino]-9-methyl-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 12972 | |
| EGFR | EGFR | TK | 5yu9 | B | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9434 | |
| EGFR | EGFR | TK | 6d8e | A | | (4-fluorophenyl)methyl {2-[(1-methyl-1h-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate | Human | 10374 | |
| EGFR | EGFR | TK | 5hg8 | A | A | n-[3-({2-[(1-methyl-1h-pyrazol-4-yl)amino]-7h-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)phenyl]propanamide | Human | 6380 | |
| EGFR | EGFR | TK | 9p9u | A | | 3-(furan-2-yl)-n-[5-(furan-2-yl)-2-methoxyphenyl]-1h-pyrazolo[3,4-d]pyrimidin-4-amine
| Human | 15869 | |
| EGFR | EGFR | TK | 4ll0 | B | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 796 | |
| EGFR | EGFR | TK | 9klw | A | | n-[4-[4-amino-6-ethynyl-5-(3-quinolyl)pyrrolo[2,3-d]pyrimidin-7-yl]norbornan-1-yl]pyrimidine-5-carboxamide | Human | 15870 | |
| EGFR | EGFR | TK | 9ews | A | | 1-[3-pyridin-4-yl-2-[3-(2-pyrimidin-2-ylethynyl)phenyl]-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | Human | 15871 | |
| EGFR | EGFR | TK | 3vjn | A | | phosphoaminophosphonic acid-adenylate ester | Human | 872 | |
| EGFR | EGFR | TK | 8hv3 | A | | ~{n}-pyridin-2-ylprop-2-enamide | Human | 15067 | |
| EGFR | EGFR | TK | 6v5p | B | B | 4-[4-(4-fluorophenyl)-2-(3-methoxypropyl)-1h-imidazol-5-yl]-2-phenyl-3h-pyrrolo[2,3-b]pyridine | Human | 12200 | |
| EGFR | EGFR | TK | 6duk | D | B | phosphoaminophosphonic acid-adenylate ester | Human | 11062 | |
| EGFR | EGFR | TK | 9gc4 | A | | 1-[2-[3-(3-chloranyl-6-fluoranyl-pyridin-2-yl)oxyphenyl]-3-pyrimidin-4-yl-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | Human | 15872 | |
| EGFR | EGFR | TK | 7lgs | A | B | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 13905 | |
| EGFR | EGFR | TK | 4g5j | A | B | n-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3s)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide | Human | 852 | |
| EGFR | EGFR | TK | 4i24 | B | | (2e)-n-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide | Human | 910 | |
| EGFR | EGFR | TK | 7jxw | A | A | n-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | Human | 13875 | |
| EGFR | EGFR | TK | 7a2a | B | B | (2r)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-2-phenyl-n-(1,3-thiazol-2-yl)acetamide | Human | 12973 | |
| EGFR | EGFR | TK | 2rfe | D | | - | Human | 807 | |
| EGFR | EGFR | TK | 4r3r | A | | - | Human | 887 | |
| EGFR | EGFR | TK | 2itu | A | B | 1,2,3,4-tetrahydrogen staurosporine | Human | 859 | |
| EGFR | EGFR | TK | 4lrm | C | | n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}propanamide | Human | 781 | |
| EGFR | EGFR | TK | 6tfz | B | A | ~{n}-[2-(2-hydroxyethyloxy)-5-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12830 | |
| EGFR | EGFR | TK | 1m17 | A | A | [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine | Human | 873 | |
| EGFR | EGFR | TK | 7sye | A | | - | Human | 14028 | |
| EGFR | EGFR | TK | 4lqm | A | | n-[4-(3-bromo-phenylamino)-quinazolin-6-yl]-acrylamide | Human | 785 | |
| EGFR | EGFR | TK | 4rj4 | A | | n-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1-(propan-2-yl)-2-(1h-pyrazol-4-yl)-1h-pyrrolo[3,2-c]pyridin-6-amine | Human | 866 | |
| EGFR | EGFR | TK | 9njn | A | | n-[2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-({(4m)-4-[(4s)-8-methylimidazo[1,2-a]pyridin-3-yl]pyrimidin-2-yl}amino)phenyl]propanamide | Human | 15873 | |
| EGFR | EGFR | TK | 9ghs | A | | (~{n}~{e})-2-(1-methylpyrazol-4-yl)-~{n}-[3-[(3~{r})-1-propanoylazepan-3-yl]-1~{h}-benzimidazol-2-ylidene]pyridine-4-carboxamide | Human | 15874 | |
| EGFR | EGFR | TK | 5em8 | A | | 4-[(2-methoxyphenyl)amino]-~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-2-oxidanylidene-1~{h}-pyridine-3-carboxamide | Human | 6306 | |
| EGFR | EGFR | TK | 6v5n | D | B | 3-[4-(4-fluorophenyl)-5-(2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-imidazol-2-yl]propan-1-ol | Human | 12201 | |
| EGFR | EGFR | TK | 6v6k | B | A | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12202 | |
| EGFR | EGFR | TK | 5xgn | A | | 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole | Human | 8553 | |
| EGFR | EGFR | TK | 6lub | A | B | n-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine | Human | 12917 | |
| EGFR | EGFR | TK | 7ky0 | A | | (20r)-10,15,20-trimethyl-2-[(4-methylpiperazin-1-yl)methyl]-18,19,20,21-tetrahydro-15h,17h-12,8-(metheno)pyrazolo[3',4':2,3][1,5,10,12]oxatriazacycloheptadecino[12,11-a]benzimidazol-7(6h)-one | Human | 14073 | |
| EGFR | EGFR | TK | 7u9a | A | | 4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol | Human | 14527 | |
| EGFR | EGFR | TK | 5cno | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 884 | |
| EGFR | EGFR | TK | 8a2d | A | A | (2r)-2-[4-[bis(fluoranyl)methyl]-6-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-7-methyl-indazol-2-yl]-2-spiro[6,7-dihydropyrrolo[1,2-c]imidazole-5,1'-cyclopropane]-1-yl-n-(1,3-thiazol-2-yl)ethanamide | Human | 14463 | |
| EGFR | EGFR | TK | 5yu9 | A | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9428 | |
| EGFR | EGFR | TK | 6wak | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13440 | |
| EGFR | EGFR | TK | 5gmp | A | A | n-[3-[2-[[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino]-5-methyl-7-oxidanylidene-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide | Human | 8167 | |
| EGFR | EGFR | TK | 4riy | D | | adenosine-5'-diphosphate | Human | 856 | |
| EGFR | EGFR | TK | 6tg0 | B | A | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(2-hydroxyethyloxy)phenyl]propanamide | Human | 12834 | |
| EGFR | EGFR | TK | 9pwi | A | A | n-[2-({1-methyl-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl}methyl)phenyl]prop-2-enamide | Human | 16258 | |
| EGFR | EGFR | TK | 4zse | B | A | phosphoaminophosphonic acid-adenylate ester | Human | 6695 | |
| EGFR | EGFR | TK | 7zyn | A | B | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 14728 | |
| EGFR | EGFR | TK | 7zyq | A | B | phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1h-indol-3-yl)pyrimidine-5-carboxylate | Human | 14729 | |
| EGFR | EGFR | TK | 6tg1 | B | A | ~{n}-[5-[4-[[4-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12836 | |
| EGFR | EGFR | TK | 6tfw | B | | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12837 | |
| EGFR | EGFR | TK | 7ukv | A | | n-[5-{[(4p)-4-{4-[(dimethylamino)methyl]-3-phenyl-1h-pyrazol-1-yl}pyrimidin-2-yl]amino}-4-methoxy-2-(morpholin-4-yl)phenyl]propanamide | Human | 14528 | |
| EGFR | EGFR | TK | 9gc6 | A | | 1-[2-[5-fluoranyl-4-(2-fluorophenyl)pyridin-2-yl]-3-pyrimidin-4-yl-4,6-dihydropyrrolo[3,4-d]imidazol-5-yl]propan-1-one | Human | 15882 | |
| EGFR | EGFR | TK | 9jq1 | A | | 2,2-bis(chloranyl)-~{n}-[5-[[5-chloranyl-4-[(2-dimethylphosphorylphenyl)amino]pyrimidin-2-yl]amino]-4-methoxy-2-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]ethanamide | Human | 15883 | |
| EGFR | EGFR | TK | 6p1d | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 11868 | |
| EGFR | EGFR | TK | 5x2c | B | A | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9569 | |
| EGFR | EGFR | TK | 5x2c | B | C | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9570 | |
| EGFR | EGFR | TK | 7zyq | A | A | phenyl 2-[[4-[4-(dimethylamino)piperidin-1-yl]-2-methoxy-phenyl]amino]-4-(1h-indol-3-yl)pyrimidine-5-carboxylate | Human | 14730 | |
| EGFR | EGFR | TK | 4jq7 | A | | (2s)-2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]-2-phenylethanol | Human | 801 | |
| EGFR | EGFR | TK | 6v6k | C | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12209 | |
| EGFR | EGFR | TK | 6v66 | A | A | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12178 | |
| EGFR | EGFR | TK | 2itq | A | B | 1,2,3,4-tetrahydrogen staurosporine | Human | 846 | |
| EGFR | EGFR | TK | 5j9y | A | B | (r)-1-(3-(4-amino-3-(naphthalen-1-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one | Human | 6945 | |
| EGFR | EGFR | TK | 5xdl | A | | n-[3-[[2-[[4-(4-ethanoylpiperazin-1-yl)-2-methoxy-phenyl]amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide | Human | 9066 | |
| EGFR | EGFR | TK | 6p1d | D | A | 10-benzyl-8-fluoro-5,10-dihydro-11h-dibenzo[b,e][1,4]diazepin-11-one | Human | 11884 | |
| EGFR | EGFR | TK | 9pwi | A | B | n-[2-({1-methyl-7-[4-(4-methylpiperazin-1-yl)anilino]-2-oxo-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2h)-yl}methyl)phenyl]prop-2-enamide | Human | 16259 | |
| EGFR | EGFR | TK | 6v6k | D | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12212 | |
| EGFR | EGFR | TK | 5x2c | B | B | 9-cyclopentyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9571 | |
| EGFR | EGFR | TK | 6p8q | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 11875 | |
| EGFR | EGFR | TK | 8hv9 | A | B | ~{n}-(4-phenylpyridin-2-yl)prop-2-enamide | Human | 15070 | |
| EGFR | EGFR | TK | 6wa2 | A | B | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13442 | |
| EGFR | EGFR | TK | 6v6o | D | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12213 | |
| EGFR | EGFR | TK | 9xu9 | A | | 5-chloranyl-~{n}4-(2-dimethylphosphorylphenyl)-~{n}2-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitro-phenyl]pyrimidine-2,4-diamine | Human | 15885 | |
| EGFR | EGFR | TK | 5xgn | B | | - | Human | 8554 | |
| EGFR | EGFR | TK | 4r5s | A | | n-[4-({[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino}methyl)phenyl]propanamide | Human | 775 | |
| EGFR | EGFR | TK | 5hcx | A | | ~{n}-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-2-methyl-1-propan-2-yl-imidazo[4,5-c]pyridin-6-amine | Human | 7040 | |
| EGFR | EGFR | TK | 6tfw | A | | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-[2-(dimethylamino)ethoxy]phenyl]propanamide | Human | 12838 | |
| EGFR | EGFR | TK | 5gty | H | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8357 | |
| EGFR | EGFR | TK | 2gs7 | B | | phosphoaminophosphonic acid-adenylate ester | Human | 795 | |
| EGFR | EGFR | TK | 6v6k | F | B | n-[3-({4-[4-(4-fluorophenyl)-2-(methylsulfanyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12214 | |
| EGFR | EGFR | TK | 3ug1 | A | B | - | Human | 799 | |
| EGFR | EGFR | TK | 5x2f | A | B | 9-cyclohexyl-n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-purine-2,8-diamine | Human | 9535 | |
| EGFR | EGFR | TK | 6v6o | G | A | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12215 | |
| EGFR | EGFR | TK | 2itw | A | B | 1,2,3,4-tetrahydrogen staurosporine | Human | 914 | |
| EGFR | EGFR | TK | 7a2a | A | B | (2r)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-2-phenyl-n-(1,3-thiazol-2-yl)acetamide | Human | 12976 | |
| EGFR | EGFR | TK | 4rj7 | A | A | 2,6-dichloro-n-{2-[(2-{[(2s)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide | Human | 793 | |
| EGFR | EGFR | TK | 5cno | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 894 | |
| EGFR | EGFR | TK | 5gty | F | B | 1-[(3r)-3-[4-azanyl-3-[3-chloranyl-4-[(6-methylpyridin-2-yl)methoxy]phenyl]pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one | Human | 8364 | |
| EGFR | EGFR | TK | 7a2a | A | A | (2r)-2-(1-oxo-1,3-dihydro-2h-isoindol-2-yl)-2-phenyl-n-(1,3-thiazol-2-yl)acetamide | Human | 12977 | |
| EGFR | EGFR | TK | 5yu9 | D | B | 1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}prop-2-en-1-one | Human | 9429 | |
| EGFR | EGFR | TK | 5x2a | B | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9526 | |
| EGFR | EGFR | TK | 8hv1 | A | | 3-(3-bromophenyl)-1,4-dihydro-1,2,4-triazole-5-thione | Human | 15072 | |
| EGFR | EGFR | TK | 2itt | A | A | 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-n-[(1r)-1-phenylethyl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 892 | |
