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Search results (51 entries covering 33 PDB structures)

#KinaseFamilyGroupPDBChain(Alternate) Model Orthosteric ligandOrganismDetails File
CDK8CDKCMGC6qtjA~{n},~{n}-dimethyl-2-[4-[4-(2,6-naphthyridin-4-yl)phenyl]pyrazol-1-yl]ethanamideHuman12093
CDK8CDKCMGC5hvyABn-{(3s)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-n'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}ureaHuman6552
CDK8CDKCMGC4f7jAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)ureaHuman3842
CDK8CDKCMGC5hnbAB[6-hydroxy-3-(3-methylbenzyl)-1h-indazol-5-yl][(3s)-3-hydroxypyrrolidin-1-yl]methanoneHuman6563
CDK8CDKCMGC5fgkAB8-[3-(3-azanyl-2~{h}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneHuman6388
CDK8CDKCMGC4f70A1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl)ethyl]ureaHuman3852
CDK8CDKCMGC5xqxAn-methyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamideHuman8313
CDK8CDKCMGC6tpaA1-[4-chloranyl-3-(trifluoromethyl)phenyl]-3-(5-oxidanylidene-6-pyridin-4-yl-pyrido[2,3-b][1,5]benzoxazepin-9-yl)ureaHuman13160
CDK8CDKCMGC5xs2AB3-chloranyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamideHuman8314
CDK8CDKCMGC4crlAcortistatin aHuman6096
CDK8CDKCMGC4g6lA-Human3851
CDK8CDKCMGC5idpAA(3-amino-1h-indazol-5-yl)[(2s)-2-(4-fluorophenyl)piperidin-1-yl]methanoneHuman7317
CDK8CDKCMGC5fgkAA8-[3-(3-azanyl-2~{h}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneHuman6391
CDK8CDKCMGC6r3sAB6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamideHuman12141
CDK8CDKCMGC5hvyAAn-{(3s)-1-[2-(methylamino)pyrimidin-4-yl]pyrrolidin-3-yl}-n'-{4-[(morpholin-4-yl)methyl]-3-(trifluoromethyl)phenyl}ureaHuman6553
CDK8CDKCMGC5hbjAA8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneHuman6390
CDK8CDKCMGC4f6uAA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]ureaHuman3849
CDK8CDKCMGC4f7jAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl)ureaHuman3843
CDK8CDKCMGC4f7sABn-(2-phenylethyl)quinazolin-4-amineHuman3853
CDK8CDKCMGC5bnjA8-{3-chloro-5-[4-(1-methyl-1h-pyrazol-4-yl)phenyl]pyridin-4-yl}-2,8-diazaspiro[4.5]decan-1-oneHuman6152
CDK8CDKCMGC3rgfAA4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3841
CDK8CDKCMGC5hnbAA[6-hydroxy-3-(3-methylbenzyl)-1h-indazol-5-yl][(3s)-3-hydroxypyrrolidin-1-yl]methanoneHuman6562
CDK8CDKCMGC6qtgA2-[4-(4-isoquinolin-4-ylphenyl)pyrazol-1-yl]-~{n},~{n}-dimethyl-ethanamideHuman12094
CDK8CDKCMGC4f7nA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5-hydroxypentyl)ureaHuman3847
CDK8CDKCMGC5i5zAn-methyl-8-(1-methyl-2,2-dioxo-2,3-dihydro-1h-2lambda~6~,1-benzothiazol-5-yl)-1,6-naphthyridine-2-carboxamideHuman6536
CDK8CDKCMGC5idnAA[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)methanoneHuman7322
CDK8CDKCMGC5hbhA5-[5-chloranyl-4-[1-(2-methoxyethyl)-1,8-diazaspiro[4.5]decan-8-yl]pyridin-3-yl]-1-methyl-3~{h}-2,1-benzothiazole 2,2-dioxideHuman6387
CDK8CDKCMGC5icpAB[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanoneHuman7321
CDK8CDKCMGC6y0aAA6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamideHuman13306
CDK8CDKCMGC5hbeAA8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{h}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneHuman6389
CDK8CDKCMGC4f6sA1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]ureaHuman3848
CDK8CDKCMGC3rgfAB4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamideHuman3846
CDK8CDKCMGC5ceiAB4-(4-iodophenoxy)-n-methylthieno[2,3-c]pyridine-2-carboxamideHuman6403
CDK8CDKCMGC4f6wAn-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine-1-carboxamideHuman3845
CDK8CDKCMGC4f7lAtert-butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)propyl]carbamateHuman3840
CDK8CDKCMGC4f6uAB1-[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl)propyl]ureaHuman3844
CDK8CDKCMGC6t41A~{n}-[(4-chlorophenyl)methyl]quinazolin-4-amineHuman11908
CDK8CDKCMGC5idpAB(3-amino-1h-indazol-5-yl)[(2s)-2-(4-fluorophenyl)piperidin-1-yl]methanoneHuman7320
CDK8CDKCMGC5icpAA[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](5-methylimidazo[5,1-b][1,3,4]thiadiazol-2-yl)methanoneHuman7318
CDK8CDKCMGC8tqcCB-Human15963
CDK8CDKCMGC5xs2AA3-chloranyl-4-pyridin-4-yl-1h-pyrrole-2-carboxamideHuman8315
CDK8CDKCMGC8tq2CB-Human15964
CDK8CDKCMGC5idnAB[(2s)-2-(4-chlorophenyl)pyrrolidin-1-yl](3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)methanoneHuman7319
CDK8CDKCMGC5hbjAB8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-oneHuman6385
CDK8CDKCMGC6y0aAB6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamideHuman13305
CDK8CDKCMGC8tq2CA-Human15965
CDK8CDKCMGC8tqcCA-Human15966
CDK8CDKCMGC6r3sAA6-[5-chloranyl-4-[(1~{s})-1-oxidanylethyl]pyridin-3-yl]-3,4-dihydro-2~{h}-1,8-naphthyridine-1-carboxamideHuman12140
CDK8CDKCMGC5ceiAA4-(4-iodophenoxy)-n-methylthieno[2,3-c]pyridine-2-carboxamideHuman6404
CDK8CDKCMGC4f7sAAn-(2-phenylethyl)quinazolin-4-amineHuman3850
CDK8CDKCMGC5hbeAB8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{h}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-oneHuman6386
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