| IRAK4 | IRAK | TKL | 8v2f | A | A | n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15333 | |
| BRAF | RAF | TKL | 9bfb | A | A | n-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide | Human | 15365 | |
| IRAK4 | IRAK | TKL | 6mom | B | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11745 | |
| IRAK4 | IRAK | TKL | 5w85 | A | | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide | Human | 8560 | |
| MLKL | TKL-Unique | TKL | 7jxu | A | | - | Human | 13394 | |
| ACVR1 (ALK2) | STKR | TKL | 8c7z | A | A | 9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1]benzoxepino[5,4-c]pyridine | Human | 14605 | |
| MLKL | TKL-Unique | TKL | 5ko1 | A | A | [(1~{r})-2-[(4-fluorophenyl)amino]-2-oxidanylidene-1-phenyl-ethyl] 3-azanylpyrazine-2-carboxylate | Human | 7269 | |
| IRAK4 | IRAK | TKL | 5uit | A | | 1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | Human | 7606 | |
| IRAK4 | IRAK | TKL | 7qg5 | A | A | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | 14211 | |
| IRAK4 | IRAK | TKL | 7qg1 | A | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]-5-oxidanylidene-pyrido[4,3-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 14212 | |
| IRAK4 | IRAK | TKL | 6vql | B | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12394 | |
| IRAK4 | IRAK | TKL | 5t1t | C | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7564 | |
| MLKL | TKL-Unique | TKL | 5knj | A | | 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea | Human | 7270 | |
| LRRK2 | LRRK | TKL | 8u1b | A | | - | Human | 15387 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10905 | |
| ACVR1 (ALK2) | STKR | TKL | 6acr | B | | n-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1h-pyrazol-4-yl]pyrimidin-2-amine | Human | 10968 | |
| IRAK4 | IRAK | TKL | 6ti8 | C | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12945 | |
| IRAK4 | IRAK | TKL | 6o95 | A | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11104 | |
| IRAK4 | IRAK | TKL | 5kx8 | D | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6961 | |
| MLKL | TKL-Unique | TKL | 6bwk | A | | - | Human | 10038 | |
| MLKL | TKL-Unique | TKL | 7jw7 | A | | - | Human | 13395 | |
| IRAK4 | IRAK | TKL | 2nru | A | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1748 | |
| IRAK4 | IRAK | TKL | 6thz | A | | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12948 | |
| IRAK4 | IRAK | TKL | 2oic | A | | staurosporine | Human | 1739 | |
| MLKL | TKL-Unique | TKL | 4mwi | A | B | - | Human | 3049 | |
| MLKL | TKL-Unique | TKL | 7jxu | B | | - | Human | 13396 | |
| MLKL | TKL-Unique | TKL | 6lk5 | A | | - | Human | 13094 | |
| MLKL | TKL-Unique | TKL | 5knj | B | | 1-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]-3-[4-(trifluoromethyloxy)phenyl]urea | Human | 7268 | |
| MLKL | TKL-Unique | TKL | 6o5z | A | | - | Human | 12782 | |
| MAP3K7 (TAK1) | MLK | TKL | 5gjf | A | | n-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(3-phenylureido)phenyl)thiazole-4-carboxamide | Human | 7264 | |
| MLKL | TKL-Unique | TKL | 4mwi | A | A | - | Human | 3047 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | B | B | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6063 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | D | A | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6072 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | A | C | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9798 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | C | A | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6070 | |
| BRAF | RAF | TKL | 7shv | A | B | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 14481 | |
| BRAF | RAF | TKL | 7shv | A | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 14482 | |
| RIPK2 | RIPK | TKL | 8aza | B | | - | Human | 14473 | |
| MAP3K7 (TAK1) | MLK | TKL | 5gjg | A | | n-(2-isopropoxy-4-(4-methylpiperazine-1-carbonyl)phenyl)-2-(3-(phenylcarbamoyl)phenyl)thiazole-4-carboxamide | Human | 7265 | |
| LIMK1 | LISK | TKL | 8aau | L | B | ~{n}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide | Human | 14554 | |
| LIMK1 | LISK | TKL | 8aau | L | A | ~{n}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide | Human | 14555 | |
| MAP3K12 (DLK) | MLK | TKL | 8deg | A | | methyl (1s,4s)-5-{(4p)-4-[5-amino-6-(difluoromethoxy)pyrazin-2-yl]-6-[(1r,4r)-2-azabicyclo[2.1.1]hexan-2-yl]pyridin-2-yl}-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate | Human | 14557 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | C | B | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6067 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | A | A | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9791 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | A | A | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6068 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | B | B | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9794 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | D | B | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9801 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | C | A | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6069 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | C | B | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6073 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | A | A | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6059 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | C | A | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9799 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | C | B | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9793 | |
| TNNI3K (HH498) | MLK | TKL | 7mgk | A | B | n-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-n'-[3-(trifluoromethyl)phenyl]urea | Human | 13970 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | D | A | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6066 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7m | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13666 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | A | B | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6071 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | D | B | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6074 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | B | C | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9797 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | B | A | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6065 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7q | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13670 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | C | C | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9796 | |
| IRAK4 | IRAK | TKL | 8atn | A | A | ~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 14965 | |
| ACVR1 (ALK2) | STKR | TKL | 6t8n | A | B | cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone | Human | 11830 | |
| IRAK4 | IRAK | TKL | 4yp8 | C | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1735 | |
| IRAK4 | IRAK | TKL | 6ege | D | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10896 | |
| IRAK4 | IRAK | TKL | 8br6 | A | A | ~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide | Human | 15191 | |
| IRAK4 | IRAK | TKL | 6o8u | B | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11120 | |
| IRAK4 | IRAK | TKL | 8br7 | A | | 3-nitro-~{n}-[2-[2-oxidanylidene-2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]indazol-5-yl]benzamide | Human | 15188 | |
| IRAK4 | IRAK | TKL | 4ztn | A | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6007 | |
| IRAK4 | IRAK | TKL | 6o94 | C | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11118 | |
| IRAK4 | IRAK | TKL | 2oic | D | | staurosporine | Human | 1755 | |
| RIPK2 | RIPK | TKL | 6sze | B | B | 5-amino-1-phenylpyrazole-4-carboxamide | Human | 11758 | |
| IRAK4 | IRAK | TKL | 6o9d | D | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11114 | |
| RIPK2 | RIPK | TKL | 5w5o | P | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8581 | |
| IRAK4 | IRAK | TKL | 4y73 | A | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9123 | |
| IRAK4 | IRAK | TKL | 5k7g | D | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8716 | |
| BMPR1B | STKR | TKL | 3mdy | C | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1500 | |
| BMPR1B | STKR | TKL | 3mdy | C | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1503 | |
| BMPR1B | STKR | TKL | 3mdy | A | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1502 | |
| IRAK4 | IRAK | TKL | 5k7g | A | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8722 | |
| IRAK4 | IRAK | TKL | 6o94 | B | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11098 | |
| IRAK4 | IRAK | TKL | 6o8u | C | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11093 | |
| IRAK4 | IRAK | TKL | 6o94 | B | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11117 | |
| MLKL | TKL-Unique | TKL | 5ko1 | A | B | [(1~{r})-2-[(4-fluorophenyl)amino]-2-oxidanylidene-1-phenyl-ethyl] 3-azanylpyrazine-2-carboxylate | Human | 7271 | |
| IRAK4 | IRAK | TKL | 6vql | D | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12392 | |
| IRAK4 | IRAK | TKL | 6uya | A | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11810 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | D | B | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6064 | |
| TNNI3K (HH498) | MLK | TKL | 7mgk | A | A | n-(3,5-dichloro-4-{[6-(methylamino)pyrimidin-4-yl]oxy}phenyl)-n'-[3-(trifluoromethyl)phenyl]urea | Human | 13968 | |
| IRAK4 | IRAK | TKL | 6o8u | B | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11096 | |
| IRAK4 | IRAK | TKL | 5uit | B | | 1-{[(2s)-5-oxopyrrolidin-2-yl]methoxy}-7-[(propan-2-yl)oxy]isoquinoline-6-carboxamide | Human | 7597 | |
| LIMK2 | LISK | TKL | 5nxd | A | B | 4-[(3-chlorophenyl)sulfamoyl]-~{n}-(phenylmethyl)-~{n}-propyl-benzamide | Human | 7621 | |
| BRAF | RAF | TKL | 5csw | A | | dabrafenib | Human | 6433 | |
| BRAF | RAF | TKL | 6v2w | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13026 | |
| BRAF | RAF | TKL | 7m0t | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13525 | |
| MAP3K9 (MLK1) | MLK | TKL | 3dtc | A | | 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12h)-one | Human | 3839 | |
| MAP3K9 (MLK1) | MLK | TKL | 4uy9 | A | B | - | Human | 6128 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | C | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1269 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | S | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1259 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | R | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1256 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | L | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1265 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | T | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1264 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | A | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1266 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | O | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1262 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | M | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1268 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | V | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1271 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | E | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1263 | |
| LIMK2 | LISK | TKL | 5nxd | B | B | 4-[(3-chlorophenyl)sulfamoyl]-~{n}-(phenylmethyl)-~{n}-propyl-benzamide | Human | 7622 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | B | B | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6060 | |
| BRAF | RAF | TKL | 5ita | B | | n-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | Human | 6943 | |
| BRAF | RAF | TKL | 5ct7 | B | | 1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine | Human | 6033 | |
| BRAF | RAF | TKL | 3ii5 | A | | n-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 3116 | |
| BRAF | RAF | TKL | 5jsm | B | A | n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide) | Human | 7060 | |
| BRAF | RAF | TKL | 6uan | C | | - | Human | 11642 | |
| BRAF | RAF | TKL | 5ita | A | | n-{2-cyano-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | Human | 6940 | |
| BRAF | RAF | TKL | 4wo5 | A | | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | Human | 3079 | |
| BRAF | RAF | TKL | 9twb | B | | adenosine-5'-diphosphate | Human | 16210 | |
| BRAF | RAF | TKL | 6v34 | B | | 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | Human | 13199 | |
| BRAF | RAF | TKL | 4g9c | B | | 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamide | Human | 3067 | |
| BRAF | RAF | TKL | 6pp9 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 11711 | |
| BRAF | RAF | TKL | 3psd | B | | 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazole | Human | 3083 | |
| BRAF | RAF | TKL | 3q4c | A | | [(1,2,3,4,5,6-eta)-(1s,2r,3r,4r,5s,6s)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5h-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~n~1~,n~12~)ruthenium(1+) | Human | 7251 | |
| BRAF | RAF | TKL | 6xfp | A | B | 4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide | Human | 13404 | |
| BRAF | RAF | TKL | 7m0v | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13522 | |
| BRAF | RAF | TKL | 4e26 | B | | 5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol | Human | 3102 | |
| BRAF | RAF | TKL | 3psd | A | | 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1h-pyrazol-4-yl]indeno[1,2-c]pyrazole | Human | 3142 | |
| BRAF | RAF | TKL | 5vam | A | A | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8185 | |
| BRAF | RAF | TKL | 9o2z | A | | - | Human | 16211 | |
| BRAF | RAF | TKL | 4ksq | A | | n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | Human | 3065 | |
| BRAF | RAF | TKL | 5val | B | | n-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide | Human | 8188 | |
| BRAF | RAF | TKL | 5jrq | A | | (3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanone | Human | 7061 | |
| BRAF | RAF | TKL | 1uwh | B | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3109 | |
| BRAF | RAF | TKL | 5fd2 | B | | 6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purine | Human | 6602 | |
| BRAF | RAF | TKL | 4mne | G | A | - | Human | 3071 | |
| BRAF | RAF | TKL | 1uwj | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3135 | |
| IRAK4 | IRAK | TKL | 7c2v | C | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 12999 | |
| IRAK4 | IRAK | TKL | 7c2v | A | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 13001 | |
| IRAK4 | IRAK | TKL | 7c2v | C | B | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 13003 | |
| BRAF | RAF | TKL | 8c7y | A | A | ~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide | Human | 14629 | |
| BRAF | RAF | TKL | 8c7y | A | B | ~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide | Human | 14628 | |
| LRRK2 | LRRK | TKL | 8txz | A | A | - | Human | 15056 | |
| LRRK2 | LRRK | TKL | 8tzf | A | | - | Human | 15059 | |
| ACVR1 (ALK2) | STKR | TKL | 5s84 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13734 | |
| ACVR1 (ALK2) | STKR | TKL | 5s84 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13656 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7l | A | C | - | Human | 13665 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7l | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13676 | |
| ACVR1 (ALK2) | STKR | TKL | 5s78 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13716 | |
| ACVR1 (ALK2) | STKR | TKL | 5s84 | A | C | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13722 | |
| ACVR1 (ALK2) | STKR | TKL | 5s8b | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13726 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7l | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13736 | |
| ACVR1 (ALK2) | STKR | TKL | 5s8b | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13721 | |
| IRAK4 | IRAK | TKL | 7qg2 | A | B | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14215 | |
| MLKL | TKL-Unique | TKL | 7mon | A | | n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 13980 | |
| RIPK3 | RIPK | TKL | 7mon | B | | n-[4-({2-[(cyclopropanecarbonyl)amino]pyridin-4-yl}oxy)-3-fluorophenyl]-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide | Human | 13979 | |
| BRAF | RAF | TKL | 8f7p | A | B | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 14702 | |
| BRAF | RAF | TKL | 8f7o | A | B | 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | Human | 14703 | |
| LRRK2 | LRRK | TKL | 8tzg | A | A | - | Human | 15051 | |
| LRRK2 | LRRK | TKL | 8tzg | A | B | - | Human | 15053 | |
| BRAF | RAF | TKL | 3c4c | A | | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | Human | 3115 | |
| BRAF | RAF | TKL | 8f7p | A | A | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 14705 | |
| LRRK2 | LRRK | TKL | 8u7l | A | | - | Human | 15184 | |
| BRAF | RAF | TKL | 5hi2 | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 6515 | |
| RAF1 | RAF | TKL | 3omv | A | | (1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime | Human | 937 | |
| IRAK4 | IRAK | TKL | 8br5 | A | B | ~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15189 | |
| BRAF | RAF | TKL | 8c7x | A | B | ~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide | Human | 14627 | |
| BRAF | RAF | TKL | 8f7o | A | A | 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | Human | 14704 | |
| BRAF | RAF | TKL | 8c7x | A | A | ~{n}-[3-[(5-chloranyl-1~{h}-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-bis(fluoranyl)phenyl]-3-(2-cyanopropan-2-yl)benzamide | Human | 14630 | |
| RIPK1 | RIPK | TKL | 4itj | A | A | n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide | Human | 575 | |
| LIMK1 | LISK | TKL | 7b8w | A | | 2-(2-methylpropanoylamino)-~{n}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide | Human | 14126 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7d | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13668 | |
| RIPK1 | RIPK | TKL | 4itj | A | B | n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide | Human | 572 | |
| RIPK1 | RIPK | TKL | 4itj | B | B | n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide | Human | 574 | |