| EGFR | EGFR | TK | 8hv8 | A | | ~{n}-pyrazolo[1,5-a]pyridin-2-ylprop-2-enamide | Human | 15073 | |
| EGFR | EGFR | TK | 7jxq | A | B | (2r)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2h-isoindol-2-yl}-n-(1,3-thiazol-2-yl)acetamide | Human | 13880 | |
| EGFR | EGFR | TK | 6jz0 | A | | e-4-(dimethylamino)-n-[3-[4-[[(1s)-2-oxidanyl-1-phenyl-ethyl]amino]-6-phenyl-furo[2,3-d]pyrimidin-5-yl]phenyl]but-2-enamide | Human | 11845 | |
| EGFR | EGFR | TK | 2itu | A | A | 1,2,3,4-tetrahydrogen staurosporine | Human | 779 | |
| EGFR | EGFR | TK | 5cal | A | | 2,2-dimethyl-3-[(4-{[2-methyl-1-(propan-2-yl)-1h-imidazo[4,5-c]pyridin-6-yl]amino}pyrimidin-2-yl)amino]propanamide | Human | 6195 | |
| EGFR | EGFR | TK | 5x2a | C | A | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9537 | |
| EGFR | EGFR | TK | 8wd4 | A | | ~{n}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{s})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide | Human | 15074 | |
| EGFR | EGFR | TK | 3w33 | A | A | 4-{[4-(1-benzothiophen-4-yloxy)-3-chlorophenyl]amino}-n-(2-hydroxyethyl)-8,9-dihydro-7h-pyrimido[4,5-b]azepine-6-carboxamide | Human | 782 | |
| EGFR | EGFR | TK | 6v6o | F | B | n-[3-({4-[4-(4-fluorophenyl)-2-(3-hydroxypropyl)-1h-imidazol-5-yl]pyridin-2-yl}amino)-4-methoxyphenyl]propanamide | Human | 12220 | |
| EGFR | EGFR | TK | 6wa2 | B | B | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-fluoro-5-hydroxybenzamide | Human | 13444 | |
| EGFR | EGFR | TK | 5ug8 | A | B | n-[(3r,4r)-4-fluoro-1-{6-[(1-methyl-1h-pyrazol-4-yl)amino]-9-(propan-2-yl)-9h-purin-2-yl}pyrrolidin-3-yl]propanamide | Human | 7514 | |
| EGFR | EGFR | TK | 8a27 | A | B | (2r)-2-(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1h-isoindol-2-yl]-n-(1,3-thiazol-2-yl)ethanamide | Human | 14465 | |
| EGFR | EGFR | TK | 4zjv | A | B | - | Human | 843 | |
| EGFR | EGFR | TK | 6tfz | A | A | ~{n}-[2-(2-hydroxyethyloxy)-5-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12840 | |
| EGFR | EGFR | TK | 9gi9 | A | | 3-[(3-chloranyl-2-methoxy-phenyl)amino]-2-[3-[[(2~{r})-oxolan-2-yl]methoxy]pyridin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one | Human | 15889 | |
| EGFR | EGFR | TK | 6tfy | A | B | ~{n}-[5-[4-[[3-chloranyl-4-(pyridin-2-ylmethoxy)phenyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]-2-(3-oxidanylpropoxy)phenyl]propanamide | Human | 12841 | |
| EGFR | EGFR | TK | 9ngp | A | | (6m)-1-{2-[(5s,8ar)-hexahydropyrrolo[1,2-a]pyrazin-2(1h)-yl]-1-methyl-4-[(1r,4r)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]-1h-imidazo[4,5-c]pyridin-6-yl}-6-(4-methoxypyridin-3-yl)-4-methyl-1h-pyrazolo[4,3-c]pyridine | Human | 15890 | |
| EGFR | EGFR | TK | 8sc7 | A | C | n-[(5p)-2-chloro-5-(4-{[(1r)-1-phenylethyl]amino}quinazolin-6-yl)pyridin-3-yl]methanesulfonamide | Human | 15326 | |
| EGFR | EGFR | TK | 7zyp | A | | propan-2-yl 2-[[4-(4-azanylpiperidin-1-yl)-2-methoxy-phenyl]amino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate | Human | 14731 | |
| EGFR | EGFR | TK | 6tfu | A | | ~{n}-[3-[4-[[1-(phenylmethyl)indazol-5-yl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 12844 | |
| EGFR | EGFR | TK | 6wak | D | A | phosphoaminophosphonic acid-adenylate ester | Human | 13446 | |
| EGFR | EGFR | TK | 3w32 | A | | 4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-n-[2-(methylsulfonyl)ethyl]-8,9-dihydro-7h-pyrimido[4,5-b]azepine-6-carboxamide | Human | 784 | |
| EGFR | EGFR | TK | 8gk5 | A | | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15327 | |
| EGFR | EGFR | TK | 7jxm | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13883 | |
| EGFR | EGFR | TK | 4zse | C | B | phosphoaminophosphonic acid-adenylate ester | Human | 6698 | |
| EGFR | EGFR | TK | 3w33 | A | B | 4-{[4-(1-benzothiophen-4-yloxy)-3-chlorophenyl]amino}-n-(2-hydroxyethyl)-8,9-dihydro-7h-pyrimido[4,5-b]azepine-6-carboxamide | Human | 869 | |
| EGFR | EGFR | TK | 7er2 | A | | 5-chloranyl-n2-[3-chloranyl-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n4-(2-dimethylphosphorylphenyl)pyrimidine-2,4-diamine | Human | 14194 | |
| EGFR | EGFR | TK | 7sz5 | A | | - | Human | 14030 | |
| EGFR | EGFR | TK | 5x2a | B | B | n2-[4-(4-methylpiperazin-1-yl)phenyl]-n8-phenyl-9-propan-2-yl-purine-2,8-diamine | Human | 9548 | |
| EGFR | EGFR | TK | 4jq8 | A | | n-[3-(4-{[(1s)-2-hydroxy-1-phenylethyl]amino}-6-phenylfuro[2,3-d]pyrimidin-5-yl)phenyl]-n~3~,n~3~-dimethyl-beta-alaninamide | Human | 821 | |
| EGFR | EGFR | TK | 6p1l | B | | phosphoaminophosphonic acid-adenylate ester | Human | 11886 | |
| EGFR | EGFR | TK | 6s8a | A | | ~{n}-[3-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-methylpropoxy)-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]phenyl]propanamide | Human | 11728 | |
| EGFR | EGFR | TK | 5cnn | B | B | phosphoaminophosphonic acid-adenylate ester | Human | 803 | |
| EGFR | EGFR | TK | 6wak | C | A | n-(3-{5-[2-(acetylamino)pyridin-4-yl]-2-(methylsulfanyl)-1h-imidazol-4-yl}phenyl)-2-[(1-oxo-1,3-dihydro-2h-isoindol-2-yl)methyl]benzamide | Human | 13449 | |
| EGFR | EGFR | TK | 2rf9 | A | | - | Human | 876 | |
| EGFR | EGFR | TK | 2jiv | B | A | n-(4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)butanamide | Human | 830 | |
| EGFR | EGFR | TK | 7lgs | C | B | ~{n}-[2-[2-(dimethylamino)ethyl-methyl-amino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]propanamide | Human | 15376 | |
| EGFR | EGFR | TK | 2rf9 | B | | - | Human | 883 | |
| EGFR | EGFR | TK | 4riw | D | | adenosine-5'-diphosphate | Human | 848 | |
| EGFR | EGFR | TK | 6vhp | A | | n-{3-[(4-{4-(4-fluorophenyl)-2-[(2-methoxyethyl)sulfanyl]-1h-imidazol-5-yl}pyridin-2-yl)amino]-4-methoxyphenyl}propanamide | Human | 12182 | |
| EGFR | EGFR | TK | 3poz | A | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 7308 | |
| EGFR | EGFR | TK | 3w2p | A | A | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-4-(dimethylamino)butanamide | Human | 829 | |
| EGFR | EGFR | TK | 7sz0 | A | B | - | Human | 14031 | |
| EGFR | EGFR | TK | 3gop | A | B | - | Human | 886 | |
| EGFR | EGFR | TK | 3ika | A | A | n-{3-[(5-chloro-2-{[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 802 | |
| EGFR | EGFR | TK | 3gt8 | B | | phosphoaminophosphonic acid-adenylate ester | Human | 847 | |
| EGFR | EGFR | TK | 5xgm | A | | 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole | Human | 8552 | |
| EGFR | EGFR | TK | 4zse | D | A | phosphoaminophosphonic acid-adenylate ester | Human | 6694 | |
| EGFR | EGFR | TK | 2gs2 | A | | - | Human | 849 | |
| EGFR | EGFR | TK | 3w2s | A | A | 1-{3-[2-chloro-4-({5-[2-(2-hydroxyethoxy)ethyl]-5h-pyrrolo[3,2-d]pyrimidin-4-yl}amino)phenoxy]phenyl}-3-cyclohexylurea | Human | 778 | |
| TYK2-b | JakB | TK | 6nsl | B | B | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11953 | |
| TYK2-b | JakB | TK | 6nze | A | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11444 | |
| TYK2-b | JakB | TK | 7ax4 | B | | 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide | Human | 13498 | |
| TYK2-b | JakB | TK | 5tkd | A | B | 6-[(3,5-dimethylphenyl)amino]-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 7326 | |
| TYK2-b | JakB | TK | 6nzq | B | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11495 | |
| TYK2-b | JakB | TK | 6nzp | A | B | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11501 | |
| TYK2-b | JakB | TK | 6nzr | A | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11505 | |
| TYK2-b | JakB | TK | 4wov | A | B | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2199 | |
| TYK2-b | JakB | TK | 6nzh | A | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11450 | |
| TYK2-b | JakB | TK | 6nzf | B | B | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11445 | |
| TYK2-b | JakB | TK | 6nzh | B | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11452 | |
| TYK2-b | JakB | TK | 4wov | A | A | 2-methoxy-n-({6-[1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl]pyridin-2-yl}methyl)acetamide | Human | 2196 | |
| TYK2-b | JakB | TK | 8s99 | A | B | (8s)-n-[(1r,2s)-2-fluorocyclopropyl]-5-{[(1m,2'm)-3'-fluoro-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}-7-(methylamino)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14850 | |
| TYK2-b | JakB | TK | 6nze | A | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11453 | |
| TYK2-b | JakB | TK | 6nsl | A | B | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11954 | |
| TYK2-b | JakB | TK | 6nsl | A | A | 6-{[1-(4-cyanophenyl)-2-oxo-1,2-dihydropyridin-3-yl]amino}-n-cyclopropyl-8-(methylamino)imidazo[1,2-b]pyridazine-3-carboxamide | Human | 11952 | |
| TYK2-b | JakB | TK | 4oli | A | | 2-chloro-n-{2-[(cyclopropylcarbonyl)amino]pyridin-4-yl}benzamide | Human | 2198 | |
| TYK2-b | JakB | TK | 6nzr | B | A | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11498 | |
| TYK2-b | JakB | TK | 6nzh | A | B | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11442 | |
| TYK2-b | JakB | TK | 8s9a | A | B | (8s)-n-[(1r,2r)-2-methoxycyclobutyl]-7-(methylamino)-5-{[(1p,2'p)-2-oxo-2h-[1,2'-bipyridin]-3-yl]amino}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 14851 | |
| TYK2-b | JakB | TK | 6nze | B | A | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11448 | |
| TYK2-b | JakB | TK | 5c03 | A | B | phosphothiophosphoric acid-adenylate ester | Human | 6044 | |
| TYK2-b | JakB | TK | 8tb5 | A | A | n-{(3p)-3-[3-(dimethylsulfamoyl)phenyl]-1h-pyrrolo[2,3-c]pyridin-5-yl}cyclopropanecarboxamide | Human | 14958 | |
| TYK2-b | JakB | TK | 6nzq | A | A | 6-[(5-fluoro-4-methylpyridin-2-yl)amino]-4-[(2-methoxy-3-{[(pyridin-2-yl)methyl]carbamoyl}phenyl)amino]-n-methylpyridine-3-carboxamide | Human | 11502 | |
| TYK2-b | JakB | TK | 6nzf | A | A | 6-[(5-fluoropyridin-2-yl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11446 | |
| TYK2-b | JakB | TK | 6nzh | B | A | 6-[(cyclopropanecarbonyl)amino]-n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}pyridine-3-carboxamide | Human | 11447 | |
| TYK2-b | JakB | TK | 6nzr | B | B | n-methyl-4-{[2-(methylsulfonyl)phenyl]amino}-6-[(pyridin-2-yl)amino]pyridazine-3-carboxamide | Human | 11500 | |
| TYK2-b | JakB | TK | 5c03 | B | B | phosphothiophosphoric acid-adenylate ester | Human | 6045 | |
| TYK2-b | JakB | TK | 6nze | B | B | 4-[(2-carbamoylphenyl)amino]-6-[(5-fluoropyridin-2-yl)amino]-n-methylpyridine-3-carboxamide | Human | 11443 | |
| TYK2-b | JakB | TK | 7k7q | A | A | 6-[(cyclopropanecarbonyl)amino]-4-({3-[6-(dimethylcarbamoyl)pyridazin-3-yl]-2-methoxyphenyl}amino)-n-methylpyridazine-3-carboxamide | Human | 13838 | |
| TYK2-b | JakB | TK | 5c01 | A | | - | Human | 7222 | |
| TYK2-b | JakB | TK | 6nzp | A | A | 6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(1-methyl-1h-1,2,4-triazol-3-yl)phenyl]amino}-n-methylpyridazine-3-carboxamide | Human | 11504 | |
| ALK | ALK | TK | 2yjs | A | | - | Human | 5373 | |
| PTK2 (FAK) | FAK | TK | 1mp8 | A | | adenosine-5'-diphosphate | Human | 217 | |
| PTK2 (FAK) | FAK | TK | 4ebw | A | B | - | Human | 219 | |
| PTK2 (FAK) | FAK | TK | 3bz3 | A | A | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 228 | |
| PTK2 (FAK) | FAK | TK | 6yvs | C | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13307 | |
| PTK2 (FAK) | FAK | TK | 6yvy | B | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13267 | |
| PTK2 (FAK) | FAK | TK | 6yxv | D | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13308 | |
| PTK2 (FAK) | FAK | TK | 2ijm | A | A | adenosine-5'-triphosphate | Human | 215 | |
| PTK2 (FAK) | FAK | TK | 6yvs | D | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13309 | |
| PTK2 (FAK) | FAK | TK | 6yvs | A | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13310 | |
| PTK2 (FAK) | FAK | TK | 4i4e | A | C | [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone | Human | 234 | |
