Search results (109 entries covering 60 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
Btk (BTK)TecTK8s93AA2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-oneMouse14997
Abl1 (ABL1)AblTK1m52A6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-oneMouse5720
Abl1 (ABL1)AblTK3oy3A5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1h-imidazole-2-carboxamideMouse5711
Abl1 (ABL1)AblTK3dk3BA2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5712
Abl1 (ABL1)AblTK6hd6BB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10610
Abl1 (ABL1)AblTK3mssB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5730
Abl1 (ABL1)AblTK3k5vAA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5734
Abl1 (ABL1)AblTK3dk3AB2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5729
Abl1 (ABL1)AblTK3k5vBB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5722
Abl1 (ABL1)AblTK3dk6A2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5725
Abl1 (ABL1)AblTK3ik3B3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideMouse5739
Abl1 (ABL1)AblTK1m52B6-(2,6-dichloro-phenyl)-8-methyl-2-(3-methylsulfanyl-phenylamino)-8h-pyrido[2,3-d]pyrimidin-7-oneMouse5715
Abl1 (ABL1)AblTK3ms9AA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5733
Jak2 (JAK2)JakATK4gl9D2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-oneMouse6935
Jak2 (JAK2)JakATK4gl9B2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-oneMouse6936
Jak2 (JAK2)JakATK4gl9C2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-oneMouse6934
Jak2 (JAK2)JakATK4gl9A2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz[h]-imidaz[4,5-f]isoquinoline-7-oneMouse6933
Src (SRC)SrcTK6f3fAadenosine-5'-diphosphateMouse9461
Tyk2 (TYK2)JakATK4e1zAn-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1h-indazol-3-yl]furan-2-carboxamideMouse5828
Abl1 (ABL1)AblTK6hd6BA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10611
Abl1 (ABL1)AblTK6hd4BA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10648
Abl1 (ABL1)AblTK3oy3B5-[(5-{[4-{[4-(2-hydroxyethyl)piperazin-1-yl]methyl}-3-(trifluoromethyl)phenyl]carbamoyl}-2-methylphenyl)ethynyl]-1-methyl-1h-imidazole-2-carboxamideMouse5738
Tyk2 (TYK2)JakATK4e20An-[4-(3-amino-1h-indazol-5-yl)phenyl]-3-chlorobenzenesulfonamideMouse5827
Tyro3 (TYRO3)AxlTK3qupA(5-fluoro-1h-indol-2-yl)[(3r)-1'-[(3r)-piperidin-3-yl]spiro[indole-3,3'-pyrrolidin]-1(2h)-yl]methanoneMouse5799
Abl1 (ABL1)AblTK3dk7B2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5714
Abl1 (ABL1)AblTK2qohB5-[3-(2-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylpyridine-3-carboxamideMouse5716
Insr (INSR)InsRTK8eyxA-Mouse14496
Insr (INSR)InsRTK8eyyA-Mouse14497
Epha4 (EphA4)EphTK2helA-Mouse5812
Epha4 (EphA4)EphTK2y6mAA-Mouse5809
Epha4 (EphA4)EphTK2xyuA5-(5-fluoro-2-methylphenyl)-6,7,8,9-tetrahydro-3h-pyrazolo[3,4-c]isoquinolin-1-amineMouse5810
Epha4 (EphA4)EphTK2y6oAAn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse5814
Abl1 (ABL1)AblTK3ms9AB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5708
Abl1 (ABL1)AblTK6hd4AA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10645
Btk (BTK)TecTK8s93AB2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-oneMouse14996
Btk (BTK)TecTK8s9fAn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse14998
Btk (BTK)TecTK8gmbA2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2h-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6h)-oneMouse14999
Insr (INSR)InsRTK8dtlB-Mouse14362
Btk (BTK)TecTK8ff0A6-azanyl-9-[(3~{r})-1-[(~{e})-but-2-enoyl]pyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-oneMouse14834
Btk (BTK)TecTK8fd9AAacalabrutinibMouse14836
Btk (BTK)TecTK8fd9ABacalabrutinibMouse14835
Ephb2 (EphB2)EphTK2henBadenosine-5'-diphosphateMouse5804
Ephb2 (EphB2)EphTK1jpaAphosphoaminophosphonic acid-adenylate esterMouse5806
Ephb2 (EphB2)EphTK2henAadenosine-5'-diphosphateMouse5807
Ephb2 (EphB2)EphTK2henDadenosine-5'-diphosphateMouse5803
Ephb2 (EphB2)EphTK2henCadenosine-5'-diphosphateMouse5808
Jak1 (JAK1)JakATK8ewyA-Mouse14664
Src (SRC)SrcTK8xn8AAadenosine-5'-diphosphateMouse15182
Src (SRC)SrcTK8xn8ABadenosine-5'-diphosphateMouse15183
Abl1 (ABL1)AblTK3ms9BA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5713
Lyn (LYN)SrcTK2zvaAn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse5774
Lyn (LYN)SrcTK2zv7A-Mouse5771
Abl1 (ABL1)AblTK1opjB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5736
Abl1 (ABL1)AblTK6hd6AA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10609
Abl1 (ABL1)AblTK1opkA6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8h)-oneMouse5709
Lyn (LYN)SrcTK2zv8Aphosphoaminophosphonic acid-adenylate esterMouse5772