| IRAK4 | IRAK | TKL | 8br6 | A | B | ~{n}-[6-methoxy-2-(2-methylsulfonylethyl)-1,3-dihydroindazol-5-yl]-6-(2-oxidanylpropan-2-yl)pyridine-2-carboxamide | Human | 15190 | |
| TNNI3K (HH498) | MLK | TKL | 7mgj | A | | n-methyl-4-[4-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]pyridine-2-carboxamide | Human | 13969 | |
| IRAK4 | IRAK | TKL | 8br5 | A | A | ~{n}-[2,3-dimethyl-6-(1~{h}-pyrazol-5-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15187 | |
| ACVR1 (ALK2) | STKR | TKL | 5s89 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13688 | |
| BRAF | RAF | TKL | 6xlo | A | | 3-(2-cyanopropan-2-yl)-n-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide | Human | 13618 | |
| BRAF | RAF | TKL | 9bfb | A | B | n-{2-chloro-3-[(3,5-dimethyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-fluorophenyl}-3-fluoropropane-1-sulfonamide | Human | 15366 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | D | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1258 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | H | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1260 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2j | A | B | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(8h)-one | Human | 2115 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2x7o | E | | (3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide | Human | 2097 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2x7o | C | | (3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide | Human | 2104 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3tzm | A | A | 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1h-imidazol-2-yl]benzamide | Human | 2095 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2j | A | A | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(8h)-one | Human | 2124 | |
| IRAK4 | IRAK | TKL | 2nru | B | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1749 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | B | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1273 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3tzm | A | B | 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1h-imidazol-2-yl]benzamide | Human | 2110 | |
| IRAK4 | IRAK | TKL | 6lxy | D | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13161 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2g | A | B | 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6h)-one | Human | 2114 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8u | A | | - | Human | 6616 | |
| IRAK4 | IRAK | TKL | 4ztn | B | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6005 | |
| IRAK4 | IRAK | TKL | 7c2w | A | A | - | Human | 12996 | |
| IRAK4 | IRAK | TKL | 4ztl | A | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5994 | |
| RIPK2 | RIPK | TKL | 6sze | A | A | 5-amino-1-phenylpyrazole-4-carboxamide | Human | 11759 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7r | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13731 | |
| IRAK4 | IRAK | TKL | 5uis | D | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7602 | |
| IRAK4 | IRAK | TKL | 2nry | C | A | staurosporine | Human | 1779 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8s | A | B | - | Human | 6609 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8t | A | A | - | Human | 6608 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qu0 | A | A | 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1h-imidazol-5-yl]imidazo[1,2-b]pyridazine-3-carbonitrile | Human | 11967 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3faa | E | | n-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1h-imidazol-2-yl]acetamide | Human | 2098 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3kcf | B | | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3h-pyrazol-3-one | Human | 2106 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1b6c | D | | - | Human | 2126 | |
| BRAF | RAF | TKL | 4mne | F | A | - | Human | 3099 | |
| RIPK2 | RIPK | TKL | 6s1f | D | | ~{n}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide | Human | 11732 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8w | A | A | staurosporine | Human | 6611 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e90 | A | B | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | Human | 6607 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | X | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1275 | |
| RAF1 | RAF | TKL | 8u1l | C | | - | Human | 15219 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e90 | A | A | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | Human | 6610 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1rw8 | A | | 3-(4-fluorophenyl)-2-(6-methylpyridin-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole | Human | 2100 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3kcf | C | | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3h-pyrazol-3-one | Human | 2093 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 6b8y | A | A | n-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9553 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5fri | A | B | n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | Human | 6893 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8z | A | A | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | Human | 6618 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qu0 | A | B | 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1h-imidazol-5-yl]imidazo[1,2-b]pyridazine-3-carbonitrile | Human | 11964 | |
| RAF1 | RAF | TKL | 8chf | A | | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 15220 | |
| RAF1 | RAF | TKL | 8cpd | A | | - | Human | 15221 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3faa | C | | n-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1h-imidazol-2-yl]acetamide | Human | 2130 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2x7o | A | | (3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide | Human | 2127 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qik | A | A | n-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10657 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2k | A | A | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6h)-one | Human | 2135 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qim | A | A | n-{4-[3-(5-methoxypyridin-2-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10658 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3kcf | D | | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3h-pyrazol-3-one | Human | 2119 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3faa | D | | n-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1h-imidazol-2-yl]acetamide | Human | 2132 | |
| RAF1 | RAF | TKL | 9mmp | C | | - | Human | 15540 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2g | A | A | 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6h)-one | Human | 2123 | |
| BRAF | RAF | TKL | 4xv1 | B | | - | Human | 6216 | |
| BRAF | RAF | TKL | 4pp7 | B | | n-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | Human | 3126 | |
| BRAF | RAF | TKL | 3skc | A | | 2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide | Human | 3100 | |
| BRAF | RAF | TKL | 5jsm | C | B | n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide) | Human | 7063 | |
| BRAF | RAF | TKL | 6cad | B | | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 9575 | |
| BRAF | RAF | TKL | 4g9c | A | | 3-{[3-(2-cyanopropan-2-yl)benzoyl]amino}-2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)benzamide | Human | 3084 | |
| RIPK2 | RIPK | TKL | 6s1f | B | | ~{n}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide | Human | 11730 | |
| ACVR1 (ALK2) | STKR | TKL | 9l04 | A | | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-[4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl]pyrimidin-2-amine | Human | 15732 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 8ygz | A | A | - | Human | 15262 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 8ygz | A | B | - | Human | 15263 | |
| RIPK2 | RIPK | TKL | 6es0 | A | | 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid | Human | 9574 | |
| BRAF | RAF | TKL | 6u2h | D | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 11569 | |
| RIPK2 | RIPK | TKL | 6szj | A | A | 5-amino-1-~{tert}-butyl-3-(3-methoxyphenyl)pyrazole-4-carboxamide | Human | 11848 | |
| BRAF | RAF | TKL | 3tv4 | A | | n-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide | Human | 3054 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | A | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2676 | |
| BRAF | RAF | TKL | 5jsm | D | B | - | Human | 7053 | |
| BRAF | RAF | TKL | 7m0y | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13520 | |
| BRAF | RAF | TKL | 6nsq | B | | 5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amine | Human | 11329 | |
| BRAF | RAF | TKL | 4fk3 | A | | n-{2,4-difluoro-3-[(5-pyridin-3-yl-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide | Human | 3118 | |
| BRAF | RAF | TKL | 5csx | A | | n-(3-{5-[(1-ethylpiperidin-4-yl)(methyl)amino]-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-1-yl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6432 | |
| RIPK2 | RIPK | TKL | 5w5o | F | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8582 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | P | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1270 | |
| RIPK2 | RIPK | TKL | 5j7b | A | | 6-(tert-butylsulfonyl)-n-(5-fluoro-2h-indazol-3-yl)quinolin-4-amine | Human | 6637 | |
| RIPK2 | RIPK | TKL | 6szj | B | B | 5-amino-1-~{tert}-butyl-3-(3-methoxyphenyl)pyrazole-4-carboxamide | Human | 11851 | |
| LRRK2 | LRRK | TKL | 9ygt | A | | - | Human | 15824 | |
| LRRK2 | LRRK | TKL | 9y7a | A | | - | Human | 15825 | |
| LRRK2 | LRRK | TKL | 9cho | A | | - | Human | 15826 | |
| LRRK2 | LRRK | TKL | 9ybp | A | | - | Human | 15827 | |
| LRRK2 | LRRK | TKL | 9y67 | A | B | - | Human | 15828 | |
| LRRK2 | LRRK | TKL | 9y68 | A | B | - | Human | 15829 | |
| LRRK2 | LRRK | TKL | 8vh4 | A | | - | Human | 15830 | |
| RIPK1 | RIPK | TKL | 24ib | A | | methyl (3~{s})-5-methyl-4-oxidanylidene-3-[[3-(phenylmethyl)-1~{h}-1,2,4-triazol-5-yl]carbonylamino]-2,3-dihydro-1,5-benzoxazepine-7-carboxylate | Human | 15844 | |
| RIPK1 | RIPK | TKL | 9gtg | A | | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 15845 | |
| RIPK1 | RIPK | TKL | 24ic | A | | (3~{s})-~{n}-(cyclopropylmethyl)-5-methyl-4-oxidanylidene-3-[[5-(phenylmethyl)-4~{h}-1,2,4-triazol-3-yl]carbonylamino]-2,3-dihydro-1,5-benzoxazepine-7-carboxamide | Human | 15846 | |
| RIPK1 | RIPK | TKL | 9q32 | A | | methyl 1-[(2,6-dichlorophenyl)methyl]-1h-pyrazole-3-carboxylate | Human | 15847 | |
| RIPK1 | RIPK | TKL | 9gty | A | | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 15848 | |
| RIPK2 | RIPK | TKL | 6rn8 | B | | 2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethyl dihydrogen phosphate | Human | 11431 | |
| RIPK2 | RIPK | TKL | 6ul8 | A | A | (5s,6s,8r)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide | Human | 11847 | |
| BRAF | RAF | TKL | 5c9c | B | B | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 3119 | |
| ARAF | RAF | TKL | 9zdq | A | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 15960 | |
| ARAF | RAF | TKL | 9zdq | A | B | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 15961 | |
| BRAF | RAF | TKL | 6p7g | C | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12807 | |
| RIPK2 | RIPK | TKL | 6ul8 | A | B | (5s,6s,8r)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide | Human | 11849 | |
| IRAK4 | IRAK | TKL | 9pst | A | | n-[(1r,4r)-4-(5-{(6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)cyclohexyl]acetamide | Human | 15982 | |
| IRAK4 | IRAK | TKL | 8sce | A | A | n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15983 | |
| BRAF | RAF | TKL | 8dgt | A | B | phosphothiophosphoric acid-adenylate ester | Human | 14830 | |
| IRAK4 | IRAK | TKL | 8scv | A | B | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15973 | |
| IRAK4 | IRAK | TKL | 9na2 | A | | (6p)-6-[(8r)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-(methylamino)pyridine-3-carboxamide | Human | 15974 | |
| IRAK4 | IRAK | TKL | 9r9k | A | | ~{n}-[3-aminocarbonyl-1-(oxan-4-yl)pyrazol-4-yl]-2-(2-methylpyridin-4-yl)-1,3-oxazole-4-carboxamide | Human | 15975 | |
| IRAK4 | IRAK | TKL | 8scv | B | A | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15976 | |
| IRAK4 | IRAK | TKL | 9psu | A | | n-[(1r,5s,8r)-3-(5-{(6p)-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)-3-azabicyclo[3.2.1]octan-8-yl]acetamide | Human | 15977 | |
| IRAK4 | IRAK | TKL | 9r9g | A | | n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15978 | |
| IRAK4 | IRAK | TKL | 8scv | B | B | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15979 | |
| IRAK4 | IRAK | TKL | 9na6 | A | | (6p)-4-{[(1s)-1-cyanoethyl]amino}-6-[(8s)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-n-[(2s)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 15980 | |
| IRAK4 | IRAK | TKL | 8scv | A | A | 6-[(5-cyanopyrimidin-2-yl)amino]-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15981 | |
| IRAK4 | IRAK | TKL | 9pss | A | | (7p,8s)-7-{(5m)-5-[1-(oxan-4-yl)-1h-1,2,3-triazol-4-yl]-4-[(propan-2-yl)amino]pyridin-2-yl}pyrrolo[1,2-b]pyridazine-3-carbonitrile | Human | 15984 | |
| IRAK4 | IRAK | TKL | 9r9j | A | | ~{n}-[2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)indazol-5-yl]-1-(2-methylpyridin-4-yl)pyrazole-3-carboxamide | Human | 15985 | |
| IRAK4 | IRAK | TKL | 8scw | A | | (6m)-6-(5-cyano-1h-pyrazolo[3,4-b]pyridin-1-yl)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15986 | |
| IRAK4 | IRAK | TKL | 8sce | A | B | n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-[(5-fluoropyrimidin-4-yl)amino]-4-[(propan-2-yl)amino]pyridine-3-carboxamide | Human | 15987 | |
| ILK | MLK | TKL | 9d5e | A | | gefitinib | Human | 15992 | |
| LIMK1 | LISK | TKL | 9z6e | A | B | - | Human | 16002 | |
| LIMK1 | LISK | TKL | 9z6e | A | A | - | Human | 16003 | |
| ILK | MLK | TKL | 9d5h | A | | gefitinib | Human | 15989 | |
| ILK | MLK | TKL | 9d5f | A | | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile | Human | 15990 | |
| ILK | MLK | TKL | 9d5i | A | | adenosine-5'-triphosphate | Human | 15991 | |
| ILK | MLK | TKL | 9d5p | A | | [6,7-bis(2-methoxy-ethoxy)quinazoline-4-yl]-(3-ethynylphenyl)amine | Human | 15993 | |
| RIPK2 | RIPK | TKL | 4c8b | B | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1253 | |
| BRAF | RAF | TKL | 6p7g | B | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12806 | |
| BRAF | RAF | TKL | 4rzv | A | | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6944 | |
| BRAF | RAF | TKL | 4mnf | B | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 3124 | |
| RAF1 | RAF | TKL | 8gae | D | | - | Human | 14715 | |
| RIPK3 | RIPK | TKL | 9lfu | A | | 2-cyclopentyl-~{n}-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine | Human | 16128 | |
| BRAF | RAF | TKL | 5c9c | B | A | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 3138 | |
| BRAF | RAF | TKL | 4mne | G | B | - | Human | 3073 | |
| ACVR1 (ALK2) | STKR | TKL | 6t8n | B | A | cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone | Human | 11828 | |
| BRAF | RAF | TKL | 8vys | A | | (3s)-n-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide | Human | 16203 | |
| BRAF | RAF | TKL | 9rtq | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 16204 | |
| BRAF | RAF | TKL | 9rtr | B | | phosphoaminophosphonic acid-adenylate ester | Human | 16205 | |
| RIPK1 | RIPK | TKL | 5tx5 | A | A | gsk2982772 | Human | 8214 | |
| RIPK1 | RIPK | TKL | 4neu | B | A | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea | Human | 568 | |
| RIPK1 | RIPK | TKL | 6nw2 | A | B | (5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide | Human | 11041 | |
| RIPK1 | RIPK | TKL | 6r5f | B | | [(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | Human | 11044 | |
| RIPK1 | RIPK | TKL | 5tx5 | A | B | gsk2982772 | Human | 8217 | |
| RIPK1 | RIPK | TKL | 6nyh | B | | (5s)-n-[(3s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide | Human | 11056 | |
| RIPK1 | RIPK | TKL | 6ocq | A | A | 1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one | Human | 11046 | |
| RIPK1 | RIPK | TKL | 4ith | A | B | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 567 | |
| RIPK1 | RIPK | TKL | 4iti | B | B | 1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone | Human | 569 | |
| RIPK2 | RIPK | TKL | 5ar4 | B | | 4-[5-(4-fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-3h-imidazol-4-yl]-pyridine | Human | 6187 | |
| RIPK1 | RIPK | TKL | 6c3e | A | A | 2-benzyl-5-nitro-1h-benzimidazole | Human | 9750 | |
| RIPK1 | RIPK | TKL | 7ydx | A | B | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-phenylethyl]indole-3-carboxamide | Human | 14710 | |
| RIPK1 | RIPK | TKL | 4ith | B | A | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 564 | |
| RIPK1 | RIPK | TKL | 6rln | B | | ~{n}-[(3~{s})-7,9-bis(fluoranyl)-2-oxidanylidene-1,3,4,5-tetrahydro-1-benzazepin-3-yl]-3-(phenylmethyl)-1~{h}-1,2,4-triazole-5-carboxamide | Human | 11382 | |
| RIPK1 | RIPK | TKL | 6r5f | C | | [(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | Human | 11042 | |
| RIPK1 | RIPK | TKL | 6c4d | A | | (3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile | Human | 9754 | |
| RIPK1 | RIPK | TKL | 4iti | B | A | 1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone | Human | 562 | |
| RIPK1 | RIPK | TKL | 5tx5 | B | A | gsk2982772 | Human | 8216 | |
| RIPK1 | RIPK | TKL | 6ocq | B | B | 1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one | Human | 11045 | |
| RIPK1 | RIPK | TKL | 4ith | B | B | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 571 | |
| RIPK1 | RIPK | TKL | 5hx6 | B | | 5-benzyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide | Human | 6418 | |
| RIPK1 | RIPK | TKL | 6c4d | C | | (3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile | Human | 9756 | |
| RIPK1 | RIPK | TKL | 6nw2 | A | A | (5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide | Human | 11040 | |
| RIPK1 | RIPK | TKL | 6c3e | B | A | 2-benzyl-5-nitro-1h-benzimidazole | Human | 9755 | |