| PTK2 (FAK) | FAK | TK | 4i4e | A | A | [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone | Human | 245 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | C | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13311 | |
| PTK2 (FAK) | FAK | TK | 4gu6 | B | B | n-(3-{[(5-cyano-2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-n-methylmethanesulfonamide | Human | 223 | |
| PTK2 (FAK) | FAK | TK | 4ebv | A | C | - | Human | 224 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | B | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13312 | |
| PTK2 (FAK) | FAK | TK | 4gu6 | B | A | n-(3-{[(5-cyano-2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-n-methylmethanesulfonamide | Human | 240 | |
| PTK2 (FAK) | FAK | TK | 4q9s | A | | 3,5-dihydro[1,2,4]triazino[3,4-c][1,4]benzoxazin-2(1h)-one | Human | 247 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | C | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13315 | |
| PTK2 (FAK) | FAK | TK | 4kab | B | | 3-methyl-1,5-dihydropyrazolo[4,3-c]pyrazole | Human | 250 | |
| PTK2 (FAK) | FAK | TK | 6yoj | A | B | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{h}-quinolin-2-one | Human | 13316 | |
| PTK2 (FAK) | FAK | TK | 4i4f | A | A | - | Human | 238 | |
| PTK2 (FAK) | FAK | TK | 3bz3 | A | B | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 227 | |
| PTK2 (FAK) | FAK | TK | 4k8a | A | | 3-bromo-5-(2h-tetrazol-5-yl)pyridine | Human | 244 | |
| PTK2 (FAK) | FAK | TK | 4gu9 | B | | n-(2-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 221 | |
| PTK2 (FAK) | FAK | TK | 4kab | A | | 3-methyl-1,5-dihydropyrazolo[4,3-c]pyrazole | Human | 242 | |
| PTK2 (FAK) | FAK | TK | 6yvy | C | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13269 | |
| PTK2 (FAK) | FAK | TK | 4i4f | A | C | - | Human | 232 | |
| PTK2 (FAK) | FAK | TK | 2etm | B | | 7-pyridin-2-yl-n-(3,4,5-trimethoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-2-amine | Human | 225 | |
| PTK2 (FAK) | FAK | TK | 7pi4 | D | A | - | Human | 13913 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | B | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13317 | |
| PTK2 (FAK) | FAK | TK | 6yvs | D | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13318 | |
| PTK2 (FAK) | FAK | TK | 4i4e | A | B | [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone | Human | 216 | |
| PTK2 (FAK) | FAK | TK | 2ijm | B | A | adenosine-5'-diphosphate | Human | 220 | |
| PTK2 (FAK) | FAK | TK | 6yvy | A | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13270 | |
| PTK2 (FAK) | FAK | TK | 4kao | B | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 253 | |
| PTK2 (FAK) | FAK | TK | 6yoj | A | A | 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{h}-quinolin-2-one | Human | 13319 | |
| PTK2 (FAK) | FAK | TK | 6yvs | C | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13320 | |
| PTK2 (FAK) | FAK | TK | 4k9y | A | B | 1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 233 | |
| PTK2 (FAK) | FAK | TK | 6yt6 | B | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-1,3-dihydroindol-5-yl)amino]pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13272 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | D | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13321 | |
| PTK2 (FAK) | FAK | TK | 6yxv | C | | ~{n}-methyl-~{n}-[3-[(~{e})-[2-phenylazanyl-5-(trifluoromethyl)pyrimidin-4-yl]iminomethyl]pyridin-2-yl]methanesulfonamide | Human | 13322 | |
| PTK2 (FAK) | FAK | TK | 4gu6 | A | B | n-(3-{[(5-cyano-2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-n-methylmethanesulfonamide | Human | 226 | |
| PTK2 (FAK) | FAK | TK | 6yvs | A | A | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13323 | |
| PTK2 (FAK) | FAK | TK | 7pi4 | D | B | - | Human | 13914 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | A | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13325 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | B | A | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13326 | |
| PTK2 (FAK) | FAK | TK | 3pxk | A | | 6-(4,4-dimethylpent-2-yn-1-yl)-1lambda~4~-pyrrolo[2,3-d][1,3]thiazole | Human | 241 | |
| PTK2 (FAK) | FAK | TK | 6yvy | D | B | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13274 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | D | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13330 | |
| PTK2 (FAK) | FAK | TK | 4i4f | A | B | - | Human | 251 | |
| PTK2 (FAK) | FAK | TK | 4k9y | A | C | 1-[4-(6-amino-9h-purin-9-yl)phenyl]-3-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea | Human | 229 | |
| PTK2 (FAK) | FAK | TK | 6yvs | B | B | 5-[[4-(pyridin-3-ylmethylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino]-1,3-dihydroindol-2-one | Human | 13331 | |
| PTK2 (FAK) | FAK | TK | 4kao | A | | 1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[4-(pyridin-3-yl)phenyl]urea | Human | 248 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | A | A | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13332 | |
| PTK2 (FAK) | FAK | TK | 6yq1 | D | B | ~{n}-methyl-~{n}-[3-[[[2-[(2-oxidanylidene-3,4-dihydro-1~{h}-quinolin-6-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide | Human | 13333 | |
| PTK2 (FAK) | FAK | TK | 6yvy | A | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13275 | |
| PTK2 (FAK) | FAK | TK | 6yr9 | C | B | n-methyl-n-(2-{[2-(2-oxo-2,3-dihydro-1h-indol-5-ylamino)-5-trifluoromethyl-pyrimidin-4-ylamino]-methyl}-phenyl)-methanesulfonamide | Human | 13334 | |
| PTK2 (FAK) | FAK | TK | 4k8a | B | | 3-bromo-5-(2h-tetrazol-5-yl)pyridine | Human | 239 | |
| PTK2 (FAK) | FAK | TK | 2ijm | A | B | adenosine-5'-triphosphate | Human | 243 | |
| PTK2 (FAK) | FAK | TK | 6yvy | B | A | 4-{[4-{[(1r,2r)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-n-methylbenzenesulfonamide | Human | 13276 | |
| PTK2 (FAK) | FAK | TK | 2ijm | B | B | adenosine-5'-diphosphate | Human | 249 | |
| PTK2 (FAK) | FAK | TK | 4gu6 | A | A | n-(3-{[(5-cyano-2-phenyl-1h-pyrrolo[2,3-b]pyridin-4-yl)amino]methyl}pyridin-2-yl)-n-methylmethanesulfonamide | Human | 252 | |
| ALK | ALK | TK | 2yhv | A | | - | Human | 5384 | |
| ALK | ALK | TK | 6cdt | A | | - | Human | 11263 | |
| ALK | ALK | TK | 7btt | A | B | 2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5h-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone | Human | 13483 | |
| ALK | ALK | TK | 5iug | A | A | n-[3-(4-{[(5-tert-butyl-1,2-oxazol-3-yl)carbamoyl]amino}-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6640 | |
| ALK | ALK | TK | 4fnx | A | | - | Human | 5366 | |
| ALK | ALK | TK | 7jyt | A | A | 3-(3-methyl-1h-pyrazol-5-yl)pyridine | Human | 13238 | |
| ALK | ALK | TK | 6mx8 | A | B | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | 10799 | |
| ALK | ALK | TK | 4dce | A | | (3s)-n-(4-methylbenzyl)-1-{2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}piperidine-3-carboxamide | Human | 5379 | |
| ALK | ALK | TK | 5aac | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6690 | |
| ALK | ALK | TK | 3lct | A | A | adenosine-5'-diphosphate | Human | 5393 | |
| ALK | ALK | TK | 4cnh | A | | 3-[(1r)-1-(5-fluoro-2-methoxyphenyl)ethoxy]-5-(1-methyl-1h-1,2,3-triazol-5-yl)pyridin-2-amine | Human | 5388 | |
| ALK | ALK | TK | 5iui | A | A | n-[3-(4-amino-3-methylphenyl)-1h-pyrazol-5-yl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide | Human | 6641 | |
| ALK | ALK | TK | 7jys | A | B | 3-(3-chlorophenyl)-5-methyl-1h-pyrazole | Human | 13239 | |
| ALK | ALK | TK | 5fto | A | B | entrectinib | Human | 6521 | |
| ALK | ALK | TK | 4ctb | A | | (5r)-8-amino-3-fluoro-5,19-dimethyl-20-oxo-5,18,19,20-tetrahydro-11,7-(azeno)pyrido[2',1':2,3]imidazo[4,5-h][2,5,11]benzoxadiazacyclotetradecine-14-carbonitrile | Human | 5395 | |
| ALK | ALK | TK | 2yfx | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5402 | |
| ALK | ALK | TK | 5aaa | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6691 | |
| ALK | ALK | TK | 5ftq | A | A | n-[5-(3,5-difluorobenzyl)-1h-indazol-3-yl]-2-[(4-hydroxycyclohexyl)amino]-4-(4-methylpiperazin-1-yl) benzamide | Human | 6519 | |
| ALK | ALK | TK | 4anl | A | | - | Human | 5385 | |
| ALK | ALK | TK | 7jy4 | A | | 1-{(1s,2s)-1-(2,4-difluorophenyl)-2-[2-(3-methyl-1h-pyrazol-5-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl}methanamine | Human | 13240 | |
| ALK | ALK | TK | 7jyr | A | B | 4-{[(1r,2r)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1h-pyrazol-3-yl)benzonitrile | Human | 13241 | |
| ALK | ALK | TK | 5aac | A | B | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6686 | |
| ALK | ALK | TK | 5a9u | A | B | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6685 | |
| ALK | ALK | TK | 4cd0 | A | | (2r)-2-[5-(6-amino-5-{(1r)-1-[2-(1,3-dihydro-2h-1,2,3-triazol-2-yl)-5-fluorophenyl]ethoxy}pyridin-3-yl)-4-methyl-1,3-thiazol-2-yl]propane-1,2-diol | Human | 5407 | |
| ALK | ALK | TK | 2xp2 | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5394 | |
| ALK | ALK | TK | 4fob | A | | n-{1-[cis-4-(hydroxymethyl)cyclohexyl]-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl}-3-(prop-2-en-1-ylsulfamoyl)benzamide | Human | 5377 | |
| ALK | ALK | TK | 2xba | A | | 5-[(2r)-2-hydroxy-2-phenylacetyl]-3-({[4-(4-methylpiperazin-1-yl)phenyl]carbonyl}amino)-1,6-dihydropyrrolo[3,4-c]pyrazol-5-ium | Human | 5408 | |
| ALK | ALK | TK | 4foc | A | | methyl cis-4-[2-(benzoylamino)-6-(piperidin-1-ylmethyl)-1h-benzimidazol-1-yl]cyclohexanecarboxylate | Human | 5392 | |
| ALK | ALK | TK | 6mx8 | A | A | 5-chloro-n~4~-[2-(dimethylphosphoryl)phenyl]-n~2~-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine | Human | 10798 | |
| ALK | ALK | TK | 6e0r | A | A | n-[(1s)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1h-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1h-pyrrolo[2,3-b]pyridin-6-amine | Human | 11268 | |
| ALK | ALK | TK | 7btt | A | A | 2-(dimethylamino)-1-[5-methoxy-6-[[4-[(2-propan-2-ylsulfonylphenyl)amino]-5h-pyrrolo[3,2-d]pyrimidin-2-yl]amino]-2,3-dihydroindol-1-yl]ethanone | Human | 13484 | |
| ALK | ALK | TK | 5aa8 | A | B | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6684 | |
| ALK | ALK | TK | 2xb7 | A | | 5-chloro-n-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-n'-(2-propan-2-ylsulfonylphenyl)pyrimidine-2,4-diamine | Human | 5365 | |
| ALK | ALK | TK | 4z55 | A | B | n~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]-2h-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Human | 6392 | |
| ALK | ALK | TK | 5aa8 | A | A | (10r)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile | Human | 6688 | |
| ALK | ALK | TK | 7jyt | A | B | 3-(3-methyl-1h-pyrazol-5-yl)pyridine | Human | 13242 | |
| ALK | ALK | TK | 3lcs | A | A | staurosporine | Human | 5381 | |
| ALK | ALK | TK | 7jyr | A | A | 4-{[(1r,2r)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1h-pyrazol-3-yl)benzonitrile | Human | 13243 | |
| ALK | ALK | TK | 4z55 | A | A | n~6~-[5-methyl-4-(1-methylpiperidin-4-yl)-2-(propan-2-yloxy)phenyl]-n~4~-[2-(propan-2-ylsulfonyl)phenyl]-2h-pyrazolo[3,4-d]pyrimidine-4,6-diamine | Human | 6393 | |
| ALK | ALK | TK | 4ccu | A | | 2-(5-(6-amino-5-((r)-1-(5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl)ethoxy)pyridin-3-yl)-4-methylthiazol-2-yl)propan-2-ol | Human | 5396 | |
| ALK | ALK | TK | 6edl | A | B | n-[(1s)-1-(2,4-difluorophenyl)ethyl]-3-(5-methyl-1h-pyrazol-3-yl)imidazo[1,2-b]pyridazin-6-amine | Human | 11265 | |
| ALK | ALK | TK | 4cmu | A | | (10r)-7-amino-12-fluoro-1,3,10,16-tetramethyl-16,17-dihydro-1h-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10h)-one | Human | 5398 | |
| ALK | ALK | TK | 5kz0 | A | | 2-[(1~{r})-1-[2-azanyl-5-(1,3-dimethylpyrazol-4-yl)pyridin-3-yl]oxyethyl]-4-fluoranyl-~{n},~{n}-dimethyl-benzamide | Human | 6970 | |
| ALK | ALK | TK | 5aab | A | A | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 6689 | |
| ALK | ALK | TK | 4anq | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5368 | |
| ALK | ALK | TK | 6e0r | A | B | n-[(1s)-1-(5-fluoropyridin-2-yl)ethyl]-1-(5-methyl-1h-pyrazol-3-yl)-3-[(oxetan-3-yl)sulfonyl]-1h-pyrrolo[2,3-b]pyridin-6-amine | Human | 11266 | |
| ALK | ALK | TK | 7jys | A | A | 3-(3-chlorophenyl)-5-methyl-1h-pyrazole | Human | 13244 | |
| ALK | ALK | TK | 6ebw | A | A | [6-{[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1h-pyrazol-3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone | Human | 11269 | |
| ALK | ALK | TK | 6ebw | A | B | [6-{[(1s)-1-(5-fluoropyridin-2-yl)ethyl]amino}-1-(5-methyl-1h-pyrazol-3-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl](morpholin-4-yl)methanone | Human | 11264 | |
| ALK | ALK | TK | 4ccb | A | | 3-[(1r)-1-[5-fluoranyl-2-(1,2,3-triazol-2-yl)phenyl]ethoxy]-5-(3-methyl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5390 | |
| ALK | ALK | TK | 3l9p | A | A | - | Human | 5363 | |
| ALK | ALK | TK | 3lcs | A | B | staurosporine | Human | 5376 | |
| ALK | ALK | TK | 5imx | A | | 5-chloro-n~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-n~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1h-pyrazol-4-yl}pyrimidine-2,4-diamine | Human | 6604 | |
| ALK | ALK | TK | 7r7k | A | | 4-(6-amino-5-{(1r)-1-[5-fluoro-2-(2h-1,2,3-triazol-2-yl)phenyl]ethoxy}pyridin-3-yl)-2,3-dihydro-1h-isoindol-1-one | Human | 14267 | |
| ALK | ALK | TK | 4ans | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 5374 | |
| PTK2B (PYK2) | FAK | TK | 8xox | A | B | n-methyl-n-{3-[({2-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide | Human | 15172 | |
| TEK (TIE2) | Tie | TK | 2oo8 | X | | n-{3-[3-(dimethylamino)propyl]-5-(trifluoromethyl)phenyl}-4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]benzamide | Human | 5556 | |
| TEK (TIE2) | Tie | TK | 4x3j | A | | 1-[4-(4-amino-5-oxopyrido[2,3-d]pyrimidin-8(5h)-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea | Human | 5552 | |
| TEK (TIE2) | Tie | TK | 3l8p | A | | 2-methyl-11-(1-methylethyl)-8-[(2s)-tetrahydro-2h-pyran-2-yl]-2,11,12,13-tetrahydro-4h-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one | Human | 5548 | |
| TEK (TIE2) | Tie | TK | 6mwe | A | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10711 | |
| TEK (TIE2) | Tie | TK | 6mwe | B | B | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10713 | |
| TEK (TIE2) | Tie | TK | 1fvr | B | | - | Human | 5554 | |
| TEK (TIE2) | Tie | TK | 2p4i | A | | 4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamide | Human | 5549 | |
| TEK (TIE2) | Tie | TK | 6mwe | B | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10712 | |
| TEK (TIE2) | Tie | TK | 2p4i | B | | 4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-n-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamide | Human | 5550 | |
| TEK (TIE2) | Tie | TK | 1fvr | A | | - | Human | 5551 | |
| TEK (TIE2) | Tie | TK | 2osc | A | | n-{4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide | Human | 5555 | |
| TEK (TIE2) | Tie | TK | 6mwe | A | A | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1h-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide | Human | 10710 | |
| EPHB2 (EphB2) | Eph | TK | 3zfm | A | | - | Human | 2731 | |
| ITK | Tec | TK | 4m0z | A | A | 4-(carbamoylamino)-1-(7-methoxynaphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 45 | |
| ITK | Tec | TK | 3qgw | B | A | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 65 | |
| ITK | Tec | TK | 3qgw | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 57 | |
| ITK | Tec | TK | 4ppc | A | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 13 | |
| ITK | Tec | TK | 4l7s | B | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 25 | |
| ITK | Tec | TK | 3v8t | A | B | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 5 | |
| ITK | Tec | TK | 3v5j | A | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 80 | |
| ITK | Tec | TK | 3qgy | B | A | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 52 | |
| ITK | Tec | TK | 4pqn | A | A | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 42 | |
| ITK | Tec | TK | 4qd6 | A | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 59 | |
| ITK | Tec | TK | 4mf1 | B | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 18 | |
| ITK | Tec | TK | 1sm2 | A | | staurosporine | Human | 74 | |
| ITK | Tec | TK | 4kio | A | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 76 | |
| ITK | Tec | TK | 4pp9 | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-2h-indazole-3-carboxamide | Human | 20 | |
| ITK | Tec | TK | 4m14 | A | | 4-(carbamoylamino)-1-[7-(propan-2-yloxy)naphthalen-1-yl]-1h-pyrazole-3-carboxamide | Human | 58 | |
| ITK | Tec | TK | 3qgy | B | B | n-{5-[2-(methylamino)pyrimidin-4-yl]-2-oxo-1,2-dihydropyridin-3-yl}-4-(piperidin-1-yl)benzamide | Human | 66 | |
| ITK | Tec | TK | 4kio | C | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]prop-2-en-1-one | Human | 7 | |
| ITK | Tec | TK | 4hcv | A | | 3-{4-amino-1-[(3s)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 32 | |
| ITK | Tec | TK | 1snx | B | | - | Human | 62 | |
| ITK | Tec | TK | 4qd6 | B | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 24 | |
| ITK | Tec | TK | 3qgy | A | A | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 35 | |
| ITK | Tec | TK | 4qd6 | A | A | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 23 | |
| ITK | Tec | TK | 4rfm | A | A | (4as,5ar)-n-{1-[(r)-[(2r)-1,1-dioxidotetrahydro-2h-thiopyran-2-yl](phenyl)methyl]-1h-pyrazol-4-yl}-5,5-difluoro-5a-methyl-1,4,4a,5,5a,6-hexahydrocyclopropa[f]indazole-3-carboxamide | Human | 68 | |
| ITK | Tec | TK | 3v5j | B | | 3-{4-[2-(morpholin-4-yl)ethoxy]-2-(4lambda~4~-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl}pentan-3-ol | Human | 60 | |
| ITK | Tec | TK | 4kio | D | B | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 85 | |
| ITK | Tec | TK | 3v8w | B | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 10 | |
| ITK | Tec | TK | 4ppb | B | | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 84 | |
| ITK | Tec | TK | 3t9t | A | A | (2z)-4-(dimethylamino)-n-{7-fluoro-4-[(2-methylphenyl)amino]imidazo[1,5-a]quinoxalin-8-yl}-n-methylbut-2-enamide | Human | 16 | |
| ITK | Tec | TK | 4kio | D | A | 1-[(3s)-3-{[4-(morpholin-4-ylmethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)pyrimidin-2-yl]amino}pyrrolidin-1-yl]propan-1-one | Human | 6 | |
| ITK | Tec | TK | 4m13 | A | B | - | Human | 15 | |
| ITK | Tec | TK | 4l7s | A | B | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 64 | |
| ITK | Tec | TK | 4pqn | A | B | n-{1-[(1s)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6,6-dimethyl-4,5,6,7-tetrahydro-1h-indazole-3-carboxamide | Human | 19 | |
| ITK | Tec | TK | 4l7s | B | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 37 | |
| ITK | Tec | TK | 4mf1 | A | B | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(1h-pyrazol-4-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 34 | |
| ITK | Tec | TK | 4l7s | A | A | trans-4-({4-[difluoro(4-fluorophenyl)methyl]-6-[(5-methoxy[1,3]thiazolo[5,4-b]pyridin-2-yl)amino]pyrimidin-2-yl}amino)cyclohexanol | Human | 50 | |
| ITK | Tec | TK | 3v5l | C | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 26 | |
| ITK | Tec | TK | 4hct | A | | 3-{1-[(3r)-1-acryloylpiperidin-3-yl]-4-amino-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-(3-tert-butylphenyl)benzamide | Human | 44 | |
| ITK | Tec | TK | 3v5l | B | | 3-[3-(4-methoxyphenyl)-2-(1h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 54 | |
| ITK | Tec | TK | 4m15 | A | | adenosine-5'-diphosphate | Human | 31 | |
| ITK | Tec | TK | 3qgy | A | B | 3-[(8-phenylthieno[2,3-h]quinazolin-2-yl)amino]benzenesulfonamide | Human | 72 | |
| ITK | Tec | TK | 4ppc | B | B | n-{1-[(1r)-3-(dimethylamino)-1-phenylpropyl]-1h-pyrazol-4-yl}-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 63 | |
| ITK | Tec | TK | 4m13 | A | A | - | Human | 17 | |
| ITK | Tec | TK | 4ppa | B | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 21 | |
| ITK | Tec | TK | 3v8t | B | A | 3-{2-[5-(difluoromethyl)-2h-thieno[3,2-c]pyrazol-3-yl]-1h-indol-6-yl}pentan-3-ol | Human | 39 | |
| ITK | Tec | TK | 3qgw | B | B | n-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)benzamide | Human | 14 | |
| ITK | Tec | TK | 1snu | B | | staurosporine | Human | 33 | |
| ITK | Tec | TK | 3v8w | A | | 3-[2-(5-phenyl-2h-thieno[3,2-c]pyrazol-3-yl)-1h-indol-6-yl]pentan-3-ol | Human | 43 | |
| ITK | Tec | TK | 4m0y | A | A | 4-(carbamoylamino)-1-(naphthalen-1-yl)-1h-pyrazole-3-carboxamide | Human | 9 | |
| ITK | Tec | TK | 4mf0 | B | | (1s,2s)-2-{4-[(dimethylamino)methyl]phenyl}-n-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]cyclopropanecarboxamide | Human | 28 | |
| ITK | Tec | TK | 4ppa | A | | n-[1-(3-cyanobenzyl)-1h-pyrazol-4-yl]-6-(1h-pyrazol-4-yl)-1h-indazole-3-carboxamide | Human | 38 | |
| ITK | Tec | TK | 4qd6 | B | B | trans-4-({6-[(5-phenyl-1h-pyrazol-3-yl)amino]-4-(phenylsulfonyl)pyridin-2-yl}amino)cyclohexanol | Human | 71 | |
| ITK | Tec | TK | 1sm2 | B | | staurosporine | Human | 73 | |
| ITK | Tec | TK | 1snx | A | | - | Human | 61 | |
| ITK | Tec | TK | 4hcu | A | | 3-{4-amino-1-[(3r)-1-propanoylpiperidin-3-yl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl}-n-[4-(propan-2-yl)phenyl]benzamide | Human | 81 | |
| JAK1-b | JakB | TK | 4l01 | B | A | - | Human | 1417 | |
| JAK1-b | JakB | TK | 4l00 | B | A | - | Human | 1422 | |
| JAK1-b | JakB | TK | 4l00 | A | B | - | Human | 1420 | |
| JAK1-b | JakB | TK | 4l01 | A | B | - | Human | 1418 | |
| JAK1-b | JakB | TK | 4l00 | B | B | - | Human | 1423 | |
| JAK1-b | JakB | TK | 4l01 | B | B | - | Human | 1419 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | B | B | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4819 | |
| ERBB2 (ErbB2) | EGFR | TK | 7pcd | A | B | 1-[4-[4-[[3,5-bis(chloranyl)-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]pyrimido[5,4-d]pyrimidin-6-yl]piperazin-1-yl]-4-(3-fluoranylazetidin-1-yl)butan-1-one | Human | 14319 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | A | A | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4815 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | B | A | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4816 | |
| ERBB2 (ErbB2) | EGFR | TK | 3pp0 | A | B | 2-{2-[4-({5-chloro-6-[3-(trifluoromethyl)phenoxy]pyridin-3-yl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethoxy}ethanol | Human | 4820 | |
| ERBB2 (ErbB2) | EGFR | TK | 3rcd | A | | n-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5h-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide | Human | 9325 | |
| CSF1R (FMS) | PDGFR | TK | 8cgc | A | A | [4-[4-[methyl-[(3-methylphenyl)methyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]methanol | Human | 14766 | |
| CSF1R (FMS) | PDGFR | TK | 2i0v | A | | 6-chloro-3-(3-methylisoxazol-5-yl)-4-phenylquinolin-2(1h)-one | Human | 2303 | |
| CSF1R (FMS) | PDGFR | TK | 3krl | A | A | 5-cyano-n-[4-(4-methylpiperazin-1-yl)-2-piperidin-1-ylphenyl]furan-2-carboxamide | Human | 2309 | |
| CSF1R (FMS) | PDGFR | TK | 8cgc | A | B | [4-[4-[methyl-[(3-methylphenyl)methyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]methanol | Human | 14767 | |
| CSF1R (FMS) | PDGFR | TK | 6ig8 | A | B | (3-{4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl}azetidin-1-yl)(4-{[(2s)-2,3-dihydroxypropoxy]methyl}pyridin-2-yl)methanone | Human | 11518 | |