Lyn (LYN)SrcTK2zv9A1-tert-butyl-3-(4-chloro-phenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-ylamineMouse5773
Abl1 (ABL1)AblTK1opjA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5732
Abl1 (ABL1)AblTK3dk3BB2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5737
Abl1 (ABL1)AblTK3kf4Bn-[4-(dimethylphosphoryl)phenyl]-9-[(e)-2-(5-methyl-1h-indazol-4-yl)ethenyl]-9h-purin-6-amineMouse5741
Abl1 (ABL1)AblTK3mssC4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5719
Abl1 (ABL1)AblTK3ik3A3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideMouse5731
Abl1 (ABL1)AblTK3kfaA3-{(e)-2-[6-(cyclopropylamino)-9h-purin-9-yl]ethenyl}-4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideMouse5742
Abl1 (ABL1)AblTK1fpuBn-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamideMouse5705
Abl1 (ABL1)AblTK1iepA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5703
Abl1 (ABL1)AblTK3k5vAB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5723
Abl1 (ABL1)AblTK3kf4An-[4-(dimethylphosphoryl)phenyl]-9-[(e)-2-(5-methyl-1h-indazol-4-yl)ethenyl]-9h-purin-6-amineMouse5717
Abl1 (ABL1)AblTK6hd6AB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10608
Abl1 (ABL1)AblTK1iepB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5727
Abl1 (ABL1)AblTK3dk6B2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5718
Abl1 (ABL1)AblTK3dk7A2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5704
Abl1 (ABL1)AblTK2z60A5-[3-(2-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylpyridine-3-carboxamideMouse5735
Abl1 (ABL1)AblTK3ms9BB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5706
Abl1 (ABL1)AblTK3oxzA3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamideMouse5721
Abl1 (ABL1)AblTK3mssD4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5702
Abl1 (ABL1)AblTK3dk3AA2-amino-5-[3-(1-ethyl-1h-pyrazol-5-yl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylbenzamideMouse5726
Abl1 (ABL1)AblTK2qohA5-[3-(2-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]-n,n-dimethylpyridine-3-carboxamideMouse5707
Abl1 (ABL1)AblTK1fpuAn-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-3-pyridinecarboxamideMouse5728
Abl1 (ABL1)AblTK6hd4BB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10646
Abl1 (ABL1)AblTK2hznA1-[4-(pyridin-4-yloxy)phenyl]-3-[3-(trifluoromethyl)phenyl]ureaMouse5701
Abl1 (ABL1)AblTK6hd4AB4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse10647
Abl1 (ABL1)AblTK3k5vBA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5710
Abl1 (ABL1)AblTK3kfaB3-{(e)-2-[6-(cyclopropylamino)-9h-purin-9-yl]ethenyl}-4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamideMouse5740
Abl1 (ABL1)AblTK3mssA4-(4-methyl-piperazin-1-ylmethyl)-n-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideMouse5724
Abl2 (ABL2)AblTK4xliBn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse5690
Abl2 (ABL2)AblTK4xliAn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse5689
Igf1r (IGF1R)InsRTK6pyhA-Mouse11777
Igf1r (IGF1R)InsRTK6pyhD-Mouse11776
Ephb2 (EphB2)EphTK1jpaBphosphoaminophosphonic acid-adenylate esterMouse5805
Insr (INSR)InsRTK7sl7A-Mouse14169
Insr (INSR)InsRTK7stjA-Mouse14170
Insr (INSR)InsRTK7sl6A-Mouse14171
Insr (INSR)InsRTK7sl4A-Mouse14172
Btk (BTK)TecTK9xyvAA1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-oneMouse16246
Btk (BTK)TecTK9xz2AB6-amino-7-(4-phenoxyphenyl)-9-[(3r)-1-propanoylpyrrolidin-3-yl]-7,9-dihydro-8h-purin-8-oneMouse16247
Btk (BTK)TecTK6mnyBA-Mouse11306
Btk (BTK)TecTK9xyvAC1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-oneMouse16248
Btk (BTK)TecTK9xz2AA6-amino-7-(4-phenoxyphenyl)-9-[(3r)-1-propanoylpyrrolidin-3-yl]-7,9-dihydro-8h-purin-8-oneMouse16249
Btk (BTK)TecTK4xi2A-Mouse5815
Btk (BTK)TecTK9xyyA(2e)-1-{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}but-2-en-1-oneMouse16250
Btk (BTK)TecTK6mnyBB-Mouse11309
Btk (BTK)TecTK9xyvAB1-[(3~{r})-3-[4-azanyl-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-oneMouse16251
Btk (BTK)TecTK6mnyAB5-amino-1-[(3r)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazole-4-carboxamideMouse11308
Btk (BTK)TecTK6mnyAA5-amino-1-[(3r)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1h-pyrazole-4-carboxamideMouse11307
Btk (BTK)TecTK9ejxA{(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl}(cyclopropyl)methanoneMouse16252
Tyro3 (TYRO3)AxlTK4feqA4-(cyclopentylamino)-n-[3-(2-oxopyrrolidin-1-yl)propyl]-2-{[2-(pyridin-4-yl)ethyl]amino}pyrimidine-5-carboxamideMouse5801
Tyro3 (TYRO3)AxlTK4ff8A4-(cyclopentylamino)-2-[(2-methoxybenzyl)amino]-n-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideMouse5800
Epha4 (EphA4)EphTK2y6mAB-Mouse5813
Epha4 (EphA4)EphTK2y6oABn-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamideMouse5811