| RIPK1 | RIPK | TKL | 7fd0 | A | | n-[(3s)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4h-1,2,4-triazole-3-carboxamide | Human | 14070 | |
| RIPK1 | RIPK | TKL | 5hx6 | A | | 5-benzyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide | Human | 6417 | |
| RIPK1 | RIPK | TKL | 7xmk | A | | 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide | Human | 14716 | |
| RIPK1 | RIPK | TKL | 4neu | A | B | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea | Human | 561 | |
| RIPK1 | RIPK | TKL | 6r5f | D | | [(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | Human | 11037 | |
| ACVR1 (ALK2) | STKR | TKL | 8r7g | A | B | 2-fluoranyl-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide | Human | 15266 | |
| RIPK1 | RIPK | TKL | 6c4d | D | | (3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile | Human | 9753 | |
| RIPK1 | RIPK | TKL | 6nw2 | B | A | (5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide | Human | 11039 | |
| RIPK1 | RIPK | TKL | 6r5f | A | | [(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]-[1-(5-methyl-1,3,4-oxadiazol-2-yl)piperidin-4-yl]methanone | Human | 11038 | |
| RIPK1 | RIPK | TKL | 6hho | B | | 6-[4-[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile | Human | 10784 | |
| MAP3K9 (MLK1) | MLK | TKL | 4uy9 | B | A | - | Human | 6129 | |
| MAP3K9 (MLK1) | MLK | TKL | 4uy9 | B | B | - | Human | 6130 | |
| MAP3K9 (MLK1) | MLK | TKL | 4uy9 | A | A | - | Human | 6127 | |
| RIPK2 | RIPK | TKL | 6es0 | B | | 2-[2-fluoranyl-4-[[2-fluoranyl-4-[2-(methylcarbamoyl)pyridin-4-yl]oxy-phenyl]carbamoylamino]phenyl]sulfanylethanoic acid | Human | 9573 | |
| IRAK4 | IRAK | TKL | 8dks | A | B | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14315 | |
| IRAK4 | IRAK | TKL | 8dks | A | A | (1s,2s,3r,4r)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide | Human | 14316 | |
| IRAK4 | IRAK | TKL | 6mom | D | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11744 | |
| IRAK4 | IRAK | TKL | 5uis | B | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7601 | |
| BRAF | RAF | TKL | 4rzw | B | | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6942 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | F | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1276 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | G | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1272 | |
| ACVR1 (ALK2) | STKR | TKL | 5s79 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13708 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7t | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13709 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7i | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13699 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7c | A | C | - | Human | 13702 | |
| IRAK4 | IRAK | TKL | 8atl | B | A | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14961 | |
| RIPK2 | RIPK | TKL | 5ar8 | B | | 2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide | Human | 6179 | |
| IRAK4 | IRAK | TKL | 8wtf | A | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 14960 | |
| IRAK4 | IRAK | TKL | 8atn | A | B | ~{n}-[3-methyl-2-(3-methyl-3-oxidanyl-butyl)-6-(2-oxidanylpropan-2-yl)benzimidazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 14962 | |
| IRAK4 | IRAK | TKL | 8atl | A | A | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14964 | |
| BMPR1B | STKR | TKL | 3mdy | A | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1501 | |
| BRAF | RAF | TKL | 4wo5 | B | | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | Human | 3143 | |
| BRAF | RAF | TKL | 5vam | B | B | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8187 | |
| MLKL | TKL-Unique | TKL | 8slz | A | | - | Human | 14988 | |
| BRAF | RAF | TKL | 3prf | B | | 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol | Human | 3139 | |
| BRAF | RAF | TKL | 7p3v | A | | ~{n}-[3-[5-(2-azanylpyrimidin-4-yl)-2-[(3~{s})-morpholin-3-yl]-1,3-thiazol-4-yl]-2-fluoranyl-phenyl]-2,5-bis(fluoranyl)benzenesulfonamide | Human | 13961 | |
| BRAF | RAF | TKL | 6q0j | B | A | - | Human | 11703 | |
| BRAF | RAF | TKL | 3tv6 | A | | 2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide | Human | 3080 | |
| RAF1 | RAF | TKL | 8gft | D | | - | Human | 14725 | |
| BRAF | RAF | TKL | 5jsm | A | A | - | Human | 7056 | |
| BRAF | RAF | TKL | 7m0z | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13521 | |
| BRAF | RAF | TKL | 5jsm | C | A | n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide) | Human | 7059 | |
| BRAF | RAF | TKL | 4xv1 | A | | n'-(3-{[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)-n-ethyl-n-methylsulfuric diamide | Human | 6214 | |
| BRAF | RAF | TKL | 6uuo | B | | 1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-one | Human | 12346 | |
| BRAF | RAF | TKL | 6u2h | C | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 11568 | |
| BRAF | RAF | TKL | 6q0j | A | A | - | Human | 11704 | |
| BRAF | RAF | TKL | 5hie | D | A | dabrafenib | Human | 6510 | |
| BRAF | RAF | TKL | 5hid | B | B | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6517 | |
| BRAF | RAF | TKL | 6n0q | B | A | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11770 | |
| BRAF | RAF | TKL | 6q0t | B | B | - | Human | 11700 | |
| BRAF | RAF | TKL | 3psb | B | | ethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate | Human | 3125 | |
| BRAF | RAF | TKL | 4r5y | B | | 5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one | Human | 6413 | |
| BRAF | RAF | TKL | 4pp7 | A | | n-{2,4-difluoro-3-[methyl(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}propane-1-sulfonamide | Human | 3094 | |
| BRAF | RAF | TKL | 4fc0 | B | | 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide | Human | 3069 | |
| BRAF | RAF | TKL | 5hie | A | A | dabrafenib | Human | 6516 | |
| BRAF | RAF | TKL | 5jt2 | B | | - | Human | 7057 | |
| BRAF | RAF | TKL | 4mne | B | A | - | Human | 3075 | |
| BRAF | RAF | TKL | 3tv4 | B | | n-(6-amino-5-bromopyridin-3-yl)-2,6-difluoro-3-[(propylsulfonyl)amino]benzamide | Human | 3133 | |
| BRAF | RAF | TKL | 1uwj | B | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3105 | |
| BRAF | RAF | TKL | 4xv3 | A | | n'-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-n-ethyl-n-methylsulfuric diamide | Human | 6217 | |
| BRAF | RAF | TKL | 2fb8 | A | | (1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime | Human | 3062 | |
| BRAF | RAF | TKL | 5jrq | B | | (3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)[5-(4-methoxyphenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]methanone | Human | 7054 | |
| BRAF | RAF | TKL | 5hid | A | A | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6506 | |
| BRAF | RAF | TKL | 3ii5 | B | | n-[3-(3-{4-[(dimethylamino)methyl]phenyl}pyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 3076 | |
| BRAF | RAF | TKL | 2fb8 | B | | (1z)-5-(2-{4-[2-(dimethylamino)ethoxy]phenyl}-5-pyridin-4-yl-1h-imidazol-4-yl)indan-1-one oxime | Human | 3086 | |
| BRAF | RAF | TKL | 5hie | C | B | dabrafenib | Human | 6507 | |
| BRAF | RAF | TKL | 4xv3 | B | | - | Human | 6218 | |
| BRAF | RAF | TKL | 5fd2 | A | | 6-[2-[[3-(dimethylsulfamoylamino)-2,6-bis(fluoranyl)phenyl]amino]pyridin-3-yl]-7~{h}-purine | Human | 6603 | |
| BRAF | RAF | TKL | 6u2g | B | | phosphomethylphosphonic acid adenylate ester | Human | 11567 | |
| BRAF | RAF | TKL | 4rzw | A | | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6939 | |
| BRAF | RAF | TKL | 5csw | B | | dabrafenib | Human | 6431 | |
| BRAF | RAF | TKL | 6v2w | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13032 | |
| BRAF | RAF | TKL | 3q96 | A | | (2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide | Human | 3072 | |
| BRAF | RAF | TKL | 4dbn | A | | 2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | Human | 3052 | |
| BRAF | RAF | TKL | 6n0p | A | A | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 11597 | |
| BRAF | RAF | TKL | 3ppj | B | | methyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate | Human | 3087 | |
| BRAF | RAF | TKL | 4cqe | B | | n-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide | Human | 3107 | |
| BRAF | RAF | TKL | 3og7 | B | | - | Human | 3140 | |
| BRAF | RAF | TKL | 4e4x | B | | n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide | Human | 3104 | |
| BRAF | RAF | TKL | 6v34 | A | | 6-amino-5-chloro-n-[(1r)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide | Human | 13200 | |
| BRAF | RAF | TKL | 6cad | A | | 1-(propan-2-yl)-3-({3-[3-(trifluoromethyl)phenyl]isoquinolin-8-yl}ethynyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | Human | 9576 | |
| BRAF | RAF | TKL | 4h58 | A | B | n-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine | Human | 3110 | |
| BRAF | RAF | TKL | 3idp | A | | n~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine | Human | 3077 | |
| BRAF | RAF | TKL | 4rzv | B | | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6941 | |
| BRAF | RAF | TKL | 4jvg | A | | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3134 | |
| BRAF | RAF | TKL | 4jvg | B | | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3085 | |
| IRAK3 | IRAK | TKL | 6ruu | B | | - | Human | 12769 | |
| IRAK3 | IRAK | TKL | 6ruu | A | | - | Human | 12770 | |
| IRAK3 | IRAK | TKL | 6ruu | C | | - | Human | 12771 | |
| BRAF | RAF | TKL | 5hie | C | A | dabrafenib | Human | 6513 | |
| BRAF | RAF | TKL | 3idp | B | | n~1~-(4-chlorophenyl)-6-methyl-n~5~-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine | Human | 3121 | |
| BRAF | RAF | TKL | 1uwh | A | | 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide | Human | 3127 | |
| BRAF | RAF | TKL | 4xv9 | A | A | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide | Human | 6220 | |
| BRAF | RAF | TKL | 3d4q | A | | (1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime | Human | 3095 | |
| BRAF | RAF | TKL | 6n0p | A | B | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 11596 | |
| BRAF | RAF | TKL | 5hid | A | B | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6512 | |
| BRAF | RAF | TKL | 6xag | C | A | - | Human | 12922 | |
| BRAF | RAF | TKL | 4e4x | A | | n-(2,4-difluoro-3-{2-[(3-hydroxypropyl)amino]-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl}phenyl)propane-1-sulfonamide | Human | 3051 | |
| BRAF | RAF | TKL | 3q4c | B | | - | Human | 7250 | |
| ACVR2B (ACTR2B) | STKR | TKL | 2qlu | A | | adenine | Human | 2940 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e8v | A | B | - | Human | 6622 | |
| BRAF | RAF | TKL | 4h58 | B | A | - | Human | 3097 | |
| BRAF | RAF | TKL | 4ehg | A | | n-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide | Human | 3064 | |
| BRAF | RAF | TKL | 5jsm | B | B | n,n'-{ethane-1,2-diylbis[oxyethane-2,1-diyloxy-4,1-phenylene-1h-pyrrolo[2,3-b]pyridine-5,3-diylcarbonyl(2,4-difluoro-3,1-phenylene)]}di(propane-1-sulfonamide) | Human | 7062 | |
| BRAF | RAF | TKL | 5hie | D | B | dabrafenib | Human | 6514 | |
| BRAF | RAF | TKL | 4h58 | B | B | - | Human | 3120 | |
| BRAF | RAF | TKL | 6pp9 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 11709 | |
| BRAF | RAF | TKL | 6xfp | A | A | 4-amino-n-{1-[(3-chloro-2-fluorophenyl)amino]-6-methylisoquinolin-5-yl}thieno[3,2-d]pyrimidine-7-carboxamide | Human | 13403 | |
| BRAF | RAF | TKL | 5vam | A | B | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8189 | |
| BRAF | RAF | TKL | 4jvg | D | | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3059 | |
| BRAF | RAF | TKL | 4fc0 | A | | 2-chloro-3-[(2-cyanopropan-2-yl)oxy]-n-{5-[{2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}(methyl)amino]-2-fluorophenyl}benzamide | Human | 3131 | |
| BRAF | RAF | TKL | 6nsq | A | | 5-[(4-amino-1-ethyl-1h-pyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-n-(4-chlorophenyl)-6-methylisoquinolin-1-amine | Human | 11328 | |
| BRAF | RAF | TKL | 6v2u | B | | dabrafenib | Human | 13031 | |
| MAP3K7 (TAK1) | MLK | TKL | 5v5n | A | A | n~1~-(1-propyl-1,3-dihydro-2h-benzimidazol-2-ylidene)benzene-1,3-dicarboxamide | Human | 8350 | |
| BRAF | RAF | TKL | 5hie | B | A | dabrafenib | Human | 6509 | |
| BRAF | RAF | TKL | 7m0v | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13526 | |
| BRAF | RAF | TKL | 6n0q | A | A | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11771 | |
| BRAF | RAF | TKL | 5jt2 | A | | 2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide] | Human | 7065 | |
| BRAF | RAF | TKL | 4yht | B | | 3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6443 | |
| BRAF | RAF | TKL | 3og7 | A | | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 3113 | |
| BRAF | RAF | TKL | 6n0p | B | B | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 11595 | |
| BRAF | RAF | TKL | 7m0w | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13528 | |
| RAF1 | RAF | TKL | 13du | B | | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 15537 | |
| RAF1 | RAF | TKL | 9mms | A | | phosphothiophosphoric acid-adenylate ester | Human | 15538 | |
| RIPK2 | RIPK | TKL | 5j79 | B | B | 4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol | Human | 6635 | |
| RIPK2 | RIPK | TKL | 5ng3 | B | | - | Human | 8170 | |
| RIPK2 | RIPK | TKL | 6rna | A | | 2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethanol | Human | 11433 | |
| RIPK2 | RIPK | TKL | 8x2o | A | | ~{n}-[(1~{r})-4-[4-[(6-fluoranyl-1,3-benzothiazol-5-yl)amino]thieno[2,3-d]pyrimidin-6-yl]cyclohex-3-en-1-yl]cyclopropanecarboxamide | Human | 15543 | |
| RIPK2 | RIPK | TKL | 5ng2 | B | B | staurosporine | Human | 8052 | |
| RIPK2 | RIPK | TKL | 6fu5 | B | | ~{n}-[5-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2-methoxy-phenyl]propane-1-sulfonamide | Human | 9853 | |
| RIPK2 | RIPK | TKL | 4c8b | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 1254 | |
| RIPK2 | RIPK | TKL | 5ar4 | A | | 4-[5-(4-fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-3h-imidazol-4-yl]-pyridine | Human | 6180 | |
| RIPK2 | RIPK | TKL | 6rna | B | | 2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethanol | Human | 11432 | |
| RIPK2 | RIPK | TKL | 5w5o | N | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8578 | |
| RIPK2 | RIPK | TKL | 6s1f | A | | ~{n}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide | Human | 11733 | |
| RIPK2 | RIPK | TKL | 5w5o | I | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8590 | |
| RIPK2 | RIPK | TKL | 5ar2 | A | B | - | Human | 6173 | |
| RIPK2 | RIPK | TKL | 6szj | B | A | 5-amino-1-~{tert}-butyl-3-(3-methoxyphenyl)pyrazole-4-carboxamide | Human | 11846 | |
| RIPK2 | RIPK | TKL | 5ng0 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 8057 | |
| RIPK2 | RIPK | TKL | 5ng0 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 8055 | |
| RIPK2 | RIPK | TKL | 5ng2 | A | A | staurosporine | Human | 8050 | |
| RIPK2 | RIPK | TKL | 5w5j | A | | n-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide | Human | 8593 | |
| RIPK2 | RIPK | TKL | 5w5o | L | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8585 | |
| BRAF | RAF | TKL | 4yht | A | | 3-[(5-chloro-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6442 | |
| IRAK4 | IRAK | TKL | 8atl | B | B | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14966 | |
| IRAK4 | IRAK | TKL | 5k7g | B | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8706 | |
| IRAK4 | IRAK | TKL | 5k75 | B | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8713 | |
| IRAK4 | IRAK | TKL | 2nry | A | A | staurosporine | Human | 1753 | |
| IRAK4 | IRAK | TKL | 2nru | A | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1760 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7c | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13690 | |
| BRAF | RAF | TKL | 8dgs | A | B | phosphothiophosphoric acid-adenylate ester | Human | 14829 | |
| BRAF | RAF | TKL | 8dgt | A | A | phosphothiophosphoric acid-adenylate ester | Human | 14832 | |
| MAP3K7 (TAK1) | MLK | TKL | 7nti | A | B | ~{n}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{n}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{h}-imidazole-4-carboxamide | Human | 13457 | |
| MAP3K7 (TAK1) | MLK | TKL | 4l53 | A | B | trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexanol | Human | 1892 | |
| MAP3K7 (TAK1) | MLK | TKL | 4l3p | A | | 2-(1-benzothiophen-7-yl)-4-[1-(piperidin-4-yl)-1h-pyrazol-4-yl]furo[2,3-c]pyridin-7-amine | Human | 1891 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jgb | A | | n-(2-methoxy-4-{[3-(4-methylpiperazin-1-yl)propyl]carbamoyl}phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide | Human | 6885 | |
| MAP3K7 (TAK1) | MLK | TKL | 4gs6 | A | B | (3s,5z,8s,9s,11e)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dione | Human | 1886 | |
| BRAF | RAF | TKL | 8dgs | A | A | phosphothiophosphoric acid-adenylate ester | Human | 14831 | |
| BRAF | RAF | TKL | 6p7g | D | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12808 | |
| RIPK2 | RIPK | TKL | 5ar7 | A | B | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea | Human | 6182 | |
| RIPK2 | RIPK | TKL | 5w5o | J | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8586 | |
| KSR1 | RAF | TKL | 7jv1 | D | | - | Human | 12849 | |
| KSR1 | RAF | TKL | 7juz | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12851 | |
| RIPK2 | RIPK | TKL | 5ar5 | B | B | 2-(2-(4-chlorophenyl)-1h-imidazol-5-yl)-n,1-bis(2-methoxyethyl)-1h-benzo[d]imidazole-5-carboxamide | Human | 6172 | |
| KSR1 | RAF | TKL | 7jv0 | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12853 | |
| KSR1 | RAF | TKL | 7jv1 | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12854 | |
| RIPK2 | RIPK | TKL | 6hmx | B | | 6-~{tert}-butylsulfonyl-~{n}-(3,4-dimethyl-1~{h}-pyrazol-5-yl)-7-methoxy-quinolin-4-amine | Human | 10675 | |
| RIPK2 | RIPK | TKL | 5ar5 | A | A | 2-(2-(4-chlorophenyl)-1h-imidazol-5-yl)-n,1-bis(2-methoxyethyl)-1h-benzo[d]imidazole-5-carboxamide | Human | 6189 | |
| RIPK2 | RIPK | TKL | 5ng3 | A | | - | Human | 8169 | |
| RIPK2 | RIPK | TKL | 5ar2 | A | A | - | Human | 6183 | |
| RIPK2 | RIPK | TKL | 6fu5 | A | | ~{n}-[5-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-2-methoxy-phenyl]propane-1-sulfonamide | Human | 9852 | |
| RIPK2 | RIPK | TKL | 5ar7 | B | A | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea | Human | 6178 | |
| MAP3K7 (TAK1) | MLK | TKL | 5gjd | A | | 1-(4-((1h-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-3-(5-(4-methylpiperazin-1-yl)naphthalen-2-yl)urea | Human | 7263 | |
| RIPK2 | RIPK | TKL | 5w5o | B | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8587 | |
| MAP3K7 (TAK1) | MLK | TKL | 5v5n | A | B | n~1~-(1-propyl-1,3-dihydro-2h-benzimidazol-2-ylidene)benzene-1,3-dicarboxamide | Human | 8351 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10909 | |
| IRAK4 | IRAK | TKL | 5uir | A | B | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7600 | |
| ILK | MLK | TKL | 3kmu | A | | - | Human | 4606 | |
| ILK | MLK | TKL | 3rep | A | | adenosine-5'-triphosphate | Human | 4604 | |
| BRAF | RAF | TKL | 6n0q | B | B | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11769 | |
| IRAK4 | IRAK | TKL | 8atb | A | B | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15079 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8x | A | B | staurosporine | Human | 6617 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qil | A | A | n-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10659 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1ias | D | | - | Human | 2131 | |
| ACVR1 (ALK2) | STKR | TKL | 7a21 | A | B | 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12779 | |
| IRAK4 | IRAK | TKL | 4y73 | C | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9124 | |
| IRAK4 | IRAK | TKL | 4u97 | B | | staurosporine | Human | 1742 | |
| IRAK4 | IRAK | TKL | 6f3d | A | | 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | Human | 9925 | |
| IRAK4 | IRAK | TKL | 2oic | B | | staurosporine | Human | 1752 | |
| BRAF | RAF | TKL | 7k0v | A | B | n-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea | Human | 13616 | |
| BRAF | RAF | TKL | 5c9c | A | A | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 3123 | |
| IRAK4 | IRAK | TKL | 5t1s | A | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7568 | |
| LIMK1 | LISK | TKL | 3s95 | B | A | staurosporine | Human | 1245 | |
| IRAK4 | IRAK | TKL | 5k76 | B | B | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8708 | |
| IRAK4 | IRAK | TKL | 6o9d | C | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11115 | |
| IRAK4 | IRAK | TKL | 4yp8 | A | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1740 | |
| IRAK4 | IRAK | TKL | 6o94 | D | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11108 | |
| IRAK4 | IRAK | TKL | 2nru | D | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1762 | |
| IRAK4 | IRAK | TKL | 6ti8 | C | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12946 | |
| IRAK4 | IRAK | TKL | 2nry | C | B | staurosporine | Human | 1750 | |
| IRAK4 | IRAK | TKL | 6uya | D | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11813 | |
| MAP3K12 (DLK) | MLK | TKL | 8out | A | B | (1r)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanol | Human | 14855 | |
| MAP3K12 (DLK) | MLK | TKL | 8our | A | A | 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine | Human | 14856 | |
| IRAK4 | IRAK | TKL | 6ti8 | B | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12949 | |
| IRAK4 | IRAK | TKL | 6thw | A | | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12950 | |
| IRAK4 | IRAK | TKL | 5uiu | B | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7609 | |
| IRAK4 | IRAK | TKL | 7c2v | A | A | 2-(2-methylpyridin-4-yl)-n-[2-morpholin-4-yl-5-[(3r)-3-oxidanylpyrrolidin-1-yl]-[1,3]oxazolo[4,5-b]pyridin-6-yl]-1,3-oxazole-4-carboxamide | Human | 12997 | |
| IRAK4 | IRAK | TKL | 6o94 | C | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11095 | |
| IRAK4 | IRAK | TKL | 5uiu | B | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7607 | |
| IRAK4 | IRAK | TKL | 6o95 | D | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11101 | |
| IRAK4 | IRAK | TKL | 6f3i | B | | (3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | Human | 9922 | |
| IRAK4 | IRAK | TKL | 7c2w | B | A | - | Human | 12998 | |
| IRAK4 | IRAK | TKL | 2oid | B | | phosphoaminophosphonic acid-adenylate ester | Human | 1759 | |
| IRAK4 | IRAK | TKL | 2nru | C | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1776 | |
| IRAK4 | IRAK | TKL | 2nry | A | B | staurosporine | Human | 1777 | |
| IRAK4 | IRAK | TKL | 7c2w | D | A | - | Human | 13000 | |
| IRAK4 | IRAK | TKL | 2oic | C | | staurosporine | Human | 1734 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j7s | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide | Human | 7429 | |
| ACVR1 (ALK2) | STKR | TKL | 5s88 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13657 | |
| BRAF | RAF | TKL | 8qqg | A | A | (3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide | Human | 15178 | |
| BRAF | RAF | TKL | 8qqg | A | B | (3~{s})-~{n}-[4-methyl-3-[2-morpholin-4-yl-6-[[(2~{r})-1-oxidanylpropan-2-yl]amino]pyridin-4-yl]phenyl]-3-[2,2,2-tris(fluoranyl)ethyl]pyrrolidine-1-carboxamide | Human | 15179 | |
| MAP3K7 (TAK1) | MLK | TKL | 2eva | A | B | adenosine | Human | 1882 | |
| MAP3K7 (TAK1) | MLK | TKL | 5e7r | A | | 2-chloro-n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}acetamide | Human | 7412 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7e | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13643 | |
| ACVR1 (ALK2) | STKR | TKL | 3mtf | B | B | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 1530 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7a | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13644 | |
| ACVR1 (ALK2) | STKR | TKL | 6t8n | A | A | cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone | Human | 11831 | |
| ACVR1 (ALK2) | STKR | TKL | 5s9k | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13645 | |
| ACVR1 (ALK2) | STKR | TKL | 7a21 | B | A | 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12776 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7s | A | C | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13651 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7z | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13652 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | B | B | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8519 | |
| ACVR1 (ALK2) | STKR | TKL | 5s80 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13669 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | A | A | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1528 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7x | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13692 | |
| ACVR1 (ALK2) | STKR | TKL | 5s8a | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13693 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | D | B | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11785 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | C | B | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1522 | |
| ACVR1 (ALK2) | STKR | TKL | 6i1s | A | A | (4~{s},5~{r},6~{z},9~{s},10~{s},12~{e})-16-(ethylamino)-4,5-dimethyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione | Human | 11603 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7m | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13739 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1b6c | F | | - | Human | 2103 | |
| RIPK2 | RIPK | TKL | 6s1f | C | | ~{n}-[3-[2-azanyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]-5-methoxy-phenyl]methanesulfonamide | Human | 11731 | |
| IRAK4 | IRAK | TKL | 2o8y | A | | - | Human | 1744 | |
| LRRK2 | LRRK | TKL | 8fo8 | C | | - | Human | 15133 | |
| RIPK1 | RIPK | TKL | 4iti | A | B | 1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone | Human | 563 | |
| BMPR2 | STKR | TKL | 3g2f | B | A | adenosine-5'-diphosphate | Human | 6867 | |
| BMPR2 | STKR | TKL | 3g2f | A | B | adenosine-5'-diphosphate | Human | 6868 | |
| BMPR2 | STKR | TKL | 3g2f | B | B | adenosine-5'-diphosphate | Human | 6869 | |
| RIPK2 | RIPK | TKL | 5ar5 | A | B | 2-(2-(4-chlorophenyl)-1h-imidazol-5-yl)-n,1-bis(2-methoxyethyl)-1h-benzo[d]imidazole-5-carboxamide | Human | 6175 | |
| IRAK4 | IRAK | TKL | 5kx8 | A | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6958 | |
| IRAK4 | IRAK | TKL | 6n8g | B | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10791 | |
| IRAK4 | IRAK | TKL | 4ztl | D | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5996 | |
| IRAK4 | IRAK | TKL | 5uiq | C | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7616 | |
| IRAK4 | IRAK | TKL | 4rmz | B | B | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6350 | |
| IRAK4 | IRAK | TKL | 2oib | A | B | - | Human | 1766 | |
| IRAK4 | IRAK | TKL | 4ztn | B | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6001 | |
| IRAK4 | IRAK | TKL | 6o95 | B | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11106 | |
| IRAK4 | IRAK | TKL | 2oib | C | B | - | Human | 1741 | |
| IRAK4 | IRAK | TKL | 6mom | B | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11743 | |
| IRAK4 | IRAK | TKL | 5uiu | A | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7615 | |
| IRAK4 | IRAK | TKL | 7qg3 | A | | 6-[(2~{s})-2-fluoranylpropyl]-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14213 | |
| IRAK4 | IRAK | TKL | 6thz | B | | 7-fluoranyl-~{n}-[1-(2-methyl-2-azaspiro[3.3]heptan-6-yl)pyrazol-4-yl]-4-(1-methylcyclopropyl)oxy-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12951 | |
| IRAK4 | IRAK | TKL | 6ti8 | B | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12952 | |
| IRAK4 | IRAK | TKL | 8tvm | A | A | n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15337 | |
| IRAK4 | IRAK | TKL | 8tx0 | A | | ~{n}-(1-cyclopropyl-2-oxidanylidene-pyridin-3-yl)-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)-7-propan-2-yloxy-imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15340 | |
| IRAK4 | IRAK | TKL | 5t1s | C | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7561 | |
| IRAK4 | IRAK | TKL | 2oid | C | | phosphoaminophosphonic acid-adenylate ester | Human | 1775 | |
| IRAK4 | IRAK | TKL | 5k76 | A | A | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8712 | |
| IRAK4 | IRAK | TKL | 4y73 | D | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9127 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2wou | A | | 4-({4-[(2,6-dimethylpyridin-3-yl)oxy]pyridin-2-yl}amino)benzenesulfonamide | Human | 2125 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1ias | E | | - | Human | 2134 | |
| MAP3K12 (DLK) | MLK | TKL | 8our | A | B | 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine | Human | 14852 | |
| MAP3K12 (DLK) | MLK | TKL | 8out | A | A | (1r)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanol | Human | 14853 | |
| MAP3K12 (DLK) | MLK | TKL | 8ous | A | B | (1s)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-ol | Human | 14854 | |
| MAP3K12 (DLK) | MLK | TKL | 5vo2 | A | A | 5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine | Human | 8543 | |
| MLKL | TKL-Unique | TKL | 4m67 | A | | - | Human | 3048 | |
| MLKL | TKL-Unique | TKL | 6lk6 | A | | - | Human | 13095 | |
| MLKL | TKL-Unique | TKL | 6o5z | B | | 1-[2-fluoranyl-5-(trifluoromethyl)phenyl]-3-[4-[methyl-[2-[(3-sulfamoylphenyl)amino]pyrimidin-4-yl]amino]phenyl]urea | Human | 12783 | |
| TNNI3K (HH498) | MLK | TKL | 4yfi | B | A | n-methyl-3-(9h-purin-6-ylamino)benzenesulfonamide | Human | 6061 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | B | A | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9802 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | D | A | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9792 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | A | B | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9800 | |
| TNNI3K (HH498) | MLK | TKL | 6b5j | D | C | n-methyl-3-[(6-{[4-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]benzene-1-sulfonamide | Human | 9795 | |
| IRAK4 | IRAK | TKL | 5kx8 | C | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6960 | |
| IRAK4 | IRAK | TKL | 4ztn | C | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5991 | |
| BRAF | RAF | TKL | 7k0v | A | A | n-(3,3-dimethylbutyl)-n'-{2-fluoro-5-[(5-fluoro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]-4-methylphenyl}urea | Human | 13617 | |
| BRAF | RAF | TKL | 7mfe | A | | - | Human | 14078 | |
| BRAF | RAF | TKL | 4ksq | B | | n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | Human | 3055 | |
| BRAF | RAF | TKL | 9rts | B | B | adenosine-5'-diphosphate | Human | 16215 | |
| BRAF | RAF | TKL | 6n0q | A | B | n-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1h-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide | Human | 11768 | |
| BRAF | RAF | TKL | 4mne | C | A | - | Human | 3122 | |
| BRAF | RAF | TKL | 4ksp | A | | n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | Human | 3081 | |
| BRAF | RAF | TKL | 4h58 | C | A | - | Human | 3056 | |
| BRAF | RAF | TKL | 4mnf | B | B | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 3098 | |
| IRAK4 | IRAK | TKL | 5k75 | A | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8725 | |
| IRAK4 | IRAK | TKL | 6mom | D | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11741 | |
| IRAK4 | IRAK | TKL | 4u9a | B | | staurosporine | Human | 1792 | |
| IRAK4 | IRAK | TKL | 8v2l | A | B | n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15335 | |
| IRAK4 | IRAK | TKL | 6o8u | D | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11119 | |
| IRAK4 | IRAK | TKL | 5kx8 | B | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-5-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 6959 | |
| IRAK4 | IRAK | TKL | 8tvm | A | B | n-{1-[(1r,2r)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15336 | |
| IRAK4 | IRAK | TKL | 5kx7 | B | | ~{n}-(3-aminocarbonyl-1-methyl-pyrazol-4-yl)-6-(1-methylpyrazol-4-yl)pyridine-2-carboxamide | Human | 6957 | |
| IRAK4 | IRAK | TKL | 5k75 | A | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8727 | |
| IRAK4 | IRAK | TKL | 6o9d | A | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11099 | |
| IRAK4 | IRAK | TKL | 6o9d | A | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11109 | |
| IRAK4 | IRAK | TKL | 6o8u | A | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11113 | |
| IRAK4 | IRAK | TKL | 4u9a | A | | staurosporine | Human | 1751 | |
| IRAK4 | IRAK | TKL | 6ega | B | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10910 | |
| IRAK4 | IRAK | TKL | 6o9d | C | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11112 | |
| IRAK4 | IRAK | TKL | 8atl | A | B | ~{n}-[6-methoxy-2-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indazol-5-yl]-6-[(1~{r})-2,2,2-tris(fluoranyl)-1-oxidanyl-ethyl]pyridine-2-carboxamide | Human | 14959 | |
| IRAK4 | IRAK | TKL | 6vql | C | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12393 | |
| IRAK4 | IRAK | TKL | 2nru | B | A | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1773 | |
| IRAK4 | IRAK | TKL | 5t1t | B | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7562 | |
| IRAK4 | IRAK | TKL | 6mom | C | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11738 | |
| IRAK4 | IRAK | TKL | 2nry | D | B | staurosporine | Human | 1746 | |
| IRAK4 | IRAK | TKL | 5uiq | A | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7596 | |
| IRAK4 | IRAK | TKL | 5uis | C | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7613 | |
| IRAK4 | IRAK | TKL | 6ti8 | A | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12947 | |
| IRAK4 | IRAK | TKL | 6rfi | A | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11788 | |
| IRAK4 | IRAK | TKL | 2nru | D | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1787 | |
| IRAK4 | IRAK | TKL | 6n8g | A | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10796 | |
| IRAK4 | IRAK | TKL | 5k75 | C | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8710 | |
| IRAK4 | IRAK | TKL | 5uiq | B | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7619 | |
| IRAK4 | IRAK | TKL | 4ztm | C | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 6006 | |
| IRAK4 | IRAK | TKL | 6o8u | A | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11121 | |
| IRAK4 | IRAK | TKL | 5t1t | D | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7565 | |
| RIPK1 | RIPK | TKL | 6c3e | A | B | 2-benzyl-5-nitro-1h-benzimidazole | Human | 9751 | |
| RIPK1 | RIPK | TKL | 4neu | A | A | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea | Human | 576 | |
| RIPK1 | RIPK | TKL | 4iti | A | A | 1-{(3s,3as)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2h-benzo[g]indazol-2-yl}-2-hydroxyethanone | Human | 570 | |
| RIPK1 | RIPK | TKL | 7ydx | A | A | 1-methyl-5-[2-(2-methylpropanoylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-n-[(1s)-1-phenylethyl]indole-3-carboxamide | Human | 14711 | |
| RIPK1 | RIPK | TKL | 8i2n | A | | ~{n}-methyl-1-[4-[[[1-methyl-5-(phenylmethyl)pyrazol-3-yl]carbonylamino]methyl]phenyl]benzimidazole-5-carboxamide | Human | 15186 | |
| RIPK1 | RIPK | TKL | 4neu | B | B | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea | Human | 573 | |
| RIPK1 | RIPK | TKL | 6ocq | B | A | 1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one | Human | 11048 | |
| RIPK1 | RIPK | TKL | 5tx5 | B | B | gsk2982772 | Human | 8215 | |
| RIPK1 | RIPK | TKL | 6nyh | A | | (5s)-n-[(3s)-7-methoxy-1-methyl-2-oxo-2,3,4,5-tetrahydro-1h-pyrido[3,4-b]azepin-3-yl]-5-phenyl-6,7-dihydro-5h-pyrrolo[1,2-b][1,2,4]triazole-2-carboxamide | Human | 11057 | |
| RIPK1 | RIPK | TKL | 6rln | A | | ~{n}-[(3~{s})-7,9-bis(fluoranyl)-2-oxidanylidene-1,3,4,5-tetrahydro-1-benzazepin-3-yl]-3-(phenylmethyl)-1~{h}-1,2,4-triazole-5-carboxamide | Human | 11383 | |
| RIPK1 | RIPK | TKL | 6c4d | B | | (3s)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6h-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile | Human | 9752 | |
| RIPK1 | RIPK | TKL | 4itj | B | A | n-[(1s)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1h-pyrrole-2-carboxamide | Human | 565 | |
| RIPK1 | RIPK | TKL | 4ith | A | A | (5r)-5-[(7-chloro-1h-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione | Human | 566 | |
| RIPK1 | RIPK | TKL | 6c3e | B | B | 2-benzyl-5-nitro-1h-benzimidazole | Human | 9757 | |
| RIPK1 | RIPK | TKL | 7fcz | A | | n-[(3s)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4h-1,2,4-triazole-3-carboxamide | Human | 14071 | |
| RIPK1 | RIPK | TKL | 6nw2 | B | B | (5r)-5-methyl-n-[(3s)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2h-indazole-3-carboxamide | Human | 11043 | |
| RIPK1 | RIPK | TKL | 6ocq | A | B | 1-[(2s)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one | Human | 11047 | |
| RIPK1 | RIPK | TKL | 6hho | A | | 6-[4-[(5~{s})-5-[3,5-bis(fluoranyl)phenyl]pyrazolidin-1-yl]carbonylpiperidin-1-yl]pyrimidine-4-carbonitrile | Human | 10783 | |
| BMPR2 | STKR | TKL | 6unp | A | B | adenosine-5'-diphosphate | Human | 13794 | |
| BMPR2 | STKR | TKL | 6unp | A | A | adenosine-5'-diphosphate | Human | 13795 | |
| BMPR2 | STKR | TKL | 3g2f | A | A | adenosine-5'-diphosphate | Human | 6870 | |
| KSR2 | RAF | TKL | 7jut | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12818 | |
| KSR2 | RAF | TKL | 7juv | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12819 | |
| KSR2 | RAF | TKL | 7juu | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12820 | |
| KSR2 | RAF | TKL | 7juq | B | | adenosine-5'-diphosphate | Human | 12821 | |
| KSR2 | RAF | TKL | 7jur | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12822 | |
| KSR2 | RAF | TKL | 2y4i | B | | adenosine-5'-triphosphate | Human | 1244 | |
| KSR2 | RAF | TKL | 7jus | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12823 | |
| KSR2 | RAF | TKL | 5kkr | B | | 6,7-dimethoxy-~{n}-(2-methyl-4-phenoxy-phenyl)quinazolin-4-amine | Human | 7027 | |
| LIMK2 | LISK | TKL | 5nxd | B | A | 4-[(3-chlorophenyl)sulfamoyl]-~{n}-(phenylmethyl)-~{n}-propyl-benzamide | Human | 7624 | |
| LIMK2 | LISK | TKL | 8wsw | A | B | ~{n}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide | Human | 14861 | |
| LIMK2 | LISK | TKL | 5nxd | A | A | 4-[(3-chlorophenyl)sulfamoyl]-~{n}-(phenylmethyl)-~{n}-propyl-benzamide | Human | 7623 | |
| LIMK2 | LISK | TKL | 8wsw | A | A | ~{n}-[5-[2-[2,6-bis(chloranyl)phenyl]-5-[bis(fluoranyl)methyl]pyrazol-3-yl]-1,3-thiazol-2-yl]-2-methyl-propanamide | Human | 14862 | |
| LIMK2 | LISK | TKL | 7qhg | A | B | 2-(2-methylpropanoylamino)-~{n}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide | Human | 14020 | |
| LIMK2 | LISK | TKL | 4tpt | B | | n-{4-[(1s)-1,2-dihydroxyethyl]benzyl}-n-methyl-4-(phenylsulfamoyl)benzamide | Human | 2475 | |
| LIMK2 | LISK | TKL | 7qhg | A | A | 2-(2-methylpropanoylamino)-~{n}-[2-[(phenylmethyl)-[4-(phenylsulfamoyl)phenyl]carbonyl-amino]ethyl]-1,3-thiazole-5-carboxamide | Human | 14021 | |
| LIMK2 | LISK | TKL | 4tpt | A | | n-{4-[(1s)-1,2-dihydroxyethyl]benzyl}-n-methyl-4-(phenylsulfamoyl)benzamide | Human | 2476 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | I | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1261 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | Q | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1274 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | N | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1257 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | J | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1277 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | U | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1278 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | W | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1255 | |
| ACVRL1 (ALK1) | STKR | TKL | 3my0 | K | | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1267 | |
| IRAK3 | IRAK | TKL | 6ziw | I | | phosphothiophosphoric acid-adenylate ester | Human | 12483 | |
| RAF1 | RAF | TKL | 13dv | B | | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 15539 | |
| RAF1 | RAF | TKL | 9mmr | A | | phosphothiophosphoric acid-adenylate ester | Human | 15541 | |
| RAF1 | RAF | TKL | 9mmq | A | | phosphothiophosphoric acid-adenylate ester | Human | 15542 | |
| RAF1 | RAF | TKL | 3omv | B | | (1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime | Human | 936 | |
| RIPK2 | RIPK | TKL | 5ng3 | D | | - | Human | 8172 | |
| RIPK2 | RIPK | TKL | 5w5j | B | | n-(2-chlorophenyl)pyrazolo[1,5-a]pyridine-3-carboxamide | Human | 8591 | |
| RIPK2 | RIPK | TKL | 5ar3 | B | B | phosphomethylphosphonic acid adenylate ester | Human | 6190 | |
| RIPK2 | RIPK | TKL | 5ng2 | B | A | staurosporine | Human | 8053 | |
| RIPK2 | RIPK | TKL | 5w5o | D | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8576 | |
| RIPK2 | RIPK | TKL | 6szj | A | B | 5-amino-1-~{tert}-butyl-3-(3-methoxyphenyl)pyrazole-4-carboxamide | Human | 11853 | |
| RIPK2 | RIPK | TKL | 5w5o | A | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8579 | |
| RIPK2 | RIPK | TKL | 5ng3 | C | | - | Human | 8171 | |
| RIPK2 | RIPK | TKL | 6rn8 | A | | 2-[4-(1,3-benzothiazol-5-ylamino)-6-~{tert}-butylsulfonyl-quinazolin-7-yl]oxyethyl dihydrogen phosphate | Human | 11434 | |
| RIPK2 | RIPK | TKL | 5w5o | C | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8577 | |
| RIPK2 | RIPK | TKL | 5ng0 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 8051 | |
| RIPK2 | RIPK | TKL | 6ul8 | B | B | (5s,6s,8r)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide | Human | 11850 | |
| RIPK2 | RIPK | TKL | 5ar5 | B | A | 2-(2-(4-chlorophenyl)-1h-imidazol-5-yl)-n,1-bis(2-methoxyethyl)-1h-benzo[d]imidazole-5-carboxamide | Human | 6171 | |
| RIPK2 | RIPK | TKL | 5j79 | A | B | 4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol | Human | 6636 | |
| RIPK2 | RIPK | TKL | 5w5o | G | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8580 | |
| RIPK2 | RIPK | TKL | 6hmx | A | | 6-~{tert}-butylsulfonyl-~{n}-(3,4-dimethyl-1~{h}-pyrazol-5-yl)-7-methoxy-quinolin-4-amine | Human | 10676 | |
| RIPK2 | RIPK | TKL | 5j79 | B | A | 4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol | Human | 6633 | |
| RIPK2 | RIPK | TKL | 5ar3 | A | B | phosphomethylphosphonic acid adenylate ester | Human | 6186 | |
| RIPK2 | RIPK | TKL | 5w5o | K | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8583 | |
| RIPK2 | RIPK | TKL | 5w5o | M | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8589 | |
| RIPK2 | RIPK | TKL | 5ng0 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 8054 | |
| RIPK2 | RIPK | TKL | 5ar3 | A | A | phosphomethylphosphonic acid adenylate ester | Human | 6184 | |
| RIPK2 | RIPK | TKL | 5ar7 | B | B | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea | Human | 6188 | |
| RIPK2 | RIPK | TKL | 5w5o | O | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8584 | |
| RIPK2 | RIPK | TKL | 6ul8 | B | A | (5s,6s,8r)-2-(1,3-benzothiazol-5-yl)-6-hydroxy-4,5,6,7,8,9-hexahydro-5,8-methanopyrazolo[1,5-a][1,3]diazocine-3-carboxamide | Human | 11852 | |
| RIPK2 | RIPK | TKL | 5ar3 | B | A | phosphomethylphosphonic acid adenylate ester | Human | 6177 | |
| RIPK2 | RIPK | TKL | 5ar2 | B | A | - | Human | 6185 | |
| RIPK2 | RIPK | TKL | 5j79 | A | A | 4-methyl-3-{[6-(methylsulfonyl)quinolin-4-yl]amino}phenol | Human | 6634 | |
| RIPK2 | RIPK | TKL | 5w5o | H | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8588 | |
| RIPK2 | RIPK | TKL | 5w5o | E | | 4-{6-(tert-butylsulfonyl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridin-3-yl}-6-chloropyridin-2-amine | Human | 8592 | |
| RIPK2 | RIPK | TKL | 5j7b | B | | 6-(tert-butylsulfonyl)-n-(5-fluoro-2h-indazol-3-yl)quinolin-4-amine | Human | 6632 | |
| RIPK2 | RIPK | TKL | 5ng2 | A | B | staurosporine | Human | 8056 | |
| RIPK2 | RIPK | TKL | 5ar8 | A | | 2,6-bis(fluoranyl)-n-[3-[5-[2-[(3-methylsulfonylphenyl)amino]pyrimidin-4-yl]-2-morpholin-4-yl-1,3-thiazol-4-yl]phenyl]benzenesulfonamide | Human | 6176 | |
| RIPK2 | RIPK | TKL | 6sze | B | A | 5-amino-1-phenylpyrazole-4-carboxamide | Human | 11760 | |
| RIPK2 | RIPK | TKL | 5ar2 | B | B | - | Human | 6181 | |
| RIPK2 | RIPK | TKL | 5ar7 | A | A | 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-pyridin-4-yloxyphenyl)urea | Human | 6174 | |
| RIPK2 | RIPK | TKL | 6sze | A | B | 5-amino-1-phenylpyrazole-4-carboxamide | Human | 11761 | |
| MAP3K7 (TAK1) | MLK | TKL | 7nth | A | A | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{r})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{h}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide | Human | 13456 | |
| MAP3K7 (TAK1) | MLK | TKL | 2yiy | A | | (1e)-1-[5-tert-butyl-2-(3-fluorophenyl)-1h-pyrazol-3-ylidene]-3-(4-pyridin-3-yloxyphenyl)urea | Human | 1890 | |
| MAP3K7 (TAK1) | MLK | TKL | 4l53 | A | A | trans-4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)-3-chlorofuro[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}cyclohexanol | Human | 1887 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jh6 | A | | 2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl prop-2-enoate | Human | 7427 | |
| MAP3K7 (TAK1) | MLK | TKL | 9fpd | A | | 6-[5-[6-(4-oxidanylcyclohexyl)oxy-1~{h}-pyrrolo[2,3-b]pyridin-5-yl]-1,2-oxazol-3-yl]pyridine-2-carboxamide | Human | 15551 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j9l | A | | n-(4-((2-((4-(4-methylpiperazin-1-yl)phenyl)amino)-7h-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide | Human | 7426 | |
| MAP3K7 (TAK1) | MLK | TKL | 4o91 | A | | n-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1h-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide | Human | 1888 | |
| MAP3K7 (TAK1) | MLK | TKL | 4l52 | A | B | 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}piperidin-1-yl)ethanone | Human | 1889 | |
| MAP3K7 (TAK1) | MLK | TKL | 2eva | A | A | adenosine | Human | 1884 | |
| MAP3K7 (TAK1) | MLK | TKL | 7nth | A | B | 2-[[5-[[2-[bis(fluoranyl)methoxy]phenyl]methyl-[(2~{r})-1-(methylamino)-1-oxidanylidene-propan-2-yl]carbamoyl]-1~{h}-imidazol-2-yl]carbonyl]isoindole-5-carboxamide | Human | 13458 | |
| MAP3K7 (TAK1) | MLK | TKL | 4l52 | A | A | 1-(4-{4-[7-amino-2-(1,2,3-benzothiadiazol-7-yl)furo[2,3-c]pyridin-4-yl]-1h-pyrazol-1-yl}piperidin-1-yl)ethanone | Human | 1883 | |
| MAP3K7 (TAK1) | MLK | TKL | 8gw3 | A | | - | Human | 14877 | |
| MAP3K7 (TAK1) | MLK | TKL | 4gs6 | A | A | (3s,5z,8s,9s,11e)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1h-2-benzoxacyclotetradecine-1,7(8h)-dione | Human | 1885 | |
| MAP3K7 (TAK1) | MLK | TKL | 7nti | A | A | ~{n}-[[2-[bis(fluoranyl)methoxy]phenyl]methyl]-~{n}-[2-(methylamino)-2-oxidanylidene-ethyl]-2-pyrrolidin-1-ylcarbonyl-1~{h}-imidazole-4-carboxamide | Human | 13459 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jgd | A | | n-(2-isopropoxy-3-(4-methylpiperazine-1-carbonyl)phenyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide | Human | 6884 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jga | A | | n-[5-(4-methylpiperazine-1-carbonyl)[1,1'-biphenyl]-2-yl]-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-7-carboxamide | Human | 6886 | |
| MAP3K7 (TAK1) | MLK | TKL | 5j8i | A | | n-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)oxy]phenyl}prop-2-enamide | Human | 7428 | |
| MAP3K7 (TAK1) | MLK | TKL | 5jk3 | A | | ~{n}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide | Human | 7430 | |
| MAP3K21 (MLK4) | MLK | TKL | 4uya | A | | phosphothiophosphoric acid-adenylate ester | Human | 6126 | |
| LRRK1 | LRRK | TKL | 8e04 | A | | - | Human | 14879 | |
| LRRK1 | LRRK | TKL | 8fac | A | | - | Human | 14880 | |
| LRRK1 | LRRK | TKL | 8e06 | A | | - | Human | 14881 | |
| LRRK1 | LRRK | TKL | 8e05 | A | | - | Human | 14882 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13389 | |
| ACVR1 (ALK2) | STKR | TKL | 6zgc | A | | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 12638 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7x | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13646 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | B | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1510 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7o | A | C | - | Human | 13647 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7j | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13648 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | A | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13390 | |
| ACVR1 (ALK2) | STKR | TKL | 6srh | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 11630 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7k | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13649 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | C | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1533 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | A | B | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1508 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7b | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13650 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | B | A | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1514 | |
| ACVR1 (ALK2) | STKR | TKL | 6zgc | D | | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 12639 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7i | A | C | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13653 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7r | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13654 | |
| ACVR1 (ALK2) | STKR | TKL | 6uns | A | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 13781 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7n | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13655 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | B | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12160 | |
| ACVR1 (ALK2) | STKR | TKL | 3h9r | A | | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 1531 | |
| ACVR1 (ALK2) | STKR | TKL | 6uns | A | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 13782 | |
| ACVR1 (ALK2) | STKR | TKL | 5oy6 | D | | cyclical inhibitor od36 | Human | 8534 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | C | A | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8517 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | C | B | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8513 | |
| ACVR1 (ALK2) | STKR | TKL | 7a21 | A | A | 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12777 | |
| ACVR1 (ALK2) | STKR | TKL | 6tn8 | A | A | 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one | Human | 11888 | |
| ACVR1 (ALK2) | STKR | TKL | 6zgc | C | | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 12640 | |
| ACVR1 (ALK2) | STKR | TKL | 6i1s | A | B | (4~{s},5~{r},6~{z},9~{s},10~{s},12~{e})-16-(ethylamino)-4,5-dimethyl-9,10,18-tris(oxidanyl)-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione | Human | 11604 | |
| ACVR1 (ALK2) | STKR | TKL | 6gin | B | B | 3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one | Human | 9916 | |
| ACVR1 (ALK2) | STKR | TKL | 5s9k | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13658 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7n | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13659 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | D | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1529 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7h | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13660 | |
| ACVR1 (ALK2) | STKR | TKL | 5s81 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13661 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7w | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13662 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7i | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13663 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7o | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13664 | |
| ACVR1 (ALK2) | STKR | TKL | 6srh | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 11632 | |
| ACVR1 (ALK2) | STKR | TKL | 6szm | A | A | 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine | Human | 11735 | |
| ACVR1 (ALK2) | STKR | TKL | 3mtf | A | B | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 1521 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | B | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1523 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7s | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13667 | |
| ACVR1 (ALK2) | STKR | TKL | 6z36 | B | B | 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12275 | |
| ACVR1 (ALK2) | STKR | TKL | 8c7w | A | A | 6-methyl-9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,7-dihydropyrido[4,3-d][2]benzazepine | Human | 14608 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | A | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1527 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | D | A | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8520 | |
| ACVR1 (ALK2) | STKR | TKL | 6zgc | B | | n-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2h-pyran-4-yloxy)quinazolin-4-amine | Human | 12641 | |
| ACVR1 (ALK2) | STKR | TKL | 8c7z | A | B | 9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,6-dihydro-[1]benzoxepino[5,4-c]pyridine | Human | 14604 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7f | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13671 | |
| ACVR1 (ALK2) | STKR | TKL | 5s76 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13672 | |
| ACVR1 (ALK2) | STKR | TKL | 5s89 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13673 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7z | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13674 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7u | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13675 | |
| ACVR1 (ALK2) | STKR | TKL | 4c02 | A | B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 1532 | |
| ACVR1 (ALK2) | STKR | TKL | 8c7w | A | B | 6-methyl-9-piperazin-1-yl-4-(3,4,5-trimethoxyphenyl)-5,7-dihydropyrido[4,3-d][2]benzazepine | Human | 14609 | |
| ACVR1 (ALK2) | STKR | TKL | 5oy6 | A | | cyclical inhibitor od36 | Human | 8532 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7s | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13677 | |
| ACVR1 (ALK2) | STKR | TKL | 6t8n | B | B | cyclopropyl-[4-[6-[5-(4-ethoxy-1-propan-2-yl-piperidin-4-yl)pyridin-2-yl]pyrrolo[1,2-b]pyridazin-4-yl]piperazin-1-yl]methanone | Human | 11829 | |
| ACVR1 (ALK2) | STKR | TKL | 6gin | B | A | 3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one | Human | 9920 | |
| ACVR1 (ALK2) | STKR | TKL | 6eix | A | A | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 8530 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7q | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13678 | |
| ACVR1 (ALK2) | STKR | TKL | 6tn8 | A | B | 4-[4-[(dimethylamino)methyl]-2,5-dimethoxy-phenyl]-2-methyl-2,7-naphthyridin-1-one | Human | 11887 | |
| ACVR1 (ALK2) | STKR | TKL | 5s85 | A | C | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13679 | |