| CSF1R (FMS) | PDGFR | TK | 3dpk | A | A | 8-cyclohexyl-n-methoxy-5-oxo-2-{[4-(2-pyrrolidin-1-ylethyl)phenyl]amino}-5,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | Human | 2312 | |
| CSF1R (FMS) | PDGFR | TK | 3lcd | A | A | n~3~-(2,6-dichlorobenzyl)-5-(4-{[(2r)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}phenyl)pyrazine-2,3-diamine | Human | 1241 | |
| CSF1R (FMS) | PDGFR | TK | 7tnh | A | | 2,2-dimethyl-n-[(6-methyl-5-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}pyridin-2-yl)carbamoyl]propanamide | Human | 14350 | |
| CSF1R (FMS) | PDGFR | TK | 4hw7 | A | | 5-[(5-methoxy-1h-pyrrolo[2,3-b]pyridin-3-yl)methyl]-n-[4-(trifluoromethyl)benzyl]pyridin-2-amine | Human | 2304 | |
| CSF1R (FMS) | PDGFR | TK | 6t2w | A | | 2-[(4-methoxy-2-methyl-phenyl)amino]-7-methyl-9-(4-oxidanylcyclohexyl)purin-8-one | Human | 11905 | |
| CSF1R (FMS) | PDGFR | TK | 3krj | A | B | 4-cyano-n-(2-cyclohex-1-en-1-yl-4-piperidin-4-ylphenyl)-1h-imidazole-2-carboxamide | Human | 2310 | |
| CSF1R (FMS) | PDGFR | TK | 2i1m | A | | 5-cyano-furan-2-carboxylic acid [5-hydroxymethyl-2-(4-methyl-piperidin-1-yl)-phenyl]-amide | Human | 2306 | |
| INSR | InsR | TK | 1ir3 | A | | phosphoaminophosphonic acid-adenylate ester | Human | 602 | |
| INSR | InsR | TK | 7pg0 | A | | - | Human | 14097 | |
| INSR | InsR | TK | 8yys | C | | - | Human | 16050 | |
| INSR | InsR | TK | 9puv | A | | - | Human | 16051 | |
| INSR | InsR | TK | 8x06 | A | | - | Human | 16052 | |
| INSR | InsR | TK | 9dn6 | C | | - | Human | 16053 | |
| INSR | InsR | TK | 4xlv | A | | phosphomethylphosphonic acid adenylate ester | Human | 577 | |
| INSR | InsR | TK | 1rqq | A | | thiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diester | Human | 7407 | |
| INSR | InsR | TK | 3ekn | A | A | 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide | Human | 597 | |
| INSR | InsR | TK | 1rqq | B | | thiophosphoric acid o-((adenosyl-phospho)phospho)-s-acetamidyl-diester | Human | 7406 | |
| INSR | InsR | TK | 7pg2 | A | | - | Human | 14098 | |
| INSR | InsR | TK | 3bu6 | A | | - | Human | 601 | |
| INSR | InsR | TK | 3eta | A | A | 1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea | Human | 590 | |
| INSR | InsR | TK | 3bu5 | A | | adenosine-5'-triphosphate | Human | 595 | |
| INSR | InsR | TK | 6pxw | B | | - | Human | 11591 | |
| INSR | InsR | TK | 7bw7 | A | | - | Human | 13504 | |
| INSR | InsR | TK | 8ysz | B | | - | Human | 16057 | |
| INSR | InsR | TK | 6pxv | C | | - | Human | 11590 | |
| INSR | InsR | TK | 6pxv | A | | - | Human | 11592 | |
| INSR | InsR | TK | 3ekk | A | B | 2-[(2-{[1-(n,n-dimethylglycyl)-5-methoxy-1h-indol-6-yl]amino}-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-n-methylbenzamide | Human | 581 | |
| INSR | InsR | TK | 2b4s | D | | - | Human | 583 | |
| INSR | InsR | TK | 3eta | A | B | 1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea | Human | 579 | |
| INSR | InsR | TK | 2z8c | A | | [4-({5-(aminocarbonyl)-4-[(3-methylphenyl)amino]pyrimidin-2-yl}amino)phenyl]acetic acid | Human | 587 | |
| INSR | InsR | TK | 3eta | B | A | 1-(3-{5-[4-(aminomethyl)phenyl]-1h-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea | Human | 588 | |
| INSR | InsR | TK | 2b4s | B | | - | Human | 585 | |
| INSR | InsR | TK | 1i44 | A | | phosphomethylphosphonic acid adenylate ester | Human | 582 | |
| INSR | InsR | TK | 7pg3 | A | | - | Human | 14099 | |
| INSR | InsR | TK | 5hhw | A | A | 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2~{r})-oxan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | Human | 6523 | |
| INSR | InsR | TK | 1irk | A | B | - | Human | 603 | |
| PTK7 (CCK4) | CCK4 | TK | 6vg3 | C | | - | Human | 12291 | |
| PTK7 (CCK4) | CCK4 | TK | 6vg3 | A | | - | Human | 12292 | |
| PTK7 (CCK4) | CCK4 | TK | 6vg3 | B | | - | Human | 12293 | |
| FYN | Src | TK | 2dq7 | X | | staurosporine | Human | 1941 | |
| FYN | Src | TK | 10dj | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 16102 | |
| ERBB3 (ErbB3) | EGFR | TK | 4rix | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1931 | |
| ERBB3 (ErbB3) | EGFR | TK | 4rix | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1934 | |
| ERBB3 (ErbB3) | EGFR | TK | 3lmg | B | | phosphoaminophosphonic acid-adenylate ester | Human | 1936 | |
| ERBB3 (ErbB3) | EGFR | TK | 3kex | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1939 | |
| ERBB3 (ErbB3) | EGFR | TK | 3kex | B | | phosphoaminophosphonic acid-adenylate ester | Human | 1933 | |
| ERBB3 (ErbB3) | EGFR | TK | 3lmg | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1935 | |
| ERBB3 (ErbB3) | EGFR | TK | 4riw | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1930 | |
| ERBB3 (ErbB3) | EGFR | TK | 7mn6 | A | | - | Human | 13952 | |
| ERBB3 (ErbB3) | EGFR | TK | 6op9 | A | A | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 11545 | |
| ERBB3 (ErbB3) | EGFR | TK | 7mn5 | A | | - | Human | 13953 | |
| ERBB3 (ErbB3) | EGFR | TK | 4riy | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1938 | |
| ERBB3 (ErbB3) | EGFR | TK | 6op9 | A | B | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 11544 | |
| ERBB3 (ErbB3) | EGFR | TK | 4riy | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1937 | |
| MST1R (RON) | Met | TK | 3pls | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 1491 | |
| MST1R (RON) | Met | TK | 3pls | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 1492 | |
| MST1R (RON) | Met | TK | 8zkd | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 15347 | |
| MET | Met | TK | 3ctj | A | A | 2-(4-fluorophenyl)-n-{[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide | Human | 6767 | |
| MET | Met | TK | 4knb | B | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2970 | |
| MET | Met | TK | 7b3q | A | A | 1-(phenylmethyl)-5~{h}-pyrrolo[3,2-c]pyridin-4-one | Human | 13177 | |
| MET | Met | TK | 3lq8 | A | A | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2998 | |
| MET | Met | TK | 5dg5 | B | A | n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7035 | |
| MET | Met | TK | 3lq8 | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 2964 | |
| MET | Met | TK | 3cd8 | A | B | 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline | Human | 2995 | |
| MET | Met | TK | 4eev | A | A | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 3012 | |
| MET | Met | TK | 3f66 | A | A | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 2989 | |
| MET | Met | TK | 5eob | A | A | 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline | Human | 7100 | |
| MET | Met | TK | 3f66 | B | A | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 3034 | |
| MET | Met | TK | 7b44 | A | B | 5-methoxy-1~{h}-indazole | Human | 13179 | |
| MET | Met | TK | 3l8v | A | | 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-n-(2,4-difluorophenyl)pyridine-3-carboxamide | Human | 2978 | |
| MET | Met | TK | 5hni | X | | methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate | Human | 7280 | |
| MET | Met | TK | 4knb | C | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2955 | |
| MET | Met | TK | 6sdd | A | | n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 11533 | |
| MET | Met | TK | 3zbx | A | | 6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline | Human | 3036 | |
| MET | Met | TK | 5eyd | A | A | 6-[(1~{r})-1-[8-fluoranyl-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-3-(2-methoxyethoxy)-1,6-naphthyridin-5-one | Human | 6402 | |
| MET | Met | TK | 5ya5 | A | A | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1h-indole | Human | 10040 | |
| MET | Met | TK | 4gg5 | A | B | 3-(4-methylpiperazin-1-yl)-n-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine | Human | 2953 | |
| MET | Met | TK | 3f66 | A | B | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 3027 | |
| MET | Met | TK | 2rfn | B | | 2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3h)-one | Human | 2961 | |
| MET | Met | TK | 4aoi | A | | 4-[3-(1h-pyrrolo[2,3-b]pyridin-3-ylmethyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-6-yl]benzenecarbonitrile | Human | 2958 | |
| MET | Met | TK | 3u6h | A | A | n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 2996 | |
| MET | Met | TK | 7b3w | A | A | 3-(6-fluoranyl-1~{h}-indazol-4-yl)-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13180 | |
| MET | Met | TK | 2wd1 | A | A | 1-[(2-nitrophenyl)sulfonyl]-1h-pyrrolo[3,2-b]pyridine-6-carboxamide | Human | 3032 | |
| MET | Met | TK | 5dg5 | A | A | n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7037 | |
| MET | Met | TK | 2wgj | A | | 3-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)pyridin-2-amine | Human | 3009 | |
| MET | Met | TK | 4deg | A | | 7-methoxy-n-{[6-(3-methyl-1,2-thiazol-5-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}-1,5-naphthyridin-4-amine | Human | 2981 | |
| MET | Met | TK | 7b3z | A | A | 3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13181 | |
| MET | Met | TK | 7b3q | A | B | 1-(phenylmethyl)-5~{h}-pyrrolo[3,2-c]pyridin-4-one | Human | 13182 | |
| MET | Met | TK | 6ubw | A | | n-(6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | Human | 11979 | |
| MET | Met | TK | 4gg7 | A | B | n-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | Human | 2987 | |
| MET | Met | TK | 7b3t | A | A | 3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13183 | |
| MET | Met | TK | 7b41 | A | A | 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13184 | |
| MET | Met | TK | 3zcl | A | | (s)-3-(1-(1h-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-n-isopropyl-(1,2,4)triazolo(4,3-b)pyridazin-6-amine | Human | 2990 | |
| MET | Met | TK | 5uab | A | A | n-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide | Human | 7961 | |
| MET | Met | TK | 5eob | A | B | 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline | Human | 7101 | |
| MET | Met | TK | 3f66 | B | C | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 2966 | |
| MET | Met | TK | 3dkf | A | B | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 3029 | |
| MET | Met | TK | 4r1v | A | B | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | Human | 2972 | |
| MET | Met | TK | 6sd9 | A | | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11531 | |
| MET | Met | TK | 1r0p | A | | k-252a | Human | 2991 | |
| MET | Met | TK | 3qti | A | B | 6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | Human | 3028 | |
| MET | Met | TK | 4gg5 | A | A | 3-(4-methylpiperazin-1-yl)-n-(3-nitrobenzyl)-7-(trifluoromethyl)quinolin-5-amine | Human | 2956 | |
| MET | Met | TK | 3dkf | A | C | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 2984 | |
| MET | Met | TK | 5hni | Y | | methyl (6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1h-benzimidazol-2-yl)carbamate | Human | 7278 | |
| MET | Met | TK | 5hti | A | B | n-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 8009 | |
| MET | Met | TK | 5hoa | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7279 | |
| MET | Met | TK | 4knb | C | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3001 | |
| MET | Met | TK | 5hti | A | A | n-[3-fluoro-4-({7-[2-(morpholin-4-yl)ethoxy]-1,6-naphthyridin-4-yl}oxy)phenyl]-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 8010 | |
| MET | Met | TK | 7b44 | A | A | 5-methoxy-1~{h}-indazole | Human | 13185 | |
| MET | Met | TK | 3ce3 | A | | 1-(4-fluorophenyl)-n-[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 6769 | |
| MET | Met | TK | 4eev | A | B | n-(3-fluoro-4-{[1-methyl-6-(1h-pyrazol-4-yl)-1h-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 3023 | |
| MET | Met | TK | 7b3z | A | B | 3-[3-(phenylmethyl)-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13186 | |
| MET | Met | TK | 3u6i | A | | n-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-[(2r)-2-hydroxypropyl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazole-4-carboxamide | Human | 2967 | |
| MET | Met | TK | 3zc5 | A | | 6-{(1s)-1-[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline | Human | 3003 | |
| MET | Met | TK | 3cth | A | | n-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}carbamoyl)-2-(4-fluorophenyl)acetamide | Human | 6768 | |
| MET | Met | TK | 4xyf | A | B | 6-{(1s)-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-(2-methoxyethoxy)quinoline | Human | 2982 | |
| MET | Met | TK | 7b43 | B | | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13187 | |
| MET | Met | TK | 3q6u | A | A | - | Human | 2954 | |
| MET | Met | TK | 1r1w | A | | - | Human | 3014 | |
| MET | Met | TK | 7b3v | A | A | 3-(3-methyl-1~{h}-pyrrolo[2,3-b]pyridin-5-yl)-1~{h}-pyrrolo[3,4-b]pyrrol-6-one | Human | 13188 | |
| MET | Met | TK | 3f66 | A | C | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 3011 | |
| MET | Met | TK | 5eyc | A | B | 6-[(1~{r})-1-[8-fluoranyl-6-(3-methyl-1,2-oxazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl]-1,6-naphthyridin-5-one | Human | 6400 | |
| MET | Met | TK | 3rhk | B | | 1-[(3r,4r)-4-(1h-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium | Human | 2959 | |
| MET | Met | TK | 3dkg | A | C | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 3006 | |
| MET | Met | TK | 5uad | A | | n-(6-{[6-(1-methyl-1h-pyrazol-4-yl)-1h-benzotriazol-1-yl]methyl}imidazo[1,2-b]pyridazin-2-yl)cyclopropanecarboxamide | Human | 7963 | |
| MET | Met | TK | 4knb | D | B | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2968 | |
| MET | Met | TK | 3ccn | A | | 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol | Human | 2971 | |
| MET | Met | TK | 2rfn | A | | 2-benzyl-5-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-3-methylpyrimidin-4(3h)-one | Human | 3022 | |
| MET | Met | TK | 3zxz | A | | 2-{4-[1-(quinolin-6-ylmethyl)-1h-[1,2,3]triazolo[4,5-b]pyrazin-6-yl]-1h-pyrazol-1-yl}ethanol | Human | 2999 | |
| MET | Met | TK | 5hlw | A | | 1-[2-(1-ethylpiperidin-4-yl)ethyl]-3-(6-{[6-(thiophen-2-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)urea | Human | 7275 | |
| MET | Met | TK | 4ap7 | A | | 4-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]phenol | Human | 3035 | |
| MET | Met | TK | 2g15 | A | | - | Human | 2983 | |
| MET | Met | TK | 3f66 | B | D | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 3000 | |
| MET | Met | TK | 4knb | A | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 2960 | |
| MET | Met | TK | 4mxc | A | A | n-(3-fluoro-4-{[2-({3-[(methylsulfonyl)methyl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 3033 | |
| MET | Met | TK | 3f82 | A | | n-{4-[(2-amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 2977 | |
| MET | Met | TK | 3q6u | A | B | - | Human | 2962 | |
| MET | Met | TK | 3zze | A | | (2s)-n'-[(3r)-4-chloro-7-methyl-2-oxo-2,3-dihydro-1h-indol-3-yl]-2-(4-hydroxyphenyl)propanehydrazide | Human | 2980 | |
| MET | Met | TK | 3dkc | A | B | adenosine-5'-triphosphate | Human | 2952 | |
| MET | Met | TK | 3f66 | A | D | 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol | Human | 3026 | |
| MET | Met | TK | 3qti | B | A | 6-{[6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-b]pyridazin-3-yl]methyl}quinoline | Human | 3017 | |
| MET | Met | TK | 5ho6 | A | | 1-(6-{[6-(4-fluorophenyl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}-1,3-benzothiazol-2-yl)-3-[2-(morpholin-4-yl)ethyl]urea | Human | 7277 | |
| MET | Met | TK | 4gg7 | A | A | n-(3-nitrobenzyl)-6-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-2-(trifluoromethyl)pyrido[2,3-d]pyrimidin-4-amine | Human | 3002 | |
| MET | Met | TK | 3efk | B | | 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one | Human | 2988 | |
| MET | Met | TK | 3i5n | A | | 7-methoxy-n-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]-1,5-naphthyridin-4-amine | Human | 3013 | |
| MET | Met | TK | 3efj | A | | 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3h)-one | Human | 3015 | |
| MET | Met | TK | 3r7o | A | | n-[(2r)-1,4-dioxan-2-ylmethyl]-n-methyl-n'-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}sulfuric diamide | Human | 3038 | |
| MET | Met | TK | 3dkg | A | A | 6-{[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | Human | 2993 | |
| MET | Met | TK | 3efk | A | | 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3h)-one | Human | 3018 | |
| MET | Met | TK | 4r1y | A | | 3-(diethylamino)propyl (3-{[5-(3,4-dimethoxyphenyl)-2-oxo-2h-1,3,4-thiadiazin-3(6h)-yl]methyl}phenyl)carbamate | Human | 2973 | |
| MET | Met | TK | 5dg5 | A | B | n-(2,5-difluoro-4-{[2-(1-methyl-1h-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 7034 | |
| MET | Met | TK | 2rfs | A | | n-(3-chlorophenyl)-n-methyl-2-oxo-3-[(3,4,5-trimethyl-1h-pyrrol-2-yl)methyl]-2h-indole-5-sulfonamide | Human | 2974 | |
| MET | Met | TK | 3cd8 | A | A | 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline | Human | 3008 | |
| MET | Met | TK | 3rhk | A | | 1-[(3r,4r)-4-(1h-indol-3-yl)-2,5-dioxopyrrolidin-3-yl]pyrrolo[3,2,1-ij]quinolinium | Human | 2979 | |
| MET | Met | TK | 4iwd | A | | 1-{5-oxo-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]-5h-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl}-n-(pyridin-2-ylmethyl)methanesulfonamide | Human | 2975 | |
| MET | Met | TK | 3c1x | A | | n-{[4-({5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}oxy)-3-fluorophenyl]carbamoyl}-2-(4-fluorophenyl)acetamide | Human | 3020 | |
| MET | Met | TK | 2wkm | A | | (3z)-5-[(2,6-dichlorobenzyl)sulfonyl]-3-[(3,5-dimethyl-4-{[(2s)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-1h-pyrrol-2-yl)methylidene]-1,3-dihydro-2h-indol-2-one | Human | 3021 | |
| MET | Met | TK | 6sdc | A | B | n-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide | Human | 11534 | |
| MET | Met | TK | 7b40 | A | | 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13192 | |
| MET | Met | TK | 4dei | A | | 3-{(1s)-1-[3-(2-methoxyethoxy)quinolin-6-yl]ethyl}-5-(3-methyl-1,2-thiazol-5-yl)-3,5-dihydro-4h-[1,2,3]triazolo[4,5-c]pyridin-4-one | Human | 3016 | |
| MET | Met | TK | 4knb | D | A | 7-[(1r)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[3,2-c]pyridin-6-amine | Human | 3010 | |
| MET | Met | TK | 4xmo | A | | 6-{(1r)-1-fluoro-1-[8-fluoro-6-(3-methyl-1,2-oxazol-5-yl)[1,2,4]triazolo[4,3-a]pyridin-3-yl]ethyl}-3-methoxyquinoline | Human | 3031 | |
| MET | Met | TK | 5ya5 | A | B | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1h-indole | Human | 10039 | |
| MET | Met | TK | 3ctj | A | B | 2-(4-fluorophenyl)-n-{[3-fluoro-4-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]carbamoyl}acetamide | Human | 6766 | |
| MET | Met | TK | 7b41 | A | B | 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{h}-pyrrolo[2,3-b]pyridine | Human | 13193 | |
| PTK6 (BRK) | Src | TK | 5d7v | D | B | - | Human | 6952 | |
| PTK6 (BRK) | Src | TK | 5d7v | D | A | - | Human | 6948 | |
| PTK6 (BRK) | Src | TK | 5h2u | D | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7340 | |
| PTK6 (BRK) | Src | TK | 5h2u | B | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7337 | |
| PTK6 (BRK) | Src | TK | 5d7v | A | A | - | Human | 6953 | |
| PTK6 (BRK) | Src | TK | 5h2u | D | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7344 | |
| PTK6 (BRK) | Src | TK | 6cz3 | A | B | (3-fluoro-4-{[6-methyl-3-(1h-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}phenyl)(morpholin-4-yl)methanone | Human | 9999 | |
| PTK6 (BRK) | Src | TK | 5d7v | A | B | - | Human | 6950 | |
| PTK6 (BRK) | Src | TK | 5d7v | B | A | - | Human | 6955 | |
| PTK6 (BRK) | Src | TK | 5h2u | B | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7339 | |
| PTK6 (BRK) | Src | TK | 5h2u | A | A | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 7338 | |
| PTK6 (BRK) | Src | TK | 6cz4 | A | B | 2-{[(3r,4s)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1h-imidazol-4-yl)pyridine-3-carboxamide | Human | 10000 | |
| NTRK1 (TRKA) | Trk | TK | 5kvt | A | B | entrectinib | Human | 9451 | |
| NTRK1 (TRKA) | Trk | TK | 7vkm | A | B | - | Human | 13942 | |
| NTRK1 (TRKA) | Trk | TK | 5jfv | A | B | n-{5-[4-amino-7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(4-chlorophenyl)acetamide | Human | 7503 | |
| NTRK1 (TRKA) | Trk | TK | 4yne | A | B | 6-[(2r)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine | Human | 3611 | |
| NTRK1 (TRKA) | Trk | TK | 5i8a | A | B | (6r)-3-(methylsulfanyl)-6-phenyl-1-(1h-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5h)-one | Human | 8312 | |
| NTRK1 (TRKA) | Trk | TK | 6d1y | A | A | 2,4-dichloro-n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)benzamide | Human | 9873 | |
| NTRK1 (TRKA) | Trk | TK | 6d1z | A | A | 5-{[5-(6-aminopyridin-2-yl)-2-chlorobenzene-1-carbonyl]amino}-1-phenyl-1h-pyrazole-3-carboxamide | Human | 9874 | |
| NTRK1 (TRKA) | Trk | TK | 5kmk | A | | 2-fluoranyl-~{n}-[2-(4-fluorophenyl)-6-methyl-pyridin-3-yl]-4-(trifluoromethyl)benzamide | Human | 7336 | |
| NTRK1 (TRKA) | Trk | TK | 4pms | A | B | 4-(naphthalen-1-yl)-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1h-pyrrolo[3,2-c]pyridine-2-carboxylic acid | Human | 3601 | |
| NTRK1 (TRKA) | Trk | TK | 6dkw | A | A | 5-(1-methyl-1h-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide | Human | 10056 | |
| NTRK1 (TRKA) | Trk | TK | 6dkw | A | B | 5-(1-methyl-1h-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide | Human | 10058 | |
| NTRK1 (TRKA) | Trk | TK | 6pl4 | A | A | n-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-n'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea | Human | 12463 | |
| NTRK1 (TRKA) | Trk | TK | 4pmp | A | B | 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea | Human | 3608 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | C | A | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3617 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | A | B | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3610 | |
| NTRK1 (TRKA) | Trk | TK | 5kml | A | | 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea | Human | 7333 | |
| NTRK1 (TRKA) | Trk | TK | 5jfw | A | B | 2-(4-cyanophenyl)-n-{5-[7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide | Human | 7505 | |
| NTRK1 (TRKA) | Trk | TK | 4gt5 | A | B | - | Human | 3609 | |
| NTRK1 (TRKA) | Trk | TK | 5kmn | A | | 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea | Human | 7332 | |
| NTRK1 (TRKA) | Trk | TK | 6pmb | A | | 2-[5,7-dimethyl-2-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidin-6-yl]-n-[3-(trifluoromethyl)phenyl]acetamide | Human | 12001 | |
| NTRK1 (TRKA) | Trk | TK | 6pl4 | A | B | n-{[5-(methoxymethyl)-2-(trifluoromethoxy)phenyl]methyl}-n'-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)urea | Human | 12464 | |
| NTRK1 (TRKA) | Trk | TK | 8j61 | A | | 4^6-methyl-n-(3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-14-oxo-5-oxa-13-aza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclotetradecaphan-2-yne-4^5-carboxamide | Human | 14986 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | A | A | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3602 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | A | A | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 12004 | |
| NTRK1 (TRKA) | Trk | TK | 5jfw | A | A | 2-(4-cyanophenyl)-n-{5-[7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}acetamide | Human | 7500 | |
| NTRK1 (TRKA) | Trk | TK | 6pma | A | | n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[1-(4-methoxyphenyl)-4-oxo-1,4-dihydro-5h-pyrazolo[3,4-d]pyrimidin-5-yl]acetamide | Human | 12006 | |