| ACVR1 (ALK2) | STKR | TKL | 7a21 | B | B | 4-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12778 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7c | A | D | - | Human | 13680 | |
| ACVR1 (ALK2) | STKR | TKL | 5s82 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13681 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7h | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13682 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7a | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13683 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7y | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13684 | |
| ACVR1 (ALK2) | STKR | TKL | 3mtf | B | A | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 1515 | |
| ACVR1 (ALK2) | STKR | TKL | 4c02 | A | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 1525 | |
| ACVR1 (ALK2) | STKR | TKL | 5s83 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13685 | |
| ACVR1 (ALK2) | STKR | TKL | 5s78 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13686 | |
| ACVR1 (ALK2) | STKR | TKL | 7nns | B | B | momelotinib | Human | 13464 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7p | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13687 | |
| ACVR1 (ALK2) | STKR | TKL | 6szm | B | A | 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine | Human | 11734 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7c | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13689 | |
| ACVR1 (ALK2) | STKR | TKL | 6gip | A | A | 2,5-dimethyl-6-quinolin-4-yl-3~{h}-quinazolin-4-one | Human | 9915 | |
| ACVR1 (ALK2) | STKR | TKL | 4dym | A | | 1-(3-{6-[(cyclopropylmethyl)amino]imidazo[1,2-b]pyridazin-3-yl}phenyl)ethanone | Human | 1509 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | A | A | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11779 | |
| ACVR1 (ALK2) | STKR | TKL | 6acr | A | | n-(4-methoxyphenyl)-4-[3-(pyridin-3-yl)-1h-pyrazol-4-yl]pyrimidin-2-amine | Human | 10969 | |
| ACVR1 (ALK2) | STKR | TKL | 5s76 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13691 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | D | A | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11783 | |
| ACVR1 (ALK2) | STKR | TKL | 6gin | A | B | 3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one | Human | 9918 | |
| ACVR1 (ALK2) | STKR | TKL | 6gip | A | B | 2,5-dimethyl-6-quinolin-4-yl-3~{h}-quinazolin-4-one | Human | 9917 | |
| ACVR1 (ALK2) | STKR | TKL | 6z36 | B | A | 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12276 | |
| ACVR1 (ALK2) | STKR | TKL | 5s77 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13694 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7p | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13695 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7u | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13696 | |
| ACVR1 (ALK2) | STKR | TKL | 5s81 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13697 | |
| ACVR1 (ALK2) | STKR | TKL | 7nns | B | A | momelotinib | Human | 13465 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | B | B | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1526 | |
| ACVR1 (ALK2) | STKR | TKL | 6srh | B | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 11631 | |
| ACVR1 (ALK2) | STKR | TKL | 5s77 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13698 | |
| ACVR1 (ALK2) | STKR | TKL | 6eix | A | B | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 8533 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7w | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13700 | |
| ACVR1 (ALK2) | STKR | TKL | 5s82 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13701 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | B | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13391 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | B | B | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11782 | |
| ACVR1 (ALK2) | STKR | TKL | 8pod | A | | 6-(4-piperazin-1-ylphenyl)-3-quinolin-4-yl-furo[3,2-b]pyridine | Human | 15314 | |
| ACVR1 (ALK2) | STKR | TKL | 7c3g | B | A | ~{n}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{h}-pyrazolo[5,1-c][1,4]oxazin-3-yl)pyrimidin-2-amine | Human | 13392 | |
| ACVR1 (ALK2) | STKR | TKL | 5s88 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13703 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | B | A | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11781 | |
| ACVR1 (ALK2) | STKR | TKL | 5s79 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13704 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7m | A | C | - | Human | 13705 | |
| ACVR1 (ALK2) | STKR | TKL | 5s83 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13706 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | B | A | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8516 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7v | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13707 | |
| ACVR1 (ALK2) | STKR | TKL | 6unq | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13783 | |
| ACVR1 (ALK2) | STKR | TKL | 5s85 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13710 | |
| ACVR1 (ALK2) | STKR | TKL | 5oy6 | C | | cyclical inhibitor od36 | Human | 8529 | |
| ACVR1 (ALK2) | STKR | TKL | 3oom | A | A | 1-{3-[6-(tetrahydro-2h-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone | Human | 1517 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | A | B | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8518 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7v | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13711 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7j | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13712 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7g | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13713 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | D | B | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1512 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | C | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1516 | |
| ACVR1 (ALK2) | STKR | TKL | 6unq | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13784 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | C | B | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11780 | |
| ACVR1 (ALK2) | STKR | TKL | 6unr | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13785 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7e | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13715 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7g | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13717 | |
| ACVR1 (ALK2) | STKR | TKL | 6z36 | A | A | 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12277 | |
| ACVR1 (ALK2) | STKR | TKL | 5s75 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13718 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7b | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13719 | |
| ACVR1 (ALK2) | STKR | TKL | 3mtf | A | A | 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol | Human | 1513 | |
| ACVR1 (ALK2) | STKR | TKL | 8r7g | A | A | 2-fluoranyl-6-methoxy-4-[4-methyl-5-[4-(4-propan-2-ylpiperazin-1-yl)phenyl]pyridin-3-yl]benzamide | Human | 15267 | |
| ACVR1 (ALK2) | STKR | TKL | 5s85 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13720 | |
| ACVR1 (ALK2) | STKR | TKL | 6gi6 | A | | 5-methyl-6-quinolin-5-yl-3~{h}-quinazolin-4-one | Human | 9919 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | D | B | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8515 | |
| ACVR1 (ALK2) | STKR | TKL | 3oom | A | B | 1-{3-[6-(tetrahydro-2h-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone | Human | 1518 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7t | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13723 | |
| ACVR1 (ALK2) | STKR | TKL | 5s86 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13724 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | A | B | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1524 | |
| ACVR1 (ALK2) | STKR | TKL | 5s8a | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13725 | |
| ACVR1 (ALK2) | STKR | TKL | 5oxg | A | A | 5-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 8514 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7y | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13727 | |
| ACVR1 (ALK2) | STKR | TKL | 5s80 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13728 | |
| ACVR1 (ALK2) | STKR | TKL | 3q4u | D | A | 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline | Human | 1520 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | A | B | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11784 | |
| ACVR1 (ALK2) | STKR | TKL | 5s86 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13729 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7d | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13730 | |
| ACVR1 (ALK2) | STKR | TKL | 6szm | A | B | 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine | Human | 11737 | |
| ACVR1 (ALK2) | STKR | TKL | 6szm | B | B | 1-[4-[4-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl]piperazine | Human | 11736 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7k | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13732 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7o | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13733 | |
| ACVR1 (ALK2) | STKR | TKL | 6srh | B | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 11633 | |
| ACVR1 (ALK2) | STKR | TKL | 6gin | A | A | 3-(4-morpholin-4-ylphenyl)-6-quinolin-4-yl-quinazolin-4-one | Human | 9914 | |
| ACVR1 (ALK2) | STKR | TKL | 5s7f | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13737 | |
| ACVR1 (ALK2) | STKR | TKL | 6z36 | A | B | 4-methyl-3-(4-piperidin-4-ylphenyl)-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 12278 | |
| ACVR1 (ALK2) | STKR | TKL | 5s87 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13738 | |
| ACVR2A (ACTR2) | STKR | TKL | 4asx | A | B | 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2h-pyrido[3,4-b]indol-1-one | Human | 2681 | |
| ACVR2A (ACTR2) | STKR | TKL | 3q4t | B | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 2680 | |
| ACVR2A (ACTR2) | STKR | TKL | 4asx | A | A | 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2h-pyrido[3,4-b]indol-1-one | Human | 2678 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | B | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2677 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | A | A | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2675 | |
| ACVR2A (ACTR2) | STKR | TKL | 3q4t | A | B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 2686 | |
| ACVR2A (ACTR2) | STKR | TKL | 4asx | B | A | 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2h-pyrido[3,4-b]indol-1-one | Human | 2683 | |
| ACVR2A (ACTR2) | STKR | TKL | 3q4t | A | A | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 2682 | |
| ACVR2A (ACTR2) | STKR | TKL | 3q4t | B | B | 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine | Human | 2684 | |
| ACVR2A (ACTR2) | STKR | TKL | 3soc | B | B | [4-({4-[(5-cyclopropyl-1h-pyrazol-3-yl)amino]quinazolin-2-yl}imino)cyclohexa-2,5-dien-1-yl]acetonitrile | Human | 2685 | |
| ACVR2A (ACTR2) | STKR | TKL | 4asx | B | B | 7,8-bis(chloranyl)-9-methyl-3,4-dihydro-2h-pyrido[3,4-b]indol-1-one | Human | 2679 | |
| MAP3K20 (ZAK) | MLK | TKL | 5hes | A | B | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6458 | |
| MAP3K20 (ZAK) | MLK | TKL | 5hes | B | A | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6459 | |
| MAP3K20 (ZAK) | MLK | TKL | 5x5o | A | A | n-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide | Human | 9449 | |
| MAP3K20 (ZAK) | MLK | TKL | 7yaw | A | A | ~{n}-[3-[[5-[1-[2,6-bis(fluoranyl)-3-[(3-phenylphenyl)sulfonylamino]phenyl]-1,2,3-triazol-4-yl]-1~{h}-pyrazolo[3,4-b]pyridin-3-yl]oxy]propyl]propanamide | Human | 14891 | |
| MAP3K20 (ZAK) | MLK | TKL | 7yaz | A | B | ~{n}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{s})-1-propanoylpyrrolidin-3-yl]oxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamide | Human | 14892 | |
| MAP3K20 (ZAK) | MLK | TKL | 5hes | A | A | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6460 | |
| MAP3K20 (ZAK) | MLK | TKL | 5x5o | A | B | n-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide | Human | 9448 | |
| MAP3K20 (ZAK) | MLK | TKL | 6juu | A | B | ~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]naphthalene-1-sulfonamide | Human | 12166 | |
| MAP3K20 (ZAK) | MLK | TKL | 7yaw | A | B | ~{n}-[3-[[5-[1-[2,6-bis(fluoranyl)-3-[(3-phenylphenyl)sulfonylamino]phenyl]-1,2,3-triazol-4-yl]-1~{h}-pyrazolo[3,4-b]pyridin-3-yl]oxy]propyl]propanamide | Human | 14893 | |
| MAP3K20 (ZAK) | MLK | TKL | 5hes | B | B | n-(3-{[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | Human | 6457 | |
| MAP3K20 (ZAK) | MLK | TKL | 7yaz | A | A | ~{n}-[2,4-bis(fluoranyl)-3-[4-[3-[(3~{s})-1-propanoylpyrrolidin-3-yl]oxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl]-1,2,3-triazol-1-yl]phenyl]-3-phenyl-benzenesulfonamide | Human | 14894 | |
| MAP3K20 (ZAK) | MLK | TKL | 6juu | A | A | ~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]naphthalene-1-sulfonamide | Human | 12167 | |
| MAP3K20 (ZAK) | MLK | TKL | 6jut | A | | ~{n}-[2,4-bis(fluoranyl)-3-[4-(3-methoxy-1~{h}-pyrazolo[3,4-b]pyridin-5-yl)-1,2,3-triazol-1-yl]phenyl]-3-bromanyl-benzenesulfonamide | Human | 11462 | |
| IRAK1 | IRAK | TKL | 6bfn | A | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 8698 | |
| IRAK1 | IRAK | TKL | 6bfn | B | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 8701 | |
| IRAK1 | IRAK | TKL | 6bfn | A | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 8700 | |
| IRAK1 | IRAK | TKL | 6bfn | B | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 8699 | |
| LRRK2 | LRRK | TKL | 6vno | A | 7 | - | Human | 12712 | |
| LRRK2 | LRRK | TKL | 8tzc | A | | - | Human | 15050 | |
| LRRK2 | LRRK | TKL | 8vh5 | A | | - | Human | 15819 | |
| LRRK2 | LRRK | TKL | 9oxi | A | | - | Human | 15820 | |
| LRRK2 | LRRK | TKL | 7lht | A | | - | Human | 13623 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 1 | - | Human | 12713 | |
| LRRK2 | LRRK | TKL | 6vp6 | A | | - | Human | 12714 | |
| LRRK2 | LRRK | TKL | 9om2 | A | | - | Human | 15821 | |
| LRRK2 | LRRK | TKL | 6vno | A | 5 | - | Human | 12715 | |
| LRRK2 | LRRK | TKL | 9ybl | A | B | - | Human | 15822 | |
| LRRK2 | LRRK | TKL | 9y68 | A | A | - | Human | 15823 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 5 | - | Human | 12716 | |
| LRRK2 | LRRK | TKL | 7li4 | A | | - | Human | 13624 | |
| LRRK2 | LRRK | TKL | 7lhw | A | | - | Human | 13625 | |
| LRRK2 | LRRK | TKL | 6vno | A | 10 | - | Human | 12717 | |
| LRRK2 | LRRK | TKL | 6vno | A | 8 | - | Human | 12718 | |
| LRRK2 | LRRK | TKL | 8tzb | A | | - | Human | 15052 | |
| LRRK2 | LRRK | TKL | 6vno | A | 4 | - | Human | 12719 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 4 | - | Human | 12720 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 6 | - | Human | 12721 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 8 | - | Human | 12722 | |
| LRRK2 | LRRK | TKL | 6vp8 | A | | - | Human | 12723 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 2 | - | Human | 12724 | |
| LRRK2 | LRRK | TKL | 6vno | A | 2 | - | Human | 12725 | |
| LRRK2 | LRRK | TKL | 6vp6 | B | | - | Human | 12726 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 7 | - | Human | 12727 | |
| LRRK2 | LRRK | TKL | 8tze | A | | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15054 | |
| LRRK2 | LRRK | TKL | 8tyq | A | B | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15055 | |
| LRRK2 | LRRK | TKL | 6vno | A | 9 | - | Human | 12728 | |
| LRRK2 | LRRK | TKL | 8fo9 | A | | - | Human | 15132 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 9 | - | Human | 12729 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 10 | - | Human | 12730 | |
| LRRK2 | LRRK | TKL | 7li3 | A | | - | Human | 13626 | |
| LRRK2 | LRRK | TKL | 6vno | A | 3 | - | Human | 12731 | |
| LRRK2 | LRRK | TKL | 6vno | A | 6 | - | Human | 12732 | |
| LRRK2 | LRRK | TKL | 8txz | A | B | - | Human | 15057 | |
| LRRK2 | LRRK | TKL | 9yqk | A | | - | Human | 15831 | |
| LRRK2 | LRRK | TKL | 9oxh | A | B | - | Human | 15832 | |
| LRRK2 | LRRK | TKL | 9y67 | A | A | - | Human | 15833 | |
| LRRK2 | LRRK | TKL | 9oxh | A | A | - | Human | 15834 | |
| LRRK2 | LRRK | TKL | 8tyq | A | A | 4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1h-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide | Human | 15058 | |
| LRRK2 | LRRK | TKL | 6vp7 | A | 3 | - | Human | 12733 | |
| LRRK2 | LRRK | TKL | 6vp8 | B | | - | Human | 12734 | |
| LRRK2 | LRRK | TKL | 6vno | A | 1 | - | Human | 12735 | |
| LRRK2 | LRRK | TKL | 9ybl | A | A | - | Human | 15835 | |
| LRRK2 | LRRK | TKL | 8u8b | A | | - | Human | 15185 | |
| ACVR1 (ALK2) | STKR | TKL | 6t6d | C | A | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | Human | 11778 | |
| ACVR1 (ALK2) | STKR | TKL | 5s75 | A | A | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13714 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | C | A | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1511 | |
| ACVR1 (ALK2) | STKR | TKL | 5oy6 | B | | cyclical inhibitor od36 | Human | 8531 | |
| ACVR1 (ALK2) | STKR | TKL | 4bgg | D | A | 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine | Human | 1519 | |
| ACVR1 (ALK2) | STKR | TKL | 6jux | A | A | 4-(1-ethyl-3-pyridin-3-yl-pyrazol-4-yl)-~{n}-(4-piperazin-1-ylphenyl)pyrimidin-2-amine | Human | 12161 | |
| ACVR1 (ALK2) | STKR | TKL | 5s87 | A | B | 4-methyl-3-[4-(1-methylpiperidin-4-yl)phenyl]-5-(3,4,5-trimethoxyphenyl)pyridine | Human | 13735 | |
| IRAK4 | IRAK | TKL | 6rfi | B | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11791 | |
| IRAK4 | IRAK | TKL | 4y73 | A | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9129 | |
| IRAK4 | IRAK | TKL | 6f3g | A | | ~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | Human | 9921 | |
| IRAK4 | IRAK | TKL | 4xs2 | D | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1738 | |
| IRAK4 | IRAK | TKL | 4xs2 | B | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1778 | |
| IRAK4 | IRAK | TKL | 5uis | C | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7611 | |
| IRAK4 | IRAK | TKL | 4yo6 | B | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1747 | |
| IRAK4 | IRAK | TKL | 4ztn | D | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5995 | |
| IRAK4 | IRAK | TKL | 2oib | D | B | - | Human | 1783 | |
| IRAK4 | IRAK | TKL | 4yp8 | D | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1745 | |
| IRAK4 | IRAK | TKL | 6ega | A | B | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10907 | |
| IRAK4 | IRAK | TKL | 2oib | B | A | - | Human | 1785 | |
| IRAK4 | IRAK | TKL | 4u97 | A | | staurosporine | Human | 1754 | |
| IRAK4 | IRAK | TKL | 5uiu | A | A | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 7603 | |
| IRAK4 | IRAK | TKL | 6ti8 | D | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12942 | |
| IRAK4 | IRAK | TKL | 4yo6 | A | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1763 | |
| IRAK4 | IRAK | TKL | 6f3d | B | | 4-[4-[[4-(dimethylamino)cyclohexyl]amino]-7~{h}-pyrrolo[2,3-d]pyrimidin-5-yl]cyclohexane-1-carboxamide | Human | 9924 | |
| IRAK4 | IRAK | TKL | 4ztl | B | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6009 | |
| IRAK4 | IRAK | TKL | 8v2f | A | B | n-{2-[(1r,4r)-4-(hydroxymethyl)cyclohexyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15330 | |
| IRAK4 | IRAK | TKL | 7qg2 | A | A | 6-methyl-4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[4,3-d]pyrimidin-5-one | Human | 14210 | |
| IRAK4 | IRAK | TKL | 4y73 | C | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9130 | |
| IRAK4 | IRAK | TKL | 6mom | C | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11739 | |
| IRAK4 | IRAK | TKL | 8v2l | A | A | n-{2-[4-(hydroxymethyl)phenyl]-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl}-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15331 | |
| IRAK4 | IRAK | TKL | 6tia | B | | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12943 | |
| IRAK4 | IRAK | TKL | 6thx | A | | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | 12944 | |
| IRAK4 | IRAK | TKL | 5k75 | D | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8714 | |
| IRAK4 | IRAK | TKL | 8ucc | A | | (4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15332 | |
| IRAK4 | IRAK | TKL | 5uiq | C | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7608 | |
| IRAK4 | IRAK | TKL | 5uiq | B | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7617 | |
| IRAK4 | IRAK | TKL | 6o95 | C | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11110 | |
| IRAK4 | IRAK | TKL | 6o8u | D | B | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11103 | |
| IRAK4 | IRAK | TKL | 6egd | D | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10894 | |
| IRAK4 | IRAK | TKL | 6o9d | B | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11107 | |
| IRAK4 | IRAK | TKL | 8v1o | A | | n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15334 | |
| IRAK4 | IRAK | TKL | 6o95 | A | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11102 | |
| IRAK4 | IRAK | TKL | 5k72 | B | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8711 | |
| IRAK4 | IRAK | TKL | 4rmz | B | A | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6351 | |
| IRAK4 | IRAK | TKL | 2oib | D | A | - | Human | 1736 | |
| IRAK4 | IRAK | TKL | 5uiq | A | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7612 | |
| IRAK4 | IRAK | TKL | 4ztn | D | B | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6002 | |
| IRAK4 | IRAK | TKL | 4xs2 | C | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1791 | |
| IRAK4 | IRAK | TKL | 7qg5 | A | B | 4-[(1-methylcyclopropyl)amino]-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]-6-pyrimidin-5-yl-pyrido[4,3-d]pyrimidin-5-one | Human | 14214 | |
| IRAK4 | IRAK | TKL | 4rmz | A | A | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6349 | |
| IRAK4 | IRAK | TKL | 5t1t | A | | ~{n},~{n}-dimethyl-4-(6-nitroquinazolin-4-yl)oxy-cyclohexan-1-amine | Human | 7567 | |
| IRAK4 | IRAK | TKL | 6thx | B | | 2-[4-[(1-methylcyclopropyl)amino]-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-6-yl]ethanenitrile | Human | 12953 | |
| IRAK4 | IRAK | TKL | 5uiq | D | A | 2-[(propan-2-yl)oxy]benzamide | Human | 7620 | |
| IRAK4 | IRAK | TKL | 5uir | B | A | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7595 | |
| IRAK4 | IRAK | TKL | 5uis | B | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7618 | |
| IRAK4 | IRAK | TKL | 5t1s | D | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7563 | |
| IRAK4 | IRAK | TKL | 2oid | A | | phosphoaminophosphonic acid-adenylate ester | Human | 1764 | |
| IRAK4 | IRAK | TKL | 6n8g | D | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10789 | |
| IRAK4 | IRAK | TKL | 6mom | A | A | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11742 | |
| IRAK4 | IRAK | TKL | 6f3e | B | | 2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide | Human | 9926 | |
| IRAK4 | IRAK | TKL | 6o94 | A | B | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11091 | |
| IRAK4 | IRAK | TKL | 4yp8 | B | | n-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1h-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1786 | |
| IRAK4 | IRAK | TKL | 6ege | A | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10897 | |
| IRAK4 | IRAK | TKL | 4rmz | A | B | 3-nitro-n-[1-phenyl-5-(piperidin-1-ylmethyl)-1h-benzimidazol-2-yl]benzamide | Human | 6352 | |
| IRAK4 | IRAK | TKL | 6egd | D | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10890 | |
| IRAK4 | IRAK | TKL | 8ucb | A | | 6-(difluoromethyl)-n-[(4r)-7-ethoxy-2-{[(3r)-oxolan-3-yl]methyl}imidazo[1,2-a]pyridin-6-yl]pyridine-2-carboxamide | Human | 15338 | |
| IRAK4 | IRAK | TKL | 5uis | A | A | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7604 | |
| IRAK4 | IRAK | TKL | 5k72 | D | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8721 | |
| IRAK4 | IRAK | TKL | 8tvn | A | A | n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15339 | |
| IRAK4 | IRAK | TKL | 4yo6 | A | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1793 | |
| IRAK4 | IRAK | TKL | 6eg9 | A | A | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10906 | |
| IRAK4 | IRAK | TKL | 6vql | A | | 6-[(1,3-benzothiazol-6-yl)amino]-4-(cyclopropylamino)-n-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]pyridine-3-carboxamide | Human | 12395 | |
| IRAK4 | IRAK | TKL | 6uya | A | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11811 | |
| IRAK4 | IRAK | TKL | 6lxy | E | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13162 | |
| IRAK4 | IRAK | TKL | 6o9d | B | B | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11094 | |
| IRAK4 | IRAK | TKL | 6egf | B | | phosphoaminophosphonic acid-adenylate ester | Human | 10893 | |
| IRAK4 | IRAK | TKL | 5w85 | B | | 6-[(1,3-benzothiazol-6-yl)amino]-4-{[(2s)-1-hydroxy-3-phenylpropan-2-yl]amino}-n-methylpyridine-3-carboxamide | Human | 8558 | |
| IRAK4 | IRAK | TKL | 6uya | C | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11814 | |
| IRAK4 | IRAK | TKL | 6o94 | D | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11111 | |
| IRAK4 | IRAK | TKL | 6rfj | B | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 11789 | |
| IRAK4 | IRAK | TKL | 5uiq | D | B | 2-[(propan-2-yl)oxy]benzamide | Human | 7610 | |
| IRAK4 | IRAK | TKL | 2o8y | B | | - | Human | 1732 | |
| IRAK4 | IRAK | TKL | 6f3i | A | | (3~{r})-3-[4-[[4-(4-ethanoylpiperazin-1-yl)cyclohexyl]amino]pyrrolo[2,1-f][1,2,4]triazin-5-yl]butanamide | Human | 9928 | |
| IRAK4 | IRAK | TKL | 6o9d | D | A | n-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11100 | |
| IRAK4 | IRAK | TKL | 2nry | B | B | staurosporine | Human | 1772 | |
| IRAK4 | IRAK | TKL | 6n8g | C | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10794 | |
| IRAK4 | IRAK | TKL | 6mom | A | B | 6-[7-methoxy-6-(1-methyl-1h-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl]-n-[(3r)-pyrrolidin-3-yl]pyridin-2-amine | Human | 11740 | |
| IRAK4 | IRAK | TKL | 5w84 | A | | 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide | Human | 8559 | |
| IRAK4 | IRAK | TKL | 2oib | A | A | - | Human | 1756 | |
| IRAK4 | IRAK | TKL | 6o95 | D | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11105 | |
| IRAK4 | IRAK | TKL | 6uya | C | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11808 | |
| IRAK4 | IRAK | TKL | 4ztl | C | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5998 | |
| IRAK4 | IRAK | TKL | 6n8g | D | A | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10792 | |
| IRAK4 | IRAK | TKL | 4y73 | B | A | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9128 | |
| IRAK4 | IRAK | TKL | 8atb | A | A | ~{n}-[6-ethoxy-2-[2-(4-methylpiperazin-1-yl)-2-oxidanylidene-ethyl]indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | Human | 15080 | |
| IRAK4 | IRAK | TKL | 6egd | A | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10892 | |
| IRAK4 | IRAK | TKL | 6n8g | B | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10790 | |
| IRAK4 | IRAK | TKL | 6rfi | B | A | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11790 | |
| IRAK4 | IRAK | TKL | 2oib | C | A | - | Human | 1781 | |
| IRAK4 | IRAK | TKL | 6lxy | B | | n-[(2r)-2-fluoranyl-3-methyl-3-oxidanyl-butyl]-6-[(6-fluoranylpyrazolo[1,5-a]pyrimidin-5-yl)amino]-4-(propan-2-ylamino)pyridine-3-carboxamide | Human | 13163 | |
| IRAK4 | IRAK | TKL | 4ztm | B | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5992 | |
| IRAK4 | IRAK | TKL | 6n8g | C | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10793 | |
| IRAK4 | IRAK | TKL | 4y73 | B | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9125 | |
| IRAK4 | IRAK | TKL | 8wtf | A | B | 1-{[(2s,3s,4s)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide | Human | 14963 | |
| IRAK4 | IRAK | TKL | 5uir | B | B | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7605 | |
| IRAK4 | IRAK | TKL | 6o95 | B | A | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11090 | |
| IRAK4 | IRAK | TKL | 4ztl | A | A | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6003 | |
| IRAK4 | IRAK | TKL | 4xs2 | A | | (1r,2s,3r,5r)-3-({5-(1,3-benzothiazol-2-yl)-6-chloro-2-[(3-methoxypropyl)amino]pyrimidin-4-yl}amino)-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 1765 | |
| IRAK4 | IRAK | TKL | 6uya | B | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11812 | |
| IRAK4 | IRAK | TKL | 6o94 | A | A | n-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1h-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11092 | |
| IRAK4 | IRAK | TKL | 5kx7 | A | | - | Human | 6956 | |
| IRAK4 | IRAK | TKL | 4y73 | D | B | 5-{[(1r,2s)-2-aminocyclohexyl]amino}-n-[1-methyl-3-(trifluoromethyl)-1h-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 9126 | |
| IRAK4 | IRAK | TKL | 5t1s | B | | 5-[3-(3,5-dimethylphenyl)-4-[4-(methylamino)butyl]quinolin-6-yl]pyridin-3-ol | Human | 7566 | |
| IRAK4 | IRAK | TKL | 4ztm | A | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5997 | |
| IRAK4 | IRAK | TKL | 4yo6 | B | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1769 | |
| IRAK4 | IRAK | TKL | 4ztn | A | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 5993 | |
| IRAK4 | IRAK | TKL | 6uya | B | A | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11807 | |
| IRAK4 | IRAK | TKL | 5uir | A | A | 5-(4-cyanophenyl)-3-[(propan-2-yl)oxy]naphthalene-2-carboxamide | Human | 7599 | |
| IRAK4 | IRAK | TKL | 5k7i | B | | (3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 9520 | |
| IRAK4 | IRAK | TKL | 5uis | D | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7614 | |
| IRAK4 | IRAK | TKL | 5k76 | A | B | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8715 | |
| IRAK4 | IRAK | TKL | 6ege | D | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10889 | |
| IRAK4 | IRAK | TKL | 5k72 | A | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8720 | |
| IRAK4 | IRAK | TKL | 2oib | B | B | - | Human | 1743 | |
| IRAK4 | IRAK | TKL | 6o8u | C | A | n-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11116 | |
| IRAK4 | IRAK | TKL | 6n8g | A | B | n-[2-(morpholin-4-yl)-6-(piperidin-1-yl)-1,3-benzoxazol-5-yl]-6-(1h-pyrrolo[2,3-b]pyridin-5-yl)pyridine-2-carboxamide | Human | 10795 | |
| IRAK4 | IRAK | TKL | 4ztm | D | | 5-(1,3-benzothiazol-2-yl)-2-(cyclopropylamino)-6-{[(1r,2s,3r,4r)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]amino}pyrimidin-4(3h)-one | Human | 5999 | |
| IRAK4 | IRAK | TKL | 6rfi | A | B | methyl 4-[4-[(6-cyanoquinazolin-4-yl)amino]cyclohexyl]piperazine-1-carboxylate | Human | 11787 | |
| IRAK4 | IRAK | TKL | 6ti8 | A | B | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12954 | |
| IRAK4 | IRAK | TKL | 6ege | A | B | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1h-pyrazol-5-yl)pyridine-2-carboxamide | Human | 10891 | |
| IRAK4 | IRAK | TKL | 4ztl | C | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 5990 | |
| IRAK4 | IRAK | TKL | 4yo6 | C | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1780 | |
| IRAK4 | IRAK | TKL | 5k7i | A | | (3~{a}~{r},7~{a}~{s})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 9521 | |
| IRAK4 | IRAK | TKL | 5k76 | B | A | ~{n}-(4-morpholin-4-ylcyclohexyl)-5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 8709 | |
| IRAK4 | IRAK | TKL | 2oid | D | | phosphoaminophosphonic acid-adenylate ester | Human | 1733 | |
| IRAK4 | IRAK | TKL | 5w84 | B | | 4-(benzylamino)-6-[(2-oxo-2,3-dihydro-1h-indol-5-yl)amino]pyridine-3-carboxamide | Human | 8561 | |
| IRAK4 | IRAK | TKL | 8tvn | A | B | n-{1-[(1r,2s)-2-fluorocyclopropyl]-2-oxo-1,2-dihydropyridin-3-yl}-2-[(1r,4r)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-6-[(propan-2-yl)oxy]-2h-pyrazolo[3,4-b]pyridine-5-carboxamide | Human | 15341 | |
| IRAK4 | IRAK | TKL | 6ega | B | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10912 | |
| IRAK4 | IRAK | TKL | 4yo6 | C | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1737 | |
| IRAK4 | IRAK | TKL | 4ztl | B | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6004 | |
| IRAK4 | IRAK | TKL | 6o95 | C | B | n-[(2r)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11097 | |
| IRAK4 | IRAK | TKL | 5k75 | B | B | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8717 | |
| IRAK4 | IRAK | TKL | 5k72 | C | | ~{n}4,~{n}4-dimethyl-~{n}1-[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]cyclohexane-1,4-diamine | Human | 8723 | |
| IRAK4 | IRAK | TKL | 6f3g | B | | ~{n}4,~{n}4-dimethyl-~{n}1-(5-propan-2-ylpyrrolo[3,2-d]pyrimidin-4-yl)cyclohexane-1,4-diamine | Human | 9927 | |
| IRAK4 | IRAK | TKL | 2nry | B | A | staurosporine | Human | 1758 | |
| IRAK4 | IRAK | TKL | 2nry | D | A | staurosporine | Human | 1789 | |
| IRAK4 | IRAK | TKL | 6uya | D | B | n-{2-[(2r)-2-fluoro-3-hydroxy-3-methylbutyl]-6-(morpholin-4-yl)-1-oxo-2,3-dihydro-1h-isoindol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 11809 | |
| IRAK4 | IRAK | TKL | 5k75 | D | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8718 | |
| IRAK4 | IRAK | TKL | 8ucc | B | | (4s)-2-[(1r,4s)-1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl]-n-[(8s)-6-methylpyrazolo[1,5-a]pyrimidin-3-yl]-7-[(propan-2-yl)oxy]imidazo[1,2-a]pyrimidine-6-carboxamide | Human | 15342 | |
| IRAK4 | IRAK | TKL | 4ztl | D | B | (1r,2s,3r,5r)-3-{[5-(1,3-benzothiazol-2-yl)-2-(propylamino)pyrimidin-4-yl]amino}-5-(hydroxymethyl)cyclopentane-1,2-diol | Human | 6000 | |
| IRAK4 | IRAK | TKL | 5k75 | C | A | ~{n}1-(7,8-dihydro-6~{h}-cyclopenta[2,3]thieno[2,4-~{c}]pyrimidin-1-yl)-~{n}4,~{n}4-dimethyl-cyclohexane-1,4-diamine | Human | 8724 | |
| IRAK4 | IRAK | TKL | 6egd | A | A | n-[2-methoxy-4-(morpholin-4-yl)phenyl]-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide | Human | 10895 | |
| IRAK4 | IRAK | TKL | 6eg9 | B | B | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10911 | |
| IRAK4 | IRAK | TKL | 6tia | A | | 4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(1-methylpyrazol-4-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12955 | |
| IRAK4 | IRAK | TKL | 5uis | A | B | 4-{[(3r)-piperidin-3-yl]oxy}-6-[(propan-2-yl)oxy]quinoline-7-carboxamide | Human | 7598 | |
| IRAK4 | IRAK | TKL | 5k7g | C | | (3~{a}~{s},7~{a}~{r})-1-methyl-5-[4-[[5-(oxan-4-yl)-7~{h}-pyrrolo[2,3-d]pyrimidin-4-yl]amino]cyclohexyl]-3,3~{a},4,6,7,7~{a}-hexahydropyrrolo[3,2-c]pyridin-2-one | Human | 8707 | |
| IRAK4 | IRAK | TKL | 6rfj | A | | methyl 4-[4-[[6-(cyanomethyl)-2-[(1-methylpyrazol-4-yl)amino]pyrido[3,2-d]pyrimidin-4-yl]amino]cyclohexyl]piperazine-1-carboxylate | Human | 11786 | |
| IRAK4 | IRAK | TKL | 2nru | C | B | 1-(3-hydroxypropyl)-2-[(3-nitrobenzoyl)amino]-1h-benzimidazol-5-yl pivalate | Human | 1771 | |
| IRAK4 | IRAK | TKL | 4yo6 | D | B | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1788 | |
| IRAK4 | IRAK | TKL | 4yo6 | D | A | n-(3-methyl-1-phenyl-1h-pyrazol-5-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide | Human | 1768 | |
| IRAK4 | IRAK | TKL | 7c2w | C | A | - | Human | 13002 | |
| IRAK4 | IRAK | TKL | 6ega | A | A | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-n-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 10908 | |
| IRAK4 | IRAK | TKL | 6thw | B | | 7-fluoranyl-4-(1-methylcyclopropyl)oxy-~{n}-[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]-6-(2-methylpyrimidin-5-yl)pyrido[3,2-d]pyrimidin-2-amine | Human | 12956 | |
| IRAK4 | IRAK | TKL | 4ztn | C | A | 5-(1,3-benzothiazol-2-yl)-2-(morpholin-4-yl)-6-[(3r)-piperidin-3-ylamino]pyrimidin-4(3h)-one | Human | 6008 | |
| IRAK4 | IRAK | TKL | 6ti8 | D | A | ~{n},~{n}-dimethyl-4-(1-methylcyclopropyl)oxy-2-[[1-(1-methylpiperidin-4-yl)pyrazol-4-yl]amino]pyrido[3,2-d]pyrimidine-6-carboxamide | Human | 12957 | |
| IRAK4 | IRAK | TKL | 6f3e | A | | 2-[(3~{r})-12-(4-morpholin-4-ylcyclohexyl)oxy-7-thia-9,11-diazatricyclo[6.4.0.0^{2,6}]dodeca-1(8),2(6),9,11-tetraen-3-yl]ethanamide | Human | 9923 | |
| ILK | MLK | TKL | 6mib | A | | - | Human | 10687 | |
| ILK | MLK | TKL | 3kmw | A | | adenosine-5'-triphosphate | Human | 4605 | |
| KSR1 | RAF | TKL | 7jv0 | A | | - | Human | 12848 | |
| KSR1 | RAF | TKL | 7juy | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12920 | |
| KSR1 | RAF | TKL | 7jux | A | | phosphoaminophosphonic acid-adenylate ester | Human | 14018 | |
| KSR1 | RAF | TKL | 7juw | B | | phosphoaminophosphonic acid-adenylate ester | Human | 12855 | |