| NTRK1 (TRKA) | Trk | TK | 6j5l | A | B | n-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1h-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide | Human | 11435 | |
| NTRK1 (TRKA) | Trk | TK | 5h3q | A | B | 1-[(3s,4r)-4-[3,4-bis(fluoranyl)phenyl]-1-(2-methoxyethyl)pyrrolidin-3-yl]-3-(5-ethoxy-4-methyl-2-phenyl-pyrazol-3-yl)urea | Human | 7460 | |
| NTRK1 (TRKA) | Trk | TK | 6iqn | A | | 4-[[4-azanyl-3-(4-cyclohexylpiperazin-1-yl)-9,10-bis(oxidanylidene)anthracen-1-yl]amino]benzoic acid | Human | 11951 | |
| NTRK1 (TRKA) | Trk | TK | 5i8a | A | A | (6r)-3-(methylsulfanyl)-6-phenyl-1-(1h-pyrazol-3-yl)-6,7-dihydrothieno[3,4-c]pyridin-4(5h)-one | Human | 8311 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | C | B | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3621 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | B | A | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 12007 | |
| NTRK1 (TRKA) | Trk | TK | 6dkw | B | B | 5-(1-methyl-1h-imidazol-4-yl)-2-[(1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl)oxy]benzamide | Human | 10064 | |
| NTRK1 (TRKA) | Trk | TK | 4pmt | A | A | n~4~-[4-(morpholin-4-yl)phenyl]-n~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine | Human | 3614 | |
| NTRK1 (TRKA) | Trk | TK | 6nss | A | B | n-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10h-phenoxazin-10-yl)acetamide | Human | 11176 | |
| NTRK1 (TRKA) | Trk | TK | 6npt | A | | 4-tert-butyl-n-(1,3-diphenyl-1h-pyrazol-5-yl)benzamide | Human | 11172 | |
| NTRK1 (TRKA) | Trk | TK | 5jfs | A | B | n-{4-[4-amino-7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-n'-(2,4-difluorophenyl)urea | Human | 7502 | |
| NTRK1 (TRKA) | Trk | TK | 4pmp | A | A | 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea | Human | 3613 | |
| NTRK1 (TRKA) | Trk | TK | 4f0i | B | | - | Human | 3605 | |
| NTRK1 (TRKA) | Trk | TK | 5jfx | A | | n-{5-[2-amino-7-(1-hydroxy-2-methylpropan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-3-yl}-2-(5-chloropyridin-2-yl)acetamide | Human | 7501 | |
| NTRK1 (TRKA) | Trk | TK | 6d1z | A | B | 5-{[5-(6-aminopyridin-2-yl)-2-chlorobenzene-1-carbonyl]amino}-1-phenyl-1h-pyrazole-3-carboxamide | Human | 9870 | |
| NTRK1 (TRKA) | Trk | TK | 4aoj | B | A | 5-chloranyl-n2-[(1s)-1-(5-fluoranylpyridin-2-yl)ethyl]-n4-(3-propan-2-yloxy-1h-pyrazol-5-yl)pyrimidine-2,4-diamine | Human | 3607 | |
| NTRK1 (TRKA) | Trk | TK | 6d22 | A | | - | Human | 9872 | |
| NTRK1 (TRKA) | Trk | TK | 6pl3 | A | B | 2-[(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)amino]-2-oxoethyl 4-(1h-tetrazol-1-yl)benzoate | Human | 11600 | |
| NTRK1 (TRKA) | Trk | TK | 6pmc | A | | n-(6-{[(5-chloro-2-methoxyphenyl)carbamoyl]amino}-1,3-benzothiazol-2-yl)benzamide | Human | 12002 | |
| NTRK1 (TRKA) | Trk | TK | 4yne | A | A | 6-[(2r)-2-(3-fluorophenyl)pyrrolidin-1-yl]-3-(pyridin-2-yl)imidazo[1,2-b]pyridazine | Human | 3620 | |
| NTRK1 (TRKA) | Trk | TK | 4pms | A | A | 4-(naphthalen-1-yl)-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1h-pyrrolo[3,2-c]pyridine-2-carboxylic acid | Human | 3606 | |
| NTRK1 (TRKA) | Trk | TK | 6nss | A | A | n-(8-methyl-2-phenylimidazo[1,2-a]pyrazin-3-yl)-2-(10h-phenoxazin-10-yl)acetamide | Human | 11174 | |
| NTRK1 (TRKA) | Trk | TK | 6pl2 | A | | n-(3-tert-butyl-1-phenyl-1h-pyrazol-5-yl)-2-{[1-(4-hydroxyphenyl)-1h-tetrazol-5-yl]sulfanyl}acetamide | Human | 11598 | |
| NTRK1 (TRKA) | Trk | TK | 6pme | C | B | n-[2,4-bis(morpholin-4-yl)phenyl]-3-phenoxybenzamide | Human | 12003 | |
| NTRK1 (TRKA) | Trk | TK | 5kvt | A | A | entrectinib | Human | 9450 | |
| NTRK1 (TRKA) | Trk | TK | 4f0i | A | | - | Human | 3603 | |
| NTRK1 (TRKA) | Trk | TK | 4pmm | A | B | n-(3-cyclopropyl-1-phenyl-1h-pyrazol-5-yl)-2-{4-[3-methoxy-4-(4-methyl-1h-imidazol-1-yl)phenyl]-1h-1,2,3-triazol-1-yl}acetamide | Human | 3619 | |
| NTRK1 (TRKA) | Trk | TK | 5kmj | A | B | ~{n}-(pyridin-2-ylmethyl)-2-(2-thiophen-2-ylindol-1-yl)ethanamide | Human | 7335 | |
| NTRK1 (TRKA) | Trk | TK | 5wr7 | A | | n-tert-butyl-2-[2-[6,6-dimethyl-8-(methylsulfonylamino)-11-oxidanylidene-naphtho[2,3-b][1]benzofuran-3-yl]ethynyl]-6-methyl-pyridine-4-carboxamide | Human | 8737 | |
| NTRK1 (TRKA) | Trk | TK | 5jfs | A | A | n-{4-[4-amino-7-(propan-2-yl)-7h-pyrrolo[2,3-d]pyrimidine-5-carbonyl]pyridin-2-yl}-n'-(2,4-difluorophenyl)urea | Human | 7506 | |
| BTK | Tec | TK | 8tu4 | A | C | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15355 | |
| BTK | Tec | TK | 8tu5 | A | C | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15356 | |
| BTK | Tec | TK | 5p9j | A | B | 1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one | Human | 7628 | |
| BTK | Tec | TK | 7n4r | A | A | n-{2-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]ethyl}-n~2~-phenylglycinamide | Human | 14226 | |
| BTK | Tec | TK | 6n9p | A | B | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10887 | |
| BTK | Tec | TK | 5p9f | A | B | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 7629 | |
| BTK | Tec | TK | 5p9k | A | B | 4-[4-[[5-fluoranyl-4-[[3-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]phenoxy]-~{n}-methyl-pyridine-2-carboxamide | Human | 7636 | |
| BTK | Tec | TK | 5vgo | A | B | 2-(2-methoxyethoxy)ethanol | Human | 8219 | |
| BTK | Tec | TK | 6xe4 | A | B | (1s,2s)-n-[2'-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1h)-yl)-3'-(hydroxymethyl)-1-methyl-6-oxo[1,6-dihydro[3,4'-bipyridine]]-5-yl]-2-fluorocyclopropane-1-carboxamide | Human | 12509 | |
| BTK | Tec | TK | 3oct | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2908 | |
| BTK | Tec | TK | 6nzm | D | A | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11141 | |
| BTK | Tec | TK | 8tu4 | A | B | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15357 | |
| BTK | Tec | TK | 3gen | A | B | 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane | Human | 2900 | |
| BTK | Tec | TK | 5u9d | A | A | (r)-n-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 7393 | |
| BTK | Tec | TK | 8tu5 | A | B | 1-[(1s,5s,6s)-6-methyl-6-{[(6m,8r)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}-2-azabicyclo[3.2.0]heptan-2-yl]propan-1-one | Human | 15358 | |
| BTK | Tec | TK | 6w07 | A | A | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13096 | |
| BTK | Tec | TK | 5p9l | A | B | ~{n}-[3-[[5-fluoranyl-2-[[4-(2-methoxyethoxy)phenyl]amino]pyrimidin-4-yl]amino]phenyl]propanamide | Human | 7630 | |
| BTK | Tec | TK | 6nfh | A | B | 8-(2,3-dihydro-1h-inden-5-yl)-2-({4-[(2s)-3-(dimethylamino)-2-hydroxypropoxy]phenyl}amino)-5,8-dihydropteridine-6,7-dione | Human | 10965 | |
| BTK | Tec | TK | 8tu3 | A | C | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15359 | |
| BTK | Tec | TK | 3pj1 | A | | 3-(2,6-dichlorophenyl)-7-({4-[2-(diethylamino)ethoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1h)-one | Human | 2904 | |
| BTK | Tec | TK | 5zz4 | B | | n-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 10468 | |
| BTK | Tec | TK | 7lty | A | D | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14064 | |
| BTK | Tec | TK | 6w8i | B | | - | Human | 12991 | |
| BTK | Tec | TK | 6di1 | A | A | 4-amino-2-[(3s)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide | Human | 10630 | |
| BTK | Tec | TK | 8tu4 | A | A | n-methyl-n-[(1s,3r)-3-methyl-3-{[(6m,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}cyclobutyl]propanamide | Human | 15360 | |
| BTK | Tec | TK | 8yvv | A | B | - | Human | 15361 | |
| BTK | Tec | TK | 5vfi | A | A | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-one | Human | 9602 | |
| BTK | Tec | TK | 6di3 | A | | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 10474 | |
| BTK | Tec | TK | 6di9 | A | B | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide | Human | 10476 | |
| BTK | Tec | TK | 5xyz | A | A | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9929 | |
| BTK | Tec | TK | 6tfp | D | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12021 | |
| BTK | Tec | TK | 4z3v | A | B | 4-amino-8-(5-methyl-1h-indazol-6-yl)cinnoline-3-carboxamide | Human | 2914 | |
| BTK | Tec | TK | 4ot6 | A | | 4-(methylsulfonyl)-n-[3-(8-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}imidazo[1,2-a]pyrazin-6-yl)phenyl]benzamide | Human | 2931 | |
| BTK | Tec | TK | 5j87 | C | B | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8006 | |
| BTK | Tec | TK | 6omu | A | B | 1-[4-({[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino}methyl)piperidin-1-yl]prop-2-en-1-one | Human | 11530 | |
| BTK | Tec | TK | 6di9 | A | A | 6-[(3s)-3-(acryloylamino)pyrrolidin-1-yl]-2-{[4-(tert-butylcarbamoyl)phenyl]amino}pyridine-3-carboxamide | Human | 10465 | |
| BTK | Tec | TK | 7kxo | A | B | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13568 | |
| BTK | Tec | TK | 6omu | A | C | - | Human | 11528 | |
| BTK | Tec | TK | 6bik | A | A | 4-tert-butyl-n-[2-(hydroxymethyl)-3-(1-methyl-5-{[5-(morpholine-4-carbonyl)pyridin-2-yl]amino}-6-oxo-1,6-dihydropyridazin-3-yl)phenyl]benzamide | Human | 10680 | |
| BTK | Tec | TK | 6bkh | A | B | n-[2-(hydroxymethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10677 | |
| BTK | Tec | TK | 3k54 | A | B | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 2906 | |
| BTK | Tec | TK | 8tu3 | A | A | 1-[(4r)-4-{[(6p,8s)-6-(1-methyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]oxy}azepan-1-yl]propan-1-one | Human | 15362 | |
| BTK | Tec | TK | 6w07 | A | C | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13097 | |
| BTK | Tec | TK | 4yhf | B | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2912 | |
| BTK | Tec | TK | 4nwm | B | B | 4-tert-butyl-n-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7h-purin-2-yl)phenyl]benzamide | Human | 2903 | |
| BTK | Tec | TK | 4zly | A | B | 4-aminocinnoline-3-carboxamide | Human | 2920 | |
| BTK | Tec | TK | 7lty | A | A | ~{n}-[(5~{r})-2-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-6,7,8,9-tetrahydro-5~{h}-benzo[7]annulen-5-yl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 14065 | |
| BTK | Tec | TK | 5t18 | A | B | 6-fluoro-5-(r)-(3-(s)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4h)-yl)-2-methylphenyl)-2-(s)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1h-carbazole-8-carboxamide | Human | 7507 | |
| BTK | Tec | TK | 8gc7 | A | B | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 15197 | |
| BTK | Tec | TK | 8ejb | A | A | 5-[(3r)-3-(3-methyl-2-oxoimidazolidin-1-yl)piperidin-1-yl]-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | Human | 14614 | |
| BTK | Tec | TK | 6w06 | A | A | 4-~{tert}-butyl-~{n}-[[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]methyl]benzamide | Human | 13099 | |
| BTK | Tec | TK | 6bke | A | A | n-[2-(2-hydroxyethyl)-3-{5-[(5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}phenyl]-1-benzothiophene-2-carboxamide | Human | 10681 | |
| BTK | Tec | TK | 5p9m | A | C | 6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | Human | 7641 | |
| BTK | Tec | TK | 5u9d | A | B | (r)-n-methyl-2-(3-((quinoxalin-6-ylamino)methyl)furan-2-carbonyl)-2,3,4,9-tetrahydro-1h-pyrido[3,4-b]indole-3-carboxamide | Human | 7392 | |
| BTK | Tec | TK | 6di0 | A | A | 6-(cyclohexylamino)pyridine-3-carboxamide | Human | 10629 | |
| BTK | Tec | TK | 5j87 | D | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8008 | |
| BTK | Tec | TK | 7kxo | A | A | 3-tert-butyl-n-[(1r)-6-{2-[5-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-3h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13573 | |
| BTK | Tec | TK | 6nfi | A | B | n-(3-{[(2,6-dimethylphenyl)methyl]amino}-7-methoxyindeno[1,2-c]pyrazol-6-yl)methanesulfonamide | Human | 10963 | |
| BTK | Tec | TK | 6tfp | B | | ~{n}-[3-[6-azanyl-5-[2-[methyl(propanoyl)amino]ethoxy]pyrimidin-4-yl]-5-fluoranyl-2-methyl-phenyl]-4-cyclopropyl-2-fluoranyl-benzamide | Human | 12020 | |
| BTK | Tec | TK | 4zly | A | A | 4-aminocinnoline-3-carboxamide | Human | 2926 | |
| BTK | Tec | TK | 4yhf | A | B | (2s)-2-({(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}carbonyl)-4,4-dimethylpentanenitrile | Human | 2902 | |
| BTK | Tec | TK | 6x3p | A | A | 4-{8-amino-3-[(6r,8as)-3-oxooctahydroindolizin-6-yl]imidazo[1,5-a]pyrazin-1-yl}-3-(cyclopropyloxy)-n-[4-(trifluoromethyl)pyridin-2-yl]benzamide | Human | 12516 | |
| BTK | Tec | TK | 4otf | A | A | n-{3-[6-({4-[(2r)-1,4-dimethyl-3-oxopiperazin-2-yl]phenyl}amino)-4-methyl-5-oxo-4,5-dihydropyrazin-2-yl]-2-methylphenyl}-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 2901 | |
| BTK | Tec | TK | 8e2m | A | B | (5p)-5-[4-methyl-6-(2-methylpropyl)pyridin-3-yl]-4-oxo-n-[(1r,2s)-2-propanamidocyclopentyl]-4,5-dihydro-3h-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide | Human | 14553 | |
| BTK | Tec | TK | 7l5o | A | A | (2e)-2-{(3r)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl}-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile | Human | 14272 | |
| BTK | Tec | TK | 7kxn | A | A | 3-tert-butyl-n-[(1s)-6-{2-[5-methyl-1-(propan-2-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13574 | |
| BTK | Tec | TK | 7kxp | A | A | 3-tert-butyl-n-[(1s)-6-{2-[3-methyl-1-(oxan-4-yl)-1h-pyrazol-4-yl]-1h-imidazo[4,5-b]pyridin-7-yl}-1,2,3,4-tetrahydronaphthalen-1-yl]-1,2,4-oxadiazole-5-carboxamide | Human | 13575 | |
| BTK | Tec | TK | 3ocs | A | | 4-tert-butyl-n-[2-methyl-3-(4-methyl-6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-5-oxo-4,5-dihydropyrazin-2-yl)phenyl]benzamide | Human | 2907 | |
| BTK | Tec | TK | 6w07 | A | B | ~{n}-[[2-methyl-4-[2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]phenyl]methyl]-3-propan-2-yloxy-azetidine-1-carboxamide | Human | 13102 | |
| BTK | Tec | TK | 6nzm | A | A | n-[2-fluoro-6-(pyrrolidin-1-yl)phenyl]-n'-{3-[(2r)-1-(2-hydroxyethyl)-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-2-yl]phenyl}urea | Human | 11144 | |
| BTK | Tec | TK | 7r61 | A | C | 5-{(3s)-1-[(z)-iminomethyl]piperidin-3-yl}-2-(4-phenoxyphenoxy)pyridine-3-carboxamide | Human | 13940 | |
| BTK | Tec | TK | 7kxl | A | C | 3-tert-butyl-n-({2-fluoro-4-[2-(1-methyl-1h-pyrazol-4-yl)-1h-imidazo[4,5-b]pyridin-7-yl]phenyl}methyl)-1,2,4-oxadiazole-5-carboxamide | Human | 13576 | |
| BTK | Tec | TK | 6n9p | A | A | n-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide | Human | 10886 | |
| BTK | Tec | TK | 6bln | A | A | n-(3-{5-[(1,5-dimethyl-1h-pyrazol-3-yl)amino]-6-oxo-1,6-dihydropyridazin-3-yl}-2,6-difluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide | Human | 10685 | |
| BTK | Tec | TK | 5xyz | A | B | n-[3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-1h-1,2,4-triazol-3-yl)phenyl]propanamide | Human | 9932 | |
| BTK | Tec | TK | 5j87 | B | A | n-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide | Human | 8005 | |
| RYK | Ryk | TK | 6tua | A | | - | Human | 11943 | |
| JAK1 | JakA | TK | 4fk6 | A | A | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1465 | |
| JAK1 | JakA | TK | 4e4l | B | A | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1464 | |
| JAK1 | JakA | TK | 6n7c | B | A | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11033 | |
| JAK1 | JakA | TK | 6rsh | B | A | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12467 | |
| JAK1 | JakA | TK | 6dbn | A | B | [(1s)-2,2-difluorocyclopropyl][(1r,5s)-3-{2-[(1-methyl-1h-pyrazol-4-yl)amino]pyrimidin-4-yl}-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Human | 10391 | |
| JAK1 | JakA | TK | 6n7a | A | B | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11028 | |
| JAK1 | JakA | TK | 4e4l | A | B | 1-[4-methyl-1-(methylsulfonyl)piperidin-4-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1488 | |
| JAK1 | JakA | TK | 4k6z | A | | (1r,2s)-2-{[8-oxo-2-(1h-pyrazol-4-yl)-5,8-dihydropyrido[3,4-d]pyrimidin-4-yl]amino}cyclopentanecarbonitrile | Human | 1478 | |
| JAK1 | JakA | TK | 5wo4 | B | A | 3-[(4-chloro-3-methoxyphenyl)amino]-1-[(3r,4s)-4-cyanooxan-3-yl]-1h-pyrazole-4-carboxamide | Human | 8704 | |
| JAK1 | JakA | TK | 6smb | B | B | ~{n}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{h}-indol-7-yl]-2-methyl-pyridine-3-carboxamide | Human | 12243 | |
| JAK1 | JakA | TK | 6aah | B | A | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10394 | |
| JAK1 | JakA | TK | 5e1e | A | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6250 | |
| JAK1 | JakA | TK | 6c7y | A | B | adenosine-5'-diphosphate | Human | 9867 | |
| JAK1 | JakA | TK | 4ehz | D | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1485 | |
| JAK1 | JakA | TK | 5hx8 | A | B | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6438 | |
| JAK1 | JakA | TK | 6ggh | B | B | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11086 | |
| JAK1 | JakA | TK | 6tpf | B | A | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12363 | |
| JAK1 | JakA | TK | 6n7c | B | B | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11023 | |
| JAK1 | JakA | TK | 6n7a | B | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]-2-methyl-2h-pyrazolo[4,3-c]pyridine-7-carboxamide | Human | 11015 | |
| JAK1 | JakA | TK | 4ehz | D | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1451 | |
| JAK1 | JakA | TK | 6tpe | A | | 2-[4-(3-methyl-6-oxidanylidene-1,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]ethanenitrile | Human | 12364 | |
| JAK1 | JakA | TK | 4i5c | B | A | 3-oxo-3-[(3r)-3-(pyrrolo[2,3-b][1,2,3]triazolo[4,5-d]pyridin-1(6h)-yl)piperidin-1-yl]propanenitrile | Human | 1467 | |
| JAK1 | JakA | TK | 4ivb | A | B | trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexanecarbonitrile | Human | 1479 | |
| JAK1 | JakA | TK | 4k77 | B | | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7h)-one | Human | 1475 | |
| JAK1 | JakA | TK | 6hzu | B | A | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11765 | |
| JAK1 | JakA | TK | 4ei4 | A | | (1r,3r)-3-(2-methylimidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(8h)-yl)cyclohexanol | Human | 1480 | |
| JAK1 | JakA | TK | 4fk6 | B | B | n-({1-[(1r,2r,4s)-bicyclo[2.2.1]hept-2-yl]-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl}methyl)methanesulfonamide | Human | 1459 | |
| JAK1 | JakA | TK | 5e1e | B | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6251 | |
| JAK1 | JakA | TK | 4e4n | B | | tert-butyl [(1r,3r)-3-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)cyclopentyl]carbamate | Human | 1454 | |
| JAK1 | JakA | TK | 4ehz | C | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1470 | |
| JAK1 | JakA | TK | 4e5w | B | A | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1447 | |
| JAK1 | JakA | TK | 4ivc | B | | (trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)acetonitrile | Human | 1456 | |
| JAK1 | JakA | TK | 6hzu | A | B | 2-[4-[8-oxidanylidene-2-[(~{e})-(2-oxidanylidenepyridin-3-ylidene)amino]-7~{h}-purin-9-yl]cyclohexyl]ethanenitrile | Human | 11762 | |
| JAK1 | JakA | TK | 6rsc | B | A | 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12474 | |
| JAK1 | JakA | TK | 4ehz | C | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1476 | |
| JAK1 | JakA | TK | 4ehz | A | B | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1463 | |
| JAK1 | JakA | TK | 3eyg | A | B | 3-{(3r,4r)-4-methyl-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | Human | 1453 | |
| JAK1 | JakA | TK | 6rsd | B | B | 1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12475 | |
| JAK1 | JakA | TK | 6tpf | A | A | (1~{s})-2,2-bis(fluoranyl)-~{n}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide | Human | 12366 | |
| JAK1 | JakA | TK | 6aah | B | B | 4-[[(1s,3r)-5-oxidanyl-2-adamantyl]amino]-1h-pyrrolo[2,3-b]pyridine-5-carboxamide | Human | 10395 | |
| JAK1 | JakA | TK | 5e1e | B | A | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6249 | |
| JAK1 | JakA | TK | 4e4l | E | A | - | Human | 1469 | |
| JAK1 | JakA | TK | 5hx8 | A | A | 4-[(4-aminocyclohexyl)amino]-3-(1h-benzimidazol-2-yl)-1h-pyridin-2-one | Human | 6441 | |
| JAK1 | JakA | TK | 6rse | A | B | methyl ~{n}-[4-aminocarbonyl-1-[(3~{r},4~{r})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate | Human | 12476 | |
| JAK1 | JakA | TK | 6bbu | A | B | n-{cis-3-[methyl(7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | Human | 9496 | |
| JAK1 | JakA | TK | 6ggh | A | A | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11087 | |
| JAK1 | JakA | TK | 6n77 | A | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11024 | |
| JAK1 | JakA | TK | 6ggh | A | B | ~{n}-[5-methyl-4-[7-[[(2~{r})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{h}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide | Human | 11088 | |
| JAK1 | JakA | TK | 4e5w | A | B | [4-(imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl)piperidin-1-yl][(2s)-1-(propan-2-yl)pyrrolidin-2-yl]methanone | Human | 1473 | |
| JAK1 | JakA | TK | 6n77 | A | C | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11029 | |
| JAK1 | JakA | TK | 6n7d | A | B | n-[5-(6-methoxy-1h-indazol-5-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11025 | |
| JAK1 | JakA | TK | 6n77 | B | A | n-[3-(5-chloro-2-methoxyphenyl)-1-methyl-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11030 | |
| JAK1 | JakA | TK | 6n7c | A | B | n-[5-(3-methoxynaphthalen-2-yl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11027 | |
| JAK1 | JakA | TK | 4ehz | B | A | 2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine | Human | 1448 | |
| JAK1 | JakA | TK | 6sm8 | A | A | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12248 | |
| JAK1 | JakA | TK | 6sm8 | B | B | 2-chloranyl-6-[(3~{s})-3-[(1~{s})-2-cyano-1-[4-(7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | Human | 12249 | |
| JAK1 | JakA | TK | 6rsh | B | B | 1-[(3~{r},4~{r})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide | Human | 12480 | |
| JAK1 | JakA | TK | 4ivc | A | | (trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)acetonitrile | Human | 1461 | |
| JAK1 | JakA | TK | 4k77 | A | | 4-(cyclohexylamino)pyrido[3,4-d]pyrimidin-8(7h)-one | Human | 1449 | |
| JAK1 | JakA | TK | 4ivd | B | A | 3-(trans-4-{2-[(1r)-1-hydroxyethyl]imidazo[4,5-d]pyrrolo[2,3-b]pyridin-1(6h)-yl}cyclohexyl)propanenitrile | Human | 1490 | |
| JAK1 | JakA | TK | 5e1e | A | B | 6-chloro-2-(2-fluoro-4,5-dimethoxyphenyl)-n-(piperidin-4-ylmethyl)-3h-imidazo[4,5-b]pyridin-7-amine | Human | 6248 | |
| NTRK3 (TRKC) | Trk | TK | 3v5q | B | | 1-(3-{[(3z)-2-oxo-3-(1h-pyrrol-2-ylmethylidene)-2,3-dihydro-1h-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea | Human | 97 | |
| NTRK3 (TRKC) | Trk | TK | 4ymj | A | A | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile | Human | 101 | |
| NTRK3 (TRKC) | Trk | TK | 4ymj | A | B | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile | Human | 98 | |
| NTRK3 (TRKC) | Trk | TK | 6kzd | A | | 3-[2-[6-(4-aminophenyl)imidazo[1,2-a]pyrazin-3-yl]ethynyl]-2-methyl-~{n}-[3-(4-methylpiperazin-1-yl)-5-propan-2-yl-phenyl]benzamide | Human | 11697 | |
| NTRK3 (TRKC) | Trk | TK | 4ymj | B | B | 4-[6-(benzylamino)imidazo[1,2-b]pyridazin-3-yl]benzonitrile | Human | 99 | |
| BMX | Tec | TK | 3sxr | A | | n-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide | Human | 3482 | |
| BMX | Tec | TK | 6i99 | A | | ~{n}-[2-methyl-5-[8-[4-(methylsulfonylamino)phenyl]-2-oxidanylidene-benzo[h][1,6]naphthyridin-1-yl]phenyl]-3-oxidanyl-propanamide | Human | 12348 | |