| KSR1 | RAF | TKL | 7juz | A | | - | Human | 12856 | |
| LIMK1 | LISK | TKL | 5nxc | L | | (2~{r})-2-azanyl-2-cyclohexyl-~{n}-[2-(1-methylpyrazol-4-yl)-9-oxidanylidene-3,10,11-triazatricyclo[6.4.1.0^{4,13}]trideca-1,4,6,8(13),11-pentaen-6-yl]ethanamide | Human | 7592 | |
| LIMK1 | LISK | TKL | 3s95 | A | A | staurosporine | Human | 1246 | |
| LIMK1 | LISK | TKL | 3s95 | A | B | staurosporine | Human | 1248 | |
| LIMK1 | LISK | TKL | 5hvj | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 6599 | |
| LIMK1 | LISK | TKL | 5l6w | L | | phosphothiophosphoric acid-adenylate ester | Human | 6668 | |
| LIMK1 | LISK | TKL | 5hvk | C | | phosphoaminophosphonic acid-adenylate ester | Human | 6596 | |
| LIMK1 | LISK | TKL | 5hvj | B | B | - | Human | 6595 | |
| LIMK1 | LISK | TKL | 7ats | A | | n-[3-[5-(4-chlorophenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]benzenesulfonamide | Human | 13164 | |
| LIMK1 | LISK | TKL | 5hvj | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 6598 | |
| LIMK1 | LISK | TKL | 3s95 | B | B | staurosporine | Human | 1247 | |
| LIMK1 | LISK | TKL | 5hvk | A | | phosphoaminophosphonic acid-adenylate ester | Human | 6600 | |
| LIMK1 | LISK | TKL | 5hvj | B | A | - | Human | 6597 | |
| LIMK1 | LISK | TKL | 7atu | A | | (s)-2-benzyl-6-(8-chloro-5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]oxazepin-3-yl)-7-oxo-4,5,6,7-tetrahydro-2h-pyrazolo[3,4-c]pyridine-3-carboxamide | Human | 14019 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qik | A | B | n-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1h-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10662 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qim | A | B | n-{4-[3-(5-methoxypyridin-2-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10661 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1ias | A | | - | Human | 2113 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5fri | A | A | n-[4-[(6-chloro-[1,3]dioxolo[4,5-b]pyridin-7-yl)amino]-2-pyridyl]cyclopropanecarboxamide | Human | 6894 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2x7o | D | | (3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide | Human | 2107 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qtz | A | A | 6-[1-(2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1h-imidazol-5-yl]imidazo[1,2-a]pyridine | Human | 11965 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2f | A | B | 4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8h)-one | Human | 6208 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1vjy | A | | 2-[5-(6-methylpyridin-2-yl)-2,3-dihydro-1h-pyrazol-4-yl]-1,5-naphthyridine | Human | 2096 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8s | A | A | - | Human | 6619 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5usq | A | A | n-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2h-pyrazolo[4,3-b]pyridin-7-amine | Human | 7558 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qil | A | B | n-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10660 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x0m | A | B | 4-aminopyrido[2,3-d]pyrimidin-5(8h)-one | Human | 2121 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2n | A | B | - | Human | 2109 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8z | A | B | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | Human | 6612 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1py5 | A | | 4-(3-pyridin-2-yl-1h-pyrazol-4-yl)quinoline | Human | 2094 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3hmm | A | | 2-(6-methylpyridin-2-yl)-n-pyridin-4-ylquinazolin-4-amine | Human | 2111 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1ias | C | | - | Human | 2117 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8t | A | B | - | Human | 6613 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2wot | A | B | 4-[(5,6-dimethyl-2,2'-bipyridin-3-yl)oxy]-n-(3,4,5-trimethoxyphenyl)pyridin-2-amine | Human | 2092 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3faa | B | | n-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1h-imidazol-2-yl]acetamide | Human | 2108 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5usq | A | B | n-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2h-pyrazolo[4,3-b]pyridin-7-amine | Human | 7557 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1ias | B | | - | Human | 2102 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3gxl | A | | n-1h-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine | Human | 2116 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2f | A | A | 4-amino-8-(4-aminophenyl)pyrido[2,3-d]pyrimidin-5(8h)-one | Human | 6207 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 6b8y | A | B | n-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7h-pyrrolo[2,3-d]pyrimidin-4-amine | Human | 9552 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3kcf | E | | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3h-pyrazol-3-one | Human | 2105 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2n | A | A | - | Human | 2129 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8w | A | B | staurosporine | Human | 6614 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3kcf | A | | 4-[3-(methoxymethyl)phenyl]-1,2-dimethyl-5-quinoxalin-6-yl-1,2-dihydro-3h-pyrazol-3-one | Human | 2112 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5qtz | A | B | 6-[1-(2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1h-imidazol-5-yl]imidazo[1,2-a]pyridine | Human | 11966 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1b6c | B | | - | Human | 2133 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x0m | A | A | 4-aminopyrido[2,3-d]pyrimidin-5(8h)-one | Human | 2122 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 3faa | A | | n-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1h-imidazol-2-yl]acetamide | Human | 2118 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2x7o | B | | (3z)-n-ethyl-n-methyl-2-oxo-3-(phenyl{[4-(piperidin-1-ylmethyl)phenyl]amino}methylidene)-2,3-dihydro-1h-indole-6-carboxamide | Human | 2128 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 4x2k | A | B | 4-[(3-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6h)-one | Human | 2101 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 2wot | A | A | 4-[(5,6-dimethyl-2,2'-bipyridin-3-yl)oxy]-n-(3,4,5-trimethoxyphenyl)pyridin-2-amine | Human | 2120 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 9f6x | A | | 2-[5-(1,3-benzodioxol-5-yl)-2-~{tert}-butyl-1~{h}-imidazol-4-yl]-6-methyl-pyridine | Human | 16116 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 5e8x | A | A | staurosporine | Human | 6615 | |
| TGFBR1 (TGFbR1) | STKR | TKL | 1b6c | H | | - | Human | 2099 | |
| MAP3K12 (DLK) | MLK | TKL | 5cep | A | B | n-(5-piperidin-4-yl-1-propan-2-yl-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine | Human | 6154 | |
| MAP3K12 (DLK) | MLK | TKL | 5cen | A | A | - | Human | 6157 | |
| MAP3K12 (DLK) | MLK | TKL | 5ceq | A | A | 2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Human | 6159 | |
| MAP3K12 (DLK) | MLK | TKL | 5cep | A | A | n-(5-piperidin-4-yl-1-propan-2-yl-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine | Human | 6158 | |
| MAP3K12 (DLK) | MLK | TKL | 5ceo | A | A | 2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Human | 6156 | |
| MAP3K12 (DLK) | MLK | TKL | 5ceq | A | B | 2-[[1-cyclopentyl-5-[1-(oxetan-3-yl)piperidin-4-yl]pyrazol-3-yl]amino]pyridine-4-carbonitrile | Human | 6153 | |
| MAP3K12 (DLK) | MLK | TKL | 5cen | A | B | - | Human | 6160 | |
| MAP3K12 (DLK) | MLK | TKL | 5vo2 | A | B | 5-{5-[1-(oxetan-3-yl)piperidin-4-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine | Human | 8542 | |
| MAP3K12 (DLK) | MLK | TKL | 8ous | A | A | (1s)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-ol | Human | 14857 | |
| MAP3K12 (DLK) | MLK | TKL | 5vo1 | A | B | 5-{5-[(1r,5s,6r)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine | Human | 8541 | |
| MAP3K12 (DLK) | MLK | TKL | 5vo1 | A | A | 5-{5-[(1r,5s,6r)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1h-pyrazol-3-yl}-3-(trifluoromethyl)pyridin-2-amine | Human | 8540 | |
| MAP3K12 (DLK) | MLK | TKL | 5ceo | A | B | 2-[[6-[3,3-bis(fluoranyl)pyrrolidin-1-yl]-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile | Human | 6155 | |
| RIPK3 | RIPK | TKL | 7mx3 | A | | 3-(1,3-benzothiazol-5-yl)-7-(1,3-dimethyl-1h-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine | Human | 13995 | |
| TNNI3K (HH498) | MLK | TKL | 4yff | A | B | 3-[(5-bromo-7h-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-n-methyl-4-(morpholin-4-yl)benzenesulfonamide | Human | 6062 | |
| BRAF | RAF | TKL | 4mne | C | B | - | Human | 3058 | |
| BRAF | RAF | TKL | 4h58 | A | A | n-(4-{[(2-methoxyethyl)amino]methyl}phenyl)-6-(pyridin-4-yl)quinazolin-2-amine | Human | 3137 | |
| BRAF | RAF | TKL | 4mne | B | B | - | Human | 3061 | |
| BRAF | RAF | TKL | 6q0k | B | | - | Human | 11710 | |
| BRAF | RAF | TKL | 4jvg | C | | 1-(5-tert-butyl-2-p-tolyl-2h-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea | Human | 3050 | |
| BRAF | RAF | TKL | 9ecu | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 16206 | |
| BRAF | RAF | TKL | 5vam | B | A | n-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide | Human | 8186 | |
| BRAF | RAF | TKL | 8vyu | A | | (3s)-n-{3-[5-(2-cyclopropylpyrimidin-5-yl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}-3-fluoropyrrolidine-1-sulfonamide | Human | 16207 | |
| BRAF | RAF | TKL | 3pri | A | | 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-ol | Human | 3093 | |
| BRAF | RAF | TKL | 3ppk | A | | 3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide | Human | 3106 | |
| BRAF | RAF | TKL | 7mfd | A | | - | Human | 14077 | |
| BRAF | RAF | TKL | 8vyr | A | | - | Human | 16208 | |
| BRAF | RAF | TKL | 4xv2 | A | | dabrafenib | Human | 6213 | |
| BRAF | RAF | TKL | 6q0j | B | B | - | Human | 11712 | |
| BRAF | RAF | TKL | 5jsm | D | A | - | Human | 7055 | |
| BRAF | RAF | TKL | 6q0t | B | A | - | Human | 11702 | |
| BRAF | RAF | TKL | 5ct7 | A | | 1-methyl-5-({2-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-4-yl}oxy)-n-[4-(trifluoromethyl)phenyl]-1h-benzimidazol-2-amine | Human | 6032 | |
| BRAF | RAF | TKL | 4fk3 | B | | - | Human | 3068 | |
| BRAF | RAF | TKL | 8vyp | C | | phosphothiophosphoric acid-adenylate ester | Human | 16209 | |
| BRAF | RAF | TKL | 4h58 | C | B | - | Human | 3114 | |
| BRAF | RAF | TKL | 3pri | B | | 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1h-indazol-3-yl)propan-1-ol | Human | 3103 | |
| BRAF | RAF | TKL | 9rts | B | A | adenosine-5'-diphosphate | Human | 16212 | |
| BRAF | RAF | TKL | 4g9r | A | | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 3130 | |
| BRAF | RAF | TKL | 7m0x | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 13523 | |
| BRAF | RAF | TKL | 4dbn | B | | 2-chloro-3-(1-cyanocyclopropyl)-n-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide | Human | 3070 | |
| BRAF | RAF | TKL | 4cqe | A | | n-{4-[2-(1-cyclopropylpiperidin-4-yl)-4-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide | Human | 3088 | |
| BRAF | RAF | TKL | 6xag | D | A | - | Human | 12921 | |
| BRAF | RAF | TKL | 5val | A | | n-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide | Human | 8190 | |
| BRAF | RAF | TKL | 9ecu | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 16213 | |
| BRAF | RAF | TKL | 5hie | B | B | dabrafenib | Human | 6505 | |
| BRAF | RAF | TKL | 7m0x | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 13524 | |
| BRAF | RAF | TKL | 8vyo | A | | - | Human | 16214 | |
| BRAF | RAF | TKL | 6n0p | B | A | n-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide | Human | 11594 | |
| BRAF | RAF | TKL | 4e26 | A | | 5-chloro-7-[(r)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol | Human | 3108 | |
| BRAF | RAF | TKL | 6uuo | A | | 1-[4-{[1-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorophenyl)-3-(pyrimidin-5-yl)-1h-pyrrolo[3,2-b]pyridin-5-yl](methyl)amino}pyridin-1(4h)-yl]ethan-1-one | Human | 12347 | |
| BRAF | RAF | TKL | 4xv2 | B | | dabrafenib | Human | 6219 | |
| BRAF | RAF | TKL | 5hid | B | A | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 6511 | |
| BRAF | RAF | TKL | 4mne | F | B | - | Human | 3117 | |
| BRAF | RAF | TKL | 6q0j | A | B | - | Human | 11701 | |
| BRAF | RAF | TKL | 4ehe | A | | 4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide | Human | 3112 | |
| BRAF | RAF | TKL | 5jt2 | D | | - | Human | 7066 | |
| BRAF | RAF | TKL | 6b8u | B | | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8678 | |
| BRAF | RAF | TKL | 3prf | A | | 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol | Human | 3129 | |
| BRAF | RAF | TKL | 6b8u | A | | ~{n}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide | Human | 8679 | |
| BRAF | RAF | TKL | 4r5y | A | | 5-({(1r,1as,6br)-1-[5-(trifluoromethyl)-1h-benzimidazol-2-yl]-1a,6b-dihydro-1h-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1h)-one | Human | 6414 | |
| BRAF | RAF | TKL | 6p3d | A | | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-n-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide | Human | 12809 | |
| BRAF | RAF | TKL | 6p7g | A | | 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-n-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide | Human | 12810 | |
| BRAF | RAF | TKL | 3d4q | B | | (1e)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1h-pyrazol-4-yl)-2,3-dihydro-1h-inden-1-one oxime | Human | 3060 | |
| BRAF | RAF | TKL | 4xv9 | A | B | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide | Human | 6215 | |
| BRAF | RAF | TKL | 13du | A | | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 16216 | |
| BRAF | RAF | TKL | 3tv6 | B | | 2,6-difluoro-n-(3-methoxy-2h-pyrazolo[3,4-b]pyridin-5-yl)-3-[(propylsulfonyl)amino]benzamide | Human | 3136 | |
| BRAF | RAF | TKL | 3ppj | A | | methyl 3-{[(5s)-1-(hydroxyamino)-5h-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate | Human | 3091 | |
| BRAF | RAF | TKL | 5hie | A | B | dabrafenib | Human | 6508 | |
| BRAF | RAF | TKL | 5jsm | A | B | - | Human | 7058 | |
| BRAF | RAF | TKL | 6uan | B | | - | Human | 11641 | |
| BRAF | RAF | TKL | 9rtq | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 16217 | |
| BRAF | RAF | TKL | 13dv | A | | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 16218 | |
| BRAF | RAF | TKL | 6v2u | A | | dabrafenib | Human | 13034 | |
| BRAF | RAF | TKL | 3q96 | B | | (2s)-n-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)phenyl]-7-[(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-4-yl)oxy]-1,2,3,4-tetrahydronaphthalene-2-carboxamide | Human | 3089 | |
| BRAF | RAF | TKL | 7m0u | A | | phosphoaminophosphonic acid-adenylate ester | Human | 13527 | |
| BRAF | RAF | TKL | 5jt2 | C | | 2,2'-oxybis[n-({4-[3-(3-{[dihydroxy(propyl)-lambda~4~-sulfanyl]amino}-2,6-difluorobenzene-1-carbonyl)-1h-pyrrolo[2,3-b]pyridin-5-yl]phenyl}methyl)acetamide] | Human | 7064 | |
| BRAF | RAF | TKL | 5c9c | A | B | 1-(3,3-dimethylbutyl)-3-{2-fluoro-4-methyl-5-[7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl]phenyl}urea | Human | 3074 | |
| BRAF | RAF | TKL | 3skc | B | | 2,6-difluoro-n-[(5s)-3-methoxy-5h-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide | Human | 3128 | |
| BRAF | RAF | TKL | 4mbj | B | | 2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide | Human | 3057 | |
| BRAF | RAF | TKL | 4mnf | A | B | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 3141 | |
| BRAF | RAF | TKL | 3psb | A | | ethyl 3-{[1-(hydroxyamino)-2h-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate | Human | 3111 | |
| BRAF | RAF | TKL | 6nyb | A | | phosphothiophosphoric acid-adenylate ester | Human | 11708 | |
| BRAF | RAF | TKL | 6q0t | A | B | - | Human | 11707 | |
| BRAF | RAF | TKL | 3c4c | B | | n-{3-[(5-chloro-1h-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide | Human | 3063 | |
| BRAF | RAF | TKL | 6q0t | A | A | - | Human | 11705 | |
| BRAF | RAF | TKL | 4ehe | B | | 4-amino-n-{2,6-difluoro-3-[(propylsulfonyl)amino]phenyl}thieno[3,2-d]pyrimidine-7-carboxamide | Human | 3082 | |
| BRAF | RAF | TKL | 6q0k | A | | - | Human | 11706 | |
| BRAF | RAF | TKL | 3ppk | B | | 3-[(5-hydroxynaphthalen-2-yl)amino]-n-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide | Human | 3092 | |
| BRAF | RAF | TKL | 4g9r | B | | 3-(2-cyanopropan-2-yl)-n-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | Human | 3101 | |
| BRAF | RAF | TKL | 4ehg | B | | n-{2,4-difluoro-3-[({6-[(2-hydroxyethyl)amino]pyrimidin-4-yl}carbamoyl)amino]phenyl}propane-1-sulfonamide | Human | 3078 | |
| BRAF | RAF | TKL | 4mbj | A | | 2,6-difluoro-n-(1h-imidazo[4,5-b]pyridin-6-yl)-3-[(propylsulfonyl)amino]benzamide | Human | 3090 | |
| BRAF | RAF | TKL | 4mnf | A | A | 2-{4-[(1e)-1-(hydroxyimino)-2,3-dihydro-1h-inden-5-yl]-3-(pyridin-4-yl)-1h-pyrazol-1-yl}ethanol | Human | 3096 | |
| BRAF | RAF | TKL | 4ksp | B | | n-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]acetyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide | Human | 3066 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e92 | A | B | phosphoaminophosphonic acid-adenylate ester | Human | 6623 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5qin | A | B | n-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10663 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e8v | A | A | - | Human | 6626 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e92 | A | A | phosphoaminophosphonic acid-adenylate ester | Human | 6624 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e8y | A | | staurosporine | Human | 6627 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5qin | A | A | n-{4-[3-(6-methoxypyridin-3-yl)-1h-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide | Human | 10664 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 5e91 | A | | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-n-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | Human | 6625 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 7dv6 | A | B | 5-[(3s)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine | Human | 13628 | |
| TGFBR2 (TGFbR2) | STKR | TKL | 7dv6 | A | A | 5-[(3s)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine | Human | 13629 | |